79 results on '"Maritza Dowling"'
Search Results
2. Emotional characteristics of socially isolated older adults with MCI using tablet administered NIH toolbox: I‐CONECT study
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Kexin Yu, Katherine Wild, N. Maritza Dowling, Jeffrey A. Kaye, Lisa C. Silbert, and Hiroko H. Dodge
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Psychiatry and Mental health ,Neurology (clinical) - Abstract
Examining the emotional functioning of individuals with mild cognitive impairment (MCI) could help describe their cognitive status and inform the development of interventions. This study compared the emotional characteristics of socially isolated older adults with and without MCI.We used baseline data from the Internet-based Conversational Engagement Clinical Trial. Emotional characteristics were assessed with the National Institutes of Health Toolbox Emotion Battery (NIHTB-EB). MCI status was determined with a consensus clinical diagnosis.This study included 163 participants (mean age = 81.2 years, non-Hispanic Black = 20.7%, MCI = 52.8%). MCI was associated with higher negative affect and lower psychological well-being. Non-Hispanic Black participants scored lower in sadness, higher in positive affect, and higher in meaning and purpose than non-Hispanic White participants.Older adults with MCI experience more negative emotions and worse psychological well-being than those with normal cognition. The NIHTB-EB appears to be a sensitive tool to detect emotional characteristics associated with cognitive decline.
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- 2022
3. Waist‐hip ratio as a moderator of the effects of hormone therapy on cognitive function in recently menopausal women
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Taryn T. James, N. Maritza Dowling, Carola A. Ferrer Simó, Megan Zuelsdorff, Shenikqua Bouges, Nickolas H. Lambrou, Carol A Van Hulle, Adrienne L. Johnson, Mary F. Wyman, Hector Salazar, Emre Umucu, Firat Kara, JoAnn E. Manson, Eliot A Brinton, Marcelle I. Cedars, Rogerio A. Lobo, Genevieve Neal‐Perry, Nanette F Santoro, Frederick Naftolin, Sherman M. Harman, Lubna Pal, Virginia M. Miller, Kejal Kantarci, and Carey E. Gleason
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
4. Higher systolic and diastolic blood pressures are associated with loss of white matter integrity in postmenopausal women of the KEEPS Continuation Study
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Firat Kara, Robert I. Reid, Christopher G. Schwarz, Nirubol Tosakulwong, Timothy G. Lesnick, Samantha M. Zuk, June Kendall‐Thomas, Kaely Thostenson, Denise A. Reyes, Julie A. Fields, Matthew L. Senjem, Hoon‐Ki Min, Val J. Lowe, Clifford R. Jack, Kent R. Bailey, Taryn T. James, Rogerio A. Lobo, JoAnn E. Manson, Lubna Pal, Dustin B. Hammers, Michael H. Malek‐Ahmadi, Marcelle I. Cedars, Frederick Naftolin, Virginia M. Miller, Sherman M. Harman, N. Maritza Dowling, Carey E. Gleason, and Kejal Kantarci
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
5. Comparison of Education and Episodic Memory as Modifiers of Brain Atrophy Effects on Cognitive Decline: Implications for Measuring Cognitive Reserve
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Dan M Mungas, David K. Johnson, Sarah E Tomaszewski Farias, Keith F. Widaman, Laura B. Zahodne, N. Maritza Dowling, Timothy J. Hohman, Elizabeth Rose Mayeda, Brandon E. Gavett, and Evan Fletcher
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Aging ,Brain atrophy ,Cognitive decline ,Neurodegenerative ,Alzheimer's Disease ,Medical and Health Sciences ,0302 clinical medicine ,Cognitive Reserve ,Episodic memory ,Cognitive reserve ,General Neuroscience ,05 social sciences ,Brain ,Cognition ,Experimental Psychology ,Psychiatry and Mental health ,Clinical Psychology ,Gray matter change ,Neurological ,Educational Status ,Mental health ,Psychology ,Episodic ,Clinical psychology ,MRI ,Memory, Episodic ,Gray (unit) ,Article ,050105 experimental psychology ,Education ,03 medical and health sciences ,Atrophy ,Cognitive change ,Memory ,Clinical Research ,Behavioral and Social Science ,medicine ,Acquired Cognitive Impairment ,Humans ,0501 psychology and cognitive sciences ,Cognitive Dysfunction ,Aged ,Psychology and Cognitive Sciences ,Neurosciences ,Construct validity ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,medicine.disease ,Brain Disorders ,Quality Education ,cognitive change ,Dementia ,Neurology (clinical) ,030217 neurology & neurosurgery - Abstract
Objective:This study compared the level of education and tests from multiple cognitive domains as proxies for cognitive reserve.Method:The participants were educationally, ethnically, and cognitively diverse older adults enrolled in a longitudinal aging study. We examined independent and interactive effects of education, baseline cognitive scores, and MRI measures of cortical gray matter change on longitudinal cognitive change.Results:Baseline episodic memory was related to cognitive decline independent of brain and demographic variables and moderated (weakened) the impact of gray matter change. Education moderated (strengthened) the gray matter change effect. Non-memory cognitive measures did not incrementally explain cognitive decline or moderate gray matter change effects.Conclusions:Episodic memory showed strong construct validity as a measure of cognitive reserve. Education effects on cognitive decline were dependent upon the rate of atrophy, indicating education effectively measures cognitive reserve only when atrophy rate is low. Results indicate that episodic memory has clinical utility as a predictor of future cognitive decline and better represents the neural basis of cognitive reserve than other cognitive abilities or static proxies like education.
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- 2021
6. Estimation of dementia prevalence at the local level in the United States
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Erin E. Bennett, Abraham Kwan, Kan Z. Gianattasio, Brittany Engelman, N. Maritza Dowling, and Melinda C. Power
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prevalence ,RC952-954.6 ,Alzheimer's disease ,Psychiatry and Mental health ,needs assessment ,Geriatrics ,mental disorders ,surveillance ,Neurology (clinical) ,Neurology. Diseases of the nervous system ,RC346-429 ,Research Articles ,Research Article ,dementia - Abstract
Introduction Ensuring adequate and equitable distribution of resources to support persons living with dementia relies on understanding the burden and distribution of dementia in a population. Our goal was to develop an approach to estimate dementia prevalence at the local level in the United States using publicly available data. Methods Our approach combines publicly available data on dementia prevalence and demographic data from the US Census to estimate dementia prevalence. We illustrate this approach by estimating dementia prevalence in persons aged 65 and older in Philadelphia, PA; Chicago, IL; and Atlanta, GA. Results Overall, we estimate the prevalence of dementia among those 65 and older to be 11.9% in Philadelphia, 11.8% Chicago, and 12.3% in Atlanta. Estimates across Philadelphia localities vary from 9.3% to 15.9%. Discussion Our approach provides a cost‐effective method to generate estimates of dementia prevalence at the local level. HIGHLIGHTS Brain health needs assessments require understanding of local dementia prevalence. Our approach can be used to estimate dementia prevalence in individual communities. This information can inform decisions about distribution of resources.
