1. Improvement of anti-prion efficacy with stearoxy conjugation of hydroxypropyl methylcellulose in prion-infected mice.
- Author
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Teruya K, Oguma A, Iwabuchi S, Nishizawa K, and Doh-Ura K
- Subjects
- Animals, Mice, Disease Models, Animal, Hypromellose Derivatives chemistry, Prion Diseases drug therapy
- Abstract
Prion diseases are fatal transmissible neurodegenerative disorders. Among known anti-prions, hydroxypropyl methylcellulose compounds (HPMCs) are unique in their chemical structure and action. They have several excellent anti-prion properties but the effectiveness depends on the prion-infected mouse model. In the present study, we investigated the effects of stearoxy-modified HPMCs on prion-infected cells and mice. Stearoxy modification improved the anti-prion efficacy of HPMCs in prion-infected cells and significantly prolonged the incubation period in a lower HPMC-responding mouse model. However, stearoxy modification showed no improvement over nonmodified HPMCs in an HPMC-responding mouse model. These results offer a new line of inquiry for use with prion-infected mice that do not respond well to HPMCs., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kenta Teruya reports financial support was provided by the Japan Society for the Promotion of Science [grant numbers 19K22479 and 23K05036]. Kenta Teruya has patent #P2017-93414 issued to Tohoku University. Katsumi Doh-ura has patent #P2017-93414 issued to Tohoku University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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