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Your search keyword '"Hönzke S"' showing total 2 results
Start Over Author "Hönzke S" Topic psoriasis
2 results on '"Hönzke S"'

1. How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

Author

Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, and Mundhenk L

Subjects
Administration, Cutaneous, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Humans, Imiquimod immunology, Immunosuppressive Agents administration & dosage, Male, Mice, Mice, Hairless, Mice, Inbred BALB C, Psoriasis immunology, Skin immunology, Tacrolimus administration & dosage, Treatment Outcome, Immunosuppressive Agents therapeutic use, Psoriasis drug therapy, Skin drug effects, Tacrolimus therapeutic use
Published
2018
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2. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis.

Author

Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, and Mundhenk L

Subjects
Administration, Cutaneous, Animals, Biocompatible Materials chemistry, Cells, Cultured, Epidermis drug effects, Epidermis metabolism, Humans, Keratinocytes drug effects, Male, Mice, Mice, Inbred BALB C, Drug Carriers chemistry, Nanoparticles chemistry, Psoriasis drug therapy, Skin Absorption
Abstract

Inflammatory disorders of the skin pose particular therapeutic challenges due to complex structural and functional alterations of the skin barrier. Penetration of several anti-inflammatory drugs is particularly problematic in psoriasis, a common dermatitis condition with epidermal hyperplasia and hyperkeratosis. Here, we tested in vivo dermal penetration and biological effects of dendritic core-multishell-nanocarriers (CMS) in a murine skin model of psoriasis and compared it to healthy skin. In both groups, CMS exclusively localized to the stratum corneum of the epidermis with only very sporadic uptake by Langerhans cells. Furthermore, penetration into the viable epidermis of nile red as a model for lipophilic compounds was enhanced by CMS. CMS proved fully biocompatible in several in vitro assays and on normal and psoriatic mouse skin. The observations support the concept of CMS as promising candidates for drug delivery in inflammatory hyperkeratotic skin disorders in vivo., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2017
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