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Objective: To study the relationship between the angiomotin (Amot) and Yes-associated protein 1 (YAP1) expression and clinicopathological parameters and prognosis in type I endometrial cancer (EC) tissues. Methods: 75 type I EC patients who were diagnosed and treated in Affiliated Hospital of Xuzhou Medical University from January 2014 to June 2017 were selected as the study object (EC group), 30 patients with pathologically confirmed atypical hyperplasia endometrial tissue specimens diagnosed and treated during the same period were selected as the atypical hyperplasia endometrial group, and 30 patients with pathologically confirmed normal endometrial tissue specimens during the same period were selected as the normal endometrial group. The Amot and YAP1 protein expressions in each group were detected by immunohistochemistry. Spearman rank correlation was used to analyze the correlation between Amot and YAP1 protein expression in type I EC cancer tissues. The differences of Amot and YAP1 protein expression in cancer tissues of type I EC patients with different clinicopathological characteristics were compared. Kaplan-Meier analysis (Log-rank test) was used to analyze the relationship between the expression of Amot and YAP1 protein and the survival prognosis of type I EC patients. Univariate and multivariate COX regression analysis was used to analyze the factors affecting the survival prognosis of type I EC patients. Results: The positive rates of Amot and YAP1 protein expression in type I EC tissues were 80.00%(60/75) and 85.33%(64/75), respectively, which were significantly higher than those in atypical hyperplasia endometrial tissue 43.33% (13/30) and 46.67% (14/30), and the difference was statistically significant (all P＜0.05). The positive rates of Amot and YAP1 protein in atypical hyperplasia endometrial tissue were significantly higher than those in normal endometrial tissue with 16.67% (5/30) and 20.00% (6/30), and the difference was statistically significant (all P＜0.05). There was a significant positive correlation between Amot and YAP1 protein expression in type I EC cancer tissues(P＜0.05). The positive rates of Amot and YAP1 protein expression in EC type I patients with different International Federation of Gynecology and Obstetrics (FIGO) stages, histological grades and lymph node metastasis were statistically significant (P＜0.05). The cumulative survival time of Amot-positive expression typeⅠEC patients was significantly lower than that of Amot-negative expression typeⅠEC patients (P＜0.05). The cumulative survival time of patients with YAP1-positive expression of typeⅠEC was significantly lower than that of patients with YAP1-negative expression of typeⅠEC (P＜0.05). Amot-positive expression, YAP1 positive expression, FIGO stage Ⅲ and lymph node metastasis were independent risk factors for poor prognosis in patients with EC type I (P＜0.05). Conclusion: The Amot and YAP1 protein positive expression increased in type I EC cancer tissues, which are related to FIGO stage, histological grade and lymph node metastasis. The positive expression of Amot protein and YAP1 protein is one of the risk factors affecting the poor prognosis of patients with type I EC. [ABSTRACT FROM AUTHOR]

Too many types of congenital esophageal atresia with a great diversity and variability bring dilemmas to clinical management. In clinical cases of first-stage end-to-end esophageal anastomosis, operative failure and error occur frequently due to inaccurate preoperative examinations and evaluations. Subsequent treatment becomes extremely difficult so that therapeutic efficacy is poor. Subsequent complications and sequelae adversely affect the quality of life. Based upon an etiological analysis of actual clinical cases, this review proposed practical and feasible clinical measures of avoid surgical failures and operative errors to improve the therapeutic outcomes of esophageal atresia. [ABSTRACT FROM AUTHOR]

Background and purpose: Perineural invasion is a prognostic factor in colorectal cancer. It is unclear whether perineural invasion is a prognostic factor in in node-negative (ypⅠ-Ⅱ) rectal cancer patients who received neoadjuvant radiotherapy because there may be varying degrees of tumor regression. This study aimed to investigate prognostic value of perineural invasion in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Methods: A total of 5 222 patients who received neoadjuvant radiotherapy and were diagnosed with stage ypⅠ-Ⅱ rectal cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018 were identified and clinicopathological features and cancer-specific survival outcomes were retrospectively analyzed. Chi-square analysis