1. High pressure study of molecular dynamics of protic ionic liquid lidocaine hydrochloride.
- Author
-
Swiety-Pospiech A, Wojnarowska Z, Pionteck J, Pawlus S, Grzybowski A, Hensel-Bielowka S, Grzybowska K, Szulc A, and Paluch M
- Subjects
- Temperature, Ionic Liquids chemistry, Lidocaine chemistry, Molecular Dynamics Simulation, Pressure
- Abstract
In this paper, we investigate the effect of pressure on the molecular dynamics of protic ionic liquid lidocaine hydrochloride, a commonly used pharmaceutical, by means of dielectric spectroscopy and pressure-temperature-volume methods. We observed that near T(g) the pressure dependence of conductivity relaxation times reveals a peculiar behavior, which can be treated as a manifestation of decoupling between ion migration and structural relaxation times. Moreover, we discuss the validity of thermodynamic scaling in lidocaine HCl. We also employed the temperature-volume Avramov model to determine the value of pressure coefficient of glass transition temperature, dT(g)/dP|(P = 0.1). Finally, we investigate the role of thermal and density fluctuations in controlling of molecular dynamics of the examined compound.
- Published
- 2012
- Full Text
- View/download PDF