1. Continuous daily assessment of multiple sclerosis disability using remote step count monitoring
- Author
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Block, VJ, Lizée, A, Crabtree-Hartman, E, Bevan, CJ, Graves, JS, Bove, R, Green, AJ, Nourbakhsh, B, Tremblay, M, Gourraud, P-A, Ng, MY, Pletcher, MJ, Olgin, JE, Marcus, GM, Allen, DD, Cree, BAC, and Gelfand, JM
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Autoimmune Disease ,Neurosciences ,Multiple Sclerosis ,Neurodegenerative ,Neurological ,Accelerometry ,Biomechanical Phenomena ,Disability Evaluation ,Female ,Humans ,Male ,Middle Aged ,Monitoring ,Ambulatory ,Multiple Sclerosis ,Chronic Progressive ,Multiple Sclerosis ,Relapsing-Remitting ,Prospective Studies ,Reproducibility of Results ,Telemedicine ,Walking ,Multiple sclerosis ,Outcome measurement ,Remote physical activity monitoring ,Accelerometer ,Progressive ,Relapsing ,Neurology & Neurosurgery ,Clinical sciences - Abstract
Disability measures in multiple sclerosis (MS) rely heavily on ambulatory function, and current metrics fail to capture potentially important variability in walking behavior. We sought to determine whether remote step count monitoring using a consumer-friendly accelerometer (Fitbit Flex) can enhance MS disability assessment. 99 adults with relapsing or progressive MS able to walk ≥2-min were prospectively recruited. At 4 weeks, study retention was 97% and median Fitbit use was 97% of days. Substudy validation resulted in high interclass correlations between Fitbit, ActiGraph and manual step count tally during a 2-minute walk test, and between Fitbit and ActiGraph (ICC = 0.76) during 7-day home monitoring. Over 4 weeks of continuous monitoring, daily steps were lower in progressive versus relapsing MS (mean difference 2546 steps, p
- Published
- 2017