1. Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study.
- Author
-
Ogawa, Chikara, Morita, Masahiro, Omura, akina, Noda, Teruyo, Kubo, atsushi, Matsunaka, Toshihiro, Tamaki, Hiroyuki, Shibatoge, Mitsushige, Tsutsui, akemi, Senoh, Tomonori, Nagano, Takuya, Takaguchi, Kouichi, Tani, Joji, Morishita, asahiro, Yoneyama, Hirohito, Masaki, Tsutomu, Moriya, akio, ando, Masaharu, Deguchi, akihiro, and Kokudo, Yasutaka
- Subjects
HOSPITALS ,CONFIDENCE intervals ,HEPATOCELLULAR carcinoma ,MEDICAL cooperation ,RESEARCH ,SURVIVAL ,TREATMENT effectiveness ,DISEASE progression ,HAND-foot syndrome ,SORAFENIB ,PROGNOSIS ,THERAPEUTICS - Abstract
Objective: To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. Methods: The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general hospitals in Kagawa Prefecture, Japan. Results: At the start of sorafenib therapy, 23.6% of the patients had HCC of a Child-Pugh class other than A. The initial sorafenib dose was 800 mg in 9.2% of the patients and 400 mg in 64.3%. Time to progression was 129 days (95% CI: 87.3-170.7) and the median overall survival (OS) was 392 days (95% CI: 316.0-468.0). The OS of the patients with Child- Pugh class A HCC was significantly better than that of the patients with Child-Pugh class B HCC (p < 0.0001). The survival curves for Child-Pugh class A-5 points and class A-6 points were significantly different, with that for class A-5 points being better (p < 0.0001). A significant difference was observed between the patients who exhibited HFS and those who did not, with the former exhibiting a better survival rate (p < 0.001). In addition, the survival rate of the patients who received post-progression treatment after sorafenib therapy was significantly better than that of the patients who did not (p < 0.001). Conclusion: In sorafenib therapy, patients with HFS and those who received post-progression treatment exhibited good OS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF