27 results on '"Hui Mian Xu"'
Search Results
2. Effect of neoadjuvant chemotherapy in patients with gastric cancer: a PRISMA-compliant systematic review and meta-analysis
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Zhi-Feng Miao, Xing-Yu Liu, Zhen-Ning Wang, Ting-Ting Zhao, Ying-Ying Xu, Yong-Xi Song, Jin-Yu Huang, Hao Xu, and Hui-Mian Xu
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Gastric cancer ,Neoadjuvant chemotherapy ,Meta-analysis ,Overall aurvival ,Prognosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Neoadjuvant chemotherapy (NAC) is extensively used in the treatment of patients with gastric cancer (GC), particularly in high risk, advanced gastric cancer. Previous trials testing the efficacy of NAC have reported inconsistent results. Methods This study compares the combined use of NAC and surgery with surgery alone for GC by using a meta-analytic approach. We performed an electronic search of PubMed, EmBase, and the Cochrane Library to identify randomized controlled trials (RCTs) on NAC published before Oct 2015. The primary outcome of the studies was data on survival rates for patients with GC. The summary results were pooled using the random-effects model. We included 12 prospective RCTs reporting data on 1538 GC patients. Results Patients who received NAC were associated with significant improvement of OS (P = 0.001) and PFS (P
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- 2018
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3. Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data
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Wei Wang, Yu-Jie Yang, Ri-Hong Zhang, Jing-Yu Deng, Zhe Sun, Sharvesh Raj Seeruttun, Zhen-Ning Wang, Hui-Mian Xu, Han Liang, and Zhi-Wei Zhou
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Gastrectomy ,Stomach Neoplasms ,Humans ,General Medicine ,Lymph Nodes ,Prognosis ,Neoplasm Staging - Abstract
Background Currently, there is no formal consensus regarding a standard classification for gastric cancer (GC) patients with Methods All patients in this study underwent R0 gastrectomy. The overall survival (OS) difference between the Limited and Adequate set from a large Chinese multicenter dataset was analyzed. Using the 8th American Joint Committee on Cancer (AJCC) pathological nodal classification (pN) for GC as base, a modified nodal classification (N’) resembling similar analogy as the 8th AJCC pN classification was developed. The performance of the proposed and 8th AJCC GC subgroups was compared and validated using the Surveillance, Epidemiology, and End Results (SEER) dataset comprising of 10,208 multi-ethnic GC cases. Results Significant difference in OS between the Limited and Adequate set (corresponding N0–N3a) using the 8th AJCC system was observed but the OS of N0limited vs. N1adequate, N1limited vs. N2adequate, N2limited vs. N3aadequate, and N3alimited vs. N3badequate subgroups was almost similar in the Chinese dataset. Therefore, we formulated an N’ classification whereby only the nodal subgroups of the Limited set, except for pT1N0M0 cases as they underwent less extensive surgeries (D1 or D1 + gastrectomy), were re-classified to one higher nodal subgroup, while those of the Adequate set remained unchanged (N’0 = N0adequate + pT1N0M0limited, N’1 = N1adequate + N0limited (excluding pT1N0M0limited), N’2 = N2adequate + N1limited, N’3a = N3aadequate + N2limited, and N’3b = N3badequate + N3alimited). This N’ classification demonstrated less heterogeneity in OS between the Limited and Adequate subgroups. Further analyses demonstrated superior statistical performance of the pTN’M system over the 8th AJCC edition and was successfully validated using the SEER dataset. Conclusion The proposed nodal staging strategy was successfully validated in large multi-ethnic GC datasets and represents a practical approach for homogenizing the classification of GC cohorts comprising of patients with
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- 2021
4. Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation
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Zhe Sun, Wei Wang, Sharvesh Raj Seeruttun, Hui Mian Xu, Zhiwei Zhou, Zhenning Wang, Cheng Fang, Jing Yu Deng, and Han Liang
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0301 basic medicine ,Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Prognosis prediction ,Adolescent ,Pathological TNM staging system ,Adenocarcinoma ,lcsh:RC254-282 ,03 medical and health sciences ,Gastric adenocarcinoma ,Young Adult ,0302 clinical medicine ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Staging system ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Chinese ,business.industry ,External validation ,Cancer ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Prognosis ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Akaike information criterion (AIC) ,SEER ,030104 developmental biology ,Multicenter study ,030220 oncology & carcinogenesis ,Cohort ,Original Article ,Female ,business ,Gastric cancer - Abstract
Background The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) pathological tumor-node-metastasis (pTNM) staging system may have increased accuracy in predicting prognosis of gastric cancer due to its important modifications from previous editions. However, the homogeneity in prognosis within each subgroup classified according to the 8th edition may still exist. This study aimed to compare and analyze the prognosis prediction abilities of the 8th and 7th editions of AJCC/UICC pTNM staging system for gastric cancer and propose a modified pTNM staging system with external validation. Methods In total, clinical data of 7911 patients from three high-capacity institutions in China and 10,208 cases from the Surveillance, Epidemiology, and End Results (SEER) Program Registry were analyzed. The homogeneity, discriminatory ability, and monotonicity of the gradient assessments of the 8th and 7th editions of AJCC/UICC pTNM staging system were compared using log-rank χ2, linear-trend χ2, likelihood-ratio χ2 statistics and Akaike information criterion (AIC) calculations, on which a modified pTNM classification with external validation using the SEER database was proposed. Results Considerable stage migration, mainly for stage III, between the 8th and 7th editions was observed in both cohorts. The survival rates of subgroups of patients within stage IIIA, IIIB, or IIIC classified according to both editions were significantly different, demonstrating poor homogeneity for patient stratification. A modified pTNM staging system using data from the Chinese cohort was then formulated and demonstrated an improved homogeneity in these abovementioned subgroups. This staging system was further validated using data from the SEER cohort, and similar promising results were obtained. Compared with the 8th and 7th editions, the modified pTNM staging system displayed the highest log-rank χ2, linear-trend χ2, likelihood-ratio χ2, and lowest AIC values, indicating its superior discriminatory ability, monotonicity, homogeneity and prognosis prediction ability in both populations. Conclusions The 8th edition of AJCC/UICC pTNM staging system is superior to the 7th edition, but still results in homogeneity in prognosis prediction. Our modified pTNM staging system demonstrated the optimal stratification and prognosis prediction ability in two large cohorts of different gastric cancer populations.
