10 results on '"Gezer, Halise Hande"'
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2. Autonomic dysfunction and cardiovascular risk in psoriatic arthritis
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Gezer, Halise Hande, Acer Kasman, Sevtap, and Duruöz, Mehmet Tuncay
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- 2023
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3. Validity and psychometric characteristics of the self-administered comorbidity questionnaire in patients with psoriatic arthritis
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Erdem Gürsoy, Didem, Gezer, Halise Hande, Acer Kasman, Sevtap, and Duruöz, Mehmet Tuncay
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- 2022
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4. Assessment of autonomic dysfunction with the COMPASS-31 and its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis
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Gezer, Halise Hande, Erdem Gürsoy, Didem, Acer Kasman, Sevtap, and Duruöz, Mehmet Tuncay
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- 2022
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5. The impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-network
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Duruöz, Mehmet Tuncay, Gezer, Halise Hande, Nas, Kemal, Kilic, Erkan, Sargin, Betül, Acer Kasman, Sevtap, Alkan, Hakan, Sahin, Nilay, Cengiz, Gizem, Cuzdan, Nihan, Albayrak Gezer, İlknur, Keskin, Dilek, Mulkoglu, Cevriye, Resorlu, Hatice, Ataman, Sebnem, Bal, Ajda, Kucukakkas, Okan, Yurdakul, Ozan Volkan, Melikoglu, Meltem Alkan, Ayhan, Fikriye Figen, Baykul, Merve, Bodur, Hatice, Calis, Mustafa, Capkin, Erhan, Devrimsel, Gul, Gök, Kevser, Hizmetli, Sami, Kamanlı, Ayhan, Keskin, Yaşar, Ecesoy, Hilal, Kutluk, Öznur, Sen, Nesrin, Sendur, Ömer Faruk, Tekeoglu, İbrahim, Tolu, Sena, Toprak, Murat, and Tuncer, Tiraje
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- 2020
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6. The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters.
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Gezer, Halise Hande and Duruöz, Mehmet Tuncay
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SACROILIAC joint , *MAGNETIC resonance imaging , *BLOOD sedimentation , *ANKYLOSING spondylitis , *DISEASE duration , *PSORIATIC arthritis - Abstract
Objectives: This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics. Methods: Forty PsA patients (32 females, mean age 46.4 years) who had been documented to have active or structural lesions on SIJ MRI were retrospectively evaluated. Disease duration, medications, and disease activity, including Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), minimal disease activity (MDA), and Ankylosing Spondylitis Disease Activity Score (ASDAS) were recorded. On sacroiliac MRI scans, the SPARCC scores of sacroiliac joint inflammation (SIS) and sacroiliac joint structural damage (SSS) were evaluated. Results: The mean disease duration was 51.4 ± 70.4 months. MRI showed active inflammation in 30 patients (75%) and at least 1 structural lesion in 32 patients (92.5%). The most prevalent structural lesion was erosion (82.5%), followed by fat metaplasia (65%), backfill (12.5%), and ankylosis (2.5%). Only fat metaplasia scores were significantly higher in men than in women (P =.007). Of clinical and laboratory parameters, only C‐reactive protein (CRP) was significantly higher in the presence of active inflammation (P =.01). The SIS score was significantly correlated with disease duration (r = −.35) and CRP levels (r =.42,). The SSS score was inversely correlated with BASDAI (r = −.37), ASDAS‐CRP (r = −.39), and ASDAS – erythrocyte sedimentation rate (r = −.32). The overall SPARCC scores did not differ between patients in DAPSA remission and non‐remission and between those in MDA and non‐MDA. Conclusion: Although radiologic involvement is generally not severe in AxPsA, MRI still provides additional information about inflammatory activity and structural lesions. CRP may be helpful in monitoring the radiologic disease activity in AxPsA. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Inconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: Challenges to Rheumatologists.
