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Introduction The comorbidity between depressive disorders and addiction is far from being random. Through substances, users try to ameliorate their feelings of sadness, reduce present anxiety. The phenomena of tolerance and dependence quickly worsen the situation, and make any attempt at withdrawal more difficult. Objectives The objective of this study is to analyze the addictive behavior in patients diagnosed with depressive disorder. Methods This is a retrospective descriptive study carried out by analyzing hospitalization records in the addictology department of the psychiatric university hospital Ar-Razi in Salé over a period of one year (from August 2020 to August 2021). The diagnoses are established according to the DSM 5 diagnostic criteria. Results Of 141 patient records initially entered, nine records were not usable and 54 patients had a diagnosis of depressive disorder constituting 40.9% of admissions to the service. The average age was 37.9 years (16; 69). Among our depressed and substance-using patients, the most frequent comorbidity was personality disorders (29.6%) followed by anxiety disorders (11.1% of cases). Thirty-five percent of patients reported at least one suicide attempt in the past and 11.1% had experienced sexual abuse. The average age of onset of addiction in our sample was 17.8 years (11; 31). The most used substance was tobacco (n=44) followed by alcohol (n=43), cannabis and then benzodiazepines. Conclusions The relationship between depression and substance use remains complex. Although depressed patients often turn to drugs in search of a state of well-being, withdrawal from these substances can also aggravate or cause the depression. Disclosure of Interest None Declared

Introduction Childbirth can be a very painful experience, especially vaginally. It can have many complications. The obstetrical complications of caesarean section are well studied but its psychological complications are little mentioned. Most women recover quickly after giving birth, but others seem to have more difficulty. Researchers have attempted to identify perinatal risk factors for the development of post-traumatic stress disorder in parturients and caesarean section seems to be one of the predictors. Objectives The objective of our study is to detect post traumatic stress disorder in women after vaginal delivery. Methods This is a cross-sectional descriptive study conducted among women from the general population who have given birth vaginally. The information was collected using a questionnaire distributed on social networks. Symptom severity was quantified using the PTSD checklist for DSM-V (PCL-5).PCL-5 is a 20-item self-assessment that measures the 20 DSM-5 symptoms of PTSD. She rates each symptom from 0 (not at all) to 4 (extremely). The score varies from 0 to 80. A threshold of 33 allows screening for post-traumatic stress disorder. Results 61 women took part in this study, 81.5% of whom gave birth vaginally between the ages of 20 and 30.70.3% of the participants gave birth vaginally once, 44.4% twice and 7.3% of the women in our sample had a caesarean three times.Regarding the indication of the high way in our sample: the narrowing of the pelvis and fetal distress were in 22.2%. Exceeding term was in 18.5% of cases.In our sample, 59.3% of the women had planned their vaginal delivery and 40.7% had given birth urgently.Regarding the results of the PCL-5 scale (PTSD checklist for DSM-V), the score varies between 0 and 48 with a median score equal to 12. 3.7% of the participants had a score greater than 33. Conclusions Post-traumatic stress disorder can accompany childbirth, especially when it is high and in an emergency. Postpartum post traumatic stress disorder affects the mother-child relationship and can be complicated by depressive disorder. Medical monitoring of pregnancy, good medical and family support for the parturient and preparation for childbirth are necessary to better start the maternity experience. Disclosure of Interest None Declared

