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Your search keyword '"Andriola, Ileana"' showing total 10 results
Start Over Author "Andriola, Ileana" Topic psychiatry and mental health
10 results on '"Andriola, Ileana"'

1. Does social cognition change? Evidence after 4 years from the Italian Network for Research on Psychoses

Author

Rocca, Paola, Rucci, Paola, Montemagni, Cristiana, Rossi, Alessandro, Bertolino, Alessandro, Aguglia, Eugenio, Altamura, Carlo A, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Brasso, Claudio, Carpiniello, Bernardo, Del Favero, Elisa, Dell'Osso, Liliana, Di Fabio, Fabio, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marchesi, Carlo, Martinotti, Giovanni, Monteleone, Palmiero, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, Maj, Mario, Silvio, Bellino, Paola, Bozzatello, Vincenzo, Villari, Pierluigi, Selvaggi, Enrico, D’Ambrosio, Linda, Antonucci, Stefano, Barlati, Giacomo, Deste, Gabriele, Nibbio, Federica, Pinna, Benedetta, Olivieri, Daniela, Manca, Carmen, Concerto, Laura, Fusar Poli, Alessandro, Rodolico, Mauro, Pettorruso, Giacomo, D’Andrea, Alessio, Mosca, Mario, Altamura, Fiammetta, Gallone, Laura, De Masi, Pietro, Calcagno, Valeria, Placenti, Alice, Trabucco, Valeria, Bianchini, Laura, Giusti, Silvia, Mammarella, Arianna, Di Berardo, Ramona, di Stefano, Matteo, Marcatili, Valentina, Ciappolino, Luisa, Belloni, Paola, Bucci, Giuseppe, Piegari, Luigi, Giuliani, Francesco, Brando, Carla, Gramaglia, Eleonora, Gambaro, Pierluigi, Prosperini, Angela, Favaro, Enrico, Collantoni, Paolo, Meneguzzo, Matteo, Tonna, Paolo, Ossola, Maria Lidia, Gerra, Claudia, Carmassi, Virginia, Pedrinelli, Barbara, Carpita, Cascino, Giammarco, Giulio, Corrivetti, Gianfranco, Del Buono, Tommaso, Accinni, Antonino, Buzzanca, Marianna, Frascarelli, Anna, Comparelli, Roberto, Brugnoli, Isabella, Berardelli, Simone, Bolognesi, Alessandro, Cuomo, Arianna, Goracci, Giorgio, Di Lorenzo, Cinzia, Niolu, Michele, Ribolsi., Rocca, Paola, Rucci, Paola, Montemagni, Cristiana, Rossi, Alessandro, Bertolino, Alessandro, Aguglia, Eugenio, Altamura, Carlo A, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Brasso, Claudio, Carpiniello, Bernardo, Del Favero, Elisa, Dell'Osso, Liliana, Di Fabio, Fabio, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marchesi, Carlo, Martinotti, Giovanni, Monteleone, Palmiero, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Subjects
schizophrenia, Psychiatry and Mental health, recovery, Follow-up, reliable and clinically significant change (RCSC), social cognition, theory of mind
Abstract

Background Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up. Methods The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up. Results In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery. Conclusions The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.