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- 2021
7. Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease
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Christopher R. Nicholas, Lindsay R. Clark, Bruce P. Hermann, Rebecca L. Koscik, Sterling C. Johnson, Mark A. Sager, Sanjay Asthana, N. Maritza Dowling, Annie M. Racine, and Sara E. Berman
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Male ,Gerontology ,Aging ,Disease ,Article ,050105 experimental psychology ,Diagnostic Self Evaluation ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,medicine ,Humans ,Dementia ,Cognitive Dysfunction ,Genetic Predisposition to Disease ,0501 psychology and cognitive sciences ,Longitudinal Studies ,Family history ,Association (psychology) ,business.industry ,General Neuroscience ,05 social sciences ,Neuropsychology ,Cognition ,Middle Aged ,medicine.disease ,stomatognathic diseases ,Psychiatry and Mental health ,Clinical Psychology ,Female ,Neurology (clinical) ,Alzheimer's disease ,business ,030217 neurology & neurosurgery - Abstract
Objectives: The purpose of this study was to investigate the longitudinal trajectory of self- and informant-subjective cognitive complaints (SCC), and to determine if SCC predict longitudinal changes in objective measures (OM) of cognitive function. Methods: The study included healthy and cognitively normal late middle-aged adults enriched with a family history of AD who were evaluated at up to three visits over a 4-year period. At each visit (Visit 1–3), self- and informant-SCC and OM were evaluated. Linear mixed models were used to determine if the longitudinal rate of change of self- and informant-SCC were associated with demographic variables, depressive symptoms, family history (FH), and apolipoprotein epsilon 4 (APOE4) status. The same modeling approach was used to examine the effect of Visit 1 SCC on longitudinal cognitive change after controlling for the same variables. Results: At Visit 1, more self-SCC were associated with fewer years of education and more depressive symptoms. SCC were also associated with poorer performance on cognitive measures, such that more self-SCC at Visit 1 were associated with poorer performance on memory and executive functioning measures at Visit 1, while more informant-SCC were associated with faster rate of longitudinal decline on a measure of episodic learning and memory. FH and APOE4 status were not associated with SCC. Discussion: Self- and informant-SCC showed an association with OM, albeit over different time frames in our late middle-aged sample. Additional longitudinal follow-up will likely assist in further clarifying these relationships as our sample ages and more pronounced cognitive changes eventually emerge. (JINS, 2017, 23, 617–626)
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- 2017
8. Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts
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Allen D. Roses, Auriel A. Willette, Sterling C. Johnson, Bruce P. Hermann, Alexandra M.V. Wennberg, Rebecca L. Koscik, Michael W. Lutz, N. Maritza Dowling, Joseph L. Webb, Jennifer M. Oh, Sanjay Asthana, and Barbara B. Bendlin
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0301 basic medicine ,Gerontology ,Epidemiology ,Health Policy ,Physiology ,Cognition ,Disease ,Biology ,medicine.disease ,Outer mitochondrial membrane ,03 medical and health sciences ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,030104 developmental biology ,0302 clinical medicine ,Developmental Neuroscience ,Global function ,medicine ,Biomarker (medicine) ,Neurology (clinical) ,Geriatrics and Gerontology ,Alzheimer's disease ,Family history ,030217 neurology & neurosurgery ,Cohort study - Abstract
Introduction Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa ( TOMM40 ) rs10524523 (‘523) poly-T length on memory decline. Methods For 912 nonapolipoprotein e4 middle-aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 ‘523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed. Results For FH negative participants, gene-dose preservation of memory and global cognition was seen for "very long" versus "short" carriers. For FH positive, an opposite gene-dose decline was seen for very long versus short carriers. Maternal FH was a stronger predictor in aged, but not middle-aged, participants. Similar gene-dose effects were seen for the mitochondrial biomarker aspartate aminotransferase. Discussion These results may clarify conflicting findings on TOMM40 poly-T length and AD-related decline.
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- 2017
9. An approach for estimating item sensitivity to within-person change over time: An illustration using the Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS-Cog)
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Sien Deng, N. Maritza Dowling, and Daniel M. Bolt
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Male ,Psychometrics ,PsycINFO ,Neuropsychological Tests ,behavioral disciplines and activities ,Sensitivity and Specificity ,Article ,Developmental psychology ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,Alzheimer Disease ,medicine ,Humans ,Dementia ,Cognitive Dysfunction ,Longitudinal Studies ,030212 general & internal medicine ,Sensitivity (control systems) ,Cognitive decline ,skin and connective tissue diseases ,Aged ,Aged, 80 and over ,Models, Statistical ,Middle Aged ,medicine.disease ,Cognitive test ,Psychiatry and Mental health ,Clinical Psychology ,Female ,sense organs ,Alzheimer's disease ,Psychology ,030217 neurology & neurosurgery ,Cognitive psychology - Abstract
When assessments are primarily used to measure change over time, it is important to evaluate items according to their sensitivity to change, specifically. Items that demonstrate good sensitivity to between-person differences at baseline may not show good sensitivity to change over time, and vice versa. In this study, we applied a longitudinal factor model of change to a widely used cognitive test designed to assess global cognitive status in dementia, and contrasted the relative sensitivity of items to change. Statistically nested models were estimated introducing distinct latent factors related to initial status differences between test-takers and within-person latent change across successive time points of measurement. Models were estimated using all available longitudinal item-level data from the Alzheimer's Disease Assessment Scale-Cognitive subscale, including participants representing the full-spectrum of disease status who were enrolled in the multisite Alzheimer's Disease Neuroimaging Initiative. Five of the 13 Alzheimer's Disease Assessment Scale-Cognitive items demonstrated noticeably higher loadings with respect to sensitivity to change. Attending to performance change on only these 5 items yielded a clearer picture of cognitive decline more consistent with theoretical expectations in comparison to the full 13-item scale. Items that show good psychometric properties in cross-sectional studies are not necessarily the best items at measuring change over time, such as cognitive decline. Applications of the methodological approach described and illustrated in this study can advance our understanding regarding the types of items that best detect fine-grained early pathological changes in cognition. (PsycINFO Database Record
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- 2016
10. Arterial spin labeling reveals relationships between resting cerebral perfusion and motor learning in Parkinson’s Disease
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Amy Barzgari, Frances Thiesen, Alexandra Wey, Christopher R. Nicholas, Catherine L. Gallagher, Vincent Pozorski, Erika J. Starks, N. Maritza Dowling, Sterling C. Johnson, Ozioma C. Okonkwo, Jennifer M. Oh, and Jitka Sojkova
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Male ,Parkinson's disease ,Audiology ,Brain mapping ,Functional Laterality ,Behavioral Neuroscience ,0302 clinical medicine ,Thalamus ,Basal ganglia ,Image Processing, Computer-Assisted ,Medicine ,Motor skill ,Aged, 80 and over ,Cerebral Cortex ,Brain Mapping ,05 social sciences ,Brain ,Neurodegenerative Diseases ,Parkinson Disease ,Middle Aged ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Neurology ,Cerebral blood flow ,Cerebral cortex ,Cerebrovascular Circulation ,Female ,Motor learning ,psychological phenomena and processes ,medicine.medical_specialty ,Cognitive Neuroscience ,Movement ,Motor Activity ,050105 experimental psychology ,Article ,Fingers ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Cerebral perfusion pressure ,Aged ,Tomography, Emission-Computed, Single-Photon ,business.industry ,Electron Spin Resonance Spectroscopy ,medicine.disease ,nervous system ,Spin Labels ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Parkinson’s disease (PD) is an age-related neurodegenerative disease that produces changes in movement, cognition, sleep, and autonomic function. Motor learning involves acquisition of new motor skills through practice, and is affected by PD. The purpose of the present study was to evaluate regional differences in resting cerebral blood flow (rCBF), measured using arterial spin labeling (ASL) MRI, during a finger-typing task of motor skill acquisition in PD patients compared to age- and gender-matched controls. Voxel-wise multiple linear regression models were used to examine the relationship between rCBF and several task variables, including initial speed, proficiency gain, and accuracy. In these models, a task-by-disease group interaction term was included to investigate where the relationship between rCBF and task performance was influenced by PD. At baseline, perfusion was lower in PD subjects than controls in the right occipital cortex. The task-by-disease group interaction for initial speed was significantly related to rCBF (p
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- 2019
11. Common Sense Model Factors Affecting African Americans' Willingness to Consult a Healthcare Provider Regarding Symptoms of Mild Cognitive Impairment
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Wade Gunn, Susan Flowers Benton, Ashley Kaseroff, Carey E. Gleason, Dorothy F. Edwards, and N. Maritza Dowling
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Male ,Gerontology ,Cross-sectional study ,media_common.quotation_subject ,Article ,Statistics, Nonparametric ,Structural equation modeling ,03 medical and health sciences ,Wisconsin ,0302 clinical medicine ,Surveys and Questionnaires ,Perception ,mental disorders ,medicine ,Humans ,Dementia ,Cognitive Dysfunction ,030212 general & internal medicine ,Healthcare Disparities ,Aged ,media_common ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Memory Disorders ,Middle Aged ,Patient Acceptance of Health Care ,medicine.disease ,Anticipation ,Health equity ,Black or African American ,Psychiatry and Mental health ,Cross-Sectional Studies ,Harm ,Survey data collection ,Female ,Geriatrics and Gerontology ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objective Although at increased risk for developing dementia compared with white patients, older African Americans are diagnosed later in the course of dementia. Using the common sense model (CSM) of illness perception, we sought to clarify processes promoting timely diagnosis of mild cognitive impairment (MCI) for African American patients. Design, Setting, Participants In-person, cross-sectional survey data were obtained from 187 African American (mean age: 60.44 years). Data were collected at social and health-focused community events in three southern Wisconsin cities. Measurements The survey represented a compilation of published surveys querying CSM constructs focused on early detection of memory disorders, and willingness to discuss concerns about memory loss with healthcare providers. Derived CSM variables measuring perceived causes, consequences, and controllability of MCI were included in a structural equation model predicting the primary outcome: Willingness to discuss symptoms of MCI with a provider. Results Two CSM factors influenced willingness to discuss symptoms of MCI with providers: Anticipation of beneficial consequences and perception of low harm associated with an MCI diagnosis predicted participants' willingness to discuss concerns about cognitive changes. No association was found between perceived controllability and causes of MCI, and willingness to discuss symptoms with providers. Conclusions These data suggest that allaying concerns about the deleterious effects of a diagnosis, and raising awareness of potential benefits, couldinfluence an African American patient's willingness to discuss symptoms of MCI with a provider. The findings offer guidance to designers of culturally congruent MCI education materials, and healthcare providers caring for older African Americans.