Introduction Schizophrenia is a chronic illness, affecting approximately 1% of the general population. The more chronic a treatment is, the poorer the quality of adherence. In fact, approximately 60% of patients with schizophrenia are incompletely or non-adherent within one year of the first episode. Poor adherence has consequences in terms of clinical status, quality of life and psychosocial functioning due to associated relapses. One of the main factors of poor compliance is the use of addictive substances. Half of schizophrenic patients have, or have had, an addictive comorbidity during their life. Moreover, schizophrenic patients with addictive comorbidity have a more severe symptomatology and have more associated physical, psychological and social problems, representing a challenge in the management Objectives The objective of our work is to evaluate the impact of addictive comorbidity on medication adherence and relapse. Methods This is a cross-sectional study, carried out in patients with schizophrenia hospitalized or followed in ambulatory consultation, at the psychiatric hospital Ar-razi of Salé. The data collection (sociodemographic, clinical and therapeutic) is carried out by a questionnaire established for this purpose. The use of substances is evaluated according to the DSM-V criteria Results A total of 110 schizophrenic patients were followed or hospitalized, of which 61.8% had a substance use disorder. The average age of onset of substance use was 18 years. The duration of substance use ranged from 1 to 11 years and up to 49 years for tobacco and cannabis. 72% of the addicts tried to stop their use alone or in outpatient settings, only 17% in inpatient settings. The average duration of abstinence was 11 months and ranged from 1 to 18 years. 81% reported remission of the disease after abstinence. The hospitalization rate was 88.2% for addicts versus 85% for non-addicts. The number of hospitalizations was 180 for addicts versus 78 for non-addicts. The cumulative duration of hospitalization is 208 months against 96 months for addicts. The duration of remission is 5 months for addicts and 24 months for non-addicts. 71% of non-addicts patients have well observed their treatment against 57% of addicts Conclusions The weight of co-morbid addictions represents between 1/5 and 1/3 of the factors at stake in the compliance and the risk of relapse of patients suffering from schizophrenia. The development of specific care strategies for a global management of addiction and schizophrenia should be a priority. Disclosure of Interest None Declared

Introduction Depression is second only to cardiovascular disease as a cause of disability and affects 3 to 5% of the general population. The therapist always tries to guarantee a total remission of the symptoms of depression, but partial remission remains frequent. Objectives Evaluating the quality of remission in a group of patients followed for major depressive disorder at the Arrazi Hospital in Salé. Methods Cross-sectional study in adult patients followed up in consultation for major depressive disorder according to DSM-V criteria and having been under treatment for at least 2 months. Information was collected using a hetero questionnaire containing information on sociodemographic data and the depressive episode. The quality of remission is assessed using the Hamilton Rating Scale for Depression. Results We recruited 70 patients followed for major depressive disorder at 2 months of evolution. The Hamilton scale revealed that 40% of patients were in partial remission. Conclusions Residual symptoms can be the cause of relapse in major depressive disorder, hence the interest in seeking both a symptomatic remission and a complete functional remission, and this by the evaluation and the continuous management of the patients. Disclosure of Interest None Declared

Introduction Wernicke’s encephalopathy (WE) is a severe neuropsychiatric syndrome resulting from thiamine deficiency (vit B1) wich is often associated with chronic alcoholism. The classical presentation is characterized by ophtalmoplegia, ataxia and confusion. Unfortunately, WE is still underdiagnosed because it may not always show up with a classical presentation in one hand, and could also be seen in other non alcoholic condition in an other hand which delay diagnosis and managment of early proper treatement Objectives This case highlights the importance of considering atypical presentations of Wernicke’s encephalopathy, it’s medical etiologies and the importance of improving diagnosis to manage early treatement Methods We reported a case of a pregnant women who consulted for alterated mental status , asthenia and occurs to have Wernicke’s encephalopathy due to hyperemesis gravidarum Results Mrs X is a 35-year-old pregnant women with a past medical history of a cesarian, an hospitalisation in third month of this pregnancy for vomits, no known psychiatric illness or history of substance abuse. She was brought to the gynecology emergency department for asthenia and altered mental status. MRS X, was lethargic, had not eaten for several days, vomiting for more than a month. On the medical evaluation she appeared confused, disoriented, and unresponsive to verbal or manual redirection and prompting. She had also ataxia and gait incoordination. Laboratory testing was remarkable for lactic acidosis (blood lactate concentration lipasemia and normal electrolyte levels, cerebrospinal fluid (CSF) culture was unremarkable. A brain MRI was done and showed FLAIR signal abnormalities around the third ventricle and periaqueductal, suggesting Gayet-Wernicke encephalopathy. Thiamine (vit B1) 500mg thrice a day was administrated for the next days in associtation with vitamin B6. Conclusions Wernicke encephalopathy (WE) is an acute reaction to thiamine deficiency which usually presents with a classical triad. However, Clinicians tend to ignore WE in other non-alcoholic clinical settings and the diagnosis becomes even more difficult when thiamine deficiency presents with unusual neuropsychiatric signs and symptoms like catatonia. This case highlights the importance of considering atypical presentations of WE, it’s medical etiologies and the necessity of a complete medical evaluation and appropriate investigations to make prompt diagnosis and early management. Disclosure of Interest None Declared

