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Aim. To assess clinical and predictive value of serum IL-18 in ST elevation myocardial infarction.Material and methods. Totally, 132 patients included, hospitalized to Kemerovo cardiovascular dispensary due to STEMI with

Objective: To study the prognostic significance of serum NGAL (sNGAL) and cystatin C in the acute phase of ST-segment elevation myocardial infarction (STEMI) in the late disease period. Material and Methods: 357 patients with STEMI, admitted to hospital within 24 h of symptom onset, were included in the study. Serum creatinine levels with the calculation of glomerular filtration rate (GFR) using the MDRD as well as levels of sNGAL and cystatin C were measured on day 1 and 12–14. Results: All patients were divided into 2 groups according to their estimated GFR: with and without renal dysfunction (RD), defined as a decrease of GFR < 60 ml/min/1.73 m2. Within 3 years of follow-up, the composite endpoint (CEP) were assessed (CEP – death + non-fatal cardiovascular events). The ROC curve analysis was used to determine the thresholds for every biomarker, involved in the CEP development: NGAL (≥ 1.25 ng / ml) and cystatin C (≥ 1.9 mg / l). On day 12–14 of hospitalization elevated NGAL ≥ 1.25 ng / mL was associated with a 3-fold increased risk for adverse cardio vascular events in a 3-year follow up after STEMI; whereas, elevated cystatin C ≥ 1.9 mg/l – with a 2-fold increased risk for the CEP, and signs of RD, found in patients before the discharge from the hospital, – with a 1.5-fold increased cardiovascular risk. The model considering an increase of NGAL over 1.25 ng / l has the highest prognostic value, while the models based on the levels of cystatin C and GFR are of equal prognostic value. Conclusion: The most promising issue in the prognosis of long-term adverse outcomes in patients with STEMI may be considered the assessment of RD using new biomarkers such as sNGAL.

The course of perioperative period in 719 patients undergoing CABG in the Research Institute for Complex Issues of Cardiovascular Diseases between March, 2011 and April, 2012 was evaluated. All the patients had creatinine concentrations, glomerular filtration rate (GFR by MDRD) and daily urine microalbumin levels measured before CABG and at day 7 after CABG. Major event rates were assessed (myocardial infarction, stroke or transient ischemic attack, acute or decompensated chronic renal failure or remediastinotomy) during the hospital stay. The EuroSCORE was calculated for each patient. Different EuroSCORE risk patients had similar serum creatinine levels while microalbumin concentrations in daily urine were significantly higher in moderate and high EuroSCORE risk groups before the surgery as compared to low-risk patients. Patients who experienced postoperative events had significantly higher microalbuminuria both before and after surgery while there were no differences in such renal dysfunction markers as creatinine and GFR. Preoperative microalbuminuria assessment can act as a marker of complicated postoperative period after CABG.