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- 2016
12. Cerebrospinal Fluid Markers of Alzheimer’s Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer’s Disease
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Siobhan M. Hoscheidt, Kelsey E. Melah, Sanjay Asthana, Daniel J. Destiche, Mark A. Sager, Sharon Yuan-Fu Lu, N. Maritza Dowling, Howard A. Rowley, Nagesh Adluru, Sterling C. Johnson, Barbara B. Bendlin, Ozioma C. Okonkwo, Andrew L. Alexander, Kaj Blennow, Henrik Zetterberg, Lisa C. Bratzke, Carey E. Gleason, and Cynthia M. Carlsson
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Microglia ,Disease stages ,General Neuroscience ,General Medicine ,Disease ,Asymptomatic ,White matter microstructure ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Immune system ,Cerebrospinal fluid ,medicine ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,Neuroinflammation - Abstract
Background The immune response in Alzheimer’s disease (AD) involves activation of microglia which may remove β-amyloid. However, overproduction of inflammatory compounds may exacerbate neural damage in Alzheimer’s disease. AD pathology accumulates years before diagnosis, yet the extent to which neuroinflammation is involved in the earliest disease stages is unknown.
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- 2016
13. Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease
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Elizabeth A. Boots, Laura D. Ellingson, Dorothy F. Edwards, Dane B. Cook, Maritza Dowling, Jacob B. Lindheimer, Mark A. Sager, Rebecca L. Koscik, Jennifer M. Oh, Catherine L. Gallagher, Jacob D. Meyer, Sterling C. Johnson, Aaron J. Stegner, Ozioma C. Okonkwo, Howard A. Rowley, Stephanie A. Schultz, Cynthia M. Carlsson, Stephanie M. Van Riper, Ryan J. Dougherty, Bruce P. Hermann, Barbara B. Bendlin, and Sanjay Asthana
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0301 basic medicine ,Gerontology ,medicine.medical_specialty ,Family history ,Physical activity ,Medial temporal atrophy ,Neuroimaging ,Disease ,Temporal lobe ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Dementia ,Psychiatry ,RC346-429 ,Exercise ,Diagnostic Assessment & Prognosis ,RC952-954.6 ,Alzheimer's disease ,medicine.disease ,Psychiatry and Mental health ,030104 developmental biology ,Geriatrics ,APOE ε4 ,Neurology (clinical) ,Neurology. Diseases of the nervous system ,Psychology ,030217 neurology & neurosurgery - Abstract
Introduction Physical activity (PA) is associated with brain health in older adults. However, it is unknown whether the current physical activity recommendations (PAR) impart substantive benefit. The objective of this study was to compare temporal lobe volumes between older adults who met PAR and those who did not. Methods Ninety‐one enrollees from the Wisconsin Registry for Alzheimer's Prevention wore an accelerometer for seven consecutive days to quantify their PA behaviors and underwent a T‐1 anatomic magnetic resonance imaging scan. Participants were categorized as either having met PAR or not based on the US Department of Health and Human Services recommendations of 150 minutes of moderate‐to‐vigorous physical activity per week. Results Participants who met PAR possessed significantly greater inferior (η2P = .050) and anterior (η2P = .055) temporal lobe volumes compared with those who did not (P
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- 2016
14. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation
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Barbara B. Bendlin, Bradley T. Christian, Jennifer M. Oh, Annie M. Racine, Henrik Zetterberg, Catherine L. Gallagher, Christopher R. Nicholas, Lindsay R. Clark, Ansel T. Hillmer, N. Maritza Dowling, Todd E. Barnhart, Dhanabalan Murali, Kaj Blennow, Rebecca L. Koscik, Tobey J. Betthauser, Howard A. Rowley, Sanjay Asthana, Cynthia M. Carlsson, Sterling C. Johnson, and Ozioma C. Okonkwo
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0301 basic medicine ,Preclinical AD ,Pathology ,medicine.medical_specialty ,Amyloid ,YKL-40 ,PiB ,Disease ,CSF Biomarkers ,NFL ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,β amyloid ,Medicine ,Linear mixed-effects ,business.industry ,Aβ42 ,Biological parametric mapping ,Alzheimer's disease ,Psychiatry and Mental health ,030104 developmental biology ,PET ,Neurology (clinical) ,Tau ,Preclinical stage ,business ,030217 neurology & neurosurgery ,Biomarkers ,MCP-1 - Abstract
IntroductionBiomarkers are urgently needed for the critical yet understudied preclinical stage of Alzheimer's disease (AD).MethodsCerebrospinal fluid (CSF) collection, [C-11]Pittsburgh compound B (PiB) amyloid imaging, and magnetic resonance imaging were acquired in 104 cognitively healthy adults enriched with risk for sporadic AD. Image-derived cerebral β-amyloid (Aβ) burden, measured concurrently and longitudinally, was regressed on CSF measures of Aβ, neural injury, and inflammation, as well as ratios with Aβ42. Linear mixed-effects regression was used to model the effect of the CSF measures that predicted longitudinal brain amyloid accumulation on longitudinal cognitive decline, measured by memory test scores.ResultsAt baseline, Aβ42/Aβ40 and all CSF ratios to Aβ42 were associated with PiB binding in AD-vulnerable regions. Longitudinally, Aβ42/Aβ40 and ratios of total tau (t-tau), phosphorylated-tau (p-tau), neurofilament light protein, and monocyte chemoattractant protein-1 to Aβ42 were associated with increased Aβ deposition over 2 years, predominantly in lateral parietal and temporal cortex. However, these CSF ratios were not significantly associated with cognitive decline, and the effect seems to be largely driven by Aβ42 in the denominator.DiscussionThese results corroborate previous findings that t-tau/Aβ42 and p-tau/Aβ42 are the strongest candidate biomarkers during the preclinical time frame. They support a framework in which neural injury and amyloid deposition are likely occurring simultaneously. It may be that neurodegenerative processes influence progressive amyloid accumulation, even in the preclinical time frame. CSF biomarkers for nonspecific axonal injury and inflammation may provide more information at more advanced stages of the preclinical time course.
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- 2015
15. Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition
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Bruce P. Hermann, Barbara B. Bendlin, Catherine L. Gallagher, James H. Stein, Claudia E. Korcarz, Henrik Zetterberg, Bradley T. Christian, Jean Einerson, Jennifer M. Oh, Sanjay Asthana, Dorothy F. Edwards, Sterling C. Johnson, Stephanie A. Schultz, Ozioma C. Okonkwo, Maritza Dowling, Mark A. Sager, Cynthia M. Carlsson, Elizabeth A. Boots, Rebecca L. Koscik, Rodrigo P. Almeida, and Kaj Blennow
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Adult ,Male ,Oncology ,Amyloid ,medicine.medical_specialty ,Context (language use) ,Neuropsychological Tests ,Verbal learning ,Article ,Cohort Studies ,chemistry.chemical_compound ,Oxygen Consumption ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Aged ,Psychiatric Status Rating Scales ,Diminution ,Amyloid beta-Peptides ,Aniline Compounds ,General Neuroscience ,Neuropsychology ,Cardiorespiratory fitness ,Cognition ,Middle Aged ,Verbal Learning ,Peptide Fragments ,Thiazoles ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,chemistry ,Physical Fitness ,Positron-Emission Tomography ,Cohort ,Exercise Test ,Physical therapy ,Female ,Neurology (clinical) ,Cognition Disorders ,Pittsburgh compound B ,Psychology - Abstract
The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer’s disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer’s Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C Pittsburgh Compound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples, from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning & Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (ppJINS, 2015, 21, 841–850)
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- 2015
16. F2‐01‐03: AN UPDATE ON MENOPAUSAL HORMONE THERAPY TRIALS
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Maritza Dowling, Kelly N. Morgan, and Carey E. Gleason
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Oncology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,medicine ,Neurology (clinical) ,Menopausal hormone therapy ,Geriatrics and Gerontology ,business - Published
- 2018
17. P4‐305: IMPACT OF SIMVASTATIN ON CEREBRAL BLOOD FLOW, PULSATILITY INDEX, AND ALZHEIMER'S DISEASE BIOMARKERS: A CLINICAL TRIAL
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Sterling C. Johnson, Chuck Illingworth, Maritza Dowling, Carson Hoffman, Rick Chappell, Patrick A. Turski, Barbara B. Bendlin, Henrik Zettenberg, Natanya S. Russek, Sanjay Asthana, Cynthia M. Carlsson, Benjamin P. Austin, Yue Ma, Oliver Wieben, Jennifer M. Oh, Karen K. Lazar, Howard A. Rowley, Leonardo A. Rivera, Laura E. Jacobson, Carey E. Gleason, Kaj Blennow, Lindsay R. Clark, Sara E. Berman, and Hanna Blazel
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medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Alzheimer's disease biomarkers ,Pulsatility index ,Clinical trial ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Cerebral blood flow ,Simvastatin ,Internal medicine ,Cardiology ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,medicine.drug - Published
- 2018
18. O2‐03‐02: ASSOCIATION OF SLEEP QUALITY AND AMYLOID BURDEN WITH FUNCTIONAL ABILITY IN A SAMPLE OF VIETNAM VETERANS WITH PTSD AND TBI
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Robert T. Turner, Maritza Dowling, and Jeanne Geiger-Brown
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Sleep quality ,Epidemiology ,business.industry ,Health Policy ,Sample (statistics) ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Medicine ,Amyloid burden ,Neurology (clinical) ,Functional ability ,Geriatrics and Gerontology ,Association (psychology) ,business ,Clinical psychology - Published
- 2018
19. Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle‐age adults at risk of AD
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Stephanie A. Schultz, Sterling C. Johnson, Mark A. Sager, Jennifer M. Oh, Ozioma C. Okonkwo, Barbara B. Bendlin, Rebecca L. Koscik, Bruce P. Hermann, Asenath LaRue, Howard A. Rowley, N. Maritza Dowling, Sanjay Asthana, Catherine L. Gallagher, and Cynthia M. Carlsson
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Preclinical AD ,medicine.medical_specialty ,media_common.quotation_subject ,Cortical thinning ,Neuroimaging ,Subjective memory ,Disease ,lcsh:Geriatrics ,Audiology ,lcsh:RC346-429 ,Cortical thickness ,Cognition ,Perception ,medicine ,Effects of sleep deprivation on cognitive performance ,lcsh:Neurology. Diseases of the nervous system ,media_common ,Subjective memory complaints ,business.industry ,Middle age ,lcsh:RC952-954.6 ,Psychiatry and Mental health ,cardiovascular system ,Neurology (clinical) ,Artificial intelligence ,Psychology ,business - Abstract
Background Subjective memory complaints (SMCs) represent an individual's perception of subtle changes in memory in the absence of objective impairment in memory. However, it is not fully known whether persons with SMCs harbor brain alterations related to Alzheimer's disease (AD) or whether they indeed demonstrate poorer cognitive performance. Methods The participants were 261 middle‐age adults (mean age 54.30 years) enrolled in the Wisconsin Registry for Alzheimer's Prevention, a registry of cognitively normal adults at risk of AD. They answered a question pertaining to subjective memory, completed a comprehensive neuropsychological examination, and subsequently underwent a volumetric magnetic resonance imaging scan. Cortical thickness measurements were derived from 10 a priori regions of interest involved in AD. Analyses of covariance were conducted to investigate the group differences in cortical thickness and neuropsychological measures. Results Compared with individuals without SMCs, those with SMCs had significant cortical thinning in the entorhinal, fusiform, posterior cingulate, and inferior parietal cortices and significantly reduced amygdala volume. Similarly, those with SMCs had significantly lower test scores on measures of Immediate Memory, Verbal Learning & Memory, and Verbal Ability. Additional adjustment for depressive symptoms (which differed between the groups) attenuated only the findings for the entorhinal cortex (P = .061) and Verbal Ability (P = .076). Conclusion At‐risk, cognitively healthy individuals with SMCs exhibit cortical thinning in brain regions affected by AD and poorer performance on objective memory tests. These findings suggest that, in some individuals, SMCs might represent the earliest stages of AD.
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- 2015
20. [IC‐P‐066]: AD FAMILY HISTORY MODULATES EFFECTS OF TOMM40 ‘523’ POLY‐T ON MTL ATROPHY AND HYPOMETABOLISM IN PRECLINICAL AND AD COHORTS
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Barbara B. Bendlin, Maritza Dowling, Joseph L. Webb, Rebecca L. Koscik, Allen D. Roses, Michael W. Lutz, Jennifer M. Oh, Sanjay Asthana, Auriel A. Willette, Bruce P. Hermann, Sterling C. Johnson, and Alexandra M.V. Wennberg
- Subjects
Oncology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Atrophy ,Developmental Neuroscience ,Internal medicine ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Family history ,business - Published
- 2017
21. [O2–07–06]: CHANGES IN BRAIN STRUCTURE THREE YEARS AFTER THE END OF MENOPAUSAL HORMONE THERAPIES IN A RANDOMIZED CONTROLLED TRIAL
- Author
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Kent R. Bailey, Jeffrey L. Gunter, Nirubol Tosakulwong, Megan L. Settell, Virginia M. Miller, Maritza Dowling, Lynne T. Shuster, Clifford R. Jack, Matthew L. Senjem, Timothy G. Lesnick, Kejal Kantarci, Samantha M. Zuk, Carey E. Gleason, and Walter A. Rocca
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,law.invention ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Randomized controlled trial ,law ,Internal medicine ,Physical therapy ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Hormone - Published
- 2017
22. [P3–021]: THE ROLE OF CARDIOVASCULAR HEALTH IN MODERATING THE EFFECTS OF POSTMENOPAUSAL HORMONE THERAPY ON NEUROIMAGING OUTCOMES
- Author
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Samantha M. Zuk, Carey E. Gleason, Lynne T. Shuster, Jeffrey L. Gunter, Kent R. Bailey, Virginia M. Miller, Clifford R. Jack, Maritza Dowling, and Kejal Kantarci
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Cardiovascular health ,medicine.medical_treatment ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Neuroimaging ,medicine ,Neurology (clinical) ,Hormone therapy ,Geriatrics and Gerontology ,Intensive care medicine ,business ,Clinical psychology - Published
- 2017
23. Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease
- Author
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Asenath LaRue, Rebecca L. Koscik, Stephanie A. Schultz, Jennifer M. Oh, Jordan Larson, Sanjay Asthana, Catherine L. Gallagher, Maritza Dowling, Howard A. Rowley, Cynthia M. Carlsson, Bruce P. Hermann, Barbara B. Bendlin, Sterling C. Johnson, Ozioma C. Okonkwo, and Mark A. Sager
- Subjects
Male ,Risk ,Cognitive Neuroscience ,Prodromal Symptoms ,Neuropsychological Tests ,Verbal learning ,Article ,Developmental psychology ,Cohort Studies ,Behavioral Neuroscience ,Cellular and Molecular Neuroscience ,Cognition ,Neuroimaging ,Alzheimer Disease ,Image Processing, Computer-Assisted ,Humans ,Middle frontal gyrus ,Radiology, Nuclear Medicine and imaging ,Gray Matter ,Least-Squares Analysis ,Episodic memory ,Cognitive Behavioral Therapy ,Neuropsychology ,Brain ,Organ Size ,Middle Aged ,Magnetic Resonance Imaging ,Cognitive test ,Psychiatry and Mental health ,Neurology ,Posterior cingulate ,Female ,Neurology (clinical) ,Psychology ,human activities ,Clinical psychology - Abstract
This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer’s disease (AD). Three hundred twenty-nine cognitively normal, middle-aged adults (age range, 43.2–73.8 years) enrolled in the Wisconsin Registry for Alzheimer’s Prevention (WRAP) participated in this study. They reported their current engagement in cognitive activities using a modified version of the Cognitive Activity Scale (CAS), underwent a structural MRI scan, and completed a comprehensive cognitive battery. FreeSurfer was used to derive gray matter (GM) volumes from AD-related regions of interest (ROIs), and composite measures of episodic memory and executive function were obtained from the cognitive tests. Covariate-adjusted least squares analyses were used to examine the association between the Games item on the CAS (CAS-Games) and both GM volumes and cognitive composites. Higher scores on CAS-Games were associated with greater GM volumes in several ROIs including the hippocampus, posterior cingulate, anterior cingulate, and middle frontal gyrus. Similarly, CAS-Games scores were positively associated with scores on the Immediate Memory, Verbal Learning & Memory, and Speed & Flexibility domains. These findings were not modified by known risk factors for AD. In addition, the Total score on the CAS was not as sensitive as CAS-Games to the examined brain and cognitive measures. For some individuals, participation in cognitive activities pertinent to game playing may help prevent AD by preserving brain structures and cognitive functions vulnerable to AD pathophysiology.