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- 2018
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5. The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression
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Ya-nan Xing, Xiao-yan Xu, Xue Yang, Hua-chuan Zheng, Hui-mian Xu, Yang Zheng, and Yasuo Takano
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Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Biology ,medicine.disease_cause ,Pathology and Forensic Medicine ,Metastatic carcinoma ,Stomach Neoplasms ,Cell Line, Tumor ,medicine ,Carcinoma ,Humans ,Stomach cancer ,Tissue microarray ,Tumor Suppressor Proteins ,Cancer ,Prognosis ,medicine.disease ,Gene Expression Regulation, Neoplastic ,Gastric Dysplasia ,Cell Transformation, Neoplastic ,Gastric Mucosa ,Dysplasia ,Disease Progression ,Female ,Carcinogenesis ,Transcription Factors - Abstract
ING5 can interact with p53, thereby inhibiting cell growth and inducing apoptosis. To clarify the roles of ING5 in gastric tumorigenesis and progression, its expression was examined by immunohistochemistry on a tissue microarray containing gastric nonneoplastic mucosa (n = 119), dysplasia (n = 50), and carcinomas (n = 429), with its comparison with clinicopathologic parameters of the carcinomas. ING5 expression was analyzed in gastric carcinoma tissues and cell lines (MKN28, MKN45, AGS, GT-3 TKB, and KATO-III) by Western blot and reverse transcriptase-polymerase chain reaction. ING5 protein was found to distribute to the nuclei of gastric carcinoma cells with similar messenger RNA levels. An increased expression of ING5 messenger RNA was observed in gastric carcinoma in comparison with paired mucosa (P < .05). Lower expression of nuclear ING5 was detected in gastric dysplasia and carcinoma than that in nonneoplastic mucosa (P < .05). Gastric nonneoplastic mucosa and metastatic carcinoma showed more expression of cytoplasmic ING5 than did gastric carcinoma and dysplasia (P < .05). Nuclear ING5 expression was negatively correlated with tumor size, depth of invasion, lymph node metastasis, and clinicopathologic staging (P < .05), whereas cytoplasmic ING5 was positively associated with depth of invasion, venous invasion, lymph node metastasis, and clinicopathologic staging (P < .05). Nuclear ING5 was more expressed in older than younger carcinoma patients (P < .05). There was a higher expression of nuclear ING5 in intestinal-type than diffuse-type carcinoma (P < .05), whereas it was the converse for cytoplasmic ING5 (P < .05). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent. It was suggested that aberrant ING5 expression may contribute to pathogenesis, growth, and invasion of gastric carcinomas and could be considered as a promising marker to gauge aggressiveness and prognosis of gastric carcinoma.
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- 2011
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6. Prognostic significance of the metastatic lymph node ratio in T3 gastric cancer patients undergoing total gastrectomy
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Jun, Feng, Yun-Fei, Wu, Hui-Mian, Xu, Shu-Bao, Wang, and Jun-Qing, Chen
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Adult ,Male ,China ,Adenocarcinoma ,Middle Aged ,Prognosis ,Survival Rate ,ROC Curve ,Gastrectomy ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Female ,Lymph Nodes ,Aged ,Follow-Up Studies ,Neoplasm Staging ,Retrospective Studies - Abstract
The International Union Against Cancer tumor node metastasis classification is routinely applied for evaluating the prognosis of patients with gastric cancer. However, results are still heterogeneous. This study was therefore carried out to evaluate the prognostic significance of the metastatic lymph node (LN) ratio in T3 gastric cancer patients undergoing gastrectomy.Clinical data of 109 LN- positive cases were retrospectively analyzed. Spearman correlation analysis was used to determine the correlation coefficiency. Survival time was determined by Kaplan-Meier and Log-rank test. Multivariate analysis was performed using the Cox model. ROC curves were used to compare the accuracy of the number of metastatic LN and metastatic LN ratio.The metastatic LN ratio did not correlate with the number of LN when at least 15 nodes were dissected, whereas the number of metastatic LN did. Univariate analysis showed that the metastatic LN ratio influenced significantly the survival time, while multivariate analysis revealed it to be a major independent prognostic factor.The metastatic LN ratio can be used as a major independent prognostic factor for the patients with T3 gastric cancer.
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- 2012
7. [Clinicopathological characteristics and prognostic factors in patients with stage III gastric cancer]
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Yan, Xu, Zhe, Sun, Zhen-ning, Wang, and Hui-mian, Xu
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Adult ,Aged, 80 and over ,Male ,Young Adult ,Stomach Neoplasms ,Humans ,Female ,Middle Aged ,Prognosis ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
To investigate the clinicopathological characteristics and prognostic factors of stage III gastric cancer.A retrospectively study of 1007 patients with Stage III gastric cancer in a single institute in China was performed. The patients underwent surgical resection from January 1991 to December 2005. Univariate and multivariate analyses were performed using log-rank test and Cox proportional hazards model to access the prognostic factors in stage III gastric cancer patients who received curative (R0) gastric resection.The mean age of the 1007 patients was 58.7 years and the male-to-female ratio was 2.6:1.0. There were 242 patients with stage IIIA disease, 403 patients with stage IIIB, and 362 patients with stage IIIC. R0, R1, and R2 resection were performed in 754 patients (74.9%), 56 patients (5.5%), and 197 patients (19.6%), respectively. The 5-year survival rate (37.8%) of patients who received R0 resection was significant higher than that of patients who received R1(21.2%) and R2(8.9%) resection (P0.05). Multivariate analysis revealed that pN stage, pT stage, and Borrmann type were independent prognostic factors (all P0.01).Stage III gastric cancer patients have certain clinicopathological characteristics and R0 resection should be performed if possible. Lymph node count, depth of tumor invasion, and Borrmann type are independent prognostic factors in stage III gastric cancer patients undergoing R0 resection.
