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1. European Surveillance System on Contact Allergies (ESSCA)

Author

Dittmar, Daan, Uter, Wolfgang, Bauer, Andrea, Fortina, Anna B, Bircher, Andreas J, Czarnecka-Operacz, Magdalena, Dugonik, Aleksandra, Elsner, Peter, Gallo, Rosella, Ghaffar, Sharizan A, Giménez-Arnau, Anna, Johnston, Graham A, Kręcisz, Beata, Filon, Francesca L, Rustemeyer, Thomas, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Schnuch, Axel, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philipp, Corradin, Maria T, Valiukevičienė, Skaidra, Vok, Marko, Weisshaar, Elke, Wilkinson, Mark, Schuttelaar, Marie L, Aberer W, Ballmer-Weber B, Grabbe J, Beiteke U, Brasch J, Fuchs T, John SM, Mahler V, Pesonen M, Jolanki R, Rantanen T, Armario-Hita JC, Fernández-Redondo V, García-Gavín J, Mercader P, Ruiz I, Silvestre JF, Balato A, Ayala F, Peserico A, Sliuziaviciene G, Kieć-Świerczyńska M, Kmecl T, Pandurovic MK, Kecelj N, Lunder T, Simončič Godnič M, Chowdhury MMU, Cooper SM, English JSC, Cousen P, Horne HL, Gawkrodger DJ, Holden C, Sabroe R, Green CM, King CM, Ormerod AD, Samson JE, Statham B, Stone N, White I., Dittmar, Daan, Uter, Wolfgang, Bauer, Andrea, Fortina, Anna B, Bircher, Andreas J, Czarnecka-Operacz, Magdalena, Dugonik, Aleksandra, Elsner, Peter, Gallo, Rosella, Ghaffar, Sharizan A, Giménez-Arnau, Anna, Johnston, Graham A, Kręcisz, Beata, Filon, Francesca L, Rustemeyer, Thoma, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Schnuch, Axel, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philipp, Corradin, Maria T, Valiukevičienė, Skaidra, Vok, Marko, Weisshaar, Elke, Wilkinson, Mark, Schuttelaar, Marie L, Aberer, W, Ballmer-Weber, B, Grabbe, J, Beiteke, U, Brasch, J, Fuchs, T, John, Sm, Mahler, V, Pesonen, M, Jolanki, R, Rantanen, T, Armario-Hita, Jc, Fernández-Redondo, V, García-Gavín, J, Mercader, P, Ruiz, I, Silvestre, Jf, Balato, A, Ayala, F, Peserico, A, Sliuziaviciene, G, Kieć-Świerczyńska, M, Kmecl, T, Pandurovic, Mk, Kecelj, N, Lunder, T, Simončič Godnič, M, Chowdhury, Mmu, Cooper, Sm, English, Jsc, Cousen, P, Horne, Hl, Gawkrodger, Dj, Holden, C, Sabroe, R, Green, Cm, King, Cm, Ormerod, Ad, Samson, Je, Statham, B, Stone, N, White, I., Dermatology, Public Health Research (PHR), Fortina, Ana B., Bircher, Andreas J., Ghaffar, Sharizan A., Johnston, Graham A., Larese Filon, Francesca., Corradin, Maria T., Schuttelaar, Marie L., Aberer, Werner, Ballmer-Weber, Barbara, Grabbe, Jürgen, Beiteke, Ulrike, Brasch, Jochen, Fuchs, Thoma, John, Swen Malte, Mahler, Vera, Pesonen, Maria, Jolanki, Riitta, Rantanen, Tapio, Armario-Hita, José Carlo, Fernández-Redondo, Virginia, García-Gavín, Juan, Mercader, Pedro, Ruiz, Inmaculada, Silvestre, Juan Fco., Balato, Anna, Ayala, Fabio, Peserico, Andrea, Sliuziaviciene, Gondinga, Kieć-Świerczyńska, Marta, Kmecl, Tanja, Pandurovic, Maja Kalac, Kecelj, Nada, Lunder, Tomaž, Simončič Godnič, Mojca, Chowdhury, Mahbub M. U., Cooper, Susan M., English, John S. C., Cousen, Philippa, Horne, Helen L., Gawkrodger, David J., Holden, Catherine, Sabroe, Ruth, Green, Cathy M., King, Codagh M., Ormerod, Anthony D., Samson, Jane E., Statham, Barry, Stone, Natalie, and White, Ian

