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Start Over Author "Basu TN" Topic protein kinase inhibitors
2 results on '"Basu TN"'

1. Chronic lymphocytic leukaemia-associated insect bite-like reaction responding to ibrutinib, an immunomodulatory Bruton tyrosine kinase inhibitor.

Author

Wimalachandra M, Basu TN, Salisbury J, Attard N, Calonje E, and Patten PEM

Subjects
Adenine therapeutic use, Humans, Male, Middle Aged, Skin Diseases etiology, Adenine analogs & derivatives, Agammaglobulinaemia Tyrosine Kinase antagonists & inhibitors, Leukemia, Lymphocytic, Chronic, B-Cell complications, Piperidines therapeutic use, Protein Kinase Inhibitors therapeutic use, Skin pathology, Skin Diseases drug therapy
Published
2021
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2. A mitogen-activated protein kinase kinase inhibitor induced compound skin toxicity with oedema in metastatic malignant melanoma.

Author

Thomas CL, Mortimer PS, Larkin JM, Basu TN, Gore ME, and Fearfield L

Subjects
Acrylonitrile adverse effects, Adult, Female, Humans, Male, Melanoma secondary, Middle Aged, Skin Neoplasms secondary, Acrylonitrile analogs & derivatives, Aniline Compounds adverse effects, Edema chemically induced, Melanoma drug therapy, Mitogen-Activated Protein Kinase Kinases antagonists & inhibitors, Protein Kinase Inhibitors adverse effects, Skin Diseases chemically induced, Skin Neoplasms drug therapy
Abstract

We report three cases of skin toxicity associated with oral mitogen-activated protein kinase kinase (MEK) inhibitor treatment for metastatic malignant melanoma (MM). All three patients developed oedema, and a single patient experienced eyelash trichomegaly. This is the first known report of eyelash trichomegaly secondary to MEK inhibitor use. We also discuss possible mechanisms for MEK inhibitor-associated oedema development. This series supports the role of the dermatologist in the screening and management of patients in the rapidly developing oncology setting, as new targeted agents can give rise to marked skin toxicity., (© 2015 British Association of Dermatologists.)

Published
2016
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