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- 2012
8. [Prognostic value of metastatic lymph node ratio in gastric cancer]
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Bao-Li-de, A La-teng, Yi-ming, Li, Cai-gang, Liu, Bin-bin, Wang, Hui-mian, Xu, Jun-qing, Chen, Shu-bao, Wang, and Ping, Lu
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Adult ,Aged, 80 and over ,Male ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Female ,Lymph Nodes ,Middle Aged ,Prognosis ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
To evaluate the value of the metastatic to examined lymph nodes (rN) ratio in gastric cancer patients who underwent radical resection.In this retrospective study, data were collected from the medical records of 710 patients who underwent radical gastrectomy (R0) for gastric cancer from 1980 to 2006 in the Department of Surgical Oncology at the First Affiliated Hospital of China Medical University. The patients were divided into 2 groups according to the number of examined lymph nodes: Group 1 consisted of 327 patients with15 examined lymph nodes and Group 2 consisted of 383 patients with ≥15 lymph nodes. rN categories staging and pN categories were divided separately according to the metastatic lymph node ratio and the examined lymph nodes. The prognostic factors were analyzed by univariate (Log-rank) and multivariate (Cox model) analysis methods.The median survival time was 74 months (95% CI:55.6-92.4 months) in Group 1 and 96 months (95% CI:77.8-119.2 months) in Group 2, and the difference was not statistically significant (P0.05). On multivariate analysis, the N ratio remained as an independent prognostic factor in both Group 1 (P0.01, RR=1.225, 95% CI:1.102-1.362) and Group 2 (P0.01, RR=1.421, 95% CI:1.269-1.592). However, pN stage was an independent prognostic factor only in Group 1. When the rN ratio classification was applied, there were no significant differences between each categories (P0.05). However, the overall survival of patients with pN1 disease in Group 1 was significantly shorter than that in Group 2 according to the pN stage classification (P0.01).The metastatic lymph node ratio is an independent prognostic factor of the prognosis of gastric cancer. The staging system based on metastatic lymph node ratio (rN) is more reliable than the system based on the number of metastatic lymph nodes in the prediction of the prognosis of gastric cancer.
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- 2012
9. Splenic hilar lymph node metastasis independently predicts poor survival for patients with gastric cancers in the upper and/or the middle third of the stomach
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Guo-Lian, Zhu, Zhe, Sun, Zhen-Ning, Wang, Ying-Ying, Xu, Bao-Jun, Huang, Yan, Xu, Zhi, Zhu, and Hui-Mian, Xu
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Male ,Splenic Neoplasms ,Liver Neoplasms ,Adenocarcinoma ,Middle Aged ,Prognosis ,Survival Rate ,Stomach Neoplasms ,Lymphatic Metastasis ,Splenectomy ,Humans ,Lymph Node Excision ,Female ,Peritoneal Neoplasms ,Follow-Up Studies ,Neoplasm Staging ,Retrospective Studies - Abstract
Effectiveness of splenectomy for advanced gastric cancers occupying the upper and/or the middle third of the stomach is still in debate. The aim of the present study is to elucidate the impact of splenectomy on patient survival by investigating the pathological characteristics and prognostic significance of splenic hilar lymph node metastasis.Clinicopathologic and prognostic data of 265 patients with gastric cancer in the upper and/or the middle third of the stomach who underwent the operation of en bloc resection of primary cancer and D2/D3 lymphadenectomy combined with splenectomy were retrospectively reviewed.Multivariate analysis revealed pT category, pN category, and distant lymph node metastasis independently correlated with the presence of splenic hilar lymph node metastasis. Prognoses of patients with positive splenic hilar lymph nodes were significantly poorer than that of patients with negative splenic hilar lymph nodes for the entire study population and for those who underwent R0 resection, but not for those who underwent R1-2 resection. There was no significant difference in survival between patients who underwent R0 resection with positive splenic hilar lymph nodes and those who underwent R1-2 resection. Splenic hilar lymph node metastasis was one of independent indicators predicting worse prognosis and the presence of distant metastasis after surgery. Subset analysis according to the TNM stage revealed there were significant differences in survival between patients with and without splenic hilar lymph node metastasis.Splenic hilar lymph node metastasis should be considered as one of incurable factors. Consequently, the efficiency of splenectomy aiming at prolonging survival for patients with high risk of splenic hilar lymph nodes metastasis should be questioned, although resection of invasive organs form gastric cancers has been recommended if R0 surgery could be achieved.
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- 2011
10. Prognostic significance of lymph node station 7 for patients with gastric cancers underwent radical surgery
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Jian-Hua, Tong, Zhe, Sun, Zhi, Zhu, Zhen-Ning, Wang, Ying-Ying, Xu, Bao-Jun, Huang, Yan, Xu, and Hui-Mian, Xu
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Male ,Adenocarcinoma ,Middle Aged ,Prognosis ,Survival Rate ,Gastrectomy ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Lymph Node Excision ,Female ,Neoplasm Invasiveness ,Prospective Studies ,Follow-Up Studies ,Neoplasm Staging ,Retrospective Studies - Abstract
To investigate the validity of gastric cancers with nodes metastasis at Level II stations limited to No. 7 being classified as level-based n1 stage disease and the impact of this revision on lymph node staging.Clinicopathologic features and prognosis of 1,606 node positive gastric cancers were retrospectively reviewed. Four patient groups were classified according to the status of node involvement: Group A, 734 patients with node metastasis at Level I stations; Group B, 317 patients with nodes metastasis at Level II stations limited to No. 7; Group C, 501 patients with nodes metastasis at Level II stations besides No. 7; and Group D, 54 patients with nodes metastasis at Level III stations.Although the extent of node metastasis for patients in Group B was more severe than that for patients in Group A, clinicopathologic features (especially pT stage) were not significantly different. Although overall survival for patients in Group B was significantly worse than that for patients in Group A, no significant differences in prognosis could be observed when stratified by pN or rN category. A revised level-based n category was established by considering cancers in Group B as level-based n1 stage disease. Multivariate analysis confirmed rN category and the revised level-based n category independently predicted patients' survival. A novel N category was established by combining rN category and the revised level-based n category. Further analysis revealed the novel N category had better homogeneity, discriminatory ability, and monotonicity of gradients than the other node categories, indicating the novel N system might be the most valuable node staging system for prognostic assessment.It might be more suitable for cancers in Group B being classified as level-based n1 stage disease. And we recommend the anatomical location of metastatic lymph nodes also being considered in the categorization of lymph node metastasis.