- Published
- 2014
24. Chronotropic Response and Cognitive Function in a Cohort at Risk for Alzheimer's Disease
- Author
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Stephanie A. Schultz, Dane B. Cook, N. Maritza Dowling, Ryan J. Dougherty, Jennifer M. Oh, James H. Stein, Cynthia M. Carlsson, Dorothy F. Edwards, Jean Einerson, Claudia E. Korcarz, Sterling C. Johnson, Rebecca L. Koscik, Lena L. Law, Ozioma C. Okonkwo, Bruce P. Hermann, Mark A. Sager, Barbara B. Bendlin, Sanjay Asthana, Catherine L. Gallagher, and Elizabeth A. Boots
- Subjects
Adult ,Male ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Neuropsychological Tests ,Verbal learning ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Heart Rate ,Internal medicine ,medicine ,Humans ,Effects of sleep deprivation on cognitive performance ,Neuropsychological assessment ,Cognitive decline ,Exercise ,Aged ,Memory Disorders ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Cognition ,General Medicine ,Recovery of Function ,Middle Aged ,Verbal Learning ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Cohort ,Cardiology ,Regression Analysis ,Female ,Geriatrics and Gerontology ,Alzheimer's disease ,business ,Cognition Disorders ,030217 neurology & neurosurgery ,Clinical psychology ,Cohort study - Abstract
The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery- two indices of cardiovascular function within the context of a graded exercise test- with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimer's disease (AD). Ninety participants (age = 63.52±5.86 years; 65.6% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal & Learning Memory, Working Memory, and Speed & Flexibility. Regression analyses, adjusted for age, sex, and education, were used to examine the association between CR, HR recovery, and cognition. We found significant associations between CR and cognitive performance in the domains of Immediate Memory, Verbal Learning & Memory, and Speed & Flexibility. In contrast, HR recovery was not significantly associated with cognitive function. The association between CR and cognition persisted even after controlling for HR recovery. Together, these findings indicatethat, in a cognitively normal, late-middle-aged cohort, CR is a stronger correlate of cognitive performance than HR recovery. Overall, this study reinforces the idea that cardiovascular health plays an important role in cognitive function, specifically in a cohort at risk for AD; and that interventions that promote vascular health may be a viable pathway to preventing or slowing cognitive decline due to AD.
- Published
- 2016
25. CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer’s pathological cascade
- Author
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Hiroko H. Dodge, N. Maritza Dowling, Nikki H. Stricker, William J. Jagust, Elena A. Erosheva, and S. Duke Han
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Amyloid beta ,Cognitive Neuroscience ,Precuneus ,Hippocampus ,Sensitivity and Specificity ,Article ,Behavioral Neuroscience ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Atrophy ,Neuroimaging ,Alzheimer Disease ,Parietal Lobe ,mental disorders ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Aged, 80 and over ,Amyloid beta-Peptides ,biology ,Parietal lobe ,Reproducibility of Results ,Organ Size ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Peptide Fragments ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,Neurology ,biology.protein ,Female ,Neurology (clinical) ,Alzheimer's disease ,Psychology ,Neuroscience ,Biomarkers ,Alzheimer's Disease Neuroimaging Initiative - Abstract
Neurofibrillary tangles (NFT) and amyloid plaques are hallmark neuropathological features of Alzheimer's disease (AD). There is some debate as to which neuropathological feature comes first in the disease process, with early autopsy studies suggesting that NFT develop first, and more recent neuroimaging studies supporting the early role of amyloid beta (Aβ) deposition. Cerebrospinal fluid (CSF) biomarkers of Aβ₄₂ and hyperphosphorylated tau (p-tau) have been shown to serve as in vivo proxy measures of amyloid plaques and NFT, respectively. The aim of this study was to examine the association between CSF biomarkers and rate of atrophy in the precuneus and hippocampus. These regions were selected because the precuneus appears to be affected early and severely by Aβ deposition, and the hippocampus similarly by NFT pathology. We predicted (1) baseline Aβ₄₂ would be related to accelerated rate of cortical thinning in the precuneus and volume loss in the hippocampus, with the latter relationship expected to be weaker, (2) baseline p-tau(181p) would be related to accelerated rate of hippocampal atrophy and cortical thinning in the precuneus, with the latter relationship expected to be weaker. Using all ADNI cohorts, we fitted separate linear mixed-effects models for changes in hippocampus and precuneus longitudinal outcome measures with baseline CSF biomarkers modeled as predictors. Results partially supported our hypotheses: Both baseline p-tau(181p) and Aβ₄₂ were associated with hippocampal atrophy over time. Neither p-tau(181p) nor Aβ₄₂ were significantly related to cortical thinning in the precuneus over time. However, follow-up analyses demonstrated that having abnormal levels of both Aβ₄₂ and p-tau(181p) was associated with an accelerated rate of atrophy in both the hippocampus and precuneus. Results support early effects of Aβ in the Alzheimer's disease process, which are less apparent than and perhaps dependent on p-tau effects as the disease progresses. However, amyloid deposition alone may be insufficient for emergence of significant morphometric changes and clinical symptoms.
- Published
- 2012
26. Awareness of Memory Abilities in Community-Dwelling Older Adults with Suspected Dementia and Mild Cognitive Impairment
- Author
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N. Maritza Dowling, Feng Lin, Sanjay Asthana, Carey E. Gleason, Whitney Wharton, Michele L. Ries, Sterling C. Johnson, and Cynthia M. Carlsson
- Subjects
Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Neuropsychological Tests ,Cognition ,Memory ,mental disorders ,medicine ,Humans ,Dementia ,Medical history ,Prospective Studies ,Original Research Article ,Effects of sleep deprivation on cognitive performance ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Psychiatric Status Rating Scales ,Memory Disorders ,Depression ,Anosognosia ,Cognitive disorder ,Neuropsychology ,Awareness ,Middle Aged ,medicine.disease ,Self Concept ,Psychiatry and Mental health ,Cross-Sectional Studies ,Data Interpretation, Statistical ,Female ,Geriatrics and Gerontology ,Cognition Disorders ,Psychology ,Psychomotor Performance ,Clinical psychology - Abstract
Aims: To examine awareness of memory abilities by groups (healthy control, suspected dementia/mild cognitive impairment, MCI, and diagnosed dementia/MCI), and to describe group differences in the relationship between awareness and cognitive performance in a community sample. Methods: In a cross-sectional design, 183 subjects were evaluated in a community setting and categorized into 3 groups based on their cognitive performance and reported medical history. Awareness of memory abilities was quantified using a published anosognosia ratio (AR) comparing the estimated to the objective memory performance by subjects. Each group was further categorized into ‘overestimators’, ‘accurate estimators’, and ‘underestimators’ based on their AR scores. Results: The suspected and diagnosed dementia/MCI groups had significantly higher AR scores than the controls. The suspected group also had a significantly larger proportion (96.2%) of overestimators than the diagnosed (73.3%) and control groups (26.1%). Impaired awareness in overestimators of the suspected and diagnosed groups was correlated with deficits in executive function, language or global cognition. Conclusion: Impaired awareness of memory abilities was prevalent in community-dwelling older adults with suspected and diagnosed dementia or MCI. Those with suspected dementia or MCI were more likely to overestimate their memory abilities than their diagnosed counterparts, suggesting that limited awareness of deficits may hinder utilization of dementia diagnostic services.
- Published
- 2010
27. Cognitive effects of soy isoflavones in patients with Alzheimer’s disease
- Author
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Carey E. Gleason, Barbara L. Fischer, N. Maritza Dowling, Kenneth D. R. Setchell, Sanjay Asthana, Craig S. Atwood, and Cynthia M. Carlsson
- Subjects
Male ,medicine.medical_specialty ,Genistein ,Placebo ,Article ,Developmental psychology ,chemistry.chemical_compound ,Cognition ,Sex Factors ,Double-Blind Method ,Alzheimer Disease ,Internal medicine ,medicine ,Verbal fluency test ,Humans ,Nootropic Agents ,Aged ,General Neuroscience ,Daidzein ,General Medicine ,Equol ,Isoflavones ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Affect ,Treatment Outcome ,chemistry ,Motor Skills ,Dietary Supplements ,Soybean Proteins ,Patient Compliance ,Phytoestrogens ,Female ,Geriatrics and Gerontology ,Alzheimer's disease ,Psychology - Abstract
Background In a previous trial, treatment with soy isoflavones was associated with improved nonverbal memory, construction abilities, verbal fluency, and speeded dexterity compared to treatment with placebo in cognitively healthy older adults. Objective The current trial aimed to examine the potential cognitive benefits of soy isoflavones in patients with Alzheimer's disease. Methods Sixty-five men and women over the age of 60 were treated with 100 mg/day soy isoflavones, or matching placebo capsules for six months. APOE genotype was determined for all participants. Cognitive outcomes and plasma isoflavone levels were measured at baseline, and at two additional time points: three and six months after baseline. Results Of the sixty-five participants enrolled, thirty-four (52.3% ) were women, and 31 (47.7% ) were APOEɛ4 positive. Average age was 76.3 (SD = 7.2) years. Fifty-nine (90.8% ) subjects completed all study visits. Plasma isoflavone levels increased in subjects treated with soy isoflavones compared to baseline and to placebo, although intersubject variability in plasma levels was large. No significant differences in treatment effects for cognition emerged between treatment groups or genders. Exploratory analyses of associations between changes in cognition and plasma isoflavone levels revealed an association between equol levels, and speeded dexterity and verbal fluency. Conclusions Six months of 100 mg/day treatment with soy isoflavones did not benefit cognition in older men and women with Alzheimer's disease. However, our results suggest the need to examine the role of isoflavone metabolism, i.e., the ability to effectively metabolize soy isoflavones by converting daidzen to equol when attempting to fully clarify the cognitive effects of isoflavones.
