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8 results on '"Hao, Rui"'

7. Dynamic changes in circulating EBV-DNA load during treatment have prognostic values in EBV+ DLBCL-NOS: a Chinese cohort study.

Author

Xing, Tong-Yao, Duan, Zi-Wen, Wang, Wei-Ting, Du, Kai-Xin, Shen, Hao-Rui, Yin, Hua, Wu, Jia-Zhu, Li, Yue, Wang, Li, Li, Jian-Yong, Liang, Jin-Hua, and Xu, Wei

Subjects
CIRCULATING tumor DNA, PROGNOSIS, DIFFUSE large B-cell lymphomas, EPSTEIN-Barr virus diseases, PROGRESSION-free survival, COHORT analysis
Abstract

EBV-positive diffuse large B-cell lymphoma, not otherwise specified (EBV+ DLBCL-NOS), is an EBV-positive clonal B-cell lymphoid proliferation and circulating EBV-DNA is a great indicator for prognosis among EBV associated disease. In this retrospective study, we report 66 EBV+ DLBCL cases among 2137 DLBCL-NOS cases diagnosed from 2013 to 2021 (prevalence of 6.0%). After a median follow-up of 27 months, progression-free survival (PFS) and overall survival (OS) at 2 years were 39.5% ± 6.2% and 53.6% ± 6.4%, respectively. Multivariate analysis showed that only the biomarker of the positivity of post treatment EBV-DNA had a borderline correlation with shorter PFS and OS (PFS: P = 0.053; OS: P = 0.065). Patients were divided into three subgroups according to dynamic changes of EBV-DNA status: EBV-DNA persistently negative group, EBV-DNA persistently positive group, and EBV-DNA transformed from positive to negative group; among the three groups, patients of the persistently positive group had worst PFS and OS (P = 0.0527 and P = 0.0139, respectively). Decline in EBV copies correlated significantly with treatment response as well. In conclusion, circulating EBV-DNA level played a vital role in prognostic and monitoring marker for EBV+ DLBCL-NOS. [ABSTRACT FROM AUTHOR]

Published
2023
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8. [Clinical role of Morphology in Diagnosing Bone Marrow Involvement of Diffuse Large B Bell Lymphoma]

Author

Xian-Yong, Jiang, Hao-Rui, Shen, Chang-Wen, Ge, Jian, Li, and Dao-Bin, Zhou

Subjects
Bone Marrow, Biopsy, Prohibitins, Humans, Bone Marrow Cells, Lymphocytes, Lymphoma, Large B-Cell, Diffuse, Prognosis
Abstract

To determine the significance of morphology of bone marrow smear for diagnosis of bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL), and to study the morphological characteristics of DLBCL cells involved in bone marrow.Four hundred and twenty cases of DLBCL diagnosed at Peking Union Hospital from 2006 to 2016 were analyzed and identified.Blinded analysis of bone marrow smear and bone marrow biopsy data showed involvement in 42 cases on smears (S), in 47cases by biopsy (B) and the in 49 cases by (S+B). There was an excellent correlation between 2 methods diagnosing the bone marrow infiltration of DLBCL independently (κ=0.889). The morphological features of DLBCL cells involved in bone marrow were of medium sizes, round or irregular nuclear. The chromatin presented dark purple rea and coarse granular, and most of them had 1-5 nucleoli. The amount of cytoplasm was moderate with the color of dark blue or greyish blue. Vacuoles and pseudopodia were common.The morphological examination of bone marrow cells has a certain role in the diagnosing bone marrow involvement in patients with DLBCL, and the atypical lymphoid cells making up ≥1% of the total nucleated cells highly suggests the bone marrow involvement in the patients with DLBCL.形态学在弥漫性大B细胞淋巴瘤骨髓侵犯诊断中的作用.确定骨髓涂片形态对弥漫性大B细胞淋巴瘤（DLBCL）骨髓侵犯诊断的作用，并研究骨髓中DLBCL细胞的形态学特征.分析北京协和医院于2006年～2016年间确诊的420例DLBCL。应用盲法分析骨髓涂片和骨髓穿刺活检的结果.骨髓涂片（S）发现42例，骨髓活检（B）发现47例，两者共计（S+B）发现49例骨髓侵犯，2种诊断DLBCL骨髓浸润的方法之间有良好相关性（κ=0.889）。骨髓中DLBCL细胞的形态特征为中等大小、圆形或不规则的细胞核；染色质呈深紫红色和粗颗粒状，多数为1-5个核仁；胞浆量适中，呈深蓝色或灰蓝色，常见空泡和伪足.骨髓细胞形态学检查在诊断DLBCL骨髓侵犯方面有一定的作用，不典型淋巴细胞占总有核细胞数1%以上时应高度重视并建议诊断为DLBCL的骨髓侵犯.

Published
2019

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