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- 2010
11. Clinicopathologic characteristics and prognosis of gastric cancer invading the subserosa
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Cheng-Gang, Jiang, Zhen-Ning, Wang, Zhe, Sun, Fu-Nan, Liu, Miao, Yu, and Hui-Mian, Xu
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Adult ,Aged, 80 and over ,Male ,Mucous Membrane ,Liver Neoplasms ,Middle Aged ,Prognosis ,Survival Rate ,Young Adult ,Serous Membrane ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Female ,Neoplasm Invasiveness ,Peritoneal Neoplasms ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
The clinicopathologic characteristics and prognosis for gastric cancer invading subserosa (SS) are still not clear.A retrospective analysis was under taken of 1,201 patients with advanced gastric cancer (pT2, pT3, and pT4a) who had undergone gastrectomy from 1980 to 2001. Clinicopathologic characteristics and prognosis of gastric cancer invading SS were compared with those of cancers invading muscularis propria (MP) and serosa (Se).Patients with cancers invading SS had larger tumors and more frequent lymphovascular invasion, lymph node and peritoneal metastasis than those with cancers invading MP. Yet, they had smaller tumors and less frequent lymphovascular invasion, lymph node and peritoneal metastasis than those with cancers invading Se. Postoperative survival with cancers invading SS was intermediate between that with cancers invading MP and Se at pN0, pN1, pN2, and pN3 stages. Multivariate analysis indicated lymph node metastasis, type of resection, curability, peritoneal metastasis, and hepatic metastasis were independent prognostic factors for patients with cancers invading SS.Clinicopathologic characteristics and prognosis of gastric cancer invading SS are intermediate between those of gastric cancers invading MP and Se.
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- 2010
12. Comparison in pathological behavioursprognosis of gastric cancers from general hospitals between ChinaJapan
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Miao, Yu, Hua-chuan, Zheng, Pu, Xia, Hiroshi, Takahashi, Shinji, Masuda, Yasuo, Takano, and Hui-mian, Xu
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Male ,China ,Japan ,Stomach Neoplasms ,Incidence ,Histological Techniques ,Age Factors ,Humans ,Female ,Prognosis ,Statistics, Nonparametric ,Neoplasm Staging ,Retrospective Studies - Abstract
Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths after lung carcinoma. The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan.Paraffin-fixed tissue samples of gastric cancer were collected retrospectively from two hospitals between 1993 to 2006 in Japan (n=2063) and during 1980-2003 in China (n=2496) respectively, and staging was done by TNM system and typing by Japanese Endoscopy Society criteria or Borrmann's classification. The histological architecture of the tumours was expressed according to Lauren's classification.Compared to Japan, the occurrence of gastric cancer was more common in younger Chinese population and prone to invasion and metastasis in muscularis propia, lymphatic, lymph node, liver, peritoneal parts, and exhibited large tumour size and high TNM staging in both the sexes and in different age groups (P0.05). Intestinal and mixed types of carcinomas were more frequently observed in Japanese patients compared to Chinese and the difference was significant (P0.05). It was observed that the commonly reported types in early gastric cancers (EGC) in Japanese patients were IIc, IIa+IIc or IIa while those of Chinese patients were IIc, III or IIb. In the case of advanced gastric cancers (AGC), type II and III were most common in both the countries. The cumulative survival rate of Chinese patients was significantly (P0.05) higher compared to Japanese in different stratified groups via depth of invasion, TNM staging or Lauren's classification.Gastric cancers in Chinese patients had more aggressive pathological characteristics and poorer prognosis than those from Japan. To reduce incidence and to improve treatment facilities, it is necessary to have a systematic screening system.
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- 2010
13. Clinicopathologic characteristics and prognosis of signet ring cell carcinoma of the stomach: results from a Chinese mono-institutional study
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Cheng-Gang, Jiang, Zhen-Ning, Wang, Zhe, Sun, Fu-Nan, Liu, Miao, Yu, and Hui-Mian, Xu
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Male ,China ,Incidence ,Carcinoma ,Middle Aged ,Prognosis ,Age Distribution ,Gastrectomy ,Stomach Neoplasms ,Multivariate Analysis ,Humans ,Female ,Neoplasm Invasiveness ,Peritoneum ,Sex Distribution ,Carcinoma, Signet Ring Cell ,Follow-Up Studies ,Proportional Hazards Models ,Retrospective Studies - Abstract
Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics, and its clinicopathologic characteristics and prognosis are still controversial.A retrospective analysis was under taken for 2,315 patients with gastric cancer who had undergone gastrectomy from 1980 to 2004. Among them, 211 patients had SRC and were compared with 2,104 patients with non-signet ring cell carcinoma (NSRC).Significant differences were noted in age, gender, and depth of tumor invasion between patients with SRC and NSRC of early gastric carcinoma. There were statistically significant differences in age, gender, macroscopic appearance, tumor size, depth of tumor invasion, peritoneal dissemination, and curability between patients with SRC and NSRC of advanced gastric carcinoma. In early gastric carcinoma, patients with SRC had a significantly better survival rate than those with NSRC, and the signet ring cell histology was an independent predictive factor. In advanced gastric carcinoma, there was no significant difference of survival rate between SRC and NSRC, and the signet ring cell histology was not an independent predictive factor.SRC is a distinct type of gastric carcinoma in terms of clinicopathologic characteristics and prognosis.
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- 2010
14. [Clinical analysis of superficial spreading early gastric cancer:a report of 62 cases]
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Bao-jun, Huang and Hui-mian, Xu
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Adult ,Gastric Mucosa ,Stomach Neoplasms ,Humans ,Female ,Middle Aged ,Prognosis ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
To clarify the clinicopathological features and prognosis, and to evaluate the rational surgical therapy for superficial spreading early gastric cancer (EGC).Superficial spreading EGC was defined as tumor invading the mucosa or submucosa layer with the diameteror =50 mm, and common EGC as tumor with diameter50 mm. The clinicopathological data of 62 patients with superficial spreading EGC and 224 patients with common EGC were collected and analyzed retrospectively.No significant differences in age, sex, differentiation, depth of invasion, growth manner, vessel involvement and lymph node metastasis were found between superficial spreading and common EGC(P0.05), but significant differences were seen in tumor site, macroscopic type, scope of gastrectomy and lymphadenectomy between the two groups(P0.05). Superficial spreading EGC located in the middle or the whole of stomach accounted for 45.2%, and presented mixed macroscopic type more frequently(48.4%), such as II(C+II(A 5 cases, II(C+II(B 9 cases and II(C+III( 16 cases, and more total gastrectomy and more D(2) lymphadenectomy(16.1% and 40.3% respectively) were executed, compared with common EGC. Due to cancer residual,two patients underwent enlargement of the scope of gastrectomy,two underwent total gastrectomy and one underwent operation again after surgery. The 5-, 10-year tumor-free survival rates for superficial spreading EGC were 98.4% and 91.4%, while 97.0% and 91.2% for the common EGC (chi(2)=1.16,P=0.282).Special clinicopathological features can be seen in superficial spreading EGC, and the lesion is superficial and extensive. Prevention of cancer residual in remnant stomach is the key point and D(2) lymphadenectomy is suitable enough for operation.