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Gezer, Halise Hande, Duruöz, Mehmet Tuncay, Nas, Kemal, Kılıç, Erkan, Sargın, Betül, Kasman, Sevtap Acer, Alkan, Hakan, Şahin, Nilay, Cengiz, Gizem, Cüzdan, Nihan, Gezer, İlknur Albayrak, Keskin, Dilek, Mülkoğlu, Cevriye, Reşorlu, Hatice, Sunar, İsmihan, Bal, Ajda, Küçükakkaş, Okan, Yurdakul, Ozan Volkan, Melikoğlu, Meltem Alkan, and Baykul, Merve
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PSORIATIC arthritis , *ARTHRITIS Impact Measurement Scales , *ANTIRHEUMATIC agents , *TREATMENT effectiveness , *SEVERITY of illness index , *PROSTATE-specific antigen , *DISEASE remission - Abstract
Objective: Currently, concerning the evaluation of psoriatic arthritis (PsA), there is no agreement on a standardized composite index for disease activity that includes all relevant domains. The present study sought to assess the rates of remission (REM)/low disease activity (LDA) and disease states [minimal disease activity (MDA), very low disease activity (VLDA)] as defined by diverse activity scales (DAPSA, DAS28-ESR) in an attempt to display discrepancies across these assessment tools for peripheral PsA.Methods: The study involved 758 patients (496 females, 262 males; mean age 47,1 years) with peripheral PsA who were registered to the Turkish League Against Rheumatism (TLAR) Network. The patients were assessed using the DAS28-ESR, DAPSA, MDA, and VLDA. The overall yield of each scale was assessed in identifying REM and LDA. The presence or absence of swollen joints was separately analysed.Results: The median disease duration was 4 years (range 0-44 years). According to DAPSA and DAS28-ESR, REM was achieved in 6.9% and 19.5% of the patients, respectively. The rates of MDA and VLDA were 16% and 2.9%, respectively. Despite the absence of swollen joints, a significant portion of patients were not considered to be in REM (296 (39.1%) patients with DAS28-ESR, 364 (48%) with DAPSA, and 394 (52%) with VLDA).Conclusion: Patients with peripheral PsA may be assigned to diverse disease activity levels when assessed with the DAS28-ESR, DAPSA, MDA and VLDA, which would inevitably have clinical implications. In patients with PsA a holistic approach seems to be necessary which includes other domains apart from joint involvement, such as skin involvement, enthesitis, spinal involvement, and patient-reported outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2022
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8. A standardized sonographic analysis of nails in psoriatic arthritis and healthy controls: Feasibility, reliability, diagnostic performance, and demographic and clinical associations.
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Acer Kasman, Sevtap, Gezer, Halise Hande, Baklacıoğlu, Hatice Şule, Erdem Gürsoy, Didem, and Duruöz, Mehmet Tuncay
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PSORIATIC arthritis , *NAILS (Anatomy) , *RECEIVER operating characteristic curves , *REGRESSION analysis , *LITERATURE reviews , *PSORIASIS , *PILOT projects , *ULTRASONIC imaging , *HEALTH status indicators , *SEVERITY of illness index ,RESEARCH evaluation - Abstract
Objectives: Subunits of the nail can be evaluated by nail ultrasonography (NUSG). The purposes of this study are to document NUSG properties (both nail-based and participant-based evaluations) in patients with psoriatic arthritis (PsA) and healthy controls and to explore the final scorings.Methods: After the literature review and a pilot study, a consensus was reached to evaluate 12 nails and 5 parameters by NUSG: nail plate impairment (NPI), nail plate thickness (NPT), nail bed thickness (NBT), nail thickness (NT), and Doppler activity (DA); further, scorings for each parameter (NPIs, NPTs, NBTs, NTs, and DAs) were calculated. Group comparisons and diagnostic performances (with ROC curve analysis) were applied to both parameters and scorings. Final scorings to predict PsA diagnosis among the NUSG scorings were reached by regression analysis. Feasibility, reliability, and clinical associations of the scores were also performed.Results: Sixty-four patients with PsA and 26 controls (3240 baseline images) were assessed. The most affected nails, PsA/control comparisons, and the ROC analysis varied among the nails, within the higher values of PsA; therefore, 12 nails remained in the scorings. Participant-based scorings showed better content and diagnostic performances than the nail-based. Diagnostic performances, feasibility, reliability, and regression analysis of the scorings documented that NPIs, NTs, and DAs were the best. Some demographics, employee status, hemoglobin, and disease activity of the participants were associated with them.Conclusions: The NUSG Index (NUSGI) including NPIs, NTs, and DAs is a feasible, reliable, and discriminative method to predict PsA diagnosis, with its rich content. Clinicaltrials.gov-ID: NCT04718428. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Gender-related differences in disease activity and clinical features in patients with peripheral psoriatic arthritis: A multi-center study.
