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Aim: The aim of this work was assessment of sepsis induced cardiac dysfunction (SIMD) in neonates with sepsis by 2-dimensional speckle tracking echocardiography, tissue Doppler as well as other conventional echocardiographic methods and its correlation with serum procalcitonin (PCT) and, cardiac troponin -T (cTnT). Methods: This study was prospective controlled cohort study that included 60 neonates with diagnosis of neonatal sepsis compared to 60 healthy newborns who were matching in age and sex. both groups was subjected to basic and advanced transthoracic echocardiography and some lab markers in order to assess sepsis induced cardiac dysfunction, and correlates the findings with serum procalcitonin, cardiac troponin -T. Results: Out of the enrolled 60 patients and 60 controls. Mean age of cases was 16.62±4.74 days and 14.85±5.88 days for controls. blood culture was positive in 48.3%; 65.5% was gram positive and 34.4% was gram negative, Median Procalcitonin among cases was 5.20 ng/ml compared to 0.22 among controls, median cTnT among cases was 0.27 compared to 0.03 among controls, LVGLS was -10.79±1.47 among cases vs -14.68±1.13 among controls, P value <0.001. mean EF was 46.03±6.93 among cases versus 62.58±5.69 among controls, P value <0.001, There was significant positive correlation between left ventricular global longitudinal strain (LV GLS) and PCT and cTnT levels. Conclusion. PCT is good markers of neonatal sepsis. cTnT is a good laboratory indicator for cardiac affection in neonatal sepsis. speckle tracking echocardiography is a promising tool in assessment of cardiac function PCT and cTnT were correlated with both LV and RV systolic dysfunction detected by tissue Doppler imaging (TDI) and STE, SIMD is very common comorbidity in neonatal sepsis, [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to determine the association between neutrophils and monocytes CD 64 molecules and cases of bronchiolitis with an associated bacterial infection. Methods: Blood samples were obtained from patients younger than 2 years old diagnosed with bronchiolitis. Complete blood count (CBC), blood culture, procalcitonin, and CD64 surface expression in neutrophils and monocytes were examined using flow cytometry. We also assessed CBC, procalcitonin, and CD64 levels in neutrophils and monocytes in 31 healthy control subjects. Results : Sixty-two patients with lower respiratory tract infections were included in the first group. The patients were divided into 34 with non-bacterial infections and 28 with possible bacterial infections. We found a significant increase in the number of positive cells in the Mean Fluorescence Intensity (MFI) of both nCD64 and mCD64 in the Possible Bacterial Infection (PBI) group. Procalcitonin levels correlated with nCD64 and nCD64%, but not with mCD64. The AUC of nCD64 was 0.873 (at a cut-off point of 4489.4; the MFI had a specificity of 73% and a sensitivity of 94%). Conclusion: Neutrophil CD64 may be a marker for bacterial infection in children with bronchiolitis. [ABSTRACT FROM AUTHOR]