Published
2023

2. Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited

Author

Koutsouleris, Nikolaos, Pantelis, Christos, Kambeitz, Joseph, Toivonen, Anna, Turtonen, Otto, Botterweck, Sonja, Kluthausen, Norman, Antoch, Gerald, Caspers, Julian, Wittsack, Hans-Jörg, Blasi, Giuseppe, Pergola, Giulio, Caforio, Grazia, Salokangas, Raimo K R, Fazio, Leonardo, Quarto, Tiziana, Gelao, Barbara, Romano, Raffaella, Andriola, Ileana, Falsetti, Andrea, Barone, Marina, Passiatore, Roberta, Sangiuliano, Marina, Surmann, Marian, Hietala, Jarmo, Bienek, Olga, Dannlowski, Udo, Solana, Ana Beatriz, Abraham, Manuela, Schirmer, Timo, Ferro, Adele, Re, Marta, Sberna, Maurizio, D'Agostino, Armando, Del Fabro, Lorenzo, Bertolino, Alessandro, Perna, Giampaolo, Nobile, Maria, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Delvecchio, Giuseppe, Maggioni, Eleonora, Squarcina, Letizia, Gritti, Davide, Brambilla, Paolo, Rossetti, Maria Gloria, Ferrari, Raffaele, Hernandez, Dena Michelle Godwin, Nalls, Michael, Rohrer, Jonathan, Ramasamy, Adaikalavan, Kwok, John, Dobson-Stone, Carol, Brooks, William, Schofield, Peter, Upthegrove, Rachel, Halliday, Glenda, Hodges, John, Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Wood, Stephen J, Cruchaga, Carlos, Cairns, Nigel, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Albani, Diego, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Lencer, Rebekka, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Landqvist Waldö, Maria, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek, Mann, David, Borgwardt, Stefan, Grafman, Jordan, Morris, Christopher, Attems, Johannes, McKeith, Ian, Thomas, Alan, Pietrini, Pietro, Huey, Edward, Wassermann, Eric, Baborie, Atik, Jaros, Evelyn, Maj, Carlo, Tierney, Michael, Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Velakoulis, Dennis, Nöthen, Markus M., Pinessi, Lorenzo, Rogaeva, Ekaterina, George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James, Schlachetzki, Johannes, Uphill, James, Collinge, John, Degenhardt, Franziska, Mead, Simon, Van Deerlin, Vivianna, Marschhauser, Anke, Regenbrecht, Frank, Thoene-Otto, Angelika, Gordulla, Jannis, Ballarini, Tommaso, Engel, Annerose, Pino, Daniele, Leuthold, Dominique, Polyakova, Maryna, Naumann, Heike, Grossman, Murray, Trojanowski, John Q, van der Zee, Julie, Van Broeckhofen, Christine, Cappa, Stefano F, Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Mueller, Karsten, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E, Hjermind, Lena E, Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Villringer, Arno, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N, Fox, Nick C, Warren, Jason D, Spillantini, Maria Grazia, Morris, Huw R, Rizzu, Patrizia, Heutink, Peter, Danek, Adrian, Snowden, Julie S, Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C, Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Fassbender, Klaus, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W, Graff-Radford, Neill R, Petersen, Ronald C, Knopman, David S, Josephs, Keith A, Fliessbach, Klaus, Boeve, Bradley F, Parisi, Joseph E, Seeley, William W, Miller, Bruce L, Karydas, Anna M, Rosen, Howard, van Swieten, John C, Dopper, Elise Gp, Seelaar, Harro, Pijnenburg, Yolande Al, Jahn, Holger, Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A, Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Kornhuber, Johannes, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebouvier, Thibaud, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B, McGuire, Philip, Landwehrmeyer, Bernhard, Hardy, John, Momeni, Parastoo, Barthel, Henryk, Elisa, Semler, Jolina, Lombardi, Christine, von Arnim, Felix, Oberahauser, Kai, Schumacher, Jan, Lehmbeck, Juan-Manuel, Maler, Anderl-Straub, Sarah, Tanja, Richter-Schmidinger, Anke, Hammer-Kaspereit, Timo, Oberstein, Felix, Müller-Sarnowski, Carola, Roßmeier, Albert, Ludolph, Jan, Kassubek, Anja, Schneider, Johannes, Levin, Prudlo, Johannes, Synofzik, Matthis, Wiltfang, Jens, Riedl, Lina, Diehl-Schmid, Janine, Otto, Markus, Meisenzahl, Eva, Falkai, Peter, Dwyer, Dominic B, Schroeter, Matthias L, Consortium, the PRONIA, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Yanis, Urquijo-Castro, Maria-Fernanda, Öztürk, Ömer, Penzel, Nora, Rangnick, Adrian, von Saldern, Sebastian, Spangemacher, Moritz, Tupac, Ana, Weiske, Johanna, Wosgien, Antonia, Krämer, Camilla, Blume, Karsten, Paul, Riya, Hedderich, Dennis, Julkowski, Dominika, Kaiser, Nathalie, Lichtenstein, Thorsten, Milz, Ruth, Nikolaides, Alexandra, Pilgram, Tanja, Seves, Mauro, Wassen, Martina, Andreou, Christina, Dong, Sen, Egloff, Laura, Harrisberger, Fabienne, Heitz, Ulrike, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Popovic, David, Day, Chris, Lowri Griffiths, Sian, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Lalousis, Paris, Denissoff, Alexander, Ellilä, Anu, Oeztuerk, Oemer, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, International FTD-Genetics Consortium (IFGC), German Frontotemporal Lobar Degeneration (FTLD) Consortium, PRONIA Consortium, and International FTD-Genetics Consortium Consortium

Subjects
Adult, Male, Medizin, genetics [Alzheimer Disease], genetics [Psychotic Disorders], Neuropsychological Tests, diagnostic imaging [Frontotemporal Dementia], diagnostic imaging [Psychotic Disorders], Machine Learning, methods [Magnetic Resonance Imaging], Brain, Female, Humans, Magnetic Resonance Imaging, Alzheimer Disease, Frontotemporal Dementia, Psychotic Disorders, Schizophrenia, pathology [Brain], genetics [Schizophrenia], ddc:610, diagnostic imaging [Brain], genetics [Frontotemporal Dementia], Settore MED/25 - Psichiatria, Psychiatry and Mental health, diagnostic imaging [Schizophrenia], diagnostic imaging [Alzheimer Disease]
Abstract

Weitere Nicht-UDE Autoren sind nicht genannt. Importance: The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far. Objective: To use machine learning to compare the expression of structural magnetic resonance imaging (MRI) patterns of behavioral-variant frontotemporal dementia (bvFTD), Alzheimer disease (AD), and schizophrenia; estimate predictability in patients with bvFTD and schizophrenia based on sociodemographic, clinical, and biological data; and examine prognostic value, genetic underpinnings, and progression in patients with clinical high-risk (CHR) states for psychosis or recent-onset depression (ROD). Design, Setting, and Participants: This study included 1870 individuals from 5 cohorts, including (1) patients with bvFTD (n = 108), established AD (n = 44), mild cognitive impairment or early-stage AD (n = 96), schizophrenia (n = 157), or major depression (n = 102) to derive and compare diagnostic patterns and (2) patients with CHR (n = 160) or ROD (n = 161) to test patterns' prognostic relevance and progression. Healthy individuals (n = 1042) were used for age-related and cohort-related data calibration. Data were collected from January 1996 to July 2019 and analyzed between April 2020 and April 2022. Main Outcomes and Measures: Case assignments based on diagnostic patterns; sociodemographic, clinical, and biological data; 2-year functional outcomes and genetic separability of patients with CHR and ROD with high vs low pattern expression; and pattern progression from baseline to follow-up MRI scans in patients with nonrecovery vs preserved recovery. Results: Of 1870 included patients, 902 (48.2%) were female, and the mean (SD) age was 38.0 (19.3) years. The bvFTD pattern comprising prefrontal, insular, and limbic volume reductions was more expressed in patients with schizophrenia (65 of 157 [41.2%]) and major depression (22 of 102 [21.6%]) than the temporo-limbic AD patterns (28 of 157 [17.8%] and 3 of 102 [2.9%], respectively). bvFTD expression was predicted by high body mass index, psychomotor slowing, affective disinhibition, and paranoid ideation (R2= 0.11). The schizophrenia pattern was expressed in 92 of 108 patients (85.5%) with bvFTD and was linked to the C9orf72 variant, oligoclonal banding in the cerebrospinal fluid, cognitive impairment, and younger age (R2= 0.29). bvFTD and schizophrenia pattern expressions forecasted 2-year psychosocial impairments in patients with CHR and were predicted by polygenic risk scores for frontotemporal dementia, AD, and schizophrenia. Findings were not associated with AD or accelerated brain aging. Finally, 1-year bvFTD/schizophrenia pattern progression distinguished patients with nonrecovery from those with preserved recovery. Conclusions and Relevance: Neurobiological links may exist between bvFTD and psychosis focusing on prefrontal and salience system alterations. Further transdiagnostic investigations are needed to identify shared pathophysiological processes underlying the neuroanatomical interface between the 2 disease spectra.

