21 results on '"Cutibacterium"'
Search Results
2. Propionibacterium (Cutibacterium) granulosum Extracellular DNase BmdE Targeting Propionibacterium (Cutibacterium) acnes Biofilm Matrix, a Novel Inter-Species Competition Mechanism.
- Author
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Bronnec V, Eilers H, Jahns AC, Omer H, and Alexeyev OA
- Subjects
- Extracellular Polymeric Substance Matrix, Humans, Acne Vulgaris microbiology, Biofilms, Deoxyribonucleases, Propionibacterium acnes enzymology
- Abstract
Acne vulgaris is the most common dermatological disorder worldwide affecting more than 80% of adolescents and young adults with a global prevalence of 231 million cases in 2019. The involvement of the skin microbiome disbalance in the pathophysiology of acne is recognized, especially regarding the relative abundance and diversity of Propionibacterium acnes a well-known dominant human skin commensal. Biofilms, where bacteria are embedded into a protective polymeric extracellular matrix, are the most prevalent life style for microorganisms. P. acnes and its biofilm-forming ability is believed to be a contributing factor in the development of acne vulgaris, the persistence of the opportunistic pathogen and antibiotic therapy failures. Degradation of the extracellular matrix is one of the strategies used by bacteria to disperse the biofilm of competitors. In this study, we report the identification of an endogenous extracellular nuclease, BmdE, secreted by Propionibacterium granulosum able to degrade P. acnes biofilm both in vivo and in vitro . This, to our knowledge, may represent a novel competitive mechanism between two closely related species in the skin. Antibiotics targeting P. acnes have been the mainstay in acne treatment. Extensive and long-term use of antibiotics has led to the selection and spread of resistant bacteria. The extracellular DNase BmdE may represent a new bio-therapeutical strategy to combat P. acnes biofilm in acne vulgaris., Competing Interests: Based on these findings an international patent application has been filed (patent #WO2020190203A1: “New compositions and methods for the treatment of acne vulgaris”, 19 March 2020) by Vakona AB where OA is a part owner. This does not alter the authors’ adherence to all the Frontiers Journals policies on sharing data and materials. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Bronnec, Eilers, Jahns, Omer and Alexeyev.)
- Published
- 2022
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3. Broad spectrum in vitro microbicidal activity of benzoyl peroxide against microorganisms related to cutaneous diseases.
- Author
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Okamoto K, Kanayama S, Ikeda F, Fujikawa K, Fujiwara S, Nozawa N, Mori S, Matsumoto T, Hayashi N, and Oda M
- Subjects
- Malassezia, Microbial Sensitivity Tests, Benzoyl Peroxide, Propionibacterium acnes
- Abstract
The in vitro microbicidal activity of benzoyl peroxide against Cutibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Malassezia furfur, Malassezia restricta, and Malassezia globosa was investigated. These strains were incubated for 1 h in the presence of 0.25, 0.5, 1, or 2 mmol/L benzoyl peroxide in phosphate buffered saline supplemented with 0.1% glycerol and 2% Tween 80. After exposure to benzoyl peroxide, counts of viable Gram-positive bacteria and fungi were markedly decreased, whereas counts of Gram-negative bacteria were unchanged. Transmission electron microscopy images showed a decrease in electron density and the destruction of C. acnes and M. restricta cell walls after exposure to 2 mmol/L benzoyl peroxide. In conclusion, this study showed that benzoyl peroxide has a potent and rapid microbicidal activity against Gram-positive bacteria and fungi that are associated with various cutaneous diseases. This suggests that the direct destruction of bacterial cell walls by benzoyl peroxide is an essential mechanism of its rapid and potent microbicidal activity against microorganisms., (© 2021 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.)
- Published
- 2021
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4. Cutibacterium subtype distribution on the skin of primary and revision shoulder arthroplasty patients.