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- 2009
15. [Clinicopathologic features and prognosis of gastric cancer in young adults]
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Chong, Lu, Zhen-ning, Wang, Zhe, Sun, and Hui-mian, Xu
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Adult ,Male ,Stomach Neoplasms ,Humans ,Female ,Prognosis ,Survival Analysis ,Proportional Hazards Models - Abstract
To analyze the clinicopathologic features and prognosis of young patients with gastric cancer by comparing with older patients.The clinicopathologic data of 157 younger adults (age,/= 40 years) with gastric cancer and 1761 cases of elder gastric cancer patients (age,40 years) was analyzed and compared retrospectively. All of the 1918 patients were surgically treated between January 1980 and December 2000.The rates of poorly differentiation, diffusive growth, Borrmann 4 type, whole-stomach invasion were significantly higher in younger cases than those in the elder counterparts (P0.05), especially in young female patients. The rate of early gastric cancer was significantly higher in young patients than that in older patients (P0.05), especially in young male patients. There was significant difference between the survival rate of younger male cases (median survival, 35 months) and younger female cases (median survival, 19 months) (P = 0.0219), but no significant difference was found between elder male and elder female (median survival, 26 vs. 30 months). TNM stage, operative curability, gross type were independent predictive factors of survival for younger patients.Younger female gastric cancer patients tends to have worse prognosis than older patients, while younger male patients have better prognosis due to higher percentage of early gastric cancer when diagnosed. Pathologic staging and operative curability are the independent predictive factors of survival for younger patients.
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- 2008
16. [Lymphadenectomy adjacent to inferior mesenteric artery root during radical operation and prognosis in rectal cancer]
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Peng, Deng, Dong-Qiu, Dai, Jun-Qing, Chen, Hui-Mian, Xu, Shu-Bao, Wang, and Ji-Xian, Shan
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Adult ,Aged, 80 and over ,Male ,Rectal Neoplasms ,Mesenteric Artery, Inferior ,Middle Aged ,Prognosis ,Survival Rate ,Treatment Outcome ,Lymphatic Metastasis ,Humans ,Lymph Node Excision ,Female ,Lymph Nodes ,Aged - Abstract
To investigate the effect of lymphadenectomy adjacent to inferior mesenteric artery root on the prognosis of rectal cancer.Clinicopathological data of 260 cases with rectal cancer undergone radical operation were analyzed retrospectively. The patients were divided into two groups. Group D(2): the lymph nodes adjacent to mesenteric artery root were not excised (n=188). Group D(3): the lymph nodes adjacent to mesenteric artery root were excised (n=72). Prognosis of two groups was compared during the follow-up period.In group D(2), the 1-, 3-, 5-year total survival rates (TS) were 97.3%, 87.2% and 77.1%, and tumor-free survival rates (TFS) were 93.1%, 83.0% and 76.8% respectively. In group D(3 ), the 1-, 3-, 5-year total survival rates (TS) were 94.4%, 79.2% and 73.6%, and tumor-free survival rates (TFS) were 86.1%, 76.4% and 71.0% respectively. The differences of TS and TFS between two groups were not significant according to Kaplan-Meier analysis (P0.05). Multivariate analysis revealed that the excision of lymph nodes adjacent to mesenteric artery root was not statistically correlated with the recurrence, metastasis and survival time after radical operation of rectal cancer.Excision of lymph nodes adjacent to inferior mesenteric artery root has no significant impact on prognosis and it is unnecessary in the radical operation of rectal cancer.
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- 2008
17. [Relationship between metastatic rate and amount of lymph nodes and prognosis of gastric cancer]
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Kai, Li, Hui-mian, Xu, and Jun-qing, Chen
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Adult ,Aged, 80 and over ,Male ,Middle Aged ,Prognosis ,Survival Analysis ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Female ,Neoplasm Invasiveness ,Lymph Nodes ,Aged ,Retrospective Studies - Abstract
to investigate the relationship between metastatic rate and amount of lymph nodes and prognosis of gastric cancer.The clinical data of 672 patients of gastric cancer with 22.7 regional metastatic lymph nodes on average were analyzed retrospectively. The patients were divided into 3 groups according to the TNM staging system (1997, 5th edition): pN0 (without metastatic lymph node), pN1 group (with 1-6 metastatic lymph nodes), pN2 group (with 7-15 metastatic lymph nodes), and pN3 group (with more than 215 metastatic lymph nodes), or into 4 groups according to the lymph node metastasis rate: rN0 group (without metastasis of lymph node), rN1 group (with a lymph node metastasis rate 010%), rN2 group (with a lymph node metastasis rate of 10%-30%), and rN3 group with a lymph node metastasis rate30%). The 5-year survival rates of different groups in these 2 classification systems and the relationship between metastatic rate and amount of lymph nodes and prognosis of gastric cancer were analyzed.According to the lymph node metastasis grading system there were 93 patients in the pN0 group, 201 in the pN1 group, 108 in the pN2 group, and 32 in the pN3 group with the 5-year survival rates of 90.3%, 65.2%, 37.0%, and 18.9% respectively (chi(2) = 12.56, P0.01). According to the lymph node metastasis system 93 patients were in the rN0 group, 183 in the rN1 group, 92 in the rN2 group, and 66 in the rN3 group, with the 5-year survival rates of 90.3%, 69.9%, 45.7%, and 10.6% respectively (chi(2) = 14.38, P0.01). If the cases in the same pN group were re-divided according to the lymph node metastasis rate, there were significant differences in the 5-year survival rate among the new rN groups (chi(2) = 5.26, P = 0.21), and there was a great difference in the distribution of prognosis among different groups. However, if the cases in the same group rN group were re-divided according to the amounts of metastatic lymph nodes, there was no significant difference in 5-year survival rate among different new pN groups (chi(2) = 0.14, P = 0.932). Multivariate COX model analysis showed that the influencing factors of the prognosis were rN grading, pN grading, infiltration depth of cancer, gross type, and size of the cancer, arranged according to the degree of closeness (P0.05); lymph nose metastasis rate was closely related with the size, infiltration depth, and gross type of the cancer (P0.05). In the same metastasis rate, the 5-year survivals rate decreased along with the increase of the amount of metastatic lymph nodes, and vice versa (chi(2) = 8.22, P = 0.004; chi(2) = 4.52, P = 0.033).The staging system based on metastatic lymph node rate is more predictable the number of metastatic lymph nodes for the prognosis of gastric cancer.