- Published
- 2015
28. Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention
- Author
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Jennifer M. Oh, Rebecca L. Koscik, Benjamin M. Doherty, Dhanabalan Murali, Asenath LaRue, Brad T. Christian, Bruce P. Hermann, N. Maritza Dowling, Barbara B. Bendlin, Mark A. Sager, Stephanie A. Schultz, Catherine L. Gallagher, Sanjay Asthana, Todd E. Barnhart, Cynthia M. Carlsson, Sterling C. Johnson, Howard A. Rowley, and Ozioma C. Okonkwo
- Subjects
Preclinical AD ,Amyloid ,Neuroimaging ,lcsh:Geriatrics ,lcsh:RC346-429 ,Cortical thickness ,chemistry.chemical_compound ,Cognition ,medicine ,Amyloid burden ,Cognitive decline ,lcsh:Neurology. Diseases of the nervous system ,medicine.diagnostic_test ,Magnetic resonance imaging ,Entorhinal cortex ,Psychiatry and Mental health ,lcsh:RC952-954.6 ,medicine.anatomical_structure ,chemistry ,Neurology (clinical) ,Pittsburgh compound B ,Psychology ,Neuroscience ,Parahippocampal gyrus - Abstract
There is a growing interest in understanding how amyloid β (Aβ) accumulation in preclinical Alzheimer's disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively normal (CN) individuals. Therefore, not much is known about the associations between Aβ burden, cortical thickness, and cognition in midlife. We examined this question in 109, CN, late to middle‐aged adults (mean age = 60.72 ± 5.65 years) from the Wisconsin Registry for Alzheimer's Prevention. They underwent Pittsburgh Compound B (PiB) and anatomical magnetic resonance (MR) imaging, and a comprehensive cognitive examination. Blinded visual rating of the PiB scans was used to classify the participants as Aβ+ or Aβ−. Cortical thickness measurements were derived from the MR images. The Aβ+ group exhibited significant thinning of the entorhinal cortex and accelerated age‐associated thinning of the parahippocampal gyrus compared with the Aβ− group. The Aβ+ group also had numerically lower, but nonsignificant, test scores on all cognitive measures, and significantly faster age‐associated cognitive decline on measures of Speed & Flexibility, Verbal Ability, and Visuospatial Ability. Our findings suggest that early Aβ aggregation is associated with deleterious changes in brain structure and cognitive function, even in midlife, and that the temporal lag between Aβ deposition and the inception of neurodegenerative/cognitive changes might be narrower than currently thought.
- Published
- 2015
29. Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease
- Author
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Catherine L. Gallagher, Howard A. Rowley, Elizabeth A. Boots, Bruce P. Hermann, Rodrigo P. Almeida, Barbara B. Bendlin, Mark A. Sager, Stephanie A. Schultz, Sterling C. Johnson, Jennifer M. Oh, Ozioma C. Okonkwo, Sanjay Asthana, Cynthia M. Carlsson, Rebecca L. Koscik, and Maritza Dowling
- Subjects
Gerontology ,Adult ,Employment ,Male ,medicine.medical_specialty ,Neuropathology ,Neuropsychological Tests ,Hippocampus ,Cohort Studies ,Atrophy ,Cognitive Reserve ,Alzheimer Disease ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Psychiatry ,Socioeconomic status ,Cognitive reserve ,Aged ,Cognitive evaluation theory ,Psychiatric Status Rating Scales ,Cognition ,General Medicine ,Original Empirical Articles ,Middle Aged ,medicine.disease ,Mental health ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Cardiovascular Diseases ,Cohort ,Regression Analysis ,Female ,Psychology ,Cognition Disorders - Abstract
Higher occupational attainment has previously been associated with increased Alzheimer's disease (AD) neuropathology when individuals are matched for cognitive function, indicating occupation could provide cognitive reserve. We examined whether occupational complexity (OCC) associates with decreased hippocampal volume and increased whole-brain atrophy given comparable cognitive function in middle-aged adults at risk for AD. Participants (n = 323) underwent structural MRI, cognitive evaluation, and work history assessment. Three complexity ratings (work with data, people, and things) were obtained, averaged across up to 3 reported jobs, weighted by years per job, and summed to create a composite OCC rating. Greater OCC was associated with decreased hippocampal volume and increased whole-brain atrophy when matched for cognitive function; results remained substantively unchanged after adjusting for several demographic, AD risk, vascular, mental health, and socioeconomic characteristics. These findings suggest that, in people at risk for AD, OCC may confer resilience to the adverse effects of neuropathology on cognition.
- Published
- 2015
30. P4‐037: Factors associated with the likelihood of providing cerebrospinal fluid for a medical research study in an ethnically diverse sample of adults
- Author
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N. Maritza Dowling, Dorothy F. Edwards, and Jennifer Dykema
- Subjects
Gerontology ,Epidemiology ,business.industry ,Health Policy ,Sample (statistics) ,Ethnically diverse ,Medical research ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
31. P3‐103: Assessing the significance of insulin resistance on cerebrospinal fluid Alzheimer's disease biomarkers and memory function in people at risk for Alzheimer's disease: Findings from the wisconsin adrc impact cohort
- Author
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Barbara B. Bendlin, Sterling C. Johnson, Ozioma C. Okonkwo, Carey E. Gleason, Howard A. Rowley, Kaj Blennow, Sanjay Asthana, Henrik Zetterberg, Jennifer M. Oh, Siobhan M. Hoscheidt, Cynthia M. Carlsson, Rachel A. Krause, and Maritza Dowling
- Subjects
Oncology ,medicine.medical_specialty ,Pathology ,Epidemiology ,business.industry ,Health Policy ,Alzheimer's disease biomarkers ,Disease ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Insulin resistance ,Developmental Neuroscience ,Internal medicine ,Cohort ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
32. P1‐204: Insulin resistance is associated with altered microstructure in the medial temporal lobe and fornix of cognitively healthy ApoE ε4 carriers
- Author
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Erika Jane Starks, Joseph Patrick O'Grady, Siobhan M. Hoscheidt, Annie M. Racine, Ozioma C. Okonkwo, Henrik Zetterberg, Cynthia M. Carlsson, Howard A. Rowley, Kaj Blennow, Sanjay Asthana, Nagesh Adluru, Andrew L. Alexander, Carey E. Gleason, N. Maritza Dowling, LeAnn DeRungs, Nancy J. Davenport, Mark A. Sager, Sterling C. Johnson, and Barbara B. Bendlin
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2015
33. IC‐P‐063: Alzheimer's disease biomarker‐based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry for Alzheimer's prevention (WRAP)
- Author
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Annie M. Racine, Christopher R. Nicholas, Lindsay R. Clark, Rebecca L. Koscik, Ozioma C. Okonkwo, Ansel T. Hillmer, Dhanabalan Murali, Todd E. Barnhart, Catherine L. Gallagher, Howard A. Rowley, N. Maritza Dowling, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Bradley T. Christian, and Sterling C. Johnson