- Author
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Hsu JE, Matsen FA 3rd, Whitson AJ, and Bumgarner RE
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Molecular Typing, Preoperative Period, Propionibacterium acnes genetics, Sequence Analysis, DNA, Shoulder Joint surgery, Arthroplasty, Replacement, Shoulder, DNA, Bacterial analysis, Propionibacterium acnes isolation & purification, Reoperation, Shoulder microbiology, Skin microbiology
- Abstract
Background: The skin of healthy shoulders is known to harbor multiple different subtypes of Cutibacterium (formerly Propionibacterium) acnes at the same time. C acnes can often be isolated from deep tissue and explant samples obtained during revision of a failed shoulder arthroplasty, presumably because the shoulder was inoculated with organisms from the patient's skin at the time of the index arthroplasty. It is possible that specific subtypes or distributions of subtypes may be associated with an increased pathogenic potential and that the skin of patients undergoing revision arthroplasty contains different distributions of the subtypes than in patients undergoing primary arthroplasty. We analyzed the subtype distribution of Cutibacterium from the skin of shoulders undergoing revision arthroplasty vs. primary arthroplasty., Methods: Preoperative skin swabs were collected from 25 patients who underwent primary shoulder arthroplasty and 27 patients who underwent revision shoulder arthroplasty. The results of semiquantitative cultures of the skin and deep tissues were reported as specimen Cutibacterium values, and scores from all deep tissue samples were added to report the total shoulder Cutibacterium score. Single-locus sequence typing (SLST) of C acnes from the skin swabs was used to determine the subtype distribution for each patient. The percentage of each subtype for each patient was averaged in patients undergoing revision arthroplasty and then compared with that in patients undergoing primary arthroplasty., Results: The C acnes subtype distribution on the skin of revision arthroplasty patients was different from that of primary shoulder arthroplasty patients, with a significantly higher percentage of SLST subtype A (36.9% vs. 16.0%, P = .0018). The distribution of SLST subtypes was similar between revision arthroplasty patients with strongly positive culture findings vs. those with weakly positive or negative culture findings., Conclusions: Significant differences in the skin Cutibacterium subtype distributions were found between shoulders undergoing revision shoulder arthroplasty and those undergoing primary shoulder arthroplasty. Future studies are needed to determine whether certain Cutibacterium subtype distributions are associated with an increased risk of arthroplasty revision., (Copyright © 2020 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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5. Proposal of new combination, Cutibacterium acnes subsp. elongatum comb. nov., and emended descriptions of the genus Cutibacterium, Cutibacterium acnes subsp. acnes and Cutibacterium acnes subsp. defendens.
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Dekio I, McDowell A, Sakamoto M, Tomida S, and Ohkuma M
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- Bacterial Typing Techniques, Base Composition, DNA, Bacterial genetics, Humans, Nucleic Acid Hybridization, RNA, Ribosomal, 16S genetics, Sequence Analysis, DNA, Phylogeny, Propionibacterium acnes classification, Skin microbiology
- Abstract
In 2016, division of the genus Propionibacterium into four distinct genera was proposed. As a consequence, the species Propionibacterium acnes was transferred to Cutibacterium gen. nov. as Cutibacterium acnes comb. nov. The three recently proposed subspecies of P. acnes were not, however, accommodated in this proposal. Following a very recent validation of a new combination for C. acnessubsp.defendens and an automatically created C. acnessubsp.acnes, we now propose the new combination, C. acnessubsp. elongatum comb. nov. The type strain of Cutibacterium acnes subsp. elongatum is JCM 18919
T (=NCTC 13655T ). On the basis of further genomic and phenotypic (haemolysis and MALDI-TOF mass spectrometry) analyses of these subspecies, we also provide emended descriptions of the genus Cutibacterium Scholz and Kilian 2016, C. acnessubsp.acnes (Gilchrist 1900) Nouioui et al. 2018, and C. acnessubsp.defendens (McDowell et al. 2016) Nouioui et al. 2018.- Published
- 2019
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6. Skin Ecology during Sebaceous Drought-How Skin Microbes Respond to Isotretinoin.