Introduction Habituellement, nous voyons dans la consultation psychiatrique des patients épileptiques pour des plaintes psychologiques. Souvent pour un trouble anxieux ou dépressif. Dans d’autres cas, nous prenons en charge des patients psychiatriques atteints d’épilepsie. Objectives L’objectif de notre travail est d’étudier la prévalence de la comorbidité psychiatrique dans une population de patients épileptiques. Methods Nous avons mené une étude transversale auprès de la consultation de l’hopital ar-razi de salé, à l’aide d’un questionnaire et d’échelles d’évaluation préétablies : le MINI (mini entretien neuropsychiatrique international), l’inventaire de la dépression de Beck, et Échelle d’anxiété de Hamilton. Results 55 patients ont répondu aux critères d’inclusion. L’âge moyen de nos patients est de 25,9 ans. Le sex-ratio F/H est de 1,6. Plus de la moitié de nos patients sont célibataires (78%). Seuls 21 % des patients ont une activité professionnelle régulière. La prévalence des troubles psychiatriques dans notre étude est de 66,6%. L’anxiété est retrouvée dans 68,2 % des cas, alors que la dépression est évaluée à 58,9 % des cas dont 23,7 % ont une dépression sévère qu’il faut traiter, avec une prédominance du sexe féminin (66,8 %). Conclusions Dans notre étude, l’ anxiété et la dépression sont les troubles psychiatriques les plus rapportés en cas d’épilepsie. Ils doivent être systématiquement recherchés pour tout épileptique et traités pour améliorer la qualité de vie des patients. Disclosure of Interest None Declared

Introduction Alcohol use disorder is a real public health problem in the world, it consists of a pathological mode of consumption which is characterized by a loss of control and craving. Depressive disorder and alcohol use disorder are among the most frequent mental pathologies and are often associated. The links between these two disorders can be of several types: Alcohol Induced Depressive Disorders, Primary Depressive Disorders and Secondary Alcohol Dependence. They can also have two-way relationships or be favored by common factors. Objectives The objective of our work is to analyze the causal links between alcohol use disorder and depression. Methods provide an update via two clinical vignettes and a review of the literature the relationship between alcohol use disorder and depression Results The causal relationships between alcohol dependence and psychiatric disorders can be of several types which are not mutually exclusive: primary alcohol dependence, secondary psychiatric disorders, induced by alcohol. This is the case for the majority of depressive disorders encountered in alcohol-dependent patients; primary psychiatric disorders and secondary alcohol dependence; alcohol dependence and anxiety and/or depressive disorders are favored by common factors, in particular personality disorders, encountered in approximately 40% of alcohol-dependent patients. Whatever the direction of causation, alcohol dependence and psychiatric disorders worsen each other over time.Depression and alcohol use disorder are among the most frequent mental pathologies and are often associated.The optimal management of patients with dual diagnosis is so-called “integrated” management, simultaneously combining alcohol and psychiatric therapeutic approaches. Conclusions Alcohol consumption impairs the prognosis of depression, increases the risk of suicide, impairs social functioning and increases recourse to the healthcare system.The optimal management of patients with dual diagnosis is so-called “integrated” management. Psychotherapeutic (individual and systemic), drug and psychosocial approaches would be necessary to maximize therapeutic success. Disclosure of Interest None Declared