Published
2022

3. Clinical, brain, and multilevel clustering in early psychosis and affective stages

Author

Dwyer, Dominic B., Buciuman, Madalina-Octavia, Ruef, Anne, Kambeitz, Joseph, Sen Dong, Mark, Stinson, Caedyn, Kambeitz-Ilankovic, Lana, Degenhardt, Franziska, Sanfelici, Rachele, Antonucci, Linda A., Lalousis, Paris Alexandros, Wenzel, Julian, Urquijo-Castro, Maria Fernanda, Popovic, David, Oeztuerk, Oemer Faruk, Haas, Shalaila S., Weiske, Johanna, Hauke, Daniel, Neufang, Susanne, Schmidt-Kraepelin, Christian, Ruhrmann, Stephan, Penzel, Nora, Lichtenstein, Theresa, Rosen, Marlene, Chisholm, Katharine, Riecher-Rössler, Anita, Egloff, Laura, Schmidt, André, Andreou, Christina, Hietala, Jarmo, Schirmer, Timo, Romer, Georg, Michel, Chantal, Rössler, Wulf, Maj, Carlo, Borisov, Oleg, Krawitz, Peter M., Falkai, Peter, Pantelis, Christos, Lencer, Rebekka, Bertolino, Alessandro, Borgwardt, Stefan, Noethen, Markus, Brambilla, Paolo, Schultze-Lutter, Frauke, Meisenzahl, Eva, Wood, Stephen J., Davatzikos, Christos, Upthegrove, Rachel, Salokangas, Raimo K. R., Koutsouleris, Nikolaos, Mackintosh, Amatya, Kaiser, Nathalie, Lichtenstein, Thorsten, Seves, Mauro, Chisholm, Katie, Reniers, Renate, Stainton, Alexandra, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Tuominen, Lauri, Luutonen, Sinikka, Paju, Janina, Tikka, Maria, Armio (Säilä), Reetta-Liina, Toivonen, Anna, Walta, Maija, Fabbro, Franco, Balestrieri, Matteo, Bonivento, Carolina, Garzitto, Marco, Cabras, Giuseppe, Piccin, Sara, Castellani, Umberto, Bellani, Marcella, Maieron, Marta, Girometti, Rossano, Zuiani, Chiara, Skafidas, Stan, Velakoulis, Dennis, Everall, Ian, Merritt, Antonia, Jovicevic, Michael, Plicht, Manuel, Bequé, Dirk, Solana Sánchez, Ana Beatriz, Hehn, Nicolas, Herrmann, Katrin, Burke, Michael X., Fernandez, Brice, Altamura, Carlo, Rango, Mario, Ferro, Adele, Belleri, Marika, Maggioni, Eleonora, Squarcina, Letizia, Re, Marta, Delvecchio, Giuseppe, Meneghelli, Anna, Monzani, Emiliano, Sassi, Roberto, Sberna, Maurizio, Gennari, Luciana, Torremante, Patrizia, Surmann, Marian, Dannlowski, Udo, Bienek, Olga, Blasi, Giuseppe, Pergola, Giulio, Quarto, Tiziana, Andriola, Ileana, Romano, Raffaella, Gelao, Barbara, Fazio, Leonardo, Korda, Alexandra, Rohner, Henrik, Mann, Matthias, Geyer, Phillip, Treit, Peter, Müller, Johannes, Frackowiak, Richard, Wasserman, Danuta, Maier, Wolfgang, Binder, Elisabeth, Woopen, Christiane, Spranger, Tade Matthias, Möhrmann, Karl-Heinz, and PRONIA Consortium

Subjects
Adult, Male, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, Medizin, Brain, Cluster Analysis, Humans, Female, Longitudinal Studies, 610 Medizin und Gesundheit, Original Investigation
Abstract