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2015
34. P4‐274: Intra‐individual cognitive variability: An alternative to invasive Alzheimer's disease biomarkers?
- Author
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Sterling C. Johnson, Carey E. Gleason, Cynthia M. Carlsson, N. Maritza Dowling, Sanjay Asthana, Rebecca L. Koscik, Vikas Singh, Eric D. Anderson, Michelle L. Wahoske, and Derek Norton
- Subjects
Oncology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Alzheimer's disease biomarkers ,Cognition ,Intra individual ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
35. P2‐210: Subjective memory complaints in middle‐aged adults with a family history of Alzheimer's disease
- Author
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N. Maritza Dowling, Chuck Illingworth, Barbara B. Bendlin, Rebecca L. Koscik, Christopher R. Nicholas, Lindsay R. Clark, Mark A. Sager, Sterling C. Johnson, Sanjay Asthana, Annie M. Racine, Bruce P. Hermann, and Jennifer M. Oh
- Subjects
medicine.medical_specialty ,Epidemiology ,Health Policy ,Disease ,Subjective memory ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Family history ,Psychology ,Psychiatry - Published
- 2015
36. O1‐01‐03: Alzheimer's disease biomarker‐based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry for Alzheimer's prevention (WRAP)
- Author
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Christopher R. Nicholas, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Catherine L. Gallagher, Ozioma C. Okonkwo, Dhanabalan Murali, Todd E. Barnhart, Lindsay R. Clark, Rebecca L. Koscik, Ansel T. Hillmer, Sanjay Asthana, Howard A. Rowley, Cynthia M. Carlsson, Bradley T. Christian, Annie M. Racine, N. Maritza Dowling, and Barbara B. Bendlin
- Subjects
Oncology ,Gerontology ,medicine.medical_specialty ,Amyloid ,Epidemiology ,business.industry ,Health Policy ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,Cohort ,medicine ,Disease biomarker ,Neurology (clinical) ,Geriatrics and Gerontology ,Cognitive decline ,business - Published
- 2015
37. O3‐01‐03: Effects of hormone therapy on brain structure in recently postmenopausal women: A randomized controlled trial
- Author
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Walter A. Rocca, Whitney Wharton, Samantha M. Zuk, Carey E. Gleason, Nirubol Tosakulwong, Jeffrey L. Gunter, N. Maritza Dowling, Timothy G. Lesnick, Sanjay Asthana, Virginia M. Miller, Lynne T. Shuster, Kent R. Bailey, Clifford R. Jack, Prashanthi Vemuri, Kejal Kantarci, and Matthew L. Senjem
- Subjects
medicine.medical_specialty ,Postmenopausal women ,Epidemiology ,business.industry ,Health Policy ,medicine.medical_treatment ,law.invention ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Neurology (clinical) ,Hormone therapy ,Geriatrics and Gerontology ,business - Published
- 2015
38. Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOE ε4 carriers
- Author
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Annie M. Racine, Cynthia M. Carlsson, Sanjay Asthana, LeAnn DeRungs, Nancy J. Davenport-Sis, Kaj Blennow, J. Patrick O’Grady, Carey E. Gleason, Sterling C. Johnson, N. Maritza Dowling, Barbara B. Bendlin, Erika J. Starks, Rozalyn M. Anderson, Mark A. Sager, Ozioma C. Okonkwo, Henrik Zetterberg, Luigi Puglielli, and Siobhan M. Hoscheidt
- Subjects
Male ,medicine.medical_specialty ,Amyloid ,medicine.medical_treatment ,Tau protein ,Apolipoprotein E4 ,Plaque, Amyloid ,tau Proteins ,Asymptomatic ,Article ,Insulin resistance ,Cerebrospinal fluid ,Wisconsin ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Aged ,Amyloid beta-Peptides ,biology ,business.industry ,General Neuroscience ,Insulin ,Neurodegeneration ,Neurofibrillary Tangles ,General Medicine ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Endocrinology ,Diabetes Mellitus, Type 2 ,biology.protein ,Homeostatic model assessment ,Regression Analysis ,Female ,Geriatrics and Gerontology ,medicine.symptom ,Insulin Resistance ,business ,Biomarkers - Abstract
BACKGROUND Insulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques. However, the extent to which IR is associated with AD pathology in the cognitively asymptomatic stages of preclinical AD remains unclear. OBJECTIVE To determine the extent to which IR is linked with amyloid and tau pathology in late-middle-age. METHOD Cerebrospinal fluid (CSF) samples collected from 113 participants enrolled in the Wisconsin Registry for Alzheimer's Prevention study (mean age = 60.6 years), were assayed for AD-related markers of interest: Aβ₄₂, P-Tau181, and T-Tau. IR was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Linear regression was used to test the effect of IR, and APOEɛ4, on tau and amyloid pathology. We hypothesized that greater IR would be associated with higher CSF P-Tau181 and T-Tau, and lower CSF Aβ₄₂. RESULTS No significant main effects of HOMA-IR on P-Tau181, T-Tau, or Aβ₄₂ were observed; however, significant interactions were observed between HOMA-IR and APOEɛ4 on CSF markers related to tau. Among APOEɛ4 carriers, higher HOMA-IR was associated with higher P-Tau181 and T-Tau. Among APOEɛ4 non-carriers, HOMA-IR was negatively associated with P-Tau181 and T-Tau. We found no effects of IR on Aβ₄₂ levels in CSF. CONCLUSION IR among asymptomatic APOEɛ4 carriers was associated with higher P-Tau181 and T-Tau in late-middle age. The results suggest that IR may contribute to tau-related neurodegeneration in preclinical AD. The findings may have implications for developing prevention strategies aimed at modifying IR in mid-life.
- Published
- 2015
39. Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease
- Author
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Dorothy F. Edwards, Mark A. Sager, Sterling C. Johnson, Jordan Larson, Asenath LaRue, Ozioma C. Okonkwo, Maritza Dowling, Jennifer M. Oh, Bruce P. Hermann, Dane B. Cook, Cynthia M. Carlsson, Barbara B. Bendlin, Elizabeth A. Boots, Howard A. Rowley, Rebecca L. Koscik, Stephanie A. Schultz, Catherine L. Gallagher, and Sanjay Asthana
- Subjects
Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Audiology ,Neuropsychological Tests ,Verbal learning ,Article ,Developmental psychology ,Behavioral Neuroscience ,Cellular and Molecular Neuroscience ,Cognition ,Alzheimer Disease ,Risk Factors ,medicine ,Middle frontal gyrus ,Humans ,Radiology, Nuclear Medicine and imaging ,Family ,Genetic Predisposition to Disease ,Effects of sleep deprivation on cognitive performance ,Longitudinal Studies ,Gray Matter ,Neuropsychology ,Brain ,Cardiorespiratory fitness ,Organ Size ,Middle Aged ,Magnetic Resonance Imaging ,White Matter ,Hyperintensity ,Psychiatry and Mental health ,Affect ,Mood ,Neurology ,Cardiovascular Diseases ,Physical Fitness ,Exercise Test ,Female ,Neurology (clinical) ,Psychology - Abstract
Cardiorespiratory fitness (CRF) is an objective measure of habitual physical activity (PA), and has been linked to increased brain structure and cognition. The gold standard method for measuring CRF is graded exercise testing (GXT), but GXT is not feasible in many settings. The objective of this study was to examine whether a non-exercise estimate of CRF is related to gray matter (GM) volumes, white matter hyperintensities (WMH), cognition, objective and subjective memory function, and mood in a middle-aged cohort at risk for Alzheimer’s disease (AD). Three hundred and fifteen cognitively healthy adults (mean age =58.58 years) enrolled in the Wisconsin Registry for Alzheimer’s Prevention underwent structural MRI scanning, cognitive testing, anthropometric assessment, venipuncture for laboratory tests, and completed a self-reported PA questionnaire. A subset (n = 85) underwent maximal GXT. CRF was estimated using a previously validated equation incorporating sex, age, body-mass index, resting heart rate, and self-reported PA. Results indicated that the CRF estimate was significantly associated with GXT-derived peak oxygen consumption, validating its use as a non-exercise CRF measure in our sample. Support for this finding was seen in significant associations between the CRF estimate and several cardiovascular risk factors. Higher CRF was associated with greater GM volumes in several AD-relevant brain regions including the hippocampus, amygdala, precuneus, supramarginal gyrus, and rostral middle frontal gyrus. Increased CRF was also associated with lower WMH and better cognitive performance in Verbal Learning & Memory, Speed & Flexibility, and Visuospatial Ability. Lastly, CRF was negatively correlated with self- and informant-reported memory complaints, and depressive symptoms. Together, these findings suggest that habitual participation in physical activity may provide protection for brain structure and cognitive function, thereby decreasing future risk for AD.
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- 2014
40. Imaging-based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairment
- Author
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Sterling C. Johnson, Ozioma C. Okonkwo, Vikas Singh, Vamsi K. Ithapu, Rick Chappell, and N. Maritza Dowling
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Male ,Epidemiology ,Multimodal Imaging ,Statistical power ,Article ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Alzheimer Disease ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Stage (cooking) ,Cognitive impairment ,Aged ,Multimodal imaging ,Aged, 80 and over ,Clinical Trials as Topic ,Amyloid beta-Peptides ,business.industry ,Health Policy ,Deep learning ,Cognition ,medicine.disease ,Magnetic Resonance Imaging ,Clinical trial ,Psychiatry and Mental health ,Positron-Emission Tomography ,Disease Progression ,Female ,Neurology (clinical) ,Artificial intelligence ,Geriatrics and Gerontology ,Psychology ,business ,Algorithm ,Algorithms ,Biomarkers - Abstract
The mild cognitive impairment (MCI) stage of Alzheimer's disease (AD) may be optimal for clinical trials to test potential treatments for preventing or delaying decline to dementia. However, MCI is heterogeneous in that not all cases progress to dementia within the time frame of a trial and some may not have underlying AD pathology. Identifying those MCIs who are most likely to decline during a trial and thus most likely to benefit from treatment will improve trial efficiency and power to detect treatment effects. To this end, using multimodal, imaging-derived, inclusion criteria may be especially beneficial. Here, we present a novel multimodal imaging marker that predicts future cognitive and neural decline from [F-18]fluorodeoxyglucose positron emission tomography (PET), amyloid florbetapir PET, and structural magnetic resonance imaging, based on a new deep learning algorithm (randomized denoising autoencoder marker, rDAm). Using ADNI2 MCI data, we show that using rDAm as a trial enrichment criterion reduces the required sample estimates by at least five times compared with the no-enrichment regime and leads to smaller trials with high statistical power, compared with existing methods.