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Duruöz, Mehmet Tuncay, Gezer, Halise Hande, Nas, Kemal, Kılıç, Erkan, Sargın, Betül, Kasman, Sevtap Acer, Alkan, Hakan, Şahin, Nilay, Cengiz, Gizem, Cüzdan, Nihan, Gezer, İlknur Albayrak, Keskin, Dilek, Mülkoğlu, Cevriye, Reşorlu, Hatice, Ataman, Şebnem, Bal, Ajda, Küçükakkaş, Okan, Yurdakul, Ozan Volkan, Melikoğlu, Meltem Alkan, and Baykul, Merve
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FIBROMYALGIA , *PSORIATIC arthritis , *INFLAMMATORY bowel diseases , *QUALITY of life , *GENDER , *PATIENTS' attitudes , *RESEARCH , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *HEALTH surveys , *SEVERITY of illness index , *COMPARATIVE studies , *PSYCHOLOGICAL tests , *QUESTIONNAIRES , *FATIGUE (Physiology) - Abstract
Objective: This study sought to compare disease activity, clinical features, and patient-reported outcomes concerning anxiety, depression, fatigue, function, quality of life, and fibromyalgia between female and male patients with peripheral PsA in a Turkish population.Methods: This multi-center Turkish League Against Rheumatism (TLAR) Network study included 1038 patients (678 females, 360 males) diagnosed with peripheral PsA according to the CASPAR criteria. The demographic and clinic parameters of the patients were recorded. Disease activity was evaluated using the scores of DAS28 and cDAPSA. Remission, minimal disease activity (MDA), and very low disease activity (VLDA) were determined. Health Assessment Questionnaire (HAQ), Short-Form-36 (SF-36), Hospital Anxiety and Depression Scale (HAD), fatigue VAS (0-10), and Fibromyalgia Rapid ScreeningTool (FiRST) were used. Disease activity and patient-reported outcomes were compared in male and female patients, and the predictors of MDA for both genders were analyzed.Results: The patients' mean age was 47.6years (SD: 12) for females and 46.3years (SD: 12.3) for males. In terms of DAS28 and cDAPSA, female patients had significantly higher disease activity scores, while male patients had significantly higher remission rates (P<0.05). There was a significant difference in the rate of MDA in favor of males (P<0.05), but not in VLDA. The incidences of dactylitis, enthesitis, tenosynovitis, and inflammatory bowel disease were similar in male and female patients, except for spondylitis, which was higher in males (P<0.05). Overall, although there was no significant between-group difference in age and disease duration, female patients had significantly higher BMI and late-onset disease (P<0.05). Female patients had higher HAD, HAQ, and FiRST and lower SF-36 scores than males (P<0.05). In both male and female patients, the disease activity score of cDAPSA was significantly correlated with the scores of FiRST, HAD, VAS-F, and HAQ (P<0.05). In regression analysis, tender joint count, swollen joint count, PASI, pain VAS, and enthesitis were the MDA predictors in both genders.Conclusion: In patients with peripheral PsA, males are more likely to develop spondylitis while other extraarticular manifestations are similar. Female patients appear to have lower rates of remission and MDA and higher levels of disease activity. Female patients experience a more severe course of PsA, with higher levels of pain and fatigue, lower quality of life, and increased functional limitations. The predictors of MDA, i.e., tender joint count, swollen joint count, PASI, pain VAS, and enthesitis are similar between the two genders. [ABSTRACT FROM AUTHOR]- Published
- 2021
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10. A Gender-based Analysis of Disease Activity and Its Relationship with Anxiety, Depression, Fatigue, and Fibromyalgia in Psoriatic Arthritis