Introduction Since the appearance of long-acting antipsychotics (LAPAs) and given the high frequency of non-adherence to treatment in psychotic disorders, LAPAs have recognized a resurgence of interest in the psychiatric literature. These long-acting drugs may pose ethical issues (e.g. limitation of freedom). Objectives The present study aims to determine the representations of long-acting antipsychotics in patients followed at Arrazi Hospital in Salé. Methods Descriptive study carried out with patients hospitalized at the Arrazi hospital in Salé and those followed in consultation who are on APAP or who have already used it. The collection of information is done using an exploitation sheet Results APAPs have been used for less than 5 years by 53.8% of patients84.6% of participants do not use APAP bychoice, in 79.2% of cases it was the doctor’s decision and in 20.8% of cases it was the family’s choiceMonotherapytreatment was the most cited benefit by our patients (76.9%)The route of administration of APAP by intramuscular injection is the problem encountered in 57.7% of our patients, while11.5% of patients find no inconvenience for the use of these psychotropics. Conclusions Negative beliefs associated with the treatment contribute to a very large part to the lack of compliance, onthe contrary, long-acting antipsychotics may be better accepted by patients when taking into account the patients’ beliefsand preferences in the development of the treatment. therapeutic project Disclosure of Interest None Declared

Introduction The herpes zoster oticus results from the reactivation of the varicella zoster virus, a DNA virus of the Herpesviridae family with strictly human-to-human contamination, affecting the geniculate ganglion of the facial nerve. The manifestations of shingles and post-herpes signs are associated with psychiatric manifestations such as anxiety, insomnia and depressive disorder. Shingles and depressive disorder share common features, such as decreased cellular immunity and a high prevalence in the elderly Objectives Is there a correlation between the intensity of depression and the comorbidity of herpes zoster and depression? Is there an explanation for this association? Can adequate therapy of the infection prevent the occurrence of the depressive disorder? Does the existence of this comorbidity affect the response to antidepressants? Methods case report and litterature Results case report Conclusions We will try to answer these questions in this work while illustrating by the case of a patient having been touched by this comorbidity and while being based on what was published in literature. Disclosure of Interest None Declared

Introduction Cannabis is an illicit substance whose use is very common among the patients we see daily in hospitals. Its use is not simply a “recreational” desire, but above all an attempt at self-medication in order to manage emotions that have become too painful. However, even if cannabis reduces the symptomatology in the moment, it worsens most psychiatric pathologies. Objectives The purpose of this study is to assess the experiences of cannabis users’ families. Methods The survey was carried out among the families of patients hospitalized at the Arrazi Hospital in Salé and those followed in consultation and who use cannabis. The collection of information is done with the help of an exploitation form. Results 34.6% of the participating families put bad company as the cause of consumption, followed by family problems, psychiatric problems come in 3rd position with a percentage of 19.2%. Cannabis use is considered as a disease in 52.8% of the families participating in the study. 58.5% of the families distinguish between good and bad cannabis use and define bad use by the use of large quantities of cannabis in 34.2% of the cases. The majority of the participating families (86.8%) saw cannabis as aggravating their loved one’s mental illness. Conclusions The understanding of the perceptions of the families towards the use of cannabis by their close relatives as well as the correction of the false perceptions will help to establish better prevention programs and better patient care especially with the family therapy which showed its utility in the management of the patients having disorders related to the use of cannabis. Disclosure of Interest None Declared

