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Your search keyword '"González‐Ruiz, Lucía"' showing total 2 results
Start Over Author "González‐Ruiz, Lucía" Topic prognosis Topic systematic review
2 results on '"González‐Ruiz, Lucía"'

1. Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Author

González-Moles, Miguel Ángel, Ayén, Ángela, González-Ruiz, Isábel, de Porras-Carrique, Teresa, González-Ruiz, Lucía, Ruiz-Ávila, Isábel, Ramos-García, Pablo, [González-Moles,MA, González-Ruiz,I, de Porras-Carrique,T, Ramos-García,P] School of Dentistry, University of Granada, Granada, Spain. [González-Moles,MA, and Ramos-García,P] Instituto de Investigación Biosanitaria ibs.Granada, Granada, Spain. [Ayén,A] Dermatology Service, San Cecilio Hospital Complex, Granada, Spain. [González-Ruiz,L] Dermatology Service, Ciudad Real General University Hospital, Ciudad Real, Spain. [Ruiz-Ávila,I] Pathology Service, San Cecilio Hospital Complex, Granada, Spain.

Subjects
Proteína de dominio de muerte asociada a Fas, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Meta-Analysis as Topic [Medical Subject Headings], Fas-associated death domain, Laryngeal squamous cell carcinoma, Information Science::Information Science::Information Services::Bibliography as Topic::Bibliometrics [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Biological Markers [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio [Medical Subject Headings], Metaanálisis, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Gene Amplification [Medical Subject Headings], Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Death Domain Receptor Signaling Adaptor Proteins::Fas-Associated Death Domain Protein [Medical Subject Headings], Revisión sistemática, Pronóstico, Carcinoma de células escamosas de cabeza y cuello, Head and neck squamous cell carcinoma, Biomarker, Prognosis, Meta-analysis, Biomarcadores, Oral squamous cell carcinoma, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Up-Regulation [Medical Subject Headings], FADD, Systematic review, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]
Abstract

Fas-associated death domain (FADD) upregulation, i.e., gene amplification, protein phosphorylation and/or overexpression, has shown promising prognostic implications in head and neck squamous cell carcinoma (HNSCC). This systematic review and meta-analysis aims to evaluate the clinicopathological and prognostic significance of FADD upregulation in HNSCC. We searched studies published before February 2020 through PubMed, Embase, Web of Science, Scopus and Google Scholar. We evaluated the quality of the studies included using the QUIPS tool. The impact of FADD upregulation on survival and clinicopathological variables was meta-analysed. We explored heterogeneity and their sources, conducted sensitivity analyses and investigated small-study effects. Thirteen studies (1,923 patients) met inclusion criteria. FADD immunohistochemical overexpression was statistically associated with worse overall survival (hazard ratio [HR] = 1.52, 95% confidence intervals [CI] = 1.28-1.81, p < 0.001), disease-specific survival (HR = 2.52, 95% CI = 1.61-3.96, p < 0.001), disease-free survival (HR = 1.67, 95% CI=1.29-2.15, p < 0.001), higher clinical stage (odds ratio [OR] = 1.72, 95% CI = 1.17-2.51, p = 0.005) and a large magnitude of effect with N+ status (OR = 2.36, 95% CI = 1.85-3.00, p < 0.001). FADD phosphorylation in ser-194 demonstrated no prognostic value, while no conclusive results can be drawn for FADD gene amplification. In conclusion, our findings indicate that immunohistochemical assessment of FADD overexpression could be incorporated into the prognostic evaluation of HNSCC. Yes

Published
2020

2. Clinicopathological and prognostic characteristics of oral squamous cell carcinomas arising in patients with oral lichen planus: A systematic review and a comprehensive meta-analysis.

Author

González-Moles, Miguel Ángel, Warnakulasuriya, Saman, González-Ruiz, Isabel, González-Ruiz, Lucía, Ayén, Ángela, Lenouvel, Daniel, Ruiz-Ávila, Isabel, and Ramos-García, Pablo

Subjects
*SQUAMOUS cell carcinoma, *ORAL lichen planus, *META-analysis, *MULTIPLE tumors, *ORAL cancer, *MOUTH tumors, *SYSTEMATIC reviews, *PROGNOSIS, *DISEASE complications
Abstract

Objectives: To evaluate current evidence in relation to the prognostic and clinicopathological significance of oral squamous cell carcinomas arising in patients with oral lichen planus (OLP-OSCC).Material and Methods: We searched PubMed, Embase, Web of Science and Scopus for studies published before May-2019. We evaluated the quality of studies (QUIPS tool). We carried out meta-analyses to fulfill our objective. We examined the between-study heterogeneity and small-study effects, and conducted sensitivity and subgroup analyses.Results: Inclusion criteria were met by 27 studies (10,505 patients with OLP, of whom 205 developed a total of 247 OSCCs). The combined 5-year mortality rate was 15.48% for OLP-OSCC (95%CI  =  7.34-25.19), clearly lower than the 34.70-50.00% mortality rate for conventional oral cancer communicated in previous official reports. Also, 14.67% (95%CI  =  6.34-24.81) of OLP-OSCC developed N+ status, compared to 47.00% of conventional oral carcinomas. Likewise, most of the OSCCs in the study were T1/T2 (93.57%, 95%CI  =  82.20-99.88) and presented at stage I/II (81.51%, 95%CI = 68.32-92.38) at the time of diagnosis, which contrasts with 50.00% of conventional carcinomas diagnosed in stages I/II. Furthermore, most of the cases were grade I (well differentiated OSCC) (67.79%; 95%CI = 43.50-88.65), in comparison to conventional OSCCs, which present typically in grade II in 90.00% of cases. Our results also show an 11.21% of the OLP-OSCC patients in this study developed multiple tumors.Conclusions: Oral squamous cell carcinomas that developed in oral lichen planus show favorable prognostic parameters, especially with regard to the mortality rate. Around 11% of OLP-OSCC patients develop multiple tumors, which confirms that OLP can lead to field cancerization. [ABSTRACT FROM AUTHOR]

Published
2020
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