- Published
- 2005
18. [Evaluation of the correlations of cell proliferation activity with lymphatic and vascular invasion and prognosis in gastric carcinoma]
- Author
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Yun-fei, Wu, Hui-mian, Xu, and Jun-qing, Chen
- Subjects
Adult ,Aged, 80 and over ,Male ,DNA, Neoplasm ,Middle Aged ,Flow Cytometry ,Prognosis ,Bromodeoxyuridine ,Stomach Neoplasms ,Lymphatic Metastasis ,Humans ,Female ,Neoplasm Invasiveness ,Lymph Nodes ,Aged ,Cell Proliferation - Abstract
To evaluate bromodeoxyuridine/DNA (BrdUrd/DNA) double-parametric flow cytometric analysis in detection of gastric carcinoma and to study the correlations of cellular BrdUrd labeling index (LI), G(2)/M phase fraction (G(2)/MPF) and DNA content, with lymphatic and vascular invasion and prognosis.Sixty cases of fresh tumor samples were examined by BrdUrd/DNA double-parametric flow cytometry.BrdUrd LI and G(2)/MPF values were both significantly higher in patients with lymphatic invasion than those without invasion (P0.01). There was statistically significant difference between the 5-year survival rates in cases with and without lymphatic invasion (P0.01). Both BrdUrd LI and G(2)/MPF values were significantly higher in patients with lymph node metastasis than those in cases without metastasis (P0.01). There was a significant difference in 5-year survival rates between patients with and without lymph node metastases. The incidence of lymph node metastasis was significantly higher in aneuploid carcinoma (P0.05), and the patients with aneuploidy had significantly poor prognosis. BrdUrd LI was significantly higher in patients with more than 5 metastatic lymph nodes than those with 1-4 metastatic lymph nodes (P0.05) and no metastasis (P0.01). G(2)/MPF values in cases with more than 5 and 1-4 metastatic lymph nodes were higher than that in cases with no metastasis (P0.01 and P0.05, respectively). There were significant differences in 5-year survival rates among patients with no lymph node metastasis, 1-4 nodes metastasis and more than 5 nodes metastasis. G(2)/MPF values were significantly higher in patients with and without vascular invasion (P0.01).Correlations exist among cellular BrdUrd LI, G(2)/MPF, DNA content and lymphatic involvement, vascular invasions and prognosis in gastric carcinoma.
- Published
- 2005
19. The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature.
- Author
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Yu-ying Lei, Jin-yu Huang, Qiong-rui Zhao, Nan Jiang, Hui-mian Xu, Zhen-ning Wang, Hai-qing Li, Shi-bo Zhang, and Zhe Sun
- Subjects
STOMACH cancer patients ,STOMACH cancer treatment ,HER2 gene ,GENE expression ,TRASTUZUMAB ,THERAPEUTICS - Abstract
Background: Human epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric cancer patients remains unclear. Our aim was to clarify this issue. Methods: Embase, PubMed, and the Cochrane Library were searched for relevant articles published up to May 2016. Outcomes of interest contained sex, age, tumor size, tumor site, tumor node metastasis (TNM) stage, distant metastasis, lymph node metastasis, Lauren's classification, differentiation grade, lymphovascular invasion, neural invasion, and multivariate analysis data for overall survival. Results: A total of 41 studies of 17,494 gastric cancer patients were identified with HER2 test. HER2 positive rate was 19. 07% (95% CI = 9.16, 28.98). There existed statistical significance between HER2 overexpression and patients' prognosis (RR = 1.47, 95% CI = 1.09, 1.98). Male patients (OR = 1.48, 95% CI = 1.34, 1.65), proximal tumors (OR = 1.25, 95% CI = 1.07, 1.47), intestinal-type tumors (OR = 3.37, 95% CI = 2.54, 4.47), advanced stage cancers (OR = 1.35, 95% CI = 1.10, 1.66), lymph node metastasis (OR = 1.26, 95% CI = 1.14, 1.41), well-differentiated cancers (OR = 1.79, 95% CI = 1.15, 2.76), and distant metastasis (OR = 1.91, 95% CI = 1.08, 3.38) were correlated with higher HER2 expression rates. However, no statistical differences existed in age, tumor size, lymphovascular invasion, or neural invasion. Subgroup analysis revealed that HER2 expression rates reported in articles from Asian (19.52%) countries were quantitatively higher than those from European (16.91%) areas. Results were consistent with those reports that define HER2 status according to trastuzumab for gastric cancer (ToGA) criteria. Conclusion: This study showed that HER2 overexpression was associated with poor prognosis in gastric cancer patients. HER2 positive rates may be associated with sex, tumor site, TNM staging system, distant metastasis, lymph node metastasis, Lauren's classification, and differentiation grade in gastric cancer patients. The HER2 expression rate in Asians may be higher than that in Europeans. This study offers a convenient way for doctors to select patients for relevant HER2 detection and following treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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20. Relations of proliferative activities of gastric carcinoma cells to lymphatic involvement, venous invasion and prognosis
- Author
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Yun-fei, Wu, Hui-mian, Xu, and Jun-qing, Chen
- Subjects
Adult ,Male ,Ploidies ,Cell Cycle ,Middle Aged ,Prognosis ,Survival Rate ,Bromodeoxyuridine ,Stomach Neoplasms ,Lymphatic Metastasis ,Mesothelin ,Humans ,Female ,Neoplasm Invasiveness ,Cell Division ,Aged - Abstract
This study was to evaluate bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometric analysis in detection of gastric carcinoma and to study the relations of cellular BrdUrd labeling indices (LI), G2/M-phase fraction (G2/MPF) and DNA ploidy pattern to lymphatic involvement, venous invasion and prognosis.Fresh tumor samples from 60 patients with gastric carcinoma were analyzed by bivariate BrdUrd/DNA flow cytometry. The results were correlated with lymphatic vessel invasion, lymphatic node metastasis, the number of metastatic lymphatic nodes, and venous invasion. Propidium iodide (PI) was used as a fluorescent probe for total cellular DNA, and a monoclonal antibody against BrdUrd was used as a probe for BrdUrd incorporated into DNA. Fluorescent-labeled goat anti-mouse antibody was used as a second antibody. S-phase fractions were measured by in vitro BrdUrd labeling, and DNA ploidy and G2/MPF were also measured. Comparison of survival was performed with the log-rank test, the Chi-square test for qualitative data, and Student's t test for quantu data.BrdUrd LI and G2/MPF values were significantly higher in tumors with lymphatic vessel invasion than in those without invasion respectively (P0.01); the patients who had tumors with lymphatic vessel invasion showed a significantly poor prognosis (P0.01). Both BrdUrd LI and G2/MPF values were significantly higher in tumors with lymphatic node metastasis than in those without metastasis (P0.01). A statistical significant difference was noted in the 5-year survival rates between the patients with lymph node metastasis and those without metastasis. Compared with diploid carcinoma, the incidence of lymph node metastasis was significantly higher in aneuploid carcinoma (P0.05), and the patients with aneuploid carcinoma showed a significantly poor prognosis (P0.05). BrdUrd LI was significantly higher in patients with more than 5 metastatic lymph nodes than those with 1 - 4 metastatic lymph nodes (P0.05) and those without metastasis (P0.01). G2/MPF values in those patients either with more than 5 metastatic lymph nodes or 1 - 4 metastatic lymph nodes were higher than those without metastasis (P0.01 and P0.05). A statistical significance was seen in the 5-year survival rates among the patients with no metastatic lymph node, 1 - 4 metastatic nodes and more than 5 metastatic nodes (P0.01). G2/MPF values were significantly higher in patients with venous invasion than in those without invasion (P0.01).Positive correlations exist between cellular BrdUrd LI, G2/MPF with lymphatic involvement and prognosis, and DNA aneuploid with lymphatic involvement and prognosis. The same was true between G2/MPF value and venous invasion in gastric carcinoma.
