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Rapid methods of analysis for anticonvulsants (phenobarbitone, carbamazepine, primidone and phenytoin simultaneously and ethosuximide), barbiturates, mexiletine, lidocaine and acetaminophen are described. All drugs are chromatographed on OV-225 at various temperatures and detected using a nitrogen specific detector. OV-225 has proved to be superior to the more common SE-30, OV-17 and OV-1 phases, particularly for the simultaneous determination of the four anticonvulsants. No problems relating to the bleed of cyanopropyl containing stationary phase into the nitrogen specific detector have been encountered.