1. Prediction of cervical metastasis and survival in cN0 oral cavity cancer using tumour 18 F-FDG PET/CT functional parameters.
- Author
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Bae MR, Roh JL, Kim JS, Choi SH, Nam SY, and Kim SY
- Subjects
- Adult, Aged, Disease-Free Survival, Female, Fluorodeoxyglucose F18 administration & dosage, Humans, Lymphatic Metastasis diagnostic imaging, Lymphatic Metastasis pathology, Middle Aged, Multimodal Imaging, Neoplasm Metastasis, Neoplasm Staging, Positron-Emission Tomography, Squamous Cell Carcinoma of Head and Neck diagnostic imaging, Squamous Cell Carcinoma of Head and Neck pathology, Squamous Cell Carcinoma of Head and Neck secondary, Tumor Burden, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms secondary, Lymphatic Metastasis diagnosis, Prognosis, Squamous Cell Carcinoma of Head and Neck diagnosis, Uterine Cervical Neoplasms diagnosis
- Abstract
Purpose: Oral cavity squamous cell carcinoma (OCC) can spread to the neck without apparent lymphadenopathy. Pretreatment detection or prediction of occult metastasis might contribute to proper management of clinically node-negative (cN0) OCC. We examined the role of tumour quantitative 18-fluorodeoxyglucose (
18 F-FDG) positron emission tomography (PET)/computed tomography (CT) measurements for predicting OCC occult metastasis and survival., Methods: This study included 130 cN0 OCC patients who underwent18 F-FDG PET/CT scanning and subsequent curative surgery and neck dissection. Maximum, peak, and mean standardized uptake value (SUVmax , SUVpeak , and SUVmean ), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were measured on pretreatment18 F-FDG PET/CT. Binary logistic regression was used to identify factors predicting occult cervical metastasis. Univariate and multivariate Cox proportional hazard regression were used to find factors associated with overall survival (OS)., Results: Pathological cervical metastasis (pN +) was found in 29 (22.3%) patients. Age, tumour differentiation, lymphovascular invasion, and T classification were significantly associated with pN + (all P < 0.05). After adjustment for these factors, MTV and TLG independently predicted pN + (P < 0.05). Invasion depth, lymphovascular invasion, T and N classifications, and overall TNM stage were significantly associated with OS. After adjustment for these factors, SUVmax and TLG independently predicted OS (all P < 0.05). Patients with TLG > 9.3 g had a 5.7-fold increased risk of overall mortality., Conclusions: Tumour18 F-FDG PET/CT parameters might predict occult metastasis and survival in cN0 OCC patients.- Published
- 2020
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