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Introduction Spinal cord injuries are known to have physical damage. They are often accompanied by urinary and fecal incontinence, disorders of tenderness, neuropathic pain and motor deficits. Therefore they have a serious impact on physical, mental and social health. Objectives The objective of our work was to assess sexual function and quality of life in men with spinal cord injuries. Methods This is a cross-sectional study enrolling patients with spinal cord injuries followed at the physical medicine consultation and/or urology department of Sahloul teaching Hospital during the period from January 2016 to January 2018. Results This study enrolled 21 patients. Mean age was 45.62 ±15.79 years. Thirteen patients were married, and nine had a primary school level of education. Thirteen patients worked as building workers. The cause of the spinal cord injury was traffic accident in 12 cases. The overall IIEF 15 was 15.57±7.46. Thirteen patients had erectile dysfunction which was rated severe in five patients. The average MSQ was 27.52 ± 26.32 with 10 patients very dissatisfied. The overall SF-36 score was 31.71± 26.16. We found a statistical correlation between quality of life impairment and sexuality impairment in almost all dimensions and especially impairment of physical activity (r²=+0.783 p

Introduction Chronic renal failure is a public health issue. It leads to a degradation of physical integrity, hormonal disorders and a great psychological impact, which can lead to sexual disorders. Objectives The aim of this study was to identify risk factors of sexual dysfunction in patients on dialysis and renal transplant patients. Methods This is a cross-sectional survey conducted in nephrology department of Sahloul teaching hospital (Sousse) and Fattouma Bourguiba teaching hospital (Monastir) over two-month period. Patients on dialysis and renal transplant patients were included. Sexuality was assessed by FSFI and IIEF 15 Results This study enrolled 137 patients (99 patients with chronic renal failure and 38 renal transplant patients). The incidence of erectile dysfunction of men on dialysis was 57% and was associated to a decrease in testosterone level (11%) and an increase in LH level (50%). Its main risk factors were age (p=0.000), the duration (p=0.009), the cardiovascular diseases (p=0.03), the anxiety (p=0.000), the depression (p=0.000) and the different aspects of erectile dysfunction (p=0.000. In women on dialysis, the most common sexual disorder noticed was sexual arousal disorder (78.8%). In the transplant, erectile dysfunction was found in 18.2% of transplant men and was associated to age was a predictive factor (p=0.03). In women, orgasm and desire disorders were the most common (69%). Renal transplantation improved erectile dysfunction in men with IIEF score rising from 14 to 27 (p=0.021). It also improved sexual life in women: increase of desire (p=0.042) and orgasm scores (p=0.034). Conclusions Sexual disorders remain common in patients on dialysis and with renal transplant. Their management requires a systematic screening to improve patients’ outcome Disclosure of Interest None Declared

Introduction Acute urinary retention (AUR) is known to have major impact on the quality of life and sexuality of patients with benign prostatic hyperplasia (BPH). However, little is known about specific approachs that could reduce this impact. Tadalafil, an efficient medication in uncomplicated BPH, may be also useful in serious complications, especially the AUR. Objectives The aim of this study is to assess the impact of Tadalafil on sexuality and quality of life in patients AUR related to BPH. Methods This is a randomized, double-blind clinical trial conducted in the Urology and Emergency Departments of Sahloul Teaching Hospital, between June 2020 and January 2022. Consenting men over the age of 45 who had an AUR complicating a BPH were included. Fifty three patients were enrolled and randomized into two groups: intervention group (n=29) in which patients received 5 mg/day of Tadalafil, and control group (n=24) in which patients received a comparable tablet of placebo. The evaluation focused on sexuality and quality of life. For theses purposes we used SF-36 short form and IIEF 15. Results Socio-demographic characteristics were comparable between both groups. Sexuality assessed by IIEF 15 was significantly better in the intervention group (p=0.02). The four SF-36 domains were also significantly improved by Tadalafil: “Physical Function” (p=0.046), “Pain” (p=0.01), “General Health” (p=0.029) and “Health change” (p=0.02). Conclusions Sexuality and quality of life could be improved by Tadalafil in complicated BPH. Disclosure of Interest None Declared

Introduction Improving health-related quality of life (HRQL) is the main goal of palliative care. It requires consensual management strategies and specific measures targeting modifiable factors that could affect the quality of life. Objectives The aim of this study was to identify factors influencing the quality of life of patients with metastatic prostate cancer in a limited resources country. Methods This is a retrospective and analytical study enrolling all patients with metastatic prostate cancer who were managed at medical oncology and urology consultations of two Tunisian teaching hospital. HRQL was measured using UCLA prostate cancer index and SF-36 SCALE. The influence of demographic and medical characteristics on HRQL was determined using t tests and analysis of variance, with Tukey’s correction for multiple comparisons. Multivariate linear regression was used to determine independent predictor Results This study enrolled 244 patients. The mean age was 72 years. The strongest determinants of overall HRQL after univariate analysis were: increased age (p = 0.006), lower income (p = 0.009), sexual function problems (p = 0.004), urinary function problems (p = 0.002) and symptoms such as pain (p = 0.001) and asthenia (p = 0.001). Conclusions Age, income, sexual and urinary functions are important determinants of HRQL in patients with metastatic prostate cancer that may require specific interventions. Disclosure of Interest None Declared