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McCoy WH 4th, Otchere E, Rosa BA, Martin J, Mann CM, and Mitreva M
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- Acne Vulgaris pathology, Case-Control Studies, Female, Hospitals, University, Humans, Male, Propionibacterium acnes isolation & purification, Recurrence, Reference Values, Risk Assessment, Sampling Studies, Treatment Outcome, Acne Vulgaris drug therapy, Acne Vulgaris microbiology, Isotretinoin administration & dosage, Microbiota drug effects, Propionibacterium acnes drug effects
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- 2019
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7. A Case of Coccidioidal Meningitis With Biofilm Obstructing VP Shunt Due to Cutibacterium acnes
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Sharma, Rupam, Johnson, Royce H, David, Gerard R, Rahimifar, Majid, and Heidari, Arash
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Infection ,Humans ,Propionibacterium acnes ,Biofilms ,Ventriculoperitoneal Shunt ,Meningitis ,Fungal ,Cutibacterium ,Propionibacterium ,coccidioidal meningitis complications ,CNS shunt infections - Abstract
Herein described is a case of biofilm obstructing ventriculoperitoneal shunt due to Cutibacteirum acnes infection in a patient with coccidioidal meningitis. Cutibacterium acnes infects and obstructs cerebral shunts by the production of biofilm; however, diagnosis is usually missed by routine aerobic cultures. Obtaining anaerobic cultures routinely in patients with foreign body implants leading to central nervous system infections could prevent a missed diagnosis of this pathogen. Penicillin G is the first-line treatment.
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- 2023
8. Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies
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Joseph McLaughlin, Steven Watterson, Alison M. Layton, Anthony J. Bjourson, Emma Barnard, and Andrew McDowell
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Propionibacterium acnes ,Cutibacterium ,phylogroups ,MLST ,clonal complex ,sequence types ,multi-omic analyses ,virulence factors ,host-microbe interactions ,novel therapeutics ,vaccination ,Biology (General) ,QH301-705.5 - Abstract
The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.
- Published
- 2019
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9. Broad spectrum in vitro microbicidal activity of benzoyl peroxide against microorganisms related to cutaneous diseases
- Author
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Masataka Oda, Shoji Kanayama, Naoki Hayashi, Kazuaki Okamoto, Tatsumi Matsumoto, Shiori Fujiwara, Koki Fujikawa, Fumiaki Ikeda, Sachi Mori, and Naoki Nozawa
- Subjects
Staphylococcus ,Concise Communications ,Cutibacterium ,Microbial Sensitivity Tests ,Dermatology ,Benzoyl peroxide ,medicine.disease_cause ,Bacterial cell structure ,Microbiology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Staphylococcus epidermidis ,medicine ,Propionibacterium acnes ,Candida albicans ,Malassezia ,Benzoyl Peroxide ,integumentary system ,biology ,Chemistry ,organic chemicals ,Concise Communication ,General Medicine ,biology.organism_classification ,Staphylococcus aureus ,030220 oncology & carcinogenesis ,microbicidal ,Bacteria ,medicine.drug - Abstract
The in vitro microbicidal activity of benzoyl peroxide against Cutibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Malassezia furfur, Malassezia restricta, and Malassezia globosa was investigated. These strains were incubated for 1 h in the presence of 0.25, 0.5, 1, or 2 mmol/L benzoyl peroxide in phosphate buffered saline supplemented with 0.1% glycerol and 2% Tween 80. After exposure to benzoyl peroxide, counts of viable Gram‐positive bacteria and fungi were markedly decreased, whereas counts of Gram‐negative bacteria were unchanged. Transmission electron microscopy images showed a decrease in electron density and the destruction of C. acnes and M. restricta cell walls after exposure to 2 mmol/L benzoyl peroxide. In conclusion, this study showed that benzoyl peroxide has a potent and rapid microbicidal activity against Gram‐positive bacteria and fungi that are associated with various cutaneous diseases. This suggests that the direct destruction of bacterial cell walls by benzoyl peroxide is an essential mechanism of its rapid and potent microbicidal activity against microorganisms.
- Published
- 2020
10. Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
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Joontae Ko, Yuri Lee, Wilhelm H. Holzapfel, Yosep Ji, Subin Yeo, Haryung Park, and Karina Arellano
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Microbiology (medical) ,QH301-705.5 ,Staphylococcus ,Cutibacterium ,medicine.disease_cause ,Microbiology ,Article ,diversity ,Propionibacterium acnes ,Virology ,Dry skin ,medicine ,Stratum corneum ,Microbiome ,Food science ,Biology (General) ,moist ,chemistry.chemical_classification ,Transepidermal water loss ,biology ,integumentary system ,Short-chain fatty acid ,dry ,biology.organism_classification ,medicine.anatomical_structure ,chemistry ,Propionate ,skin microbiome ,medicine.symptom ,short chain fatty acids - Abstract
Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion, damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and Cutibacterium levels (previously known as Propionibacterium acnes) were significantly higher (p <, 0.001) in the moist group. Levels of Cutibacterium were negatively correlated with those of Staphylococcus (p <, 0.0001) in both dry and moist groups. The moist group also had a significantly higher propionate concentration (p <, 0.001). This study showed that the microbial community and short chain fatty acid concentration may be considered as significant determinants of the SCFI of the skin.