Introduction Forensic studies often found high rates of major psychiatric and substance use disorders among inmates. These factors are linked to criminality in general, however, their involvement in recidivism among this population seems to be more important to determine. Objectives The aim of this study is to determinesociodemographic, psychiatric and forensicfactors of criminal recidivism among prisoners Methods We studied the medical files of all the offenders referred to the forensic psychiatry unit in Razi hospital for an examination between January 2010 and October 2020 and we analyzed sociodemographic, psychiatric and forensic characteristics of this population. Results The number of people who have undergone a forensic psychiatric examination was 256. Three files were not usable due to lacking data. The offenders were men in 95.7% (242) of the cases. Male inmates were found to be more likely to be re-incarcerated (p=0.029). The study showed that the level of education was an important factor in the recidivism of criminal acts (p=0.001) whilst no impact of marital status and employment were found (p=0.848; p=0.088). Family history of psychiatric illness was significantly higher among recidivist (p=0.022). Psychiatric factors associated with multiple convictions were the presence of a major psychiatric discord (p=0.0013), a personality disorder (p=0) or a substance use disorder (p=0.025).) The reason of conviction was linked with criminal recidivism as violent offense were factors of incarceration (p=0) as well as the age at first conviction (p=0) and the number of anterior incarcerations (p=0). Conclusions Our study underlines that predictive factors of criminality in general are also involved in recidivism among prisoners which is useful in establishing strategies of secondary but also primary prevention of violent crimes in particular. Disclosure of Interest None Declared

Introduction In terms of care, family has a major role to play in the evolution of psychiatric illness. Our aim in this work is to determine the family experience during the hospitalization of their sibling in the emergency room of the psychiatric university hospital Ar-Razi in Salé. Objectives Our aim in this work is to determine the family experience during the hospitalization of their sibling in the emergency room of the psychiatric university hospital Ar-Razi in Salé. Methods Our work was carried out with families of patients admitted to the emergency department of the psychiatric university hospital Ar-Razi in Salé. The data collection was carried out with the help of a questionnaire including several items. Results Sixty-five family members were included in this study. Their relatives hospitalized in the psychiatric emergency department were male in 70% of cases with an average age of 32.4 years. - In 76% of the cases, the family member interviewed was the one who requested hospitalization; - 55% of those interviewed were parents. The analysis of relatives’ feelings during the hospitalization showed: - Feelings of guilt were related to feelings of fear of exclusion and worries. - Feelings of fear and exclusion were mostly expressed by mothers of patients hospitalized for the first time At the end of the hospitalisation, 90% expressed relief, and 85% of family members were satisfied with their relative’s stay in the psychiatric emergency department. Conclusions Recognizing families as units of care and understanding their situation and experiences facilitates the post-hospitalization care process. A well-informed family about mental illness and the types of therapeutic treatments available helps optimize the treatment. Disclosure of Interest None Declared

Introduction Studies of criminality among women are relatively poor because of its lower rate compared to men and its frequent association with mental illness. Objectives The aim of this study is to determine the characteristics of female offenders referred for forensic psychiatric examination. Methods We studied the medical files of all the offenders referred to the forensic psychiatry unit in the Razi hospital for an examination between January 2010 and October 2020. Results The number of people who have undergone a forensic psychiatric examination was 256. The offenders were female in 4.29% (11) of the cases. Their average age was 35 years with a range of 17-73 years. They were mostly single (54.5%) with no education (54%). Fifty four percent of the studied population were unemployed and 63% of them lived with their families. One third of the studied population had a neurological history. Family history of psychiatric disorder was found in one case and only two had suicide attempts history. Two women had personality disorder: a borderline and a histrionic personality disorder. An average number of one hospitalization was found in this group. A criminal record was found in 47% of the cases with an average number of two offenses per person. The mean age of the first offense was 24 years old. The main crimes were: homicide (18.2%) and theft (18.2%). Three offenders were found of intellectual disability, two of them personality disorders, one of schizophrenia, one of dementia and one of depression. No psychiatric disorder was found in the rest of the cases. No drug abuse was found in this population. Conclusions The criminal and psychiatric profile of female inpatients differs from their male counterparts, which has important involvements in case management and validates the need of further searches in this field. Disclosure of Interest None Declared

