1. The complementary role of imaging modalities in Binder phenotype. Can prognostic factors of neonatal respiratory distress be found?
- Author
-
Bosselut H, Panuel M, Sigaudy S, Gorincour G, Chaumoitre K, and Bretelle F
- Subjects
- Adult, Female, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Maxillofacial Abnormalities complications, Middle Aged, Phenotype, Predictive Value of Tests, Pregnancy, Prognosis, Respiratory Distress Syndrome, Newborn etiology, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Ultrasonography, Prenatal, Maxillofacial Abnormalities diagnosis, Multimodal Imaging methods, Prenatal Diagnosis methods, Respiratory Distress Syndrome, Newborn diagnosis
- Abstract
Objective: To evaluate the complementarity between prenatal ultrasound, computed tomography, and MRI scans for fetuses with Binder phenotype., Methods: We carried out a retrospective study from January 1, 2009, to June 30, 2018, of fetuses with Binder phenotype. Prenatal ultrasound (US) data were collected. A systematic survey of the entire skeleton was performed to look for associated abnormalities such as calcifications, brachytelephalangy, and spinal stenosis. Parents were systematically offered fetal skeletal computed tomography (CT)., Results: Thirteen cases were included. Two cases of perinatal respiratory distress (18%) were observed. Chondrodysplasia punctata was diagnosed from the presence of calcifications, especially of the proximal femoral epiphyses and tarsal bones, in five cases (38%) by US and in 10 cases (83%) by CT. Calcifications of the hyoid bone were detected by CT in three cases (25%) one of which had respiratory distress. Polyhydramnios was associated with the Binder phenotype in four cases (30%) one of which had respiratory distress. One single fetus had combined polyhydramnios and laryngeal calcifications, and he suffered from perinatal respiratory distress., Conclusion: An antenatal diagnosis of Binder phenotype is often associated with chondrodysplasia punctata. We recommend the use of fetal CT as a complement to US in this condition., (© 2019 John Wiley & Sons, Ltd.)
- Published
- 2019
- Full Text
- View/download PDF