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Duruoz, Mehmet Tuncay, Gezer, Halise Hande, Nas, Kemal, Kilic, Erkan, Sargin, Betul, Kasman, Sevtap Acer, Alkan, Hakan, Sahin, Nilay, Cengiz, Gizem, Cuzdan, Nihan, Gezer, Ilknur Albayrak, Keskin, Dilek, Mulkoglu, Cevriye, Resorlu, Hatice, Ataman, Sebnem, Bal, Ajda, Kucukakkas, Okan, Yurdakul, Ozan Volkan, Meltem Alkan Melikoglu, Aydin, Yildiray, Ayhan, Fikriye Figen, Bodur, Hatice, Calis, Mustafa, Capkin, Erhan, Devrimsel, Gul, Gok, Kevser, Hizmetli, Sami, Kamanli, Ayhan, Keskin, Yasar, Kocabas, Hilal, Kutluk, Oznur, Sen, Nesrin, Sendur, Omer Faruk, Tekeoglu, Ibrahim, Tolu, Sena, Toprak, Murat, Tuncer, Tiraje, and KESKİN, Yaşar
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musculoskeletal diseases ,Fatigue and Derpression ,Psoriatic Arthritis ,Gender ,Disease Activity ,DURUÖZ M. T. , GEZER H. H. , NAS K., KILIÇ E., sargın b., acer kasman s., ALKAN H., ŞAHİN N., cengiz g., CÜZDAN COŞKUN N., et al., -A Gender-based Analysis of Disease Activity and Its Relationship with Anxiety, Depression, Fatigue, and Fibromyalgia in Psoriatic Arthritis-, American College of Rheumatology Annual Meeting 2019, 8 - 13 Kasım 2019 - Abstract
Background/Purpose: This study sought to compare the disease activity and its relationship with anxiety, depression, fatigue, and fibromyalgia of patients with psoriatic arthritis (PsA) between female and male gender in a Turkish population. Methods: This multi-center Turkish League Against Rheumatism (TLAR) Network study included 1134 patients (726 females, 408 males) diagnosed with PsA according to the CASPAR criteria. Demographic and clinic parameters of the patients were recorded. Disease activity was evaluated using the scores of DAS28, DAPSA, cDAPSA, MDA, VLDA, and BASDAI. Health Assessment Questionnaire (HAQ), SF-36, Hospital Anxiety and Depression Scale (HAD), fatigue VAS (0-10), and Fibromyalgia Rapid Screening Tool (FIRST) were assessed. Disease activity and remission rates were compared in male and female patients, and their relationship with fatigue, anxiety, depression, and fibromyalgia scores was analyzed. The Spearman correlation coefficient was used to assess correlations. Comparisons were made using the Mann-Whitney U and chi-squared tests. p< 0.05 was considered significant. Results: The mean age of the patients was 47.4 years (SD:12.1) for females, 46 years (SD:12.2) for males (Table-1). Disease activity scores of DAS28, DAPSA, cDAPSA, and BASDAI were significantly higher in women than in men (p< 0.05) (Table-2), with men having both higher remission and low-activity rates. There was a significant difference in the rate of MDA in favor of men (p< 0.05), but not in the rate of VLDA. The frequencies of dactylitis, enthesitis, inflammatory bowel disease, and arthritis were similar in men and women, while men had a higher incidence of spondylitis (p< 0.05). Both men and women with MDA had significant improvements in the scores of fatigue, HAQ, FIRST, anxiety and depression as well as in SF-36 subscales as compared with their counterparts without MDA (p< 0.05). Overall, although there was no significant between-group difference in age, body mass index, and disease duration, women had significantly higher anxiety, depression, and FIRST scores (fibromyalgia) compared with men (p< 0.05) (Table-2). In both men and women, disease activity scores of DAPSA, DAS28, and BASDAI were significantly correlated with the scores of FIRST, anxiety, depression, fatigue, and HAQ (p< 0.05). Conclusion: In patients with PsA, women seem to have lower levels of remission and higher levels of disease activity than men. In both women and men, disease activity scores are significantly correlated with fatigue, functional status, anxiety, depression, fibromyalgia, and quality of life.
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