Introduction Substance use is related to higher risk of criminality among prisoner with or without co-occurring mental disorder. This contributes to a poor correctional outcome and higher risk of suicide and other psychiatric disorders. Objectives The aim of this study is to compare offenders with substance use disorder with offenders with no addictive comorbidity. Methods We studied the medical files of all the offenders referred to the forensic psychiatry unit in the Razi hospital for an examination between January 2010 and October 2020 analyzed sociodemographic, psychiatric and criminological factors of this population. Results We found that the first group, with substance use disorder, was substantially consisted of male offenders (99.2%) compared to the second group (92%); (p=0). A significantly higher level of education was found in the second group compared to the first (p=0.004). Offenders with no substance use disorder tended to live with their family while the rest of the cases lived on their own (p=0.018), they also had three times more family history of psychiatric disorders than the other group (p=0). Psychiatric comorbidity was more important in the second group with more cases of schizophrenia and mental disability while the first group consisted mainly of people with personality disorders (p=0.018). The average number of anterior convictions was 3.12 first group and 1.33 in the second group, which is significantly lower (p=0) Conclusions Specific interventions, in particular addiction management, are required to reduce the criminal risk in this population. Disclosure of Interest None Declared

Introduction Studies have shown an increasing prevalence of mental health issues in the general population during the COVID-19 pandemic. Among them, pregnant women are a specific population at particular mental risk. Objectives The objectives of our study were to assess dysfunctional anxiety in women recovered from COVID-19 and to identify the impact of pregnancy on coronavirus-related dysfunctional anxiety. Methods This was a cross-sectional case-control study. The women in the case group have been infected with Sars-Cov 2, with a benign or pauci-symptomatic clinical form, and cured for one to two months at the time of the study without any post-COVID complications. Women included in the control group have not been infected with Sars-Cov 2 .Anxiety was assessed by the Coronavirus Anxiety Scale (CAS). Results In total, we recruited 30 women in the case group and 30 women in the control group.The average age of the case group was 35.8 ±6.8 years versus an average age of 35.3 ± 6.33 years in the control group. In each group, four women were pregnant (13.3%). Nearly one-third of the patients in the case group had a CAS score indicating dysfunctional anxiety probably related to coronavirus (33.3%), with a significant difference with the control group (p=0.026). In the case group, pregnancy was a risk factor for dysfunctional anxiety with p=0.036, OR=19.46 and CI95% = [1.21-314.00]. Conclusions COVID-19 has a negative impact on perinatal mental health. Specific support for pregnant women is recommanded during the COVID-19 pandemic. Disclosure No significant relationships.

Introduction Studies assessing the psychological impact of COVID-19 have shown that patients with COVID-19 had significantly higher levels of depression, anxiety, and post-traumatic stress symptoms than healthy controls. Objectives The objectives of our study were to assess dysfunctional anxiety in women recovered from COVID-19 and to compare it to healthy controls. Methods This is a cross-sectional case-control study. We randomly recruited women, from April 1st to 30th, 2021.The women in the case group have been infected with Sars-Cov 2, with a benign or pauci-symptomatic clinical form, and cured for one to two months at the time of the study without any post-COVID complications. Women included in the control group have not been infected with Sars-Cov 2 .Anxiety was assessed by the Coronavirus Anxiety Scale (CAS). Results In total, we recruited 30 women in the case group and 30 women in the control group.The average age of the case group was 35.8 ±6.8 years versus an average age of 35.3 ± 6.33 years in the control group. The majority of coronavirus infections were symptomatic (83.3% (n=25)). Nearly one-third of the patients in the case group had a CAS score greater than 9, indicating dysfunctional anxiety probably related to coronavirus (33.3%), with a significant difference with the control group (p=0.026). Conclusions COVID-19 is significantly associated with dysfunctional anxiety, even in mild or pauci-symptomatic clinical forms. Disclosure No significant relationships.

