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4 results on '"Ivanović Nevena"'

1. Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia.

Author

Korčok DJ, Tršić-Milanović NA, Ivanović ND, and Đorđević BI

Subjects
Humans, Lactobacillus plantarum cytology, Anemia, Iron-Deficiency microbiology, Anemia, Iron-Deficiency therapy, Dietary Supplements, Lactobacillus plantarum metabolism, Probiotics therapeutic use
Abstract

Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.

Published
2018
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2. Effects of probiotic intervention on obesity-related miRNAs

Author

Okuka Nina, Berit Hippe, Đorđević Brižita, and Ivanović Nevena

Subjects
obesity, microrna, probiotics, Pharmacy and materia medica, RS1-441
Abstract

Obesity is considered to be a chronic complex disease that increases the risk of diabetes, heart diseases and certain cancers. According to the literature, in obese people the gastrointestinal microbiota is disturbed, which could be the cause of the onset of obesity and related diseases. Moreover, there are small non-coding RNAs (microRNAs) that are disturbed in obesity, which are also considered to be a possible mechanism of probiotics' action. Certain microRNAs are involved in the development and metabolism of adipose tissue cells, as well as the secretion and action of insulin, showing that changed expression of certain miRNAs could have a significant impact on the onset and development of obesity and obesity-related diseases. Thus, miRNAs are considered to be possible markers for the diagnosis and prognosis of various metabolic diseases, and possible therapeutic targets for the treatment of obesity and related diseases. Considering the growing need of the healthcare system for nutraceuticals and dietary supplements that present effective and safe medical nutritive therapy in obese individuals, this work aimed to assess the beneficial effects of probiotics on obesity-related microRNAs. In this review, we described the role of microRNAs and probiotics in obesity and the association between probiotics and obesityrelated microRNAs. Circulating miRNAs' profile in obese individuals significantly differs from that of normal-weight individuals. miRNAs such as miR-155, miR-221, miR-24-3p, and miR181a are over-expressed, while miR-26b and 125a are under-expressed in obese patients compared to non-obese individuals. It has been found that supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus could downregulate the expression of miR-155 and miR221, and upregulate the expression of miR-26b. Supplementation with a probiotic formulation containing S. boulardii, L. plantarum 299v, and octacosanol led to the downregulation of miR155 and miR-24-3p expression. miR-125a and miR-181a were upregulated and downregulated, respectively, after the intervention with L. delbrueckii and L. rhamnosus. After reviewing the available literature, we can conclude that probiotics have beneficial effects on microRNAs altered in obesity, which could provide an effective strategy for the management of obesity.

Published
2024
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3. Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG.

Author

Korčok, Davor J., Tršić-Milanović, Nada, Ilić, Marija, Mitić, Bogdan, Đorđević, Brižita, and Ivanović, Nevena

Subjects
SACCHAROMYCES, PROBIOTICS, DIETARY supplements, BIOAVAILABILITY, PACKAGING materials, POLYVINYL chloride, NOBLE gases, MANUFACTURING processes
Abstract

Copyright of Chemical Industry / Hemijska Industrija is the property of Association of Chemical Engineers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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4. Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre

Author

Ivanović, Nevena, Đorđević, Brižita, Minić, Rajna, Stanković, Ivan, and Golić, Nataša

Subjects
Lactobacillus, ishrana visokog sadržaja masti, probiotics, probiotici, NAFLD, laktobacili, high fat diet, steatosis, steatoza
Abstract

Prema definiciji Svetske Zdravstvene Organizacije, probiotici su živi mikroorganizmi koji kada su konzumirani u adekvatnoj količini imaju povoljne efekte na zdravlje domaćina. Pod pojmom probiotskih bakterija misli se većinom na bakterije mlečne kiseline (BMK) koje obuhvataju uglavnom vrste iz rodova Lactobacillus i Bifidobacterium. Rastući je broj dokaza koji ukazuju da primena BMK može ispoljiti povoljne efekte u tretmanu komponenata metaboličkog sindroma, kao što su gojaznost, dijabetes tip 2, dislipidemije, nealkoholna masna bolest jetre (engl. Nonalcoholic Fatty Liver Disease, NAFLD). NAFLD obuhvata čitav spektar oboljenja, počev od hepatične steatoze preko nealkoholnog steatohepatitisa do hepatične fibroze. Predstavlja najčešći uzrok ozbiljnih i hroničnih oboljenja jetre kod odraslih i kod dece u zapadnim zemljama, sa prevalencom od 20-30% u opštoj odrasloj populaciji, pri čemu prevalenca korelira sa povećanom incidencom gojaznosti i metaboličkog sindroma. Nedavno objavljena istraživanja ukazuju na ulogu crevne mikrobiote u razvoju steatoze i progresiji NAFLD-a, a s obzirom da probiotici mogu delovati na više nivoa na patogenezu oboljenja, a uz to su još i bezbedni i pristupačni, nije iznenađujuće što LAB postaju sve privlačniji kao potencijalna dugoročna terapija NAFLDa. Kliničke i eksperimentalne studije sugerišu da se probiotici značajno razlikuju u efektima i mehanizmima dejstva a razlike postoje, ne samo između različitih vrsta, već i između različitih soje iste vrste. Zbog toga je najvažniji cilj ove studije bio da se razvije model NAFLD (stadijum steatoze) ishranom visokog sadržaja masti (VSM), a zatim da se ispita i izvrši poređenje dejstva oralne primene dva različita soja BMK, Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1, na imunološke i metaboličke parametre, na razvoj steatoze, kao i na sastav masnih kiselina organa kod miševa soja C57BL/6 u uslovima VSM ishrane. Nakon 16 nedelja VSM ishrane, u kojoj je 41% energije poticao od masti, kod miševa soja C57BL/6 došlo je do značajnog porasta telesne mase, i razvoja steatoze koju je pratio poremećaj lipidnih parametara i porast nivoa leptina, što odgovara početnoj fazi NAFLD (stadijum steatoze)... According to the World Health Organisation's definition, probiotics are alive microorganisms which, when consumed in adequate quantities, have beneficial effects on host's health. The term probiotics bacteria mostly refers to lactic acid bacteria (LAB) which include species from the genera Lactobacillus and Bifidobacteria. The increasing amount of evidence indicates that the usage of LAB can have positive effects on the treatment of metabolic syndrome components, such as: obesity, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease (NAFLD). NAFLD includes a whole spectar of diseases, starting from hepatic steatosis through nonalcoholic steatohepatitis to hepatic fibrosis which may further progress into ireversibile cirrhosis and hepatocellular carcinoma. NAFLD represents the most common cause of severe and chronic liver diseases in adults and children in Western countres, with the prevelance correlating with increased incidence of obesity and metabolic syndrome. Recently published research points to the role of intestinal microbiota in the development of steatosis and progression of NAFLD. Probiotics, especially LAB, can have an influence on disease pathogenesis at multiple levels and besides that they are safe and affordable. Taking into account all abovementioned reasons, it is not surprising that LAB are becoming more and more attractive as potential long-term NAFLD therapy. Clinical and experimental studies suggest that LAB differ significantly in the effects and mechanisms of action. Those differences are not only among different species but also among different strains within the same species. Because of that, the most important goal of this study was to develop a model of NAFLD (steatosis stadium) with use of high fat diet (HFD) and then to examine and to compare the effects of oral administration of two different LAB species/strains, Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1, on immunological and metabolic parameters, on steatosis development status, as well as on fatty acid composition of liver and brain in C57BL/6 mice under high fat diet regime...

Published
2016

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