1. Cardiac BNP gene activation by angiotensin II in vivo
- Author
-
Heikki Tokola, Pierre Paradis, Sampsa Pikkarainen, Jun Wang, Balazs Sarman, Theresa Majalahti, Olli Vuolteenaho, Mona Nemer, Nina Hautala, Heikki Ruskoaho, and Maria Suo-Palosaari
- Subjects
Male ,Transcriptional Activation ,Angiotensin receptor ,medicine.medical_specialty ,medicine.drug_class ,Mice, Transgenic ,030204 cardiovascular system & hematology ,Biochemistry ,Receptor, Angiotensin, Type 1 ,Rats, Sprague-Dawley ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,GATA6 Transcription Factor ,Internal medicine ,Natriuretic Peptide, Brain ,Renin–angiotensin system ,Gene expression ,Natriuretic peptide ,medicine ,Animals ,RNA, Messenger ,Promoter Regions, Genetic ,Molecular Biology ,Cells, Cultured ,030304 developmental biology ,Regulation of gene expression ,0303 health sciences ,Angiotensin II receptor type 1 ,Proto-Oncogene Proteins c-ets ,Chemistry ,Angiotensin II ,Myocardium ,Body Weight ,Promoter ,DNA ,Organ Size ,GATA4 Transcription Factor ,Rats ,Transcription Factor AP-1 ,Gene Expression Regulation ,Hypertension ,cardiovascular system ,Hypertrophy, Left Ventricular ,hormones, hormone substitutes, and hormone antagonists ,Protein Binding - Abstract
The transcription factors involved in the activation of cardiac gene expression by angiotensin II (Ang II) in vivo are not well understood. Here we studied the contribution of transcriptional elements to the activation of the cardiac B-type natriuretic peptide (BNP) gene promoter by Ang II in conscious rats and in angiotensin II type 1 receptor (AT1R) transgenic mice. Rat BNP luciferase reporter gene constructs were injected into the left ventricular wall. The mean luciferase activity was 1.8-fold higher (P
- Published
- 2007