1. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection.
- Author
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Spagnolello O, Pinacchio C, Santinelli L, Vassalini P, Innocenti GP, De Girolamo G, Fabris S, Giovanetti M, Angeletti S, Russo A, Mastroianni CM, Ciccozzi M, Ceccarelli G, and d'Ettorre G
- Subjects
- Dietary Supplements, Humans, SARS-CoV-2, COVID-19 immunology, COVID-19 physiopathology, COVID-19 prevention & control, Dysbiosis therapy, Dysbiosis virology, Gastrointestinal Microbiome immunology, Probiotics pharmacology
- Abstract
Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host's microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response ("gut-lung axis"). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia., (© 2021 S. Karger AG, Basel.)
- Published
- 2021
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