Subjects
Allergy, Allergic Contact, Occupational Dermatitis, ANGRY BACK SYNDROME, Dermatitis, SUSCEPTIBILITY, medicine.disease_cause, 030207 dermatology & venereal diseases, 0302 clinical medicine, Allergen, Quality of life, QUALITY-OF-LIFE, Adult Allergens Dermatitis, Allergic Contact Dermatitis, Atopic Europe Humans Middle Aged Patch Tests Population Surveillance Prevalence Retrospective Studies Young Adult, Prevalence, Immunology and Allergy, Medicine, Young adult, 610 Medicine & health, DERMATOLOGY IVDK, education.field_of_study, PATCH-TEST REACTIONS, Patch test, BASE-LINE SERIES, clinical epidemiology, Middle Aged, Patch Tests, DERMATITIS-RESEARCH-GROUP, contact allergy, patch test, polysensitization, Adult, Allergens, Dermatitis, Allergic Contact, Dermatitis, Atopic, Europe, Humans, Retrospective Studies, Young Adult, Population Surveillance, Atopic Europe Humans Middle Aged Patch Tests Population Surveillance Prevalence Retrospective Studies Young Adult, GENETIC-FACTORS, Allergic Contact Dermatitis, INFORMATION-NETWORK, Population, Dermatology, Atopic, 2708, 03 medical and health sciences, P-PHENYLENEDIAMINE, education, business.industry, Retrospective cohort study, Adult Allergens Dermatitis, medicine.disease, 030228 respiratory system, business, Demography
Abstract

Background. Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.Objectives. To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.Methods. Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.Results. A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.Conclusions. The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Knownrisk factors for polysensitization are confirmed in a European dermatitis population.

Published
2018
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2. Patch test results with fragrance markers of the baseline series - Analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

Author

Frosch PJ, Duus Johansen J, Schuttelaar ML, Silvestre JF, Sánchez-Pérez J, Weisshaar E, Uter W, Aberer W, Bircher A, Simon D, Ballmer-Weber B, Spring P, Frosch P, Fuchs T, Brasch J, Bauer A, Elsner P, John SM, Mahler V, Johansen JD, Giménez Arnau A, García-Gavín J, Fernández-Redondo V, Amario-Hita JC, Mercader P, Ruiz I, Jolanki R, Pesonen M, Rantanen T, Ayala F, Balato A, Peserico A, Fortina AB, Filon FL, Corradin MT, Gallo R, Valiukeviciene S, Sliuziaviciene G, Coenraads PJ, Rustemeyer T, Kręcicz B, Kieć-Świerczyńska M, Spiewak R, Sadowska A, Czarnecka-Operacz M, Dugonik A, Pandurovic MK, Kmecl T, Vok M, Godnic S, Mesto N, Lunder T, Green CM, Wilkinson M, Sansom JE, King CM, Horne HL, English JS, Johnston GA, Statham BN, Chowdhury MM, Stone N, Cooper S, Gawkrodger DJ, Sabroe R, Holden C, Ormerod AD., Frosch, Pj, Duus Johansen, J, Schuttelaar, Ml, Silvestre, Jf, Sánchez-Pérez, J, Weisshaar, E, Uter, W, Aberer, W, Bircher, A, Simon, D, Ballmer-Weber, B, Spring, P, Frosch, P, Fuchs, T, Brasch, J, Bauer, A, Elsner, P, John, Sm, Mahler, V, Johansen, Jd, Giménez Arnau, A, García-Gavín, J, Fernández-Redondo, V, Amario-Hita, Jc, Mercader, P, Ruiz, I, Jolanki, R, Pesonen, M, Rantanen, T, Ayala, F, Balato, A, Peserico, A, Fortina, Ab, Filon, Fl, Corradin, Mt, Gallo, R, Valiukeviciene, S, Sliuziaviciene, G, Coenraads, Pj, Rustemeyer, T, Kręcicz, B, Kieć-Świerczyńska, M, Spiewak, R, Sadowska, A, Czarnecka-Operacz, M, Dugonik, A, Pandurovic, Mk, Kmecl, T, Vok, M, Godnic, S, Mesto, N, Lunder, T, Green, Cm, Wilkinson, M, Sansom, Je, King, Cm, Horne, Hl, English, J, Johnston, Ga, Statham, Bn, Chowdhury, Mm, Stone, N, Cooper, S, Gawkrodger, Dj, Sabroe, R, Holden, C, and Ormerod, Ad.

Subjects
Adult, Male, Allergic Contact, Patch Test, Petrolatum, Allergen, Dermatiti, regional difference, Perfume, Europe, contact sensitization, Retrospective Studie, Population Surveillance, Dermatitis, Allergic Contact, contact allergy, fragrance, Prevalence, Immunology and Allergy, Female, patch testing, Human
Published
2015

3. Patch test results with fragrance markers of the baseline series - Analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

Author

Frosch, Pj1, 2, Duus Johansen J3, Schuttelaar, Ml4, Silvestre, Jf5, Sánchez Pérez J6, Weisshaar, E7, Uter, W8, ESSCA n. e. t. w. o. r. k. Aberer, W, Bircher, A, Simon, D, Ballmer Weber, B, Spring, P, Frosch, P, Fuchs, T, Brasch, J, Bauer, A, Elsner, P, John, Sm, Mahler, V, Weisshaar, E, Johansen, Jd, Giménez Arnau, A, Sánchez Pérez, J, Silvestre, Jf, García Gavín, J, Fernández Redondo, V, Amario Hita, Jc, Mercader, P, Ruiz, I, Jolanki, R, Pesonen, M, Rantanen, T, Ayala, F, Balato, A, PESERICO STECCHINI NEGRI DE SALVI, Andrea, Fortina, Ab, Filon, Fl, Corradin, Mt, Gallo, R, Valiukeviciene, S, Sliuziaviciene, G, Coenraads, Pj, Schuttelaar, Ml, Rustemeyer, T, Kręcicz, B, Kieć Świerczyńska, M, Spiewak, R, Sadowska, A, Czarnecka Operacz, M, Dugonik, A, Pandurovic, Mk, Kmecl, T, Vok, M, Godnic, S, Mesto, N, Lunder, T, Green, Cm, Wilkinson, M, Sansom, Je, King, Cm, Horne, Hl, English, Js, Johnston, Ga, Statham, Bn, Chowdhury, Mm, Stone, N, Cooper, S, Gawkrodger, Dj, Sabroe, R, Holden, C, Ormerod, A. d., BELLONI FORTINA, Anna, Frosch, Pj, Duus Johansen, J, Schuttelaar, Ml, Silvestre, Jf, Sánchez-Pérez, J, Weisshaar, E, Uter, W, Larese Filon, F., and Essca, Network

Subjects
Adult, Male, contact allergy, contact sensitization, fragrances, patch testing, regional differences, 2708, Immunology and Allergy, Allergic Contact, Petrolatum, Dermatitis, Prevalence, fragrance, Humans, Retrospective Studies, Medicine (all), Allergens, Patch Tests, Dermatitis, Allergic Contact, Europe, Female, Perfume, Population Surveillance, regional difference
Abstract

Contact allergy to fragrances is common, and impairs quality of life, particularly in young women. OBJECTIVE: To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries. METHODS: Data of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the TRUE Test(®) system. RESULTS: The 'basic markers' were tested on 51 477 [fragrance mix II (FM II)] to 57 123 [Myroxylon pereirae, balsam of Peru] patients, and yielded positive reactions as follows: fragrance mix I 6.9%, Myroxylon pereirae 5.4%, FM II 3.8%, colophonium 2.6%, and hydroxyisohexyl 3-cyclohexene carboxaldehyde 1.7%, with some regional differences. Prevalences with TRUE Test(®) allergens were lower. Additional fragrances were tested on 3643 (trimethylbenzenepropanol) to 14 071 (oil of turpentine) patients, and yielded between 2.6% (Cananga odorata) and 0.7% (trimethylbenzenepropanol) positive reactions. CONCLUSIONS: Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance allergens.

Published
2015

4. European Surveillance System on Contact Allergies (ESSCA): results with the European baseline series, 2013/14

Author

Marie L A Schuttelaar, Mahbub M. U. Chowdhury, Andreas J. Bircher, Ian R. White, Anna Balato, Jeanne D. Johansen, Wolfgang Uter, Aleksandra Dugonik, S.M. John, S. M. Wilkinson, Magdalena Czarnecka-Operacz, Radoslaw Spiewak, Vera Mahler, Barbara Ballmer-Weber, Andreas Bauer, F. Larese Filon, J.C. Amario-Hita, Richard L. Gallo, Marta Kieć-Świerczyńska, Javier Sánchez-Pérez, Maria Pesonen, T. Kmecl, Dagmar Simon, Elke Weisshaar, A. Belloni Fortina, Susan Cooper, Anna Sadowska-Przytocka, Thomas Rustemeyer, Beata Kręcisz, Sibylle Schliemann, Skaidra Valiukevičienė, Ana Giménez-Arnau, Uter, W, Amario-Hita, Jc, Balato, A, Ballmer-Weber, B, Bauer, A, Belloni Fortina, A, Bircher, A, Chowdhury, Mmu, Cooper, Sm, Czarnecka-Operacz, M, Dugonik, A, Gallo, R, Giménez-Arnau, A, Johansen, Jd, John, Sm, Kieć-Świerczyńska, M, Kmecl, T, Kręcisz, B, Larese Filon, F, Mahler, V, Pesonen, M, Rustemeyer, T, Sadowska-Przytocka, A, Sánchez-Pérez, J, Schliemann, S, Schuttelaar, Ml, Simon, D, Spiewak, R, Valiukevičienė, S, Weisshaar, E, White, Ir, Wilkinson, Sm., Dermatology, AII - Inflammatory diseases, AII - Cancer immunology, Public Health Research (PHR), Amario Hita, J. C., Balato, A., Ballmer Weber, B., Bauer, A., Belloni Fortina, A., Bircher, A., Chowdhury, M. M. U., Cooper, S. M., Czarnecka Operacz, M., Dugonik, A., Gallo, R., Giménez Arnau, A., Johansen, J. D., John, S. M., Kieć Świerczyńska, M., Kmecl, T., Kręcisz, B., LARESE FILON, Francesca, Mahler, V., Pesonen, M., Rustemeyer, T., Sadowska Przytocka, A., Sánchez Pérez, J., Schliemann, S., Schuttelaar, M. L., Simon, D., Spiewak, R., Valiukevičienė, S., Weisshaar, E., White, I. R., Wilkinson, S. M., and University of Zurich

Subjects
Male, Pediatrics, Allergy, Allergic Contact, Balsam of Peru, PATCH TEST SERIES, contact dermatitis, 030207 dermatology & venereal diseases, chemistry.chemical_compound, 0302 clinical medicine, Epidemiology, Prevalence, 030212 general & internal medicine, NETWORK, 610 Medicine & health, PRESERVATIVES, biology, 10177 Dermatology Clinic, Patch test, Heavy, Middle Aged, Adult, Allergens, Dermatitis, Allergic Contact, Europe, Female, Humans, Metals, Heavy, Retrospective Studies, Population Surveillance, SENSITIZATION, Infectious Diseases, Metals, FRAGRANCE MIX, RUBBER SERIES, epidemiology, patch test, medicine.medical_specialty, RECOMMENDATION, Myroxylon, Dermatology, Clinical surveillance, 2708 Dermatology, 03 medical and health sciences, SPOT-TEST, Methylisothiazolinone, Environmental health, medicine, patch testing, business.industry, sensitisation, Retrospective cohort study, 2725 Infectious Diseases, biology.organism_classification, medicine.disease, DERMATITIS, chemistry, contact allergy, business, Contact dermatitis, SKIN DISEASES
Abstract

BACKGROUND: Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, a consequence of introduction of new substances, new products or formulations, and regulatory intervention, the spectrum of contact sensitisation changes. OBJECTIVE: To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe. METHODS: Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (ESSCA, www.essca-dc.org) in consecutively patch tested patients, 2013/14, in 46 departments in 12 European countries. RESULTS: Altogether, 31689 patients were included in the analysis. Compared to a similar analysis in 2004, the prevalence of contact allergy to methylisothiazolinone went up to around 20% in several departments. In comparison, contact allergy to the metals nickel, cobalt and chromium remained largely stable, at 18.1, 5.9 and 3.2%, respectively, similar to mostly unchanged prevalences with fragrance mix I, II and Myroxylon pereirae (Balsam of Peru) at 7.3, 3.8 and 5.3%, respectively. In the subgroup of departments diagnosing (mainly) patients with occupational contact dermatitis, the prevalence of work-related contact allergies such as to epoxy resin or rubber additives was increased, compared to general dermatology departments. CONCLUSION: Continuous surveillance of contact allergy based on network data offers the identification of time trends or persisting problems, and thus enables focussing in-depth research (subgroup analyses, exposure analysis) on areas where it is needed. This article is protected by copyright. All rights reserved.

Published
2017
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