Importance Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity to investigate specificity related to affective and normative variation and to validate solutions with premorbid, longitudinal, and genetic risk measures. Objective To use machine learning techniques to cluster, compare, and combine subgroup solutions using clinical and brain structural imaging data from early psychosis and depression stages. Design, Setting, and Participants A multisite, naturalistic, longitudinal cohort study (10 sites in 5 European countries; including major follow-up intervals at 9 and 18 months) with a referred patient sample of those with clinical high risk for psychosis (CHR-P), recent-onset psychosis (ROP), recent-onset depression (ROD), and healthy controls were recruited between February 1, 2014, to July 1, 2019. Data were analyzed between January 2020 and January 2022. Main Outcomes and Measures A nonnegative matrix factorization technique separately decomposed clinical (287 variables) and parcellated brain structural volume (204 gray, white, and cerebrospinal fluid regions) data across CHR-P, ROP, ROD, and healthy controls study groups. Stability criteria determined cluster number using nested cross-validation. Validation targets were compared across subgroup solutions (premorbid, longitudinal, and schizophrenia polygenic risk scores). Multiclass supervised machine learning produced a transferable solution to the validation sample. Results There were a total of 749 individuals in the discovery group and 610 individuals in the validation group. Individuals included those with CHR-P (n = 287), ROP (n = 323), ROD (n = 285), and healthy controls (n = 464), The mean (SD) age was 25.1 (5.9) years, and 702 (51.7%) were female. A clinical 4-dimensional solution separated individuals based on positive symptoms, negative symptoms, depression, and functioning, demonstrating associations with all validation targets. Brain clustering revealed a subgroup with distributed brain volume reductions associated with negative symptoms, reduced performance IQ, and increased schizophrenia polygenic risk scores. Multilevel results distinguished between normative and illness-related brain differences. Subgroup results were largely validated in the external sample. Conclusions and Relevance The results of this longitudinal cohort study provide stratifications beyond the expression of positive symptoms that cut across illness stages and diagnoses. Clinical results suggest the importance of negative symptoms, depression, and functioning. Brain results suggest substantial overlap across illness stages and normative variation, which may highlight a vulnerability signature independent from specific presentations. Premorbid, longitudinal, and genetic risk validation suggested clinical importance of the subgroups to preventive treatments.

Published
2022

4. Accuracy of self-assessment of real-life functioning in schizophrenia

Author

Rocca, Paola, Brasso, Claudio, Montemagni, Cristiana, Bellino, Silvio, Rossi, Alessandro, Bertolino, Alessandro, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Bucci, Paola, Buzzanca, Antonino, Carpiniello, Bernardo, Cuomo, Alessandro, Dell'Osso, Liliana, Favaro, Angela, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, Maj, Mario, Bozzatello, Paola, Badino, Cristina, Giordano, Benedetta, Di Palo, Piergiuseppe, Calia, Vitalba, Papalino, Marco, Barlati, Stefano, Deste, Giacomo, Ceraso, Anna, Pinna, Federica, Olivieri, Benedetta, Manca, Daniela, Piegari, Giuseppe, Brando, Francesco, Giuliani, Luigi, Aiello, Carmen, Fusar Poli, Laura, Concerto, Carmen, Surace, Teresa, Altamura, Mario, Malerba, Stefania, Padalino, Flavia, Calcagno, Pietro, Belvederi Murri, Martino, Amerio, Andrea, Pacitti, Francesca, Socci, Valentina, Lucaselli, Alessia, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Iasevoli, Felice, Gramaglia, Carla, Gambaro, Eleonora, Gattoni, Eleonora, Tenconi, Elena, Collantoni, Enrico, Meneguzzo, Paolo, Ossola, Paolo, Tonna, Matteo, Gerra, Maria Lidia, Carmassi, Claudia, Carpita, Barbara, Cremone, Ivan Mirko, Corrivetti, Giulio, Cascino, Giammarco, Marciello, Francesca, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Girardi, Nicoletta, Accinni, Tommaso, Carlone, Luca, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Rocca, P., Brasso, C., Montemagni, C., Bellino, S., Rossi, A., Bertolino, A., Gibertoni, D., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Bucci, P., Buzzanca, A., Carpiniello, B., Cuomo, A., Dell'Osso, L., Favaro, A., Giordano, G. M., Marchesi, C., Monteleone, P., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Bozzatello, P., Badino, C., Giordano, B., Di Palo, P., Calia, V., Papalino, M., Barlati, S., Deste, G., Ceraso, A., Pinna, F., Olivieri, B., Manca, D., Piegari, G., Brando, F., Giuliani, L., Aiello, C., Poli, L. F., Concerto, C., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Amerio, A., Pacitti, F., Socci, V., Lucaselli, A., Giusti, L., Salza, A., Ussorio, D., Iasevoli, F., Gramaglia, C., Gambaro, E., Gattoni, E., Tenconi, E., Collantoni, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Marciello, F., Brugnoli, R., Comparelli, A., Corigliano, V., Girardi, N., Accinni, T., Carlone, L., Fagiolini, A., Goracci, A., Bolognesi, S., Di Lorenzo, G., Niolu, C., Ribolsi, M., Rocca P., Brasso C., Montemagni C., Bellino S., Rossi A., Bertolino A., Gibertoni D., Aguglia E., Amore M., Andriola I., Bellomo A., Bucci P., Buzzanca A., Carpiniello B., Cuomo A., Dell'Osso L., Favaro A., Giordano G.M., Marchesi C., Monteleone P., Oldani L., Pompili M., Roncone R., Rossi R., Siracusano A., Vita A., Zeppegno P., Galderisi S., Maj M., Bozzatello P., Badino C., Giordano B., Di Palo P., Calia V., Papalino M., Barlati S., Deste G., Ceraso A., Pinna F., Olivieri B., Manca D., Piegari G., Brando F., Giuliani L., Aiello C., Poli L.F., Concerto C., Surace T., Altamura M., Malerba S., Padalino F., Calcagno P., Murri M.B., Amerio A., Pacitti F., Socci V., Lucaselli A., Giusti L., Salza A., Ussorio D., Iasevoli F., Gramaglia C., Gambaro E., Gattoni E., Tenconi E., Collantoni E., Meneguzzo P., Ossola P., Tonna M., Gerra M.L., Carmassi C., Carpita B., Cremone I.M., Corrivetti G., Cascino G., Marciello F., Brugnoli R., Comparelli A., Corigliano V., Girardi N., Accinni T., Carlone L., Fagiolini A., Goracci A., Bolognesi S., Di Lorenzo G., Niolu C., and Ribolsi M.

