9 results on '"Lin, Qun"'
Search Results
2. Prediction Model Based on the Combination of Cytokines and Lymphocyte Subsets for Prognosis of SARS-CoV-2 Infection
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Luo, Ying, Mao, Liyan, Yuan, Xu, Xue, Ying, Lin, Qun, Tang, Guoxing, Song, Huijuan, Wang, Feng, and Sun, Ziyong
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- 2020
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Catalog
3. Serum soluble tumor necrosis factor-like weak inducer of apoptosis is a potential biomarker for outcome prediction of patients with aneurysmal subarachnoid hemorrhage
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Sun Jun, Lin Qun, Jun-Xia Dai, Cai Jianyong, and Zheng-Quan Yu
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0301 basic medicine ,medicine.medical_specialty ,Multivariate analysis ,Subarachnoid hemorrhage ,Clinical Biochemistry ,Apoptosis ,Inflammation ,Biochemistry ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Inducer ,Prospective Studies ,Receiver operating characteristic ,business.industry ,Glasgow Outcome Scale ,Biochemistry (medical) ,General Medicine ,Subarachnoid Hemorrhage ,Prognosis ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Tumor necrosis factor alpha ,medicine.symptom ,business ,Biomarkers - Abstract
Background Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) might contribute to brain inflammation after acute brain injury. The current study was designed to investigate whether serum soluble TWEAK (sTWEAK) can serve as a potential biomarker for functional outcome after aneurysmal subarachnoid hemorrhage (aSAH). Methods In this single-center prospective, observational study, admission serum sTWEAK concentrations were quantified among 112 aSAH patients. Impact of serum sTWEAK concentrations on a poor outcome (Glasgow outcome scale score 1–3) at 6 months after stroke onset was determined using multivariate analysis. Results Admission serum sTWEAK concentrations were intimately correlated with serum C-reactive protein concentrations, World Federation of Neurological Surgeons scores and modified Fisher scores. A total of 38 patients (33.9%) had a poor outcome at post-hemorrhagic 6 months. Admission serum sTWEAK concentrations were substantially higher in patients with a poor outcome than in the other remainders. Under receiver operating characteristic curve, serum sTWEAK concentrations significantly distinguished a poor outcome. Serum sTWEAK concentrations > 3.23 ng/ml discriminated the risk of a poor outcome with medium-high sensitivity and specificity and independently predicted a poor outcome. Conclusions Serum sTWEAK, in close correlation with inflammation and hemorrhagic severity, might represent a potential biomarker for predicting clinical outcome after aSAH. more...
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- 2020
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4. Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage
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Jun-Xia Dai, Ba Huajun, Chen Xiandong, Lu Chuan, Sun Jun, Lin Qun, Chen Maohua, and Cai Jianyong
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Stroke patient ,OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1 ,Clinical Biochemistry ,Biochemistry ,Gastroenterology ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Receptor ,biology ,business.industry ,Glasgow Outcome Scale ,Biochemistry (medical) ,Lectin ,General Medicine ,Middle Aged ,Subarachnoid Hemorrhage ,Prognosis ,Scavenger Receptors, Class E ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,biology.protein ,Female ,business ,Lipoprotein - Abstract
Oxidized low-density lipoprotein (ox-LDL) and its receptor, lectin-like ox-LDL receptor-1 (LOX-1) are involved in the pathogenesis of atherosclerosis. Expression of LOX-1 was substantially raised in the basilar arterial wall of subarachnoid hemorrhage (SAH) rabbits. We ascertained the relationship between serum soluble LOX-1 concentrations and functional outcome after human aneurysmal SAH.We enrolled 94 aneurysmal SAH patients and 94 healthy controls. Serum soluble TOX-1 concentrations were quantified using commercial enzyme-linked immunosorbent assay kit. A poor outcome was defined as Glasgow outcome scale score of 1-3.Median values of serum soluble LOX-1 in stroke patients were significantly higher than those in controls (1.5 vs. 0.4 ng/ml, P 0.001). Thirty patients (31.9%) had a poor outcome at 6 months after stroke. Serum soluble LOX-1 was a strong predictor of poor outcome (OR 5.20, 95% CI 1.25-22.04). Serum soluble LOX-1 concentrations exhibited a significant discriminatory capability (area under curve 0.811, 95% confidence interval 0.717-0.884). The predictive powers of World Federation of Neurological Surgeons grade, Hunt-Hess grade, modified Fisher grade, and serum soluble LOX-1 concentrations were comparable (all P 0.05).Serum soluble LOX-1 appears to have the potential to become a promising prognostic predictor after human aneurysmal SAH. more...
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- 2020
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5. Utility of Serum Growth Arrest-Specific Protein 6 as a Biomarker of Severity and Prognosis After Severe Traumatic Brain Injury: A Prospective Observational Study.
