13 results on '"Funahashi, Kimihiko"'
Search Results
2. Prognostic impact of CEA/CA19-9 at the time of recurrence in patients with gastric cancer
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Moriyama, Jin, Oshima, Yoko, Nanami, Tatsuki, Suzuki, Takashi, Yajima, Satoshi, Shiratori, Fumiaki, Funahashi, Kimihiko, and Shimada, Hideaki
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- 2021
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3. Serum p53 antibody: useful for detecting gastric cancer but not for predicting prognosis after surgery
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Oshima, Yoko, Suzuki, Takashi, Yajima, Satoshi, Nanami, Tatsuki, Shiratori, Fumiaki, Funahashi, Kimihiko, and Shimada, Hideaki
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- 2020
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4. The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis
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Kido, Hidenori, Kato, Shunsuke, Funahashi, Kimihiko, Shibuya, Kazutoshi, Sasaki, Yousuke, Urita, Yoshihisa, Hori, Masaaki, and Mizumura, Sunao
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- 2021
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5. Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma
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Suzuki, Takashi, Yajima, Satoshi, Ishioka, Nobuki, Nanami, Tatsuki, Oshima, Yoko, Washizawa, Naohiro, Funahashi, Kimihiko, Otsuka, Seiko, Nemoto, Tetsuo, and Shimada, Hideaki
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- 2018
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6. The Prognostic Impact of High Soluble Programmed Death Ligand 1 Levels in Patients with Hepato-Biliary-Pancreatic Cancer
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Okada, Rei, Otsuka, Yuichiro, Tsuchiya, Masaru, Maeda, Tetsuya, Ishii, Jun, Matsumoto, Yu, Ito, Yuko, Funahashi, Kimihiko, and Shimada, Hideaki
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programmed death-ligand 1 ,hepato-biliary-pancreatic cancer ,prognosis - Abstract
Original Article, Introduction: Several reports revealed that the high soluble programmed death-ligand 1(sPD-L1) level was a risk factor for poor prognosis in various tumors. To date, the clinicopathologic and prognostic impact of the sPD-L1 level in patients with hepatobiliary-pancreatic cancer have not been determined. Methods: A total of 119 patients (66 patients with hepatocellular carcinoma, 23 patients with cholangiocarcinoma, and 30 patients with pancreatic cancer) who were treated at the Toho University Omori Hospital (Tokyo, Japan) from 2008 to 2016 were retrospectively analyzed. The sPD-L1 levels were measured using an enzyme-linked immunosorbent assay for PD-L1 to evaluate the clinicopathologic and prognostic impact. Results: The sPD-L1 levels were significantly higher in the low-albumin group than in the normal-albumin group. According to the stages in hepatocellular carcinoma and cholangiocarcinoma, no significant differences were observed in the sPD-L1 levels, which gradually increased according to the stage in pancreatic cancer. Using a cut-off value of 81.6 pg/mL for the sPD-L1 level, the high sPD-L1 group showed a significantly worse prognosis compared with the low-sPD-L1 group in patients with pancreatic cancer. Multivariate analysis identified sPD-L1 level ≧ 81.6 mg/dL (p = 0.047) as an independent predictor of poor overall survival in patients with pancreatic cancer. Conclusions: Using a cut-off value of 81.6 pg/mL for the sPD-L1 level, high sPD-L1 levels were independently associated with poor prognosis in patients with pancreatic cancer. However, this association in hepatocellular carcinoma or cholangiocarcinoma was not clear.
