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Objective To explore the prognostic value of positive lymph node ratio in patients with lung adenocarcinoma, and to investigate the predictive value of the predictive model including positive lymph node ratio on the overall survival rate of patients with lung adenocarcinoma. Methods A total of 36 335 patients with lung adenocarcinoma in the SEER database from 2010 to 2016 were selected and randomly assigned to the training set and SEER verification set according to the ratio of 7∶3.X-tile software was used to determine the best cut-off point of positive lymph node ratio. The independent prognostic factors were selected by LASSO Cox regression, and a predicting model was constructed. In addition, a total of 90 patients with lung adenocarcinoma from Hubei Provincial Hospital of Integrated Chinese and Western Medicine were included as the external validation set. Results No lymph node metastasis was found in 75.1% of the patients in the SEER training set,75.0% in the SEER validation set and 44.4% in the external validation. X-tile results showed the greatest survival difference among the three groups when the positive lymph node ratio was 0.2.LASSO Cox regression analysis revealed that positive lymph node ratio, gender, age, tumor grade, tumor size, M stage and TNM stage were independent prognostic factors of lung adenocarcinoma. The nomogram containing positive lymph node ratios had a high predictive value for the overall survival rate of patients with lung adenocarcinoma in the SEER training set(AUC of three-year survival rate:0.714;AUC of five-year survival rate:0.700; AUC of ten-year survival rate: 0.718), SEER validation set(AUC of three-year survival rate: 0.710; AUC of five-year survival rate:0.709; AUC of ten-year survival rate:0.704), and external validation set(AUC of three year survival rate:0.703;AUC of five-year survival rate: 0.798; AUC of ten-year survival rate: 0.769).Conclusion The positive lymph node ratio fully considers the number of lymph node metastasis and the total number of lymph node dissections on the survival of patients with lung adenocarcinoma, which exhibited good prognostic value. The positive lymph node ratio greater than 0.2 is an independent risk factor for poor overall survival of patients with lung adenocarcinoma. The nomogram containing a positive lymph node ratio has a high predictive value for the prognosis of patients with lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of Ginkgo Ketone Ester Dropping Pills in the patients with acute ST segment elevation myocardial infarction( STEMI) and whether improving their short term prognosis. Methods: A total of 185 patients with STEMI treated by the emergency percutaneous coronary intervention (PCI) in this hospital from December 2017 to Deccmber 2018 were selected and divided into the control group (n = 93) and intervention group (n = 92) by adopting the random number table method. The two groups were treated with anticoagulation, anti-platelet, lipid regulation and reversal of ventricular remodeling according to the guidelines, meanwhile the control group orally took the placebo preparation of Ginkgo Ketone Ester Dropping Pills (8 pills/per time, three times daily), while the intervention group orally took Ginkgo Ketone Ester Dropping Pills (8 pills/ per timc,three times a day). The clinical symptoms (chest pain, chest tightness,etc.) and the incidence rate of heart failure, rate of recurrence myocardial infarction, occurrence rate of ventricular arrhythmia and cardiogenic mortality rate were compared between the two groups. Results: There were no statistically significant differences in the age, sex, smoking, hypertension, abnormal blood sugar, dyslipidemia, obesity, family history of coronary heart disease (CHD), symptoms entry time, entry balloon expansion time, proportion of single vessel lesion, proportion of multiple vessel lesions, thrombus aspiration rate, cardiogenic mortality rate in 6 months after treatment, and recurrence rate of cardiac infarction between the two groups (P>0.05). The positive proportion of CHD symptoms in the intervention group was significantly lower than that in the control group, the occurrence rate of ventricular arrhythmia and heart failure in 6 months after treatment in the intervention group was significantly lower than that in the control group, and the differences were statistically significant (P < 0.05). Conclusion: Ginkgo Ketone Ester Dropping Pills can improve the symptoms of angina pectoris, reduce the incidence of ventricular arrhythmia and heart failure in the patients with STEMI treated by direct PCI, and improve the clinical symptoms to a certain extent, but can not reduce short term (6 months) cardiogenic mortality and recurrencc rate of myocardial infarction. [ABSTRACT FROM AUTHOR]