- Published
- 2021
11. Complete Draft Genome Sequence of Cutibacterium (Propionibacterium) acnes Type Strain ATCC6919
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Xiao Zhang, Jian-Bo Ruan, Jingyao Liang, Kai-Wei Si, He-Ling Zhu, Hui-Jing Tang, Wen-Liang Zheng, and Xibao Zhang
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Whole genome sequencing ,food.ingredient ,biology ,Strain (chemistry) ,Dermatology ,lcsh:RL1-803 ,biology.organism_classification ,Microbiology ,Propionibacterium acnes ,Infectious Diseases ,Type (biology) ,Cutibacterium ,food ,lcsh:Dermatology - Abstract
Objectives:. The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes. However, the complete genetic sequence reference of C. acnes has not yet been reported. Herein, we report the complete genetic sequence of Cutibacterium acnes type strain ATCC6919. Methods:. Whole-genome sequencing of Cutibacterium acnes ATCC6919 was performed using both the Illumina Hiseq4000 and PacBio RSII single-molecule real-time sequencing platforms. The generated sequence reads were de novo assembled using the HGAP3 protocol of single-molecule real-time analysis v.2.3.0 software. The draft genome was annotated and further analyzed by various bioinformatics tools. Results:. The total genome length of Cutibacterium acnes ATCC6919 was 2,495,001 bp (60.02% G + C content), with 2,450 coding sequences including 2,358 proteins, 45 tRNAs, 9 rRNAs, and 1 sRNA. The Comprehensive Antibiotic Resistance Database showed that the gene (thy A) found in ATCC6919 was associated with resistance to aminosalicylic acid. Antimicrobial susceptibility testing showed that this isolate was not sensitive to metronidazole and sulfamethoxazole, but was sensitive to all other tested antimicrobials (erythromycin, azithromycin, clarithromycin, tetracycline, minocycline, trimethoprim, levofloxacin, ceftriaxone, and doxycycline). Conclusion:. This study reports the complete genome sequence of Cutibacterium acnes ATCC6919, which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of Cutibacterium acnes.
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- 2020
12. Unexpected positive cultures after revision shoulder arthroplasty: does it affect outcome?
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Theis Muncholm Thillemann, Kjeld Søballe, Janne Ovesen, H.V.S. Johanssen, Jeppe Lange, Brian Elmengaard, Henrik Daugaard, Anne Katrine Belling Sørensen, Bo S Olsen, Bo Zerahn, Lars Bolvig, Lars C. Gormsen, and Thomas Falstie-Jensen
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Reoperation ,medicine.medical_specialty ,Prosthesis-Related Infections ,Prospective Cohort Comparison ,Revision ,medicine.medical_treatment ,Cutibacterium ,Affect (psychology) ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biopsy ,Level I ,unexpected positive cultures ,medicine ,Humans ,Orthopedics and Sports Medicine ,Clinical significance ,Propionibacterium acnes ,Prospective Studies ,Prospective cohort study ,Retrospective Studies ,030222 orthopedics ,periprosthetic joint infection ,medicine.diagnostic_test ,business.industry ,Shoulder Joint ,030229 sport sciences ,General Medicine ,Arthroplasty ,Arthroplasty, Replacement, Shoulder ,Prognosis Study ,Orthopedic surgery ,shoulder arthroplasty ,Surgery ,Aseptic processing ,Range of motion ,business - Abstract
BACKGROUND: Several studies have confirmed a high rate of unexpected positive cultures (UPCs) after presumably aseptic revisions of shoulder arthroplasties; however, the impact on the outcome is still unclear. The purpose of this prospective study is to compare the patient-reported outcomes of standard revisions with and without the emergence of UPCs.METHODS: During a 3-year period, we included all patients who were revised for reasons other than suspicion of infection from two orthopedic centers. Five biopsies were obtained from every revision, and only cultures with the same bacteria in at least three biopsy specimens were classified as UPCs. All patients were assessed using the Oxford Shoulder Score (OSS) and range of motion preoperatively and after at least a two-year follow-up.RESULTS: In this study, 124 patients were included, with a median follow-up of 29 months (range 29-32), and UPCs emerged after 27 revisions (22%), with Cutibacterium acnes (C. acnes) accounting for 67% (18/27). At baseline, the OSS was 22 in both the culture-negative and UPC groups (p = 0.46). Then, at follow-up, the OSS was 37 in the culture-negative group and 35 in the UPC group (p = 0.91). The forward elevation increased significantly by 44° and 41° respectively in the two groups, but no statically significant difference between the culture-negative group and the UPC group was found (p = 0.66). In contrast, the external rotation was unchanged after the revision, and again, no difference in the change between the culture-negative and UPC groups (p = 0.54) was observed. Subgroup analyses stratified by different implant designs revealed equal patterns with no statistical differences in outcome.CONCLUSION: We did not find a difference in outcome after a presumed aseptic revision regardless of the emergence of UPCs. Similarly, we could not demonstrate that patients with UPCs presented with poorer function at baseline compared to culture-negative patients. The clinical relevance of UPCs thus requires further evaluation, especially in the case of C. acnes as a potential pathogenic contra merely colonizing microbe.