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- 2021
7. Prognostic Impact of Plasma Fibrinogen Changing in Patients with Resectable Pancreatic Cancer
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Okada, Rei, Otsuka, Yuichiro, Tsuchiya, Masaru, Ito, Yuko, Matsumoto, Yu, Maeda, Tetsuya, Ishii, Jun, Kubota, Yoshihisa, Funahashi, Kimihiko, and Shimada, Hideaki
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pancreatic cancer ,hyperfibrinogenemia ,prognosis - Abstract
Original Article, Introduction: Previous studies have indicated that hyperfibrinogenemia is a predictor of poor prognosis in various tumors. However, little information is available on the prognostic impact of preoperative hyperfibrinogenemia and its changing pattern in resectable pancreatic ductal adenocarcinoma (PDAC) patients. Methods: This retrospective study examined 102 PDAC patients who underwent curative surgery at Omori Medical Center, Toho University School of Medicine (Tokyo, Japan) between 2004 and 2016. Among these, 44 (43.1%) reported preoperative hyperfibrinogenemia. Results: Preoperative hyperfibrinogenemia was associated with an independent prognostic factor for patient survival. The cumulative 5-year overall survival time rate in the normal fibrinogen and hyperfibrinogen groups was 44.8% and 31.2%, respectively, with a significant difference between the two groups (P = 0.047). The prognostic factors in PDAC patients revealed preoperative hyperfibrinogenemia of 〓400 mg/dL (P = 0.017). The cumulative 5-year overall survival rates were 57.3% and 9.1% in the normalization and non-normalization groups, respectively, with a significant difference between the two groups (P = 0.008). In multivariate analysis, the prognostic factors in patients with preoperative hyperfibrinogenemia revealed a postoperative fibrinogen level of 〓400 mg/dL (P = 0.001). Conclusions: Preoperative hyperfibrinogenemia was the risk factor for reducing overall survival in PDAC patients. Among the patients with hyperfibrinogenemia, the non-normalization group after surgery revealed to be a high-risk group for poor prognosis.
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- 2019
8. Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis
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Kobayashi, Hirotoshi, Kotake, Kenjiro, Funahashi, Kimihiko, Hase, Kazuo, Hirata, Koichi, Iiai, Tsuneo, Kameoka, Shingo, Kanemitsu, Yukihide, Maeda, Koutarou, Murata, Akihiko, Ohue, Masayuki, Shirouzu, Kazuo, Takahashi, Keiichi, Watanabe, Toshiaki, Yano, Hideaki, Yatsuoka, Toshimasa, Hashiguchi, Yojiro, Sugihara, Kenichi, and Study Group for Peritoneal Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum
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- 2014
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9. Low serum creatine kinase level is associated with poor prognosis in patients with hepatocellular carcinoma: A retrospective single‑center study.
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Matsumoto, Yu, Otsuka, Yuichiro, Okada, Rei, Ito, Yuko, Kimura, Kazutaka, Ishii, Jun, Maeda, Tetsuya, Tsuchiya, Masaru, Funahashi, Kimihiko, and Shimada, Hideaki
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RECEIVER operating characteristic curves ,CANCER prognosis ,CREATINE kinase ,PATIENTS ,OVERALL survival - Abstract
Previous studies have reported low serum creatine kinase (s-CK) levels as a poor prognostic factor in various cancers. However, there have been no reports on its significance in hepatocellular carcinoma. The present study aimed to evaluate the association of the preoperative s-CK levels with clinicopathologic features and their prognostic impact on survival in patients with hepatocellular carcinoma. This retrospective study included 163 patients with hepatocellular carcinoma (127 male and 36 female patients; median age, 69 years) who underwent radical liver resection between January 2004 and December 2021. A cutoff preoperative s-CK level of 91 U/l determined by receiver operating characteristic curve analysis was used to evaluate the significance of s-CK in predicting overall and recurrence-free survival. In addition, the prognostic impact of s-CK was evaluated using univariate and multivariate analysis. s-CK level was not associated with clinicopathologic factors. Overall survival and recurrence-free survival of the low s-CK group were significantly worse compared with the high s-CK group (P=0.043 and P=0.029, respectively). By multivariate analysis, low s-CK was an independent risk factor for poor overall survival and recurrence-free survival (P=0.019 and P=0.014, respectively). This trend was the same for male patients, but no significant difference was observed for female patients. Low preoperative s-CK level might be a poor prognostic biomarker in patients with hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Prognostic and diagnostic effects of high serum midkine levels in patients with hepatocellular carcinoma.
