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We report on experimental investigations of proton acceleration from solid foils irradiated with PW-class laser-pulses, where highest proton cut-off energies were achieved for temporal pulse parameters that varied significantly from those of an ideally Fourier transform limited (FTL) pulse. Controlled spectral phase modulation of the driver laser by means of an acousto-optic programmable dispersive filter enabled us to manipulate the temporal shape of the last picoseconds around the main pulse and to study the effect on proton acceleration from thin foil targets. The results show that applying positive third order dispersion values to short pulses is favourable for proton acceleration and can lead to maximum energies of 70 MeV in target normal direction at 18 J laser energy for thin plastic foils, significantly enhancing the maximum energy compared to ideally compressed FTL pulses. The paper further proves the robustness and applicability of this enhancement effect for the use of different target materials and thicknesses as well as laser energy and temporal intensity contrast settings. We demonstrate that application relevant proton beam quality was reliably achieved over many months of operation with appropriate control of spectral phase and temporal contrast conditions using a state-of-the-art high-repetition rate PW laser system. [ABSTRACT FROM AUTHOR]

Laser-accelerated beams of Mega-electron volt protons have been produced at the Los Alamos Trident laser facility and used for high-resolution point-projection proton radiography of Au grids. The effective proton source size affords an inherent resolution of 2-3 µm in the object plane. The proton beam is characterized by ion time-of-flight Faraday cup measurements and nuclear particle track detectors. Laser-driven proton radiography appears promising as a valuable research tool for probing plasmas or modest density objects. [ABSTRACT FROM AUTHOR]

We report on the experimental observation of transverse modulations in proton beams accelerated from micrometer thick targets which were irradiated with ultra-short (30 fs) laser pulses of a peak intensity of 5 × 1020 W cm−2. The net-like proton beam modulations were recorded using radiochromic film and the data suggest a dependence on laser energy and target thickness for their onset and strength. Numerical simulations suggest that intensity-dependent instabilities in the laser-produced plasma at the target front side lead to electron beam break-up or filamentation, then serving as the source of the observed proton beam modulations. [ABSTRACT FROM AUTHOR]

Proton beams are a promising tool for the improvement of radiotherapy of cancer, and compact laser-driven proton radiation (LDPR) is discussed as an alternative to established large-scale technology facilitating wider clinical use. Yet, clinical use of LDPR requires substantial development in reliable beam generation and transport, but also in dosimetric protocols as well as validation in radiobiological studies. Here, we present the first dose-controlled direct comparison of the radiobiological effectiveness of intense proton pulses from a laser-driven accelerator with conventionally generated continuous proton beams, demonstrating a first milestone in translational research. Controlled dose delivery, precisely online and offline monitored for each out of ∼4,000 pulses, resulted in an unprecedented relative dose uncertainty of below 10 %, using approaches scalable to the next translational step toward radiotherapy application. [ABSTRACT FROM AUTHOR]

Recent experiments in the Trident laser facility (Los Alamos National Laboratory) have shown that hollow conical targets with a flat top at the tip can enhance the maximum energy of proton beams created during the interaction of an ultra-intense short laser pulse with the target (Gaillard S A et al 2011 Phys. Plasmas 18 056710). The proton energies that have been seen in these experiments are the highest energies observed so far in laser-driven proton acceleration. This is attributed to a new acceleration mechanism, direct light pressure acceleration of electrons (DLLPA), which increases the number and energy of hot electrons that drive the proton acceleration. This acceleration process of protons due to a two-temperature sheath formed at the flat-top rear side is very robust and produces a large number of protons per shot, similar to what is regularly observed in target normal sheath acceleration (Hatchett S P et al 2000 Phys. Plasmas 7 2076, Maksimchuk A et al 2000 Phys. Rev. Lett. 84 4108, Snavely R A et al 2000 Phys. Rev. Lett. 85 2945) with flat foils. In this paper, we investigate the electron kinetics during DLLPA, showing that they are governed by two mechanisms, both of which lead to continuous electron acceleration along the inner cone wall. Based on our model, we predict the scaling of the hot electron temperature and ion maximum energy with both laser and target geometrical parameters. The scaling of ThotDLLPA = mec²0 a²0/4 with the laser strength parameter a0 leads to an ion energy scaling that surpasses that of some recently proposed acceleration mechanisms such as radiation pressure acceleration (RPA), while in addition the maximum electron energy is found to scale linearly with the length of the cone neck. We find that when optimizing parameters, high proton energies suitable for applications can be reached using compact short-pulse laser systems with pulse durations of only a few tens to hundreds of laser periods. [ABSTRACT FROM AUTHOR]

We present experimental results showing a laser-accelerated proton beam maximum energy cutoff of 67.5 MeV, with more than 5 × 106 protons per MeV at that energy, using flat-top hollow microcone targets. This result was obtained with a modest laser energy of ∼80 J, on the high-contrast Trident laser at Los Alamos National Laboratory. From 2D particle-in-cell simulations, we attribute the source of these enhanced proton energies to direct laser-light-pressure acceleration of electrons along the inner cone wall surface, where the laser light wave accelerates electrons just outside the surface critical density, in a potential well created by a shift of the electrostatic field maximum with respect to that of the magnetic field maximum. Simulations show that for an increasing acceleration length, the continuous loading of electrons into the accelerating phase of the laser field yields an increase in high-energy electrons. [ABSTRACT FROM AUTHOR]

We report on the first irradiation of in vitro tumour cells with laser-accelerated proton pulses showing dose-dependent biological damage. This experiment, paving the way for future radiobiological studies with laser-accelerated protons, demonstrates the simultaneous availability of all the components indispensable for systematic radiobiological studies: a laser-plasma accelerator providing proton spectra with maximum energy exceeding 15MeV and applicable doses of a few Gy within a few minutes; a beam transport and filtering system; an in-air irradiation site; and a dosimetry system providing both online dose monitoring and absolute dose information applied to the cell sample and the full infrastructure for analysing radiation-induced damage in cells. [ABSTRACT FROM AUTHOR]

The maximum energy of protons that are accelerated forward by high-intensity, short-pulse lasers from either the front or rear surfaces of thin metal foils is compared for a large range of laser intensities and pulse durations. In the regime of moderately long laser pulse durations (300–850 fs), and for high laser intensities [(1-6)×1019 W/cm2], rear-surface acceleration is shown experimentally to produce higher energy particles with smaller divergence and a higher efficiency than front-surface acceleration. For similar laser pulse durations but for lower laser intensities (2×1018 W cm-2), the same conclusion is reached from direct proton radiography of the electric fields associated with proton acceleration from the rear surface. For shorter (30–100 fs) or longer (1–10 ps) laser pulses, the same predominance of rear-surface acceleration in producing the highest energy protons is suggested by simulations and by comparison of analytical models with measured values. For this purpose, we have revised our previous analytical model of rear-surface acceleration [J. Fuchs et al., Nat. Phys. 2, 48 (2006)] to adapt it to the very short pulse durations. Finally, it appears, for the explored parameters, that rear-surface acceleration is the dominant mechanism. [ABSTRACT FROM AUTHOR]

A mechanism that has gained great attention in the field of laser-ion acceleration due to remarkable properties of the accelerated beam is laser acceleration of protons from the rear surface of solid targets. It is shown that these protons are capable of transporting structure information from the rear surface of the target into the detector, which can be used to measure essential properties of the flow like an upper limit of the lateral beam emittance and the source area of the laser accelerated protons for a particular energy. In this Letter the essential mechanism responsible for the generation of images of surface structures by laser-accelerated protons is addressed and used to explain the experiment is described in the Letter. [ABSTRACT FROM AUTHOR]

Abstract: High intensity laser driven proton beams are at present receiving much attention. The reasons for this are many but high on the list is the potential to produce compact accelerators. However, two of the limitations of this technology is that unlike conventional nuclear RF accelerators lasers produce diverging beams with an exponential energy distribution. A number of different approaches have been attempted to monochromise these beams but it has become obvious that magnetic spectrometer technology developed over many years by accelerator physicists to transport and focus proton beams could play an important role for this purpose. This paper deals with the design and characterisation of a magnetic quadrupole system which is intended to focus and transport laser-accelerated proton beams. [Copyright &y& Elsevier]

We report experimental evidence that multi-MeV protons accelerated in relativistic laser-plasma interactions are modulated by strong filamentary electromagnetic fields. Modulations are observed when a preplasma is developed on the rear side of a μm-scale solid-density hydrogen target. Under such conditions, electromagnetic fields are amplified by the relativistic electron Weibel instability and are maximized at the critical density region of the target. The analysis of the spatial profile of the protons indicates the generation of B>10 MG and E>0.1 MV/μm fields with a μm-scale wavelength. These results are in good agreement with three-dimensional particle-in-cell simulations and analytical estimates, which further confirm that this process is dominant for different target materials provided that a preplasma is formed on the rear side with scale length ≳0.13λ0√a0. These findings impose important constraints on the preplasma levels required for high-quality proton acceleration for multipurpose applications. [ABSTRACT FROM AUTHOR]