- Published
- 2020
13. In vivo model of Propionibacterium (Cutibacterium) spp. biofilm in Drosophila melanogaster
- Author
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Oleg A. Alexeyev and Vicky Bronnec
- Subjects
food.ingredient ,Propionibacterium ,Fluorescent Antibody Technique ,Biofilm-dispersal treatment ,Immunofluorescence ,Microbiology ,Microbiology in the medical area ,Propionibacterium acnes ,Cutibacterium ,food ,In vivo ,Mikrobiologi inom det medicinska området ,medicine ,Animals ,In vivo model ,Dermatologi och venereologi ,Propionibacterium spp ,Host Microbial Interactions ,integumentary system ,medicine.diagnostic_test ,biology ,Biofilm ,fungi ,biochemical phenomena, metabolism, and nutrition ,Hair follicle ,biology.organism_classification ,Dermatology and Venereal Diseases ,Drosophila melanogaster ,Infectious Diseases ,medicine.anatomical_structure ,Biofilms - Abstract
Objectives Acne vulgaris is a common inflammatory disorder of the pilosebaceous unit and Propionibacterium acnes biofilm-forming ability is believed to be a contributing factor to the disease development. In vivo models mimicking hair follicle environment are lacking. The aim of this study was to develop an in vivo Propionibacterium spp. biofilm model in Drosophila melanogaster (fruit fly). Methods We created a sterile line of D. melanogaster able to sustain Propionibacterium spp. biofilms in the gut. In order to mimic the lipid-rich, anaerobic environment of the hair follicle, fruit flies were maintained on lipid-rich diet. Propionibacterium spp. biofilms were visualized by immunofluorescence and scanning electron microscopy. We further tested if the biofilm-dispersal activity of DNase I can be demonstrated in the developed model. Results We have demonstrated the feasibility of our in vivo model for development and study of P. acnes, P. granulosum and P. avidum biofilms. The model is suitable to evaluate dispersal as well as other agents against P. acnes biofilm. Conclusions We report a novel in vivo model for studying Propionibacterium spp. biofilms. The model can be suitable for both mechanistic as well as interventional studies.