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Ni, Bu-Kao, Cai, Jian-Yong, Wang, Xiao-Bo, Lin, Qun, Zhang, Xue-Na, and Wu, Jian-Hua
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BRAIN injuries ,LONGITUDINAL method ,BIOMARKERS ,SCIENTIFIC observation ,PROGNOSIS - Published
- 2022
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6. Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis
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Ba Huajun, Lin Qun, Chen Xiandong, Chen Maohua, Sun Jun, Lu Chuan, Cai Jianyong, Jun-Xia Dai, and Jian-Hu Lin
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Male ,0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Clinical Biochemistry ,Inflammation ,Biochemistry ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Hematoma ,Modified Rankin Scale ,Internal medicine ,otorhinolaryngologic diseases ,Humans ,Medicine ,cardiovascular diseases ,Macrophage Migration-Inhibitory Factors ,Aged ,Cerebral Hemorrhage ,Aged, 80 and over ,Intracerebral hemorrhage ,business.industry ,Stroke scale ,Biochemistry (medical) ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Pathophysiology ,nervous system diseases ,030104 developmental biology ,Cytokine ,Anesthesia ,Acute Disease ,Female ,Macrophage migration inhibitory factor ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background Intracerebral hemorrhage (ICH) pathophysiology involves inflammation. Macrophage migration inhibition factor (MIF), a pro-inflammatory cytokine, is related to prognosis of ischemic stroke. The aim of this study was to investigate whether serum MIF levels are associated with severity and outcomes in patients with acute ICH. Methods We enrolled a total of 120 consecutive ICH patients and 120 healthy controls and sampled blood on admission and at study entry respectively. Enzyme-linked immunosorbent assay was used to quantify serum MIF levels. Results Serum MIF levels were higher in patients compared with controls and correlated with hematoma volume, National Institutes of Health Stroke Scale (NIHSS) scores and plasma C-reactive protein levels. After adjusting for other significant outcome predictors, MIF in serum was an independent predictor of 6-month overall survival and unfavorable outcome (modified Rankin Scale score > 2). Areas under receiver-operating characteristic curve (ROC) of serum MIF levels, hematoma volume and NIHSS scores were similar for 6-month unfavorable outcome. Moreover, serum MIF levels significantly improved areas under ROC of hematoma volume and NIHSS scores. Conclusions MIF in serum might be a potential biomarker for reflecting inflammation, severity and prognosis of ICH patients. more...
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- 2017
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7. Serum soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 as a biomarker of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
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Chen Maohua, Cai Jianyong, Ba Huajun, Lin Qun, Sun Jun, Dai Junxia, Chen Xiandong, and Lu Chuan
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Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Ischemia ,severity ,Logistic regression ,Severity of Illness Index ,Gastroenterology ,050105 experimental psychology ,Brain Ischemia ,lectin‐like oxidized low‐density lipoprotein receptor‐1 ,lcsh:RC321-571 ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Original Research ,Receiver operating characteristic ,biology ,business.industry ,05 social sciences ,Lectin ,Intracranial Aneurysm ,Middle Aged ,Subarachnoid Hemorrhage ,Prognosis ,Scavenger Receptors, Class E ,medicine.disease ,Confidence interval ,biology.protein ,delayed cerebral ischemia ,Biomarker (medicine) ,Female ,aneurysmal subarachnoid hemorrhage ,business ,Biomarkers ,030217 neurology & neurosurgery ,Lipoprotein - Abstract
Objective Delayed cerebral ischemia (DCI) greatly contributes to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. Expression of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) was substantially raised in the basilar arterial wall of SAH rabbits. We attempted to ascertain the relationship between serum soluble LOX‐1 (sLOX‐1) levels and the occurrence of DCI after aSAH. Materials and methods We enrolled 125 aSAH patients and 125 healthy controls. Serum sLOX‐1 levels were quantified using commercial enzyme‐linked immunosorbent assay kit. The relationship between sLOX‐1 levels and DCI was analyzed utilizing the multivariate logistic regression analysis. Results Serum sLOX‐1 levels were significantly higher in stroke patients than in controls (median: 1,450.2 vs. 445.7 pg/ml, p 1,450.2 pg/ml, WFNS scores and modified Fisher scores were the independent predictors of DCI. Under receiver operating characteristic curve, serum sLOX‐1 levels exhibited a significant discriminatory capability (area under curve 0.825, 95% confidence interval 0.747–0.887). The predictive power of serum sLOX‐1 levels was similar to those of WFNS scores and modified Fisher grade (both p > .05). Moreover, serum sLOX‐1 levels significantly improved their predictive capability (both p, There is a substantial elevation in serum sLOX‐1 levels after aSAH. There is an intimate correlation of serum sLOX‐1 levels with hemorrhagic severity. There is an independent association of serum sLOX‐1 levels with delayed cerebral ischemia. more...