- Published
- 2004
21. Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveilla006Ece, epidemiology, and end results (SEER) database.
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Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jing-xu Sun, Miao Yu, and Hui-mian Xu
- Subjects
PROGNOSIS ,COLON cancer ,EPIDEMIOLOGY ,STANDARD deviations - Abstract
Background: Whether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colorectal cancer with the 6th edition of the AJCC TNM staging system (AJCC-6). Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) dataset consisting of 158,483 records was used in this study. We evaluated the predictive capacity of the two editions of the staging system using Harrell's C index and Bayesian Information Criterion (BIC). Results: There was a significant prognostic difference between patients at stage IIB and IIC (P < 0.001). Stage III patients with similar prognoses were adequately sub-grouped in the same stage according to AJCC-7. The Harrell's C index revealed a value of 0.7692 for AJCC-7, which was significantly better than 0.7663 for AJCC-6 (P < 0.001). BIC analysis provided consistent results (P < 0.001). Conclusions: This study demonstrates that AJCC-7 is superior to the AJCC-6 staging system in predictive ca [ABSTRACT FROM AUTHOR]
- Published
- 2013
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22. The Association between Individual SNPs or Haplotypes of Matrix Metalloproteinase 1 and Gastric Cancer Susceptibility, Progression and Prognosis.
- Author
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Yong-Xi Song, Xin Zhou, Zhen-Ning Wang, Peng Gao, Ai-Lin Li, Ji-Wang Liang, Jin-Liang Zhu, Ying-Ying Xu, and Hui-Mian Xu
- Subjects
STOMACH cancer ,HAPLOTYPES ,GENOTYPE-environment interaction ,CANCER invasiveness ,GENETIC polymorphisms ,MATRIX metalloproteinases ,PROGNOSIS - Abstract
Background: The single nucleotide polymorphisms (SNPs) in matrix metalloproteinase 1(MMP-1)play important roles in some cancers. This study examined the associations between individual SNPs or haplotypes in MMP-1 and susceptibility, clinicopathological parameters and prognosis of gastric cancer in a large sample of the Han population in northern China. Methods: In this case-controlled study, there were 404 patients with gastric cancer and 404 healthy controls. Seven SNPs were genotyped using the MALDI-TOF MS system. Then, SPSS software, Haploview 4.2 software, Haplo.states software and THEsias software were used to estimate the association between individual SNPs or haplotypes of MMP-1 and gastric cancer susceptibility, progression and prognosis. Results: Among seven SNPs, there were no individual SNPs correlated to gastric cancer risk. Moreover, only the rs470206 genotype had a correlation with histologic grades, and the patients with GA/AA had well cell differentiation compared to the patients with genotype GG (OR = 0.573; 95%CI: 0.353-0.929; P = 0.023). Then, we constructed a four-marker haplotype block that contained 4 common haplotypes: TCCG, GCCG, TTCG and TTTA. However, all four common haplotypes had no correlation with gastric cancer risk and we did not find any relationship between these haplotypes and clinicopathological parameters in gastric cancer. Furthermore, neither individual SNPs nor haplotypes had an association with the survival of patients with gastric cancer. Conclusions: This study evaluated polymorphisms of the MMP-1 gene in gastric cancer with a MALDI-TOF MS method in a large northern Chinese case-controlled cohort. Our results indicated that these seven SNPs of MMP-1 might not be useful as significant markers to predict gastric cancer susceptibility, progression or prognosis, at least in the Han population in northern China. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
23. Integrated Ratio of Metastatic to Examined Lymph Nodes and Number of Metastatic Lymph Nodes into the AJCC Staging System for Colon Cancer.
- Author
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Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jin-liang Zhu, Qing-chao Tang, and Hui-mian Xu
- Subjects
COLON cancer patients ,LYMPH nodes ,PROGNOSIS ,COLON cancer treatment - Abstract
Objective: At present, only the number of metastatic lymph nodes (LNs+) is used for the pN category of AJCC TNM system for colon cancer. Recently, the ratio of metastatic to examined lymph nodes (LNR) has been reported to represent powerful independent predictive capacity in colon cancer. We sought to propose a novel category (nLN) which intergrades LNR and LNs+ into the AJCC staging system for colon cancer. Design: 34476 patients from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) dataset with stage III colon cancer were reviewed. Harrell's C statistic was used to evaluate the predictive capacity. The Cox proportional hazards model was used to construct a novel category. Results: The LNR category had more predictive capacity than the pN category in whole groups of patients (Harrell's C index: 0.6194 vs 0.6113, p = 0.003). Subgroup analysis showed that the LNR category was not better than pN category in predictive capacity if the number of lymph nodes examined was more than 13. We also found that there was significant survival heterogeneity among different pN categories at the same LNR category (P<0.001). The Harrell's C index for our nLN category which intergrades LNR and LNs+ was 0.6228, which was significant higher than that of the pN category (Harrell's C index: 0.6113, P<0.001) or LNR category (Harrell's C index: 0.6194, P = 0.005), respectively. Conclusion: To evaluate the prognosis of colon cancer, our nLN category which intergrades LNR with LNs+ is more accurate than the pN category or LNR category, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
24. Clinicopathological analysis and prognostic significance of peritoneal cytology in Chinese patients with advanced gastric cancer.
