1. Longitudinal measures of maternal vitamin D and neonatal body composition
- Author
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Boghossian, Nansi S., Koo, Winston, Liu, Aiyi, Mumford, Sunni L., Tsai, Michael Y., and Yeung, Edwina H.
- Subjects
Bone densitometry -- Usage ,Body composition -- Measurement ,Newborn infants -- Physiological aspects ,Pregnant women -- Physiological aspects ,Vitamin D -- Physiological aspects ,Bone density ,Fetal development ,Pregnancy ,African Americans ,Vitamins ,Clinical trials ,Preeclampsia ,Regression analysis ,Women ,Food/cooking/nutrition ,Health - Abstract
Background/objectives Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA). Subjects/methods Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium. Results Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration Conclusion Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development., Author(s): Nansi S. Boghossian [sup.1] , Winston Koo [sup.2] , Aiyi Liu [sup.3] , Sunni L. Mumford [sup.3] , Michael Y. Tsai [sup.4] , Edwina H. Yeung [sup.3] Author Affiliations: [...]
- Published
- 2019
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