4 results on '"Suga, Sachie"'
Search Results
2. Impact of tocolysis‐intent magnesium sulfate and beta‐adrenergic agonists on perinatal brain damage in infants born between 28–36 weeks' gestation.
- Author
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Kino, Emi, Ohhashi, Masanao, Kawagoe, Yasuyuki, Sameshima, Hiroshi, Kamitomo, Masato, Suga, Sachie, Yasuhi, Ichiro, and Funakoshi, Toru
- Subjects
PREMATURE labor prevention ,ADRENERGIC beta agonists ,BRAIN injuries ,CEREBRAL palsy ,COMBINATION drug therapy ,CHILD development deviations ,CONFIDENCE intervals ,DRUG efficacy ,GESTATIONAL age ,HUMAN reproductive technology ,PREMATURE infants ,INFANT development ,LONGITUDINAL method ,MAGNESIUM sulfate ,EVALUATION of medical care ,MULTIVARIATE analysis ,PREGNANCY ,REGRESSION analysis ,RISK assessment ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,ODDS ratio ,DISEASE risk factors ,CHILDREN - Abstract
Aims: Magnesium sulfate has neuroprotective effects in preterm infants. Whether other antepartum treatments interfere with the neuroprotective actions is not well known. This study aims to explore the impacts of antenatal administration of Magnesium sulfate or beta‐2 adrenergic agonists as tocolytic agents on the developing brain in premature infants. Methods: This is a retrospective cohort study in four tertiary perinatal centers in Japan. We collected data of pregnant women and infants born between 28 and 36 weeks for tocolytic agents, gestational age, sex, antenatal corticosteroid, fetal growth restriction, pathological chorioamnionitis, low umbilical arterial pH values (<7.1), multiple pregnancy, mode of delivery and institutions after excluding clinical chorioamnionitis, non‐reassuring fetal status or major anomalies. Tocolytic agents were categorized into four groups: no‐tocolysis, magnesium sulfate, beta‐2 adrenergic agonists and the combination of them. We conducted multiple comparisons with multivariate analyses using generalized linear regression models to compare the prevalence of a poor perinatal outcome defined as infant's death, brain damage, particularly cerebral palsy and developmental delay. Results: Among 1083 infants, 39% were no‐tocolysis, 47% were magnesium sulfate, 41% were beta‐2 adrenergic agonists and 27% were combination group, including the duplication. The incidence of poor perinatal outcome was decreased by magnesium sulfate (OR 0.27, 95% CI 0.10–0.72), but not changed significantly by beta‐2 adrenergic agonists (OR 1.28, 95% CI 0.63–2.59) or the combination group (OR 2.24, 95% CI 0.67–7.54), compared with the no‐tocolysis. Conclusion: The combination therapy for tocolysis with beta‐2 adrenergic agonists diminished the magnesium sulfate neuroprotective action after adjusting for covariables. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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3. Risk factors associated with the development of postpartum diabetes in Japanese women with gestational diabetes.
- Author
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Kugishima, Yukari, Yasuhi, Ichiro, Yamashita, Hiroshi, Sugimi, So, Umezaki, Yasushi, Suga, Sachie, Fukuda, Masashi, and Kusuda, Nobuko
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GESTATIONAL diabetes ,JAPANESE women ,TYPE 2 diabetes ,GLUCOSE tolerance tests ,PREGNANCY ,DISEASE risk factors - Abstract
Background: Although the onset of gestational diabetes (GDM) is known to be a significant risk factor for the future development of type 2 diabetes, this risk specifically in women with GDM diagnosed by the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria has not yet been thoroughly investigated. This study was performed to investigate the risk factors associated with the development of postpartum diabetes in Japanese women with a history of GDM, and the effects of the differences in the previous Japanese criteria and the IADPSG criteria.Methods: This retrospective cohort study included Japanese women with GDM who underwent at least one postpartum oral glucose tolerance test (OGTT) between 2003 and 2014. Cases with overt diabetes in pregnancy were excluded. We investigated the risk factors including maternal baseline and pregnancy characteristics associated with the development of postpartum diabetes.Results: Among 354 women diagnosed with GDM during the study period, 306 (86%) (116/136 [85.3%] and 190/218 [87.2%] under the previous criteria and the IADPSG criteria, respectively) who underwent at least 1 follow-up OGTT were included in the study. Thirty-two women (10.1%) developed diabetes within a median follow-up period of 57 weeks (range, 6-292 weeks). Eleven (9.5%) and 21 (11.1%) were diagnosed as GDM during pregnancy based on the previous Japanese criteria and the IADPSG criteria, respectively, which did not significantly differ between those criteria. A multivariate logistic regression analysis revealed that HbA1c and 2-h plasma glucose (PG) at the time of the diagnostic OGTT during pregnancy were independent predictors of the development of diabetes after adjusting for confounders. The adjusted relative risk of HbA1c ≥5.6% for the development of diabetes was 4.67 (95% confidence interval, 1.53-16.73), while that of 2-h PG ≥183 mg/dl was 7.02 (2.51-20.72).Conclusions: A modest elevation of the HbA1c and 2-h PG values at the time of the diagnosis of GDM during pregnancy are independent predictors of the development of diabetes during the postpartum period in Japanese women with a history of GDM. The diagnostic criteria did not affect the incidence of postpartum diabetes. [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. Influence of the interval between antenatal corticosteroid therapy and delivery on respiratory distress syndrome.
- Author
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Yasuhi, Ichiro, Myoga, Mai, Suga, Sachie, Sugimi, So, Umezaki, Yasushi, Fukuda, Masashi, Yamashita, Hiroshi, and Kusuda, Nobuko
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DRUG side effects ,CORTICOSTEROIDS ,CONFIDENCE intervals ,FETAL diseases ,HYPERTENSION in pregnancy ,PREMATURE infants ,PLACENTA praevia ,PREGNANCY complications ,RESPIRATORY distress syndrome ,STEROIDS ,RETROSPECTIVE studies ,ODDS ratio ,CHILDREN ,PREGNANCY - Abstract
Aim In spite of the recommendation for rescue antenatal corticosteroids (ACS), the optimal time interval between primary and rescue courses has not been clearly demonstrated. The aim of this study was to determine the effects of the interval between a single ACS course and delivery on the incidence of respiratory distress syndrome (RDS). Methods In this retrospective study, we included singleton pregnant women who received a single course of ACS and delivered beyond 48 h after ACS administration between 24 and 33 weeks' gestation. The risk of RDS was compared between patients who delivered within seven days (Group I), 7-14 days (Group II) and beyond 14 days (Group III) after ACS administration. Results We included 83, 14 and 20 patients in Groups I, II and III, respectively. After adjusting for confounders, the ACS delivery interval was significantly associated with RDS in Group II (adjusted odds ratio 12.8, 95% confidence interval 1.31-164.7) and Group III (adjusted odds ratio 64.0, 95% confidence interval 1.32-5808.6). Conclusion A longer ACS delivery interval is associated with a higher risk of RDS. Thus, the use of a rescue course could be expected to reduce the incidence of RDS in patients beyond seven days after ACS administration who remain at risk for preterm delivery within seven days, especially in cases of placenta previa and/or women bearing a male fetus. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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