- Published
- 2021
14. Unravelling the eco-specificity and pathophysiological properties of Cutibacterium species in the light of recent taxonomic changes
- Author
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Itaru Dekio, Haroun N. Shah, and Akihiko Asahina
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food.ingredient ,Virulence ,Progressive macular hypomelanosis ,Species name ,Propionibacteriaceae ,Subspecies ,Biology ,medicine.disease ,biology.organism_classification ,Microbiology ,Propionibacterium acnes ,Infectious Diseases ,Type (biology) ,Cutibacterium ,food ,Evolutionary biology ,Genus ,medicine ,Animals ,Humans ,Taxonomy (biology) ,Gram-Positive Bacterial Infections ,Phylogeny ,Skin - Abstract
In 2016, a new species name Cutibacterium acnes was coined for the well-documented species, Propionibacterium acnes, one of the most successful and clinically important skin commensals. The nomenclatural changes were brought about through creation of the genus Cutibacterium, when a group of propionibacteria isolates from the skin were transferred from the genus Propionibacterium and placed in the phylum Actinobacteria. Almost simultaneously, the discovery of two novel species of Cutibacterium occurred and the proposal of three subspecies of C. acnes were reported. These dramatic changes that occurred in a long-established taxon made it challenging for the non-specialist to correlate the huge volume of hitherto published work with current findings. In this review, we aim to correlate the eco-specificity and pathophysiological properties of these newly circumscribed taxa. We envisage that this information will shed light on the pathogenic potential of new isolates and enable better assessment of their clinical importance in the foreseeable future. Currently, five species are recognized within the genus: Cutibacterium acnes, Cutibacterium avidum, Cutibacterium granulosum, Cutibacterium modestum (previously, “Propionibacterium humerusii”), and Cutibacterium namnetense. These reside in different niches reflecting their uniqueness in their genetic makeup. Their pathogenicity includes acne inflammation, sarcoidosis, progressive macular hypomelanosis, prostate cancer, and infections (bone, lumbar disc, and heart). This is also the case for the three newly described subspecies of C. acnes, which are C. acnes subspecies acnes (C. acnes type I), subspecies defendens (C. acnes type II), and subspecies elongatum (C. acnes type III). C. acnes subspecies acnes is related to inflamed acne and sarcoidosis, while subspecies defendens to prostate cancer and subspecies elongatum to progressive macular hypomelanosis. Because the current nomenclature is based upon polyphasic analyses of the biochemical and pathogenic characteristics and comparative genomics, it provides a sound basis studying the pathophysiological roles of these species.
- Published
- 2021
15. Constrictive pericarditis caused by Cutibacterium (Propionibacterium) acnes: A case report and review of literature
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Rajesh Mohey, Makhmud Abu El Kheyr, and Troels Bek Jensen
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0301 basic medicine ,Constrictive pericarditis ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Propionibacterium ,030106 microbiology ,Antibiotics ,Context (language use) ,Cutibacterium ,030204 cardiovascular system & hematology ,Gastroenterology ,Article ,Microbiology ,Incubation period ,03 medical and health sciences ,Propionibacterium acnes ,Pericarditis ,0302 clinical medicine ,Internal medicine ,medicine ,Pericardiectomy ,biology ,business.industry ,biology.organism_classification ,medicine.disease ,Infectious Diseases ,business ,Constrictive - Abstract
Constrictive and effusive-constrictive pericarditis are rare cardiac disorders. Only rarely are the conditions caused by purulent infection, and even more infrequently by anaerobe bacteria. We describe a case of constrictive - and effusive-constrictive pericarditis due to Cutibacterium (formerly Propionibacterium) acnes in a 75-year old, immunocompetent and previously healthy patient without any predisposition. The patient was successfully treated with subtotal pericardiectomy and beta-lactam antibacterials. C. acnes was the only infectious agent recovered from samples of cultured pericardial tissue. C. acnes is a microaerophilic, Gram-positive anaerobic bacillus that is a part of the normal flora. In symptomatic patients, however, positive samples should be considered as clinically relevant and not dismissed as contamination. Due to the low virulence, the capability of adherence and biofilm formation of C. acnes, diagnosing C. acnes constrictive pericarditis may be difficult. In the context of compatible symptoms, the incubation time of clinical samples should be prolonged or supplemented by polymerase chain reaction techniques. Parenteral beta-lactam antibacterials are considered the drugs of choice. Severe constrictive and effusive-constrictive pericarditis caused by C. acnes is rare, but can be seen even in otherwise healthy patients. Prolonged incubation time and polymerase chain reaction techniques may be required in order to confirm diagnosis.