- Author
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Cheng-Gang Jiang, Yan Xu, Zhen-Ning Wang, Zhe Sun, Fu-Nan Liu, Miao Yu, and Hui-Mian Xu
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STOMACH cancer patients ,CYTOLOGY ,DISEASE risk factors ,TUMOR growth ,MULTIVARIATE analysis ,CHINESE people - Abstract
Background: The influence of peritoneal cytology on survival of patients with gastric cancer has not been consistent. This study was to identify risk factors for positive peritoneal cytology and to evaluate the predictive value of positive cytology among Chinese patients with advanced gastric cancer. Methods: The study included 139 patients with gastric cancer macroscopically invading the serosa, who underwent gastrectomy and intra-operative peritoneal cytological examination. In these patients, the relationship between cytological positivity and various clinicopathological features was analysed, and survival analysis was performed to identify independent prognostic factors of significance. Results: Thirty-eight (27.3%) of 139 patients had positive peritoneal cytology. Although tumour size, lymphovascular invasion, depth of tumour invasion, lymph node metastasis and peritoneal metastasis were correlated with positive cytology, multivariate analysis revealed the depth of tumour invasion and peritoneal metastasis as the independent features affecting the cytology. Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and a significant inferior prognosis. Multivariate analysis indicated that positive peritoneal cytology was an independent prognostic factor among the curatively resected patients with advanced gastric cancer and was the prognostic factor most predictive of death for these patients (risk ratio = 2.74). Conclusions: Positive peritoneal cytology correlated with advanced features of gastric cancer. It is an independent poor prognostic factor, and it may serve as a guide for adjuvant therapeutic options to improve the survival of gastric cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
25. Log Odds of Positive Lymph Nodes.
- Author
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Zhe Sun, Yan Xu, De Hing Li, Zhen Ning Wang, Guo Man Zhu, Bao Jun Huang, Kai Li, and Hui Mian Xu
- Subjects
LYMPH nodes ,CANCER patients ,PROBABILITY theory ,MULTIVARIATE analysis ,CLASSIFICATION - Abstract
The article offers information on the log odds of positive lymph nodes (LODDS), which is the log of the ratio between the probability of being a positive lymph nodes and the probability of being a negative lymph nodes when one lymph node is retrieved. LODDS stage was identified by multivariate analysis as an independent prognostic factor, but not the number-based pN classification or ratio-based (rN) system. A conclusion on the reliability of the LODDS system is presented.
- Published
- 2010
- Full Text
- View/download PDF
26. Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer.
- Author
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Jin-yu Huang, Ying-ying Xu, Zhe Sun, Zhen-ning Wang, Zhi Zhu, Yong-xi Song, Yang Luo, Xue Zhang, and Hui-mian Xu
- Subjects
- *
CELL adhesion molecules , *STOMACH cancer , *STOMACH cancer patients , *DISEASE progression , *IMMUNOHISTOCHEMISTRY , *CELL migration , *PROGNOSIS - Abstract
BACKGROUND: The aberrant expression of junctional adhesion molecule A (JAM-A), which has a close correlation with the development, progression, metastasis, and prognosis of cancer, has been frequently reported. However, neither JAM-A expression nor its correlation with clinicopathologic variables and patient survival has been defined in gastric cancers. Moreover, little is known about the role of JAM-A in gastric cancer progression. We carried out the present study to investigate the prognostic value of JAM-A expression in gastric cancer patients. Furthermore, the biological roles of JAM-A in gastric cancer progression were also investigated. METHODS: We determined JAM-A expression in 167 primary gastric cancer tissues and 94 matched adjacent non-tumor tissues by immunohistochemistry. Transwell migration assays and matrigel invasion assays were used to explore the role of JAM-A in gastric cancer cells migration and invasion. CCK-8 assays were used to examine the effect of JAM-A on the proliferation of gastric cancer cells. RESULTS: JAM-A was downregulated in gastric cancer tissues. Low JAM-A expression was significantly associated with tumor size, lymphatic vessel invasion, lymph node metastasis, and TNM stage. Low JAM-A expression was also significantly associated with poor disease-specific survival in gastric cancer patients. Multivariate analysis demonstrated low JAM-A expression as an independent factor predicting poor survival. In addition, JAM-A had the effect on inhibition of gastric cancer cells migration and invasion. However, JAM-A had no significant effects on proliferation of gastric cancer cells. CONCLUSIONS: Low JAM-A expression correlates with poor clinical outcome and promotes cell migration and invasion in gastric cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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27. Comparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan.
- Author
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Miao Yu, Hua-chuan Zheng, Pu Xia, Hiroshi Takahashi, Shinji Masuda, Yasuo Takano, and Hui-mian Xu
- Subjects
- *
STOMACH cancer , *CANCER prognosis , *LUNG cancer , *CANCER patients - Abstract
Background & objective: Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths after lung carcinoma. The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan. Methods: Paraffin-fixed tissue samples of gastric cancer were collected retrospectively from two hospitals between 1993 to 2006 in Japan (n=2063) and during 1980-2003 in China (n=2496) respectively, and staging was done by TNM system and typing by Japanese Endoscopy Society. criteria or Borrmann's classification. The histological architecture of the tumours was expressed according to Lauren's classification. Results: Compared to Japan, the occurrence of gastric cancer was more common in younger Chinese population and prone to invasion and metastasis in muscularis propia, lymphatic, lymph node, fiver, peritoneal parts, and exhibited large tumour size and high TNM staging in both the sexes and in different age groups (P<0.05). Intestinal and mixed types of carcinomas were more frequently observed in Japanese patients compared to Chinese and the difference was significant (P<0.05). It was observed that the commonly reported types in early gastric cancers (EGC) in Japanese patients were IIc, IIa+IIc or Ila while those of Chinese patients were IIc, III or IIb. In the case of advanced gastric cancers (AGC), type II and III were most common in both the countries. The cumulative survival rate of Chinese patients was significantly (P<0.05) higher compared to Japanese in different stratified groups via depth of invasion, TNM staging or Lauren's classification. Interpretation & conclusion: Gastric cancers in Chinese patients had more aggressive pathological characteristics and poorer prognosis than those from Japan. To reduce incidence and to improve treatment facilities, it is necessary to have a systematic screening system. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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