Subjects
Self-assessment, medicine.medical_treatment, Concordance, RC435-571, schizophrenia, real-life functioning, reliability, Article, Correlation, 03 medical and health sciences, Interpersonal relationship, 0302 clinical medicine, medicine, 030212 general & internal medicine, Self-assessment, schizophrenia, diagnosis, Psychiatry, Rehabilitation, medicine.disease, Psychosis, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, Schizophrenia, Cohort, Work Skills, Psychology, Clinical psychology
Abstract

A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia patients we sought to: (1) examine the concordance of patients’ reports of their real-life functioning with the reports of their key caregiver; (2) identify which patient characteristics are associated to the differences between patients and informants. Patient-caregiver concordance of the ratings in three Specific Level of Functioning Scale (SLOF) domains (interpersonal relationships, everyday life skills, work skills) was evaluated with matched-pair t tests, the Lin’s concordance correlation, Somers’ D, and Bland–Altman plots with limits of agreement (LOA). Predictors of the patient-caregiver differences in SLOF ratings were assessed with a linear regression with multivariable fractional polynomials. Patients’ self-evaluation of functioning was higher than caregivers’ in all the evaluated domains of the SLOF and 17.6% of the patients exceeded the LOA, thus providing a self-evaluation discordant from their key caregivers. The strongest predictors of patient-caregiver discrepancies were caregivers’ ratings in each SLOF domain. In clinically stable outpatients with a moderate degree of functional impairment, self-evaluation with the SLOF scale can become a useful, informative and reliable clinical tool to design a tailored rehabilitation program.

Published
2021

5. Personal resources and depression in schizophrenia: The role of self-esteem, resilience and internalized stigma

Author

Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Belvederi Murri, Martino, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona, Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavã², Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Murri, Martino Belvederi, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona, DELLA ROCCA, Paola, Cannavò, Dario, Antonio, Vita, and Martino Belvederi, Murri

Subjects
Adult, Male, Social stigma, Adolescent, media_common.quotation_subject, Schizophrenia (object-oriented programming), Social Stigma, Affect (psychology), NO, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Settore MED/25 - Psichiatria, Avolition, Biological Psychiatry, media_common, Aged, Resilience, Depression, Resilience, Psychological, Middle Aged, Self Concept, 030227 psychiatry, Cross-Sectional Studies, Female, Schizophrenia, Schizophrenic Psychology, Psychiatry and Mental Health, Psychological, Psychological resilience, medicine.symptom, Biological psychiatry, Psychology, Psychosocial, 030217 neurology & neurosurgery, Psychopathology, Clinical psychology
Abstract

Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators. The analysis reveals that low resilience, high negative symptoms, female gender were directly associated with depression severity, and internalized stigma acted only as a mediator between avolition and resilience, with similar magnitude. The cross-sectional study design and the variable selection limit the generalizability of the study results. The model supports a complex interaction between personal resources and negative symptoms in predicting depression in schizophrenia. The clinical implication of these findings is that personal resources could be a significant target of psychosocial treatments.

Published
2017

6. Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements

Author

Piluso, Giulio, Monteleone, Palmiero, Galderisi, Silvana, Giugliano, Teresa, Bertolino, Alessandro, Rocca, Paola, Rossi, Alessandro, Mucci, Armida, Aguglia, Eugenio, Andriola, Ileana, Bellomo, Antonello, Comparelli, Anna, Gambi, Francesco, Fagiolini, Andrea, Marchesi, Carlo, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Stratta, Paolo, Tortorella, Alfonso, Steardo, Luca Jr, Bucci, Paola, Nigro, Vincenzo, Maj, Mario, Italian Network for Research on Psychoses, Montefusco, Valentina, Plescia, Giuseppe, Piegari, Giuseppe, Merlotti, Eleonora, Cimmino, Monica, Savarese, Marco, D’Ambrosio, Enrico, Atti, Anna Rita, Valsecchi, Paolo, Signorelli, Maria Salvina, Acciavatti, Tiziano, Altamura, Mario, Arzani, Costanza, Callista, Gaetano, Pacitti, Francesca, Oldani, Lucio, Gramaglia, Carla, Tenconi, Elena, Camerlengo, Annalisa, Dell’Osso, Liliana, Brugnoli, Roberto, Di Fabio, Fabio, Niolu, Cinzia, Corrivetti, Giulio, Bolognesi, Simone, Montemagni, Cristina, Piluso, G., Monteleone, P., Galderisi, S., Giugliano, T., Bertolino, A., Rocca, P., Rossi, A., Mucci, A., Aguglia, E., Andriola, I., Bellomo, A., Comparelli, A., Gambi, F., Fagiolini, A., Marchesi, C., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Stratta, P., Tortorella, A., Steardo, L., Bucci, P., Nigro, V., Maj, M., Montefusco, V., Plescia, G., Piegari, G., Merlotti, E., Cimmino, M., Savarese, M., D'Ambrosio, E., Atti, A. R., Valsecchi, P., Signorelli, M. S., Acciavatti, T., Altamura, M., Arzani, Costanza., Callista, G., Pacitti, F., Oldani, L., Gramaglia, C., Tenconi, E., Camerlengo, A., Dell'Osso, L., Brugnoli, R., Di Fabio, F., Niolu, C., Corrivetti, G., Bolognesi, S., and Montemagni, C.

