1. The role of surgery in high risk and advanced prostate cancer: A narrative review
- Author
-
Bhavan Prasad Rai, Chloe Sheila Dayan Roy, Ashwin Sachdeva, and Gokul Kandaswamy
- Subjects
medicine.medical_specialty ,Modality (human–computer interaction) ,Prostate cancer ,Manchester Cancer Research Centre ,Prostatectomy ,business.industry ,medicine.medical_treatment ,Metastasis-directed therapy ,ResearchInstitutes_Networks_Beacons/mcrc ,MEDLINE ,Context (language use) ,medicine.disease ,Radical prostatectomy ,Surgery ,Cytoreductive prostatectomy ,Clinical trial ,Metastatic disease ,Radiological weapon ,medicine ,Narrative review ,Multi-modality approach ,business ,Urooncology - Abstract
Patients with high-risk and advanced prostate cancer require safe and efficacious therapies likely to offer a survival advantage while minimizing the treatment-related toxicities. Improvements in the surgical technol-ogy, diagnostic modalities, radiological staging, and risk stratification have made surgery for high-risk and advanced prostate cancer a safe and feasible option. In this review, we outline the role of radical prostatec-tomy in high-risk localized, locally advanced, and metastatic prostate cancer. We overview available data evaluating the use of surgery in the context of a multi-modal approach and highlight ongoing trials in this area. Furthermore, the role of surgery as a non-systemic modality for metastasis-directed therapy (MDT) is also described. Emerging imaging modalities enabling more accurate staging and longer follow-up of clinical trials for prognostic endpoints are anticipated to help identify patient cohorts and treatment strategies, where the use of surgical treatments is likely to provide oncological benefits and acceptable toxicity.
- Published
- 2020
- Full Text
- View/download PDF