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- 2020
8. Thioredoxin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage
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Dai Junxia, Lin Qun, Cai Jianyong, Chen Xiandong, Lu Chuan, Ba Huajun, and Sun Jun
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Pathology ,animal structures ,Subarachnoid hemorrhage ,Inflammation ,Gastroenterology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Thioredoxins ,Internal medicine ,Severity of illness ,medicine ,Humans ,Prospective Studies ,Mortality ,Prospective cohort study ,Aged ,business.industry ,Glasgow Outcome Scale ,Odds ratio ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,Prognosis ,030104 developmental biology ,Neurology ,Apoptosis ,Female ,Neurology (clinical) ,medicine.symptom ,Thioredoxin ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Circulating levels of thioredoxin (Trx), a potent anti-oxidant that modulates inflammation, cell growth and apoptosis, are increased in various critical care conditions. The purpose of this study was to establish the relationship between serum Trx levels and prognosis of aneurysmal subarachnoid hemorrhage (aSAH).An enzyme-linked immunosorbent assay measurement of Trx was performed in serum from 132 patients and 132 healthy volunteers. Clinical outcomes included 6-month mortality and unfavorable outcome (Glasgow outcome scale score of 1-3).The serum Trx levels were significantly higher in patients than in controls (23.4±12.2 ng/mL vs.8.5±4.0 ng/mL, P0.001) and had close relation to the World Federation of Neurological Surgeons (WFNS) scores (r=0.461, P0.001) and modified Fisher scores (r=0.459, P0.001). Trx was an independent predictor for 6-month mortality (Odds ratio, 1.386; 95% confidence interval, 1.015-2.161; P0.001) and 6-month unfavorable outcome (Odds ratio, 1.297; 95% confidence interval, 1.012-2.002; P0.001). Based on receiver operating characteristic curve, TRX had similar prognostic value compared with WFNS scores and modified Fisher scores and also significantly improved their prognostic value for 6-month unfavorable outcome, but not for 6-month mortality.Elevated plasma Trx levels are correlated with the severity and poor prognosis, substantializing Trx as a potential prognostic predictive biomarker following aSAH. more...
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- 2016
9. RVD2 emerges as a serological marker in relation to severity and six-month clinical outcome following acute intracerebral hemorrhage: A prospective cohort study from a single academic institution.
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Yang, Wenjie, Lu, Tiancheng, Shan, Hao, Zou, Shengdong, Ye, Zejian, Zhang, Keyang, Lin, Qun, Dai, Junxia, Cai, Jianyong, Yu, Wenhua, Liang, Xiaolong, Zhang, Lixin, Hong, Huayong, Wang, Xianjun, and Yang, Dingbo more...
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RECEIVER operating characteristic curves , *CEREBRAL hemorrhage , *TREATMENT effectiveness , *PROGNOSIS , *DECISION making - Abstract
• There is a marked decline of serum RvD2 levels following ICH. • Serum RvD2 levels display an independent relation to stroke severity after ICH. • Serum RvD2 emerges as an independent predictor of post-ICH six-month poor prognosis. • Serum RvD2 levels may take possession of effective prognostic discriminative ability. • Clinical usability of serum RvD2 can be validated efficaciously in ICH management. Resolvin D2 (RvD2), with an anti-inflammatory activity, harbors a neuroprotective property. Here, serum RvD2 levels were detected with an attempt to explore its prognostic implication in human acute intracerebral hemorrhage (ICH). In this prospective cohort study, serum RvD2 levels of 301 ICH patients, coupled with 100 heathy individuals, were gauged. All patients were randomly divided to two groups (200 patients in the study group and 101 in the validation group) in a 2:1 ratio. Change of serum RvD2 levels after ICH was investigated, and its correlations with National Institutes of Health Stroke Scale (NIHSS) scores, hematoma volume and poststroke six-month modified Rankin Scale (mRS) scores were determined using multivariate analysis. Its independent association with poor prognosis (mRS scores of 3–6) was uncovered in the study group and its prognostic predictive value was verified in the validation group. The serum levels of RvD2 in patients displayed a notable decline upon admission, as compared to controls. The levels exhibited independent correlations with NIHSS scores, hematoma size and mRS scores. Alternatively, RvD2 levels had independent relation to a poor prognosis after ICH. Within the framework of restricted cubic spline analysis, RvD2 levels were linearly correlated with the likelihood of poor prognosis, even adjusting for NIHSS scores and hematoma size. In the context of receiver operating characteristic (ROC) curve analysis, serum RvD2 dramatically distinguished risk of poor prognosis, with similar predictive ability to NIHSS scores and hematoma volume. By employing subgroup analysis, the relationship between RvD2 levels and poor prognosis was not obviously influenced by other parameters, such as age, sex, hypertension, and more. The integrated model containing serum RvD2, NIHSS scores and hematoma volume was visualized on a nomogram and showed high predictive performance and clinical effectiveness for poor prognosis via multiple evaluation metrics, including the Hosmer-Lemeshow test, ROC curve analysis, calibration curve analysis and decision curve analysis. Clinical usefulness of serum RvD2 was verified in the validation group. Serum RvD2 levels exhibit an immediate decrease post-ICH, which could be able to accurately reflect ICH severity and efficiently prognosticate poor neurological outcomes, signifying that serum RvD2 may represent an encouraging prognostic indicator in ICH. [ABSTRACT FROM AUTHOR] more...
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- 2025
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