was used to compare clinicopathological features between two groups. Kaplan- Meier survival analysis and the log-rank test were used to estimate the 5-year cancer-specific survival. Multivariable Cox regression analyses were used to identify the independent prognostic factor. Results: Compared with patients without perineural invasion, patients with perineural invasion were more likely to be black, have elevated carcinoembryonic antigen (CEA), stage Ⅱ disease, tumor＜5 cm and poorer differentiated tumors (P＜0.05). Patients without perineural invasion had superior cancer-specific survival than those with perineural invasion (5-years survival rate: 85.3% vs 68.9%). The survival difference was more evident in patients with stage ypⅡ cancer. Multivariable Cox regression analyses demonstrated that perineural invasion was an independent prognostic factor in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Conclusion: Perineural invasion is associated with oncological outcomes of node-negative rectal cancer patients who received neoadjuvant radiotherapy, thus it could serve as a prognostic factor in these patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate value of periostin （POSTN） in immunity and prognosis of gastric cancer. Methods: POSTN expression in gastric cancer and its relationship with survival and prognosis were analyzed by bioinformatics methods. Distribution of immune cells in cancer and normal tissues in TCGA gastric cancer cohort were compared. POSTN-related immunomodulators were extracted from TISIDB database, and POSTN-related immune events were analyzed by GO and KEGG pathway enrichments. Based on POSTN associated immunomodulators, a polygenic risk prediction model was developed by Cox regression, from which risk scores were generated. Prediction accuracy of the model was evaluated by subject operating characteristic curve. Prognostic normograms with calibration curves were constructed to predict 5-year survival probability of individuals. Results: POSTN expression in gastric cancer tissues was significantly higher than that in non-tumor tissues. Overall survival of POSTN high expression group was shorter than that of POSTN low expression group. High expression of POSTN was positively correlated with high level of immune infiltration in most immune cells. KEGG pathway analysis based on 46 POSTN-associated immunomodulators revealed involvement of NF-κB signaling and cell adhesion molecules. Risk score could be used as an independent predictor of prognosis in patients with gastric cancer. Conclusion: POSTN is highly expressed in gastric cancer tissues, whose expression is correlated with overall survival of gastric cancer patients. POSTN is associated with tumor immune invasion, suggesting that POSTN may be a potential immunotherapy target for gastric cancer. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical value of dynamic intracranial pressure (ICP) monitoring combined with regional cerebral oxygen saturation (rSc02) monitoring target oriented therapy for severe traumatic brain injury (sTBI). Methods 60 patients with sTBI were randomly divided into dynamic ICP monitoring combined with rSc02 monitoring target oriented treatment group (combined monitoring group) and control group, with 30 cases in each group. The patients in the control group were treated under neurosurgical intensive care. The patients in the combined monitoring group were guided by ICP combined with rSc02 target monitoring on the basis of traditional intensive care treatment in neurosurgery. Results The Glasgow coma scale(GCS) score of patients in the combined monitoring group was higher than that in the control group. The GCS score of patients in the two groups was higher than that in the admission group, but the difference was not statistically significant (all P > 0. 05). The length of total hospital stay and the length of stay in neurosurgical intensive care unit (NSICU) in the combined monitoring group were significantly lower than those in the control group (P<0.05~0.01). At 6 months after discharge, the scores of modified Rankin Scale (mRS) and Glasgow prognosis scale (GOS) in the combined monitoring group were significantly better than those in the control group (P<0.05~0.01), and the mortality was significantly lower than that in the control group (P < 0. 05). Kaplan-Meier survival curve analysis showed that the survival time of patients in the combined monitoring group was significantly better than that in the control group (P < 0. 05). Conclusion ICP combined with rSc02 monitoring target oriented treatment can effectively shorten the total hospital stay and NSICU stay of sTBI patients, reduce the mortality and improve the prognosis of patients. [ABSTRACT FROM AUTHOR]