Introduction While several studies have assessed the impact of the COVID-19 pandemic on sexuality and sexual behavior in the general population, very few studies have assessed sexuality after Sars-Cov 2 infection. Objectives The objective of our study were to assess sexuality in women recovered from COVID-19 and to compare it to healthy controls. Methods This is a cross-sectional case-control study. We randomly recruited women, from April 1st to 30th, 2021.The women in the case group have been infected with Sars-Cov 2, with a benign or pauci-symptomatic clinical form, and cured for one to two months at the time of the study without any post-COVID complications. Women included in the control group have not been infected with Sars-Cov 2. Sexuality was assessed by the Female Sexual Function Index (FSFI). Results In total, we recruited 30 women in the case group and 30 women in the control group.The average age of the case group was 35.8 ±6.8 years versus an average age of 35.3 ± 6.33 years in the control group. The majority of coronavirus infections were symptomatic (83.3% (n=25)). An FSFI score

Introduction Studies assessing the psychological impact of COVID-19 have shown that patients with COVID-19 had significantly higher levels of depression, anxiety, and post-traumatic stress symptoms than healthy controls. Objectives The objectives of our study were to assess depression in women recovered from COVID-19 and to compare it to healthy controls. Methods It was a cross-sectional case-control study. We randomly recruited women, from April 1st to 30th, 2021.The women in the case group have been infected with Sars-Cov 2, with a benign or pauci-symptomatic clinical form, and cured for one to two months at the time of the study without any post-COVID complications. Women included in the control group have not been infected with Sars-Cov 2 .Depression was assessed by the Beck Depression Inventory (BDI). Results In total, we recruited 30 women in the case group and 30 women in the control group.The average age of the case group was 35.8 ±6.8 years versus an average age of 35.3 ± 6.33 years in the control group. The majority of coronavirus infections were symptomatic (83.3% (n=25)). The average depression score for the case group was 10.8 ±9.6 corresponding to moderate depression, while the average depression score for the control group was 6.1 ± 6.1 corresponding to mild depression. The presence of depression was more significant in the case group compared to the controls (p=0.003). Conclusions COVID-19 is significantly associated with depression, even in mild or pauci-symptomatic clinical forms. Disclosure No significant relationships.

Introduction While several studies have assessed the impact of the COVID-19 pandemic on sexuality and sexual behavior in the general population, very few studies have assessed sexuality in patients recovered from Sars-Cov 2 infection. Objectives The objectives of our study were to assess factors associated with sexuality dysfunction in women recovered from covid-19. Methods This is a case-control study. The women in the case group have been infected with Sars-Cov 2, and cured for one to two months at the time of the study, women in the control group have not been infected with Sars-Cov 2. We assessed depression, anxiety, post-traumatic stress disorder (PTSD) and sexuality in both groups using the Beck Depression Inventory (BDI), the Coronavirus Anxiety Scale (CAS), the Post traumatic stress disorder Checklist Scale (PCLS) and the Female Sexual Function Index (FSFI). Results In total, we recruited 30 women in the case group and 30 women in the control group. An FSFI score

Neuropsychiatric manifestations in Sjögren’s syndrome are common and can occur not only during its course, but also at the onset of the disease. Depression and anxiety were the most frequently described symptoms. However, the association with bipolar disorder seems to be rare and not well documented. This case report presents a patient with bipolar disorder as comorbidity with Sjögren’s syndrome, suggesting that bipolar disorder could be associated with this autoimmune disease, which could lead to delaying diagnosis and treatment. A better analysis of the clinical background should be done by psychiatrists so to help early diagnosis and adapting prescription. Corticosteroids indicated in Sjögren’s syndrome should be prescribed with caution in bipolar disorder.