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Focuses on the secretion of nucleoside diphosphate kinase (Ndk) by mucoid Pseudomonas aeruginosa 8821. Involvement of a carboxy-terminal motif in secretion; Importance of the carboxy-terminal 8 amino acids of the Ndk for its secretion into the extracellular medium; Interdependence of membrane localization of Ndk and secretion of Ndk.

Studies the cellular function of elastase in Pseudomonas aeruginosa. Role of elastase in the cleavage of nucleoside diphosphate kinase and in alginate synthesis; Major virulence factors in Pseudomonas aeruginosa; Consequence of alginate synthesis in the cystic fibrosis lungs.