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Okada, Rei, Otsuka, Yuichiro, Kajiwara, Yoji, Maeda, Tetsuya, Ishii, Jun, Kimura, Kazutaka, Matsumoto, Yu, Ito, Yuko, Funahashi, Kimihiko, and Shimada, Hideaki
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RECEIVER operating characteristic curves ,OVERALL survival ,VITAMIN K ,PROGNOSIS ,HEPATOCELLULAR carcinoma - Abstract
Midkine (MK) is a soluble cytokine, and its serum levels strongly correspond to protein expression levels in tumors. The present study aimed to clarify the clinicopathological and prognostic significance of serum MK (s-MK) in patients with hepatocellular carcinoma (HCC). Serum samples were obtained before surgery from 123 patients with HCC who had undergone surgery between January 2012 and December 2020. The receiver operating characteristic curve revealed that the best cut-off value for s-MK in differentiating HCC from healthy cases was 426 pg/ml. The clinicopathological variables and overall survival of patients were compared between the s-MK-positive group and s-MK-negative group. The sensitivity, specificity and accuracy of s-MK were 82.1, 97.4 and 88.0%, respectively. An s-MK-positive status was significantly associated with the number of tumors (≥2). The positivity rate of s-MK was significantly higher compared with that of α-fetoprotein and protein-induced by vitamin K absence-II. In total, only 28% of the patients were positive for s-MK. The s-MK-positive group showed significantly worse overall survival compared with the s-MK-negative group. Moreover, multivariate analysis revealed that an s-MK-positive status was independently associated with poor prognosis. s-MK was useful in detecting early HCC. The findings of this study indicated that the s-MK-positive status is associated with the number of tumors and can act as an independent prognostic risk factor. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Association of Serum Anti-PCSK9 Antibody Levels with Favorable Postoperative Prognosis in Esophageal Cancer.
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Ito, Masaaki, Hiwasa, Takaki, Oshima, Yoko, Yajima, Satoshi, Suzuki, Takashi, Nanami, Tatsuki, Sumazaki, Makoto, Shiratori, Fumiaki, Funahashi, Kimihiko, Li, Shu-Yang, Iwadate, Yasuo, Yamagata, Hiroki, Jambaljav, Byambasteren, Takemoto, Minoru, Yokote, Koutaro, Takizawa, Hirotaka, and Shimada, Hideaki
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ESOPHAGEAL cancer ,WESTERN immunoblotting ,PROGNOSIS ,ONCOLOGIC surgery ,OVERALL survival ,CANCER prognosis ,COLORECTAL cancer - Abstract
Background: Esophageal cancer often appears as postoperative metastasis or recurrence after radical surgery. Although we had previously reported that serum programmed cell death ligand 1 (PD-L1) level correlated with the prognosis of esophageal cancer, further novel biomarkers are required for more precise prediction of the prognosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with the cholesterol metabolism. But there was no report of relationship between serum PCSK9 antibody and cancer. Therefore, we investigated whether anti-PCSK9 antibodies could be a novel biomarker for solid cancer. Methods: Serum levels of anti-PCSK9 antibodies and antigens in patients with solid cancer were analyzed using amplified luminescence proximity homogeneous assay-linked immunosorbent assay (AlphaLISA). The reactivity of serum antibodies against recombinant PCSK9 protein was investigated by Western blotting, and the expression of PCSK9 antigens in esophageal cancer tissues was examined by immunohistochemical staining. Results: AlphaLISA showed that serum anti-PCSK9 antibody (s-PCSK9-Ab) levels were significantly higher in patients with esophageal cancer, gastric cancer, colorectal cancer, lung cancer, and breast cancer than in healthy donors, and patients with esophageal cancer had the highest levels. The presence of serum antibody in patients was confirmed by Western blotting. There was no apparent correlation between s-PCSK9-Ab and PCSK9 antigen levels. Immunohistochemical staining demonstrated the expression of PCSK9 antigen in both the cytoplasm and nuclear compartments of esophageal squamous cell carcinoma tissue but not in normal tissue. Compared with patients with low s-PCSK9-Ab levels, those with high s-PCSK9-Ab levels had a favorable postoperative prognosis after radical surgery for esophageal cancer. In the multivariate analysis, tumor depth and s-PCSK9-Ab level were identified as independent prognostic factors. In the univariate analysis of clinicopathological features, high PCSK9 antibody levels were not associated with sex, age, location, tumor depth, lymph node status, squamous cell carcinoma antigen, or p53-Ab, whereas they correlated significantly with PD-L1 levels, which were associated with unfavorable prognosis. Correlation between s-PCSK9-Ab and PD-L1 levels was also confirmed in the logistic regression analysis; therefore, low s-PCSK9-Ab levels could discriminate another poor prognosis group other than high-PD-L1 group. Conclusions: Patients with solid cancer had higher s-PCSK9-Ab levels than healthy donors. High s-PCSK9-Ab levels indicated better prognosis for overall survival after surgery in patients with esophageal cancer. [ABSTRACT FROM AUTHOR]
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- 2021
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12. What is the advantage of rectal amputation with an initial perineal approach for primary anorectal carcinoma?