- Published
- 2014
41. O4‐05‐01: INSULIN RESISTANCE AND CENTRAL OBESITY IN APOE4 CARRIERS ARE ASSOCIATED WITH INCREASES IN CEREBRAL SPINAL FLUID PHOSPHORYLATED TAU
- Author
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Carey E. Gleason, Erika J. Starks, Kaj Blennow, Joseph Patrick O'Grady, Annie M. Racine, Maritza Dowling, Mark A. Sager, Sterling C. Johnson, Ozioma C. Okonkwo, Barbara B. Bendlin, Henrik Zetterberg, Sanjay Asthana, LeAnn DeRungs, Cynthia M. Carlsson, Rozalyn M. Anderson, and Nancy J. Davenport
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Cerebral Spinal Fluid ,Health Policy ,medicine.disease ,Obesity ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Insulin resistance ,Endocrinology ,Developmental Neuroscience ,Internal medicine ,Tau phosphorylation ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2014
42. P2‐118: CEREBROSPINAL FLUID MICROGLIAL MARKERS IN ALZHEIMER'S DISEASE, MCI, AND ASYMPTOMATIC ADULTS
- Author
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Kaj Blennow, Margarete A. Wichmann, Laura E. Jacobson, Hanna Blazel, Barbara B. Bendlin, Sterling C. Johnson, Sanjay Asthana, Benjamin P. Austin, Ozioma C. Okonkwo, N. Maritza Dowling, Henrik Zetterberg, Carey E. Gleason, Cynthia M. Carlsson, and Rick Chappell
- Subjects
Pathology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Disease ,Asymptomatic ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Developmental Neuroscience ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,business - Published
- 2014
43. P1‐011: SUBJECTIVE MEMORY COMPLAINTS, CORTICAL THINNING, AND COGNITIVE DYSFUNCTION IN MIDDLE‐AGED ADULTS AT RISK FOR AD: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
- Author
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Stephanie Schultz, Jennifer Oh, Rebecca L. Koscik, N. Maritza Dowling, Catherine Gallagher, Cynthia Carlsson, Barbara B. Bendlin, Asenath LaRue, Bruce Hermann, Howard Rowley, Sanjay Asthana, Mark A. Sager, Sterling Johnson, and Ozioma Okonkwo
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2014
44. IC‐P‐078: SUBJECTIVE MEMORY COMPLAINTS, CORTICAL THINNING, AND COGNITIVE DYSFUNCTION IN MIDDLE‐AGED ADULTS AT RISK FOR AD: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
- Author
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Barbara B. Bendlin, Stephanie A. Schultz, Bruce P. Hermann, Mark A. Sager, Sanjay Asthana, Howard A. Rowley, Catherine L. Gallagher, Jennifer M. Oh, Asenath LaRue, Rebecca L. Koscik, N. Maritza Dowling, Cynthia M. Carlsson, Sterling C. Johnson, and Ozioma C. Okonkwo
- Subjects
medicine.medical_specialty ,Epidemiology ,Health Policy ,Cortical thinning ,Cognition ,Subjective memory ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychiatry ,Psychology - Published
- 2014
45. IC‐P‐118: AMYLOID BURDEN, CORTICAL THICKNESS, AND COGNITIVE FUNCTION IN THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
- Author
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Benjamin Matthew Doherty, Jennifer M. Oh, Stephanie A. Schultz, Rebecca L. Koscik, N. Maritza Dowling, Todd E. Barnhart, Dhanabalan E. Murali, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Asenath LaRue, Bruce P. Hermann, Howard A. Rowley, Sanjay Asthana, Mark A. Sager, Brad T. Christian, Sterling C. Johnson, and Ozioma C. Okonkwo
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2014
46. P2‐204: PARTICIPATION IN COGNITIVELY‐STIMULATING ACTIVITIES IS ASSOCIATED WITH BRAIN STRUCTURE AND COGNITIVE FUNCTION IN PRECLINICAL ALZHEIMER'S DISEASE
- Author
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Jordan Larson, Stephanie Schultz, Jennifer Oh, Rebecca L. Koscik, Maritza Dowling, Catherine Gallagher, Cynthia Carlsson, Howard Rowley, Barbara B. Bendlin, Sanjay Asthana, Bruce Hermann, Sterling Johnson, Mark A. Sager, Asenath LaRue, and Ozioma Okonkwo
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2014
47. IC‐01‐03: PARTICIPATION IN COGNITIVELY STIMULATING ACTIVITIES IS ASSOCIATED WITH BRAIN STRUCTURE AND COGNITIVE FUNCTION IN PRECLINICAL ALZHEIMER'S DISEASE
- Author
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Maritza Dowling, Catherine L. Gallagher, Bruce P. Hermann, Barbara B. Bendlin, Mark A. Sager, Howard A. Rowley, Jordan Larson, Rebecca L. Koscik, Jennifer M. Oh, Cynthia M. Carlsson, Asenath LaRue, Sanjay Asthana, Sterling C. Johnson, and Ozioma C. Okonkwo
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Cognition ,Neurology (clinical) ,Disease ,Geriatrics and Gerontology ,Psychology ,Neuroscience - Published
- 2014
48. P3‐344: PHYSICAL ACTIVITY MODIFIES ALZHEIMER BIOMARKERS IN PRECLINICAL AD: EVIDENCE FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
- Author
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Stephanie A. Schultz, Bruce P. Hermann, Sterling C. Johnson, Catherine L. Gallagher, Rebecca L. Koscik, Howard A. Rowley, Sanjay Asthana, Ozioma C. Okonkwo, Dane B. Cook, Maritza Dowling, Cynthia M. Carlsson, Jennifer M. Oh, Barbara B. Bendlin, Brad T. Christian, Mark A. Sager, Asenath LaRue, Jordan Larson, and Dorothy F. Edwards
- Subjects
Gerontology ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Physical activity ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology - Published
- 2014
49. O1‐12‐02: AMYLOID BURDEN, CORTICAL THICKNESS, AND COGNITIVE FUNCTION IN THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
- Author
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Mark A. Sager, Sterling C. Johnson, Asenath LaRue, Benjamin M. Doherty, Ozioma C. Okonkwo, N. Maritza Dowling, Catherine L. Gallagher, Todd E. Barnhart, Brad T. Christian, Cynthia M. Carlsson, Rebecca L. Koscik, Sanjay Asthana, Dhanabalan Murali, Stephanie A. Schultz, Howard A. Rowley, Jennifer M. Oh, Bruce P. Hermann, and Barbara B. Bendlin
- Subjects
medicine.diagnostic_test ,Amyloid ,Epidemiology ,Health Policy ,Magnetic resonance imaging ,Cognition ,Disease ,Entorhinal cortex ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,medicine.anatomical_structure ,Developmental Neuroscience ,chemistry ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Cognitive decline ,Pittsburgh compound B ,Psychology ,Neuroscience ,Parahippocampal gyrus - Abstract
There is a growing interest in understanding how amyloid b (Ab) accumulation in preclinical Alzheimer’s disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively normal (CN) individuals. Therefore, not much is known about the associations between Ab burden, cortical thickness, and cognition in midlife. We examined this question in 109, CN, late to middle-aged adults (mean age5 60.72 65.65 years) from the Wisconsin Registry for Alzheimer’s Prevention. They underwent Pittsburgh Compound B (PiB) and anatomical magnetic resonance (MR) imaging, and a comprehensivecognitiveexamination.BlindedvisualratingofthePiBscanswasusedtoclassifytheparticipants as Ab1 or Ab2. Cortical thickness measurements were derived from the MR images. The Ab1 group exhibited significant thinning of the entorhinal cortex and accelerated age-associated thinning of the parahippocampal gyrus compared with the Ab2 group. The Ab1 group also had numerically lower, butnonsignificant,testscores onallcognitivemeasures, and significantlyfasterage-associated cognitive decline on measures of Speed & Flexibility, Verbal Ability, and Visuospatial Ability. Our findings suggest that early Ab aggregation is associated with deleterious changes in brain structure and cognitive function, even in midlife, and that the temporal lag between Ab deposition and the inception of neurodegenerative/cognitive changes might be narrower than currently thought. 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
- Published
- 2014
50. IC‐01‐01: IMAGING OF TAU PATHOLOGY IN PATIENTS WITH NON‐ALZHEIMER'S DISEASE TAUOPATHIES BY [11C]PBB3‐PET
- Author
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Rebecca L. Koscik, Howard A. Rowley, Dorothy F. Edwards, Maritza Dowling, Barbara B. Bendlin, Asenath LaRue, Mark A. Sager, Jordan Larson, Sanjay Asthana, Brad T. Christian, Catherine L. Gallagher, Dane B. Cook, Jennifer M. Oh, Sterling C. Johnson, Ozioma C. Okonkwo, Stephanie A. Schultz, Bruce P. Hermann, and Cynthia M. Carlsson
- Subjects
Pathology ,medicine.medical_specialty ,Tau pathology ,Epidemiology ,business.industry ,Health Policy ,Disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Medicine ,In patient ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2014
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