- Published
- 2017
16. Proposal of new combination, Cutibacterium acnes subsp. elongatum comb. nov., and emended descriptions of the genus Cutibacterium, Cutibacterium acnes subsp. acnes and Cutibacterium acnes subsp. defendens
- Author
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Andrew McDowell, Mitsuo Sakamoto, Itaru Dekio, Shuta Tomida, and Moriya Ohkuma
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DNA, Bacterial ,food.ingredient ,Subspecies ,Microbiology ,Propionibacterium acnes ,Cutibacterium ,food ,Genus ,RNA, Ribosomal, 16S ,Genus Propionibacterium ,Humans ,Ecology, Evolution, Behavior and Systematics ,Phylogeny ,Skin ,Base Composition ,Cutibacterium acnes ,biology ,Nucleic Acid Hybridization ,General Medicine ,Sequence Analysis, DNA ,biology.organism_classification ,MALDI-TOF Mass Spectrometry ,Haemolysis ,Bacterial Typing Techniques - Abstract
In 2016, division of the genus Propionibacterium into four distinct genera was proposed. As a consequence, the species Propionibacterium acnes was transferred to Cutibacterium gen. nov. as Cutibacterium acnes comb. nov. The three recently proposed subspecies of P. acnes were not, however, accommodated in this proposal. Following a very recent validation of a new combination for C. acnes subsp. defendens and an automatically created C. acnes subsp. acnes , we now propose the new combination, C. acnes subsp. elongatum comb. nov. The type strain of Cutibacterium acnes subsp. elongatum is JCM 18919T (=NCTC 13655T). On the basis of further genomic and phenotypic (haemolysis and MALDI-TOF mass spectrometry) analyses of these subspecies, we also provide emended descriptions of the genus Cutibacterium Scholz and Kilian 2016, C. acnes subsp. acnes (Gilchrist 1900) Nouioui et al. 2018, and C. acnes subsp. defendens (McDowell et al. 2016) Nouioui et al. 2018.
- Published
- 2019
17. Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages
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Daniel A. Russell, Laura J. Marinelli, Matteo Pellegrini, Graham F. Hatfull, Robert L. Modlin, Jeff F. Miller, Noël Grosset, Charles A. Bowman, Sorel Fitz-Gibbon, Michel Gautier, Lucy Cheng, Brian Q. Dang, Deborah Jacobs-Sera, Baochen Shi, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California-University of California, Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Department of Molecular, Cell, and Developmental Biology Los Angeles, University of California, Department of Biological Sciences, Dartmouth College, Department of Molecular, Cell, and Developmental Biology, California NanoSystems Institute, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Dartmouth College [Hanover]
- Subjects
0301 basic medicine ,Prophages ,viruses ,Ingénierie des aliments ,lcsh:QR1-502 ,fromage ,human health ,Medical and Health Sciences ,lcsh:Microbiology ,Bacteriophage ,Cutibacterium ,Cheese ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,phage ,fromage suisse ,Bacteriophages ,Viral ,Phylogeny ,Genetics ,Base Composition ,Genome ,biology ,Phage genomics ,Propionibacterium freudenreichii ,Microbiology and Parasitology ,genomique ,swiss cheese ,Chromosome Mapping ,santé humaine ,Genomics ,Biological Sciences ,Microbiologie et Parasitologie ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Alimentation et Nutrition ,Research Article ,Microbiology (medical) ,food.ingredient ,propionibacterium freundenreichii ,bacteriophage ,microbiote ,cutibacterium acnés ,Genome, Viral ,Microbiology ,bactériophage ,Host Specificity ,03 medical and health sciences ,Propionibacterium acnes ,food ,Lysogenic cycle ,Food engineering ,Food and Nutrition ,Lysogeny ,Prophage ,Propionibacteriaceae ,Genetic diversity ,Agricultural and Veterinary Sciences ,Base Sequence ,Whole Genome Sequencing ,Cheese microbiota ,séquence génomique ,Human Genome ,Propionibacterium ,Genetic Variation ,Molecular Sequence Annotation ,biology.organism_classification ,030104 developmental biology ,Cutibacterium acnes ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Background A remarkable exception to the large genetic diversity often observed for bacteriophages infecting a specific bacterial host was found for the Cutibacterium acnes (formerly Propionibacterium acnes) phages, which are highly homogeneous. Phages infecting the related species, which is also a member of the Propionibacteriaceae family, Propionibacterium freudenreichii, a bacterium used in production of Swiss-type cheeses, have also been described and are common contaminants of the cheese manufacturing process. However, little is known about their genetic composition and diversity. Results We obtained seven independently isolated bacteriophages that infect P. freudenreichii from Swiss-type cheese samples, and determined their complete genome sequences. These data revealed that all seven phage isolates are of similar genomic length and GC% content, but their genomes are highly diverse, including genes encoding the capsid, tape measure, and tail proteins. In contrast to C. acnes phages, all P. freudenreichii phage genomes encode a putative integrase protein, suggesting they are capable of lysogenic growth. This is supported by the finding of related prophages in some P. freudenreichii strains. The seven phages could further be distinguished as belonging to two distinct genomic types, or ‘clusters’, based on nucleotide sequences, and host range analyses conducted on a collection of P. freudenreichii strains show a higher degree of host specificity than is observed for the C. acnes phages. Conclusions Overall, our data demonstrate P. freudenreichii bacteriophages are distinct from C. acnes phages, as evidenced by their higher genetic diversity, potential for lysogenic growth, and more restricted host ranges. This suggests substantial differences in the evolution of these related species from the Propionibacteriaceae family and their phages, which is potentially related to their distinct environmental niches. Electronic supplementary material The online version of this article (10.1186/s12866-018-1159-y) contains supplementary material, which is available to authorized users.
