1. Brain Volume Predicts Behavioral and Psychological Symptoms in Alzheimer’s Disease
- Author
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Isabelle Rouch, Catherine Padovan, Romain Bouet, Olivier Moreaud, Philippe Robert, Zaza Makaroff, Jean-Michel Dorey, Denis Federico, Nawele Boublay, Alzheimer’s Disease Neuroimaging Initiative, Marie-Odile Barrellon, Pierre Krolak-Salmon, Isabelle Gallice, Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Centre Hospitalier Universitaire [Grenoble] (CHU)
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Orbital gyri ,Behavioral Symptoms ,Neuropsychological Tests ,Cohort Studies ,03 medical and health sciences ,[SCCO]Cognitive science ,0302 clinical medicine ,Physical medicine and rehabilitation ,Neuroimaging ,Alzheimer Disease ,Predictive Value of Tests ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,Anterior cingulate cortex ,ComputingMilieux_MISCELLANEOUS ,Aged ,Aged, 80 and over ,business.industry ,General Neuroscience ,Brain ,Cognition ,General Medicine ,medicine.disease ,Mental Status and Dementia Tests ,Magnetic Resonance Imaging ,Frontal Lobe ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,medicine.anatomical_structure ,Frontal lobe ,Brain size ,Disease Progression ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Background Behavioral and psychological symptoms of dementia (BPSD) are frequent and troublesome for patients and caregivers. Considering possible preventive approaches, a better understanding of underlying neural correlates of BPSD is crucial. Objective The aim is to assess whether brain regional volume predicts behavioral changes in mild AD. Methods This work took part from the PACO study, a multicenter and prospective study that included 252 patients with mild AD from 2009 to 2014. Fifty-three patients were retained. Forty healthy matched control subjects from the ADNI cohort were included as controls. Voxel-based morphometry analysis was conducted to assess regional brain volume using baseline MRI scans as a predictor of future behavioral changes over a period of 18 months. Behavior was assessed at baseline and longitudinally at 6-month intervals using the shortened form of the Neuropsychiatric Inventory (NPI). Results The volume of 23 brain structures in frontal, temporal, parietal, occipital, subcortical regions and cerebellum predicted the evolution of NPI scores. Frontal volume was the most powerful predictor with frontal gyri, anterior cingulate cortex, and orbital gyri being particularly involved. Conclusion To our knowledge, this is the first study assessing regional brain volumes as predictors of behavioral changes considered at earlier stages of AD. Up to 23 brain structures were associated with an increased risk of developing BPSD. Frontal lobe volume was the strongest predictor of future evolution of NPI. The involvement of multiple structures in the prediction of behavior suggests a role of the main large-scale networks involved in cognition.
- Published
- 2020
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