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Funahashi, Kimihiko, Goto, Mayu, Kaneko, Tomoaki, Ushigome, Mitsunori, Kagami, Satoru, Koda, Takamaru, Nagashima, Yasuo, Yoshida, Kimihiko, and Miura, Yasuyuki
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ABDOMINOPERINEAL resection ,AMPUTATION ,SURGICAL complications ,CARCINOMA ,OPERATIVE surgery ,INJURY complications ,PERINEUM surgery ,RESEARCH ,RECTUM tumors ,RESEARCH methodology ,CANCER relapse ,RETROSPECTIVE studies ,PROGNOSIS ,EVALUATION research ,MEDICAL cooperation ,ANAL tumors ,COMPARATIVE studies - Abstract
Background: Rectal amputation (RA) remains an important surgical procedure for salvage despite advances in sphincter-preserving resection, including intersphincteric resection. The aim of this study was to compare short- and long-term outcomes of RA with an initial perineal approach to those of RA with an initial abdominal approach (conventional abdominoperineal resection (APR)) for primary anorectal cancer.Methods: We retrospectively analyzed the short- and long-term outcomes of 48 patients who underwent RA with an initial perineal approach (perineal group) and 21 patients who underwent RA with an initial abdominal approach (conventional group).Results: For the perineal group, the operation time was shorter than that for the conventional group (313 vs. 388 min, p = 0.027). The postoperative complication rate was similar between the two groups (43.8 vs. 47.6%, p = 0.766). Perineal wound complications (PWCs) were significantly fewer in the perineal group than in the conventional group (22.9 vs. 57.1%, p = 0.006). All 69 patients underwent complete TME, but positive CRM was significantly higher in the conventional group than in the perineal group (0 vs. 19.0%, p = 0.011). There were no significant differences in the recurrence (43.8 vs. 47.6%, p = 0.689), 5-year disease-free survival (63.7% vs. 56.7%, p = 0.665) and 5-year overall survival rates (82.5% vs. 66.2%, p = 0.323) between the two groups.Conclusion: These data suggest that RA with an initial perineal approach for selective primary anorectal carcinoma is advantageous in minimizing PWCs and positive CRMs. Further investigations on the advantages of this approach are necessary. [ABSTRACT FROM AUTHOR]- Published
- 2020
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13. Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer.
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Yoshida, Kimihiko, Hiwasa, Takaki, Ito, Masaaki, Ushigome, Mitsunori, Takizawa, Hirotaka, Li, Shu-Yang, Zhang, Bo-Shi, Iwadate, Yasuo, Funahashi, Kimihiko, and Shimada, Hideaki
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COLORECTAL cancer ,CARCINOEMBRYONIC antigen ,RECEIVER operating characteristic curves ,IMMUNOGLOBULINS - Abstract
Jumonji domain-containing 6 (JMJD6) protein has been reported to be upregulated in different cancer cells; however, to the best of our knowledge, no report has analyzed serum anti-JMJD6 antibodies (s-JMJD6-Abs) in patients with cancer. Therefore, the present study evaluated the clinical significance of s-JMJD6-Abs in patients with colorectal cancer. Preoperative serum samples were analyzed from 167 patients with colorectal cancer who underwent radical surgery between April 2007 and May 2012. The pathological stages were as follows Stage I (n=47), stage II (n=56), stage III (n=49) and stage IV (n=15). In addition, 96 healthy participants were analyzed as controls. s-JMJD6-Abs were analyzed by amplified luminescent proximity homology assay-linked immunosorbent assay. The cutoff value of s-JMJD6-Abs for detecting colorectal cancer was calculated to be 5,720 using the receiver operating characteristic curve. The positive rate of s-JMJD6-Abs was 37% in patients with colorectal cancer (61 of 167), independent of carcinoembryonic antigen or carbohydrate antigen 19-9 and p53-Abs. Clinicopathological factors and prognosis were compared between the s-JMJD6-Abs-positive group and the s-JMJD6-Abs-negative group. The s-JMJD6-Ab-positive status was significantly associated with older age (P=0.03), but was not associated with other clinicopathological variables. Regarding recurrence-free survival, the s-JMJD6-positive status was a significant poor prognostic factor in both univariate (P=0.02) and multivariate (P<0.01) analyses. Similarly, regarding overall survival, the s-JMJD6-Abs-positive status was a significant poor prognostic factor in both univariate (P=0.03) and multivariate (P=0.01) analyses. In conclusion, preoperative s-JMJD6-Abs was positive in 37% of patients with colorectal cancer and may be considered an independent poor prognostic biomarker. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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