Subjects
family trios, Adult, Male, DNA Copy Number Variations, Schizophrenia (object-oriented programming), Schizophrenia, de novo CNV, enhancers, genetics, Schizophrenia, genetics, enhancers, de novo CNV, family trios, family trio, Biology, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, mental disorders, Humans, Genetic Predisposition to Disease, Copy-number variation, Enhancer, Gene, Biological Psychiatry, Enhancer Elements, Genetics, Middle Aged, 030227 psychiatry, Enhancer Elements, Genetic, Settore MED/25, Italy, Psychiatry and Mental Health, Mutation, Female, enhancer, genetic, Biological psychiatry
Abstract

Objectives: Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be explored more deeply. Methods: We investigated de novo copy-number variations (CNVs) in the whole-genomic DNA obtained from 46 family trios of schizophrenia probands by using the Enhancer Chip, a customised array CGH able to investigate the whole genome with a 300-kb resolution, specific disease loci at a ten-fold higher resolution, and which was highly enriched in probes in more than 1,250 enhancer elements selected from Vista Enhancer Browser. Results: In seven patients, we found de novo CNVs, two of which overlapped VISTA enhancer elements. De novo CNVs encompass genes (CNTNAP2, MAGI1, TSPAN7 and MET) involved in brain development, while that involving the enhancer element hs1043, also includes ZIC1, which plays a role in neural development and is responsible of behavioural abnormalities in Zic mutant mice. Conclusions: These findings provide further evidence for the involvement of de novo CNVs in the pathogenesis of schizophrenia and suggest that CNVs affecting regulatory enhancer elements could contribute to the genetic vulnerability to the disorder.

Published
2017

7. The Brief Negative Symptom Scale (BNSS): Independent validation in a large sample of Italian patients with schizophrenia

Author

MUCCI, Armida, GALDERISI, Silvana, MERLOTTI, Eleonora, BUCCI, Paola, PIEGARI, Giuseppe, MAJ, Mario, Rossi, A., Rocca, P., Chieffi, M., Vignapiano, A., Campana, Teresa, De Simone, Stefania, Gallo, Olimpia, Giugliano, Rosa, LUCIANO, Mario, Montefusco, Valentina, Plescia, Giuseppe, Sampogna, Gaia, Andriola, Ileana, Porcelli, Stefano, Galluzzo, Alessandro, Signorini, Giulia, Bulgari, Viola, Pinna, Federica, Signorelli, Maria Salvina, di Giannantonio, Massimo, Bellomo, Antonello, Calcagno, Pietro, Roncone, Rita, Stratta, Paolo, Buoli, Massimiliano, Zeppegno, Patrizia, Giannunzio, Valeria, Marchesi, Carlo, Dell'Osso, Liliana, Squarcione, Chiara, Comparelli, Anna, Niolu, Cinzia, Monteleone, Palmiero, Goracci, Arianna, Montemagni, Cristiana, Mucci, Armida, Galderisi, Silvana, Merlotti, Eleonora, Rossi, A., Rocca, P., Bucci, Paola, Piegari, Giuseppe, Chieffi, M., Vignapiano, A., Maj, Mario, Campana, Teresa, De Simone, Stefania, Gallo, Olimpia, Giugliano, Rosa, Luciano, Mario, Montefusco, Valentina, Plescia, Giuseppe, Sampogna, Gaia, Andriola, Ileana, Porcelli, Stefano, Galluzzo, Alessandro, Signorini, Giulia, Bulgari, Viola, Pinna, Federica, Signorelli, Maria Salvina, di Giannantonio, Massimo, Bellomo, Antonello, Calcagno, Pietro, Roncone, Rita, Stratta, Paolo, Buoli, Massimiliano, Zeppegno, Patrizia, Giannunzio, Valeria, Marchesi, Carlo, Dell'Osso, Liliana, Squarcione, Chiara, Comparelli, Anna, Niolu, Cinzia, Monteleone, Palmiero, Goracci, Arianna, and Montemagni, Cristiana

Subjects
Adult, Male, medicine.medical_specialty, Psychometrics, Intraclass correlation, Asociality, Negative symptom, Avolition, Negative symptoms, Poor emotion expression, Primary negative symptoms, Schizophrenia, Psychiatry and Mental Health, Medicine (all), 03 medical and health sciences, 0302 clinical medicine, Brief Psychiatric Rating Scale, medicine, Humans, Affective Symptoms, Psychiatry, Settore MED/25 - Psichiatria, Discriminant validity, Anhedonia, Reproducibility of Results, Middle Aged, Female, Italy, Schizophrenic Psychology, 030227 psychiatry, Convergent validity, medicine.symptom, Primary negative symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundThe Brief Negative Symptom Scale (BNSS) was developed to address the main limitations of the existing scales for the assessment of negative symptoms of schizophrenia. The initial validation of the scale by the group involved in its development demonstrated good convergent and discriminant validity, and a factor structure confirming the two domains of negative symptoms (reduced emotional/verbal expression and anhedonia/asociality/avolition). However, only relatively small samples of patients with schizophrenia were investigated. Further independent validation in large clinical samples might be instrumental to the broad diffusion of the scale in clinical research.MethodsThe present study aimed to examine the BNSS inter-rater reliability, convergent/discriminant validity and factor structure in a large Italian sample of outpatients with schizophrenia.ResultsOur results confirmed the excellent inter-rater reliability of the BNSS (the intraclass correlation coefficient ranged from 0.81 to 0.98 for individual items and was 0.98 for the total score). The convergent validity measures had r values from 0.62 to 0.77, while the divergent validity measures had r values from 0.20 to 0.28 in the main sample (n = 912) and in a subsample without clinically significant levels of depression and extrapyramidal symptoms (n = 496). The BNSS factor structure was supported in both groups.ConclusionsThe study confirms that the BNSS is a promising measure for quantifying negative symptoms of schizophrenia in large multicenter clinical studies.