- Published
- 2018
18. Taxonomy and phylogeny of Cutibacterium (formerly Propionibacterium) acnes in inflammatory skin diseases
- Author
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M.-A. Dagnelie, Stéphane Corvec, Amir Khammari, Brigitte Dréno, Clinical and Translational Research in Skin Cancer (CRCINA-ÉQUIPE 2), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de bactériologie et hygiène hospitalière [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de dermatologie [Nantes], Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), CCSD, Accord Elsevier, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)
- Subjects
food.ingredient ,Progressive macular hypomelanosis ,Population ,Folliculitis ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Dermatology ,Biology ,Subspecies ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Propionibacterium acnes ,0302 clinical medicine ,Cutibacterium ,food ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Phylogenetics ,RNA, Ribosomal, 16S ,Acne Vulgaris ,medicine ,Humans ,education ,Phylogeny ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,Sequence Analysis, RNA ,biology.organism_classification ,medicine.disease ,Molecular Typing ,Evolutionary biology ,Multilocus sequence typing - Abstract
Summary Since its discovery, Propionibacterium acnes has undergone various name changes, and has been known since 2016, as Cutibacterium acnes. Herein we set out the history and rational of these taxonomic changes together with a description of a new genus, Cutibacterium, which includes five species within the cutaneous ecosystem. Modern microbiological techniques allow finer distinction between species and subspecies while also enabling the identification of separate subtypes within the population of Cutibacterium acnes. Phylogeny and molecular typing techniques thus provide a better understanding of the subtypes involved in certain inflammatory skin diseases, including acne, folliculitis and progressive macular hypomelanosis.
- Published
- 2018
19. 347 New status quo of taxonomy of bacterial genus Cutibacterium, including Cutibacterium acnes (Propionibacterium acnes) and several other species and subspecies
- Author
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I. Dekio
- Subjects
Cutibacterium acnes ,food.ingredient ,biology ,Zoology ,Cell Biology ,Dermatology ,Subspecies ,biology.organism_classification ,Biochemistry ,Propionibacterium acnes ,Cutibacterium ,food ,Taxonomy (biology) ,Molecular Biology - Published
- 2019
20. Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies
- Author
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Andrew McDowell, Anthony J. Bjourson, Emma Barnard, Steven Watterson, Alison M. Layton, and Joseph McLaughlin
- Subjects
0301 basic medicine ,Microbiology (medical) ,Population ,virulence factors ,Review ,Cutibacterium ,Disease ,Microbiology ,host-microbe interactions ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Ribotyping ,Propionibacterium acnes ,0302 clinical medicine ,Virology ,medicine ,Microbiome ,education ,lcsh:QH301-705.5 ,Acne ,Genetics ,education.field_of_study ,biology ,clonal complex ,novel therapeutics ,phylogroups ,vaccination ,biology.organism_classification ,medicine.disease ,3. Good health ,multi-omic analyses ,030104 developmental biology ,lcsh:Biology (General) ,Metagenomics ,sequence types ,Multilocus sequence typing ,MLST - Abstract
The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.
- Published
- 2019
21. Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies.
- Author
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McLaughlin, Joseph, Watterson, Steven, Layton, Alison M., Bjourson, Anthony J., Barnard, Emma, and McDowell, Andrew
- Subjects
CUTIBACTERIUM acnes ,ACNE ,ANAEROBIC bacteria ,SKIN diseases ,BACTERIAL diversity ,ANAEROBIC microorganisms ,GRAM-negative anaerobic bacteria - Abstract
The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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