Published
2015

8. Evolution of antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia in the real-life: A 4-year follow-up naturalistic study

Author

Palmiero Monteleone, Giammarco Cascino, Alessandro Rossi, Paola Rocca, Alessandro Bertolino, Eugenio Aguglia, Mario Amore, Ileana Andriola, Antonello Bellomo, Massimo Biondi, Claudio Brasso, Bernardo Carpiniello, Enrico Collantoni, Liliana Dell'Osso, Massimo di Giannantonio, Michele Fabrazzo, Andrea Fagiolini, Giulia Maria Giordano, Matteo Marcatili, Carlo Marchesi, Alessio Maria Monteleone, Maurizio Pompili, Rita Roncone, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj, Monteleone, Palmiero, Cascino, Giammarco, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Brasso, Claudio, Carpiniello, Bernardo, Collantoni, Enrico, Dell'Osso, Liliana, di Giannantonio, Massimo, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marcatili, Matteo, Marchesi, Carlo, Monteleone, Alessio Maria, Pompili, Maurizio, Roncone, Rita, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Subjects
Antipsychotics, Evolution, Extrapyramidal side effects, Naturalistic study, Schizophrenia, Antipsychotic, Extrapyramidal side effect, Psychiatry and Mental health, Humans, Biological Psychiatry, Antipsychotic Agents, Follow-Up Studies
Abstract

Previous studies have shown, although not consistently, that first generation antipsychotics (FGA) are associated with a prevalence of extrapyramidal symptoms (EPS) higher than second generation antipsychotics (SGA). We assessed the prevalence and the incidence of antipsychotic-induced EPS in a large sample of community-dwelling Italian persons with schizophrenia before and after a 4-year naturalistic treatment, to shed light on their natural evolution and to identify possible predicting factors. EPS and psychopathology were assessed in 571 subjects with schizophrenia before (baseline) and after 4-year follow-up. Patients underwent treatment with SGA and/or FGA according to the referring clinicians' judgment. Relationships between EPS and psychopathology were assessed by network analysis, while a linear multiple regression investigated factors correlated to the presence of EPS at follow-up. EPS were significantly more frequent in the FGA- than in the SGA-treated group, and patients with EPS presented a more severe psychopathology. Parkinsonism was directly and positively connected with poor emotional expression at baseline and with poor emotional expression and disorganization at follow-up. Over the 4-year follow-up, emergent EPS were more frequent in FGA-treated patients, while relieved EPS occurred more frequently in SGA-treated persons. The presence of EPS at follow-up was significantly associated with EPS at baseline, illness duration, antipsychotic generation and the daily dose of antipsychotic medications. After a 4-year naturalistic treatment, EPS disappeared more frequently in SGA-treated patients, while they emerged more frequently in FGA-treated individuals. Therefore, although SGA did not eliminate the risk of EPS, these drugs seem to be associated to a more favorable EPS natural evolution.

Published
2022

9. The Complex Interplay Between Physical Activity and Recovery Styles in Patients With Severe Mental Disorders in a Real-World Multicentric Study

Author

Sampogna, G, Luciano, M, Di Vincenzo, M, Andriola, I, D'Ambrosio, E, Amore, M, Serafini, G, Rossi, A, Carmassi, C, Dell'Osso, L, Di Lorenzo, G, Siracusano, A, Rossi, R, Fiorillo, A, Working Group LIFESTYLE, Bianciardi, E, Sampogna, Gaia, Luciano, Mario, Di Vincenzo, Matteo, Andriola, Ileana, D'Ambrosio, Enrico, Amore, Mario, Serafini, Gianluca, Rossi, Alessandro, Carmassi, Claudia, Dell'Osso, Liliana, Di Lorenzo, Giorgio, Siracusano, Alberto, Rossi, Rodolfo, and Fiorillo, Andrea

Subjects
Psychiatry and Mental health, lifestyle, sedentary behaviors, Settore MED/25, sedentary behavior, physical activity, severe mental disorders, mortality
Abstract

Compared with the general population, people with severe mental disorders have significantly worse physical health and a higher mortality rate, which is partially due to the adoption of unhealthy lifestyle behaviors, such as heavy smoking, use of alcohol or illicit drugs, unbalanced diet, and physical inactivity. These unhealthy behaviors may also play a significant role in the personal and functional recovery of patients with severe mental disorders, although this relationship has been rarely investigated in methodologically robust studies. In this paper, we aim to: a) describe the levels of physical activity and recovery style in a sample of patients with severe mental disorders; b) identify the clinical, social, and illness-related factors that predict the likelihood of patients performing physical activity. The global sample consists of 401 patients, with a main psychiatric diagnosis of bipolar disorder (43.4%, N = 174), psychosis spectrum disorder (29.7%; N = 119), or major depression (26.9%; N = 118). 29.4% (N = 119) of patients reported performing physical activity regularly, most frequently walking (52.1%, N = 62), going to the gym (21.8%, N = 26), and running (10.9%, N = 13). Only 15 patients (3.7%) performed at least 75 min of vigorous physical activity per week. 46.8% of patients adopted sealing over as a recovery style and 37.9% used a mixed style toward integration. Recovery style is influenced by gender (p < 0.05) and age (p < 0.05). The probability to practice regular physical activity is higher in patients with metabolic syndrome (Odds Ratio - OR: 2.1; Confidence Interval - CI 95%: 1.2-3.5; p < 0.050), and significantly lower in those with higher levels of anxiety/depressive symptoms (OR: 0.877; CI 95%: 0.771-0.998; p < 0.01). Globally, patients with severe mental disorders report low levels of physical activities, which are associated with poor recovery styles. Psychoeducational interventions aimed at increasing patients' motivation to adopt healthy lifestyle behaviors and modifying recovery styles may improve the physical health of people with severe mental disorders thus reducing the mortality rates.

Published
2022

10. The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study

Author

Eleonora Merlotti, Liliana Dell'Osso, Enrico Collantoni, Alice Ghiani, Paolo Stratta, Paola Rocca, Dino Gibertoni, Dario Cannavò, Alessandro Rossi, Alessandro Corso, Simone Bolognesi, Martino Belvedere Murri, Roberto Brugnoli, Cinzia Mingrone, Mario Altamura, Giorgio Di Lorenzo, Valeria Bianchini, Davide Gallicchio, Claudia Carmassi, Carmela Marucci, T. Acciavatti, Marina Mancini, Paola Bucci, Marco Alessandrini, M. Chieffi, A. Vignapiano, Giacomo Deste, Armida Mucci, Gaetano Callista, Mario Amore, Mario Maj, Cristiana Montemagni, Monicag Sigaudo, Stefania de Simone, Carla Gramaglia, Federica Vellante, Fabio Di Fabio, Antonio Vita, Andrea Cantisani, Pietro Calcagno, Chiara De Panfilis, Massimo Biondi, Tiziana Frieri, Arianna Goracci, Laura Giusti, Cinzia Niolu, Paola Rucci, Maria Salvina Signorelli, Stefano Porcelli, Luca Gheda, Bernardo Carpiniello, Alessandro Bertolino, Antonello Bellomo, Luca Bartoli, Alessandro Galluzzo, Rita Roncone, Maria Antonietta Nettis, Anna Comparelli, Valeria Santarelli, Andrea Fagiolini, Carlo Marchesi, Elena Tenconi, Ferdinando Diasco, Paolo Ossola, Valentina Corigliano, Alberto Siracusano, Palmiero Monteleone, Elisa Borghini, Antonella De Carolis, Federica Pinna, Carla Cremonese, Alice Lai, Maurizio Malavolta, Tiziana Pagano, Alessandro Feggi, Massimo Di Giannantonio, Alessia Maria Chiara Mirigliani Torti, Mariangela Rocco, Giuseppe Minutolo, Grazia Rutigliano, Giuseppe Rizzo, Giulio Corrivetti, Matteo Tonna, Patrizia Zeppegno, Flavia A. Padalino, Alfonso Troisi, Camilla Gesi, E. Gattoni, Simona D'Onofrio, Carmine Tomasetti, Ileana Andriola, Giuseppe Piegari, Silvana Galderisi, Eugenio Aguglia, Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Callista, Gaetano, Comparelli, Anna, Dell’Osso, Liliana, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Niolu, Cinzia, Piegari, Giuseppe, Pinna, Federica, Roncone, Rita, Stratta, Paolo, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Mancini, Marina, Nettis, Maria Antonietta, Rizzo, Giuseppe, Porcelli, Stefano, Deste, Giacomo, Galluzzo, Alessandro, Gheda, Luca, Carpiniello, Bernardo, Ghiani, Alice, Lai, Alice, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria Salvina, Acciavatti, Tiziano, Alessandrini, Marco, Vellante, Federica, Cantisani, Andrea, Altamura, Mario, Padalino, Flavia A., Pagano, Tiziana, Belvedere Murri, Martino, Calcagno, Pietro, Corso, Alessandro, D’Onofrio, Simona, Marucci, Carmela, Santarelli, Valeria, Bianchini, Valeria, Giusti, Laura, Malavolta, Maurizio, Bucci, Paola, Chieffi, Marcello, de Simone, Stefania, Merlotti, Eleonora, Rocco, Mariangela, Vignapiano, Annarita, Tomasetti, Carmine, Feggi, Alessandro, Gattoni, Eleonora, Gramaglia, Carla, Cremonese, Carla, Collantoni, Enrico, Gallicchio, Davide, de Panfilis, Chiara, Ossola, Paolo, Tonna, Matteo, Carmassi, Claudia, Gesi, Camilla, Rutigliano, Grazia, Brugnoli, Roberto, Corigliano, Valentina, de Carolis, Antonella, Di Fabio, Fabio, Mirigliani Torti, Alessia Maria Chiara, Di Lorenzo, Giorgio, Siracusano, Alberto, Troisi, Alfonso, Bartoli, Luca, Corrivetti, Giulio, Diasco, Ferdinando, Bolognesi, Simone, Borghini, Elisa, Goracci, Arianna, Frieri, Tiziana, Mingrone, Cinzia, Sigaudo, Monicag, and Sigaudo, Monica

Subjects
Male, Coping (psychology), Social stigma, Social Stigma, Severity of Illness Index, Symptom severity, Personal resource, Structural equation model, Psychosocial functioning, 0302 clinical medicine, Surveys and Questionnaires, Pharmacology (medical), Age of Onset, Antisocial Personality Disorder, General Medicine, Middle Aged, Italy, Psychiatry and Mental Health, Personal resources, Schizophrenia, Structural equation models, Biological Psychiatry, Female, Schizophrenic Psychology, Biological psychiatry, Psychology, Social Adjustment, Psychosocial, Clinical psychology, Adult, medicine.medical_specialty, Adolescent, macromolecular substances, Structural equation modeling, Young Adult, 03 medical and health sciences, Severity of illness, medicine, Humans, Psychiatry, Settore MED/25 - Psichiatria, Aged, Psychiatric Status Rating Scales, Antisocial personality disorder, Models, Theoretical, medicine.disease, Self Concept, 030227 psychiatry, Schizophrenia, Personal resources, Symptom severity, Psychosocial functioning, Structural equation models, Age of onset, 030217 neurology & neurosurgery
Abstract

The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation models to a sample of 921 patients with schizophrenia collected in a nationwide Italian study, with the aim to identify, among a large set of personal resources, those that may have an association with symptom severity or psychosocial functioning. Several relevant demographic and clinical variables were considered concurrently. Poor service engagement and poor recovery style, as well as older age and younger age at onset, were related to greater symptom severity and poorer social functioning. Higher resilience and higher education were related to better social functioning only. Poor problem-focused coping and internalized stigma, as well as male gender and depression, were related to symptom severity only. The explored variables showed distinctive and partially independent associations with symptom severity and psychosocial functioning. A deeper understanding of these relationships may inform treatment decisions.

Published
2017

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