Author: "Hesselink, J" / Topic: pregnancy - Searchworks@Jio Institute Digital Library Search Results

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1. Pregnancy in Adult Congenital Heart Disease

Author: Roos-Hesselink, J. W., Ruys, P. T. E., and Johnson, M. R.
Published: 2013
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2. Pregnant Women With Uncorrected Congenital Heart Disease Heart Failure and Mortality

Author: Sliwa, K, Baris, L, Sinning, C, Zengin-Sahm, E, Gumbiene, L, Yaseen, IF, Youssef, G, Johnson, M, Al-Farhan, H, Lelonek, M, Hall, R, Roos-Hesselink, J, and Cardiology
Subjects: OUTCOMES, Science & Technology, Cardiac & Cardiovascular Systems, SURGERY, emerging country, UNNATURAL HISTORY, EUROPEAN-SOCIETY, Eisenmenger, WORLDWIDE, REGISTRY, pulmonary hypertension, Cardiovascular System & Cardiology, CARDIAC-DISEASE, ESC GUIDELINES, pregnancy, peripartum, Life Sciences & Biomedicine, 1102 Cardiorespiratory Medicine and Haematology
Abstract: Objectives The purpose of this work was to study maternal and fetal outcomes of women with uncorrected congenital heart disease (CHD). Background Globally, CHD is an important cause of maternal morbidity and mortality in women reaching reproductive stage. Data are lacking from larger cohorts of women with uncorrected CHD. Methods The 10-year data from the European Society of Cardiology EORP ROPAC (EURObservational Research Programme Registry of Pregnancy and Cardiac disease) registry of women with uncorrected CHD were analyzed. Results Of 5,739 pregnancies in 53 countries, 3,295 women had CHD, 1,059 of which were uncorrected cases. Of these, 41.4% were from emerging countries. There were marked differences between the cardiac defects in uncorrected cases versus those in corrected CHD cases with primary shunt lesions (44.7% vs. 32.4%, respectively), valvular abnormalities (33.5% vs. 12.6%, respectively), and Tetralogy of Fallot and pulmonary atresia (0.8% vs. 20.3%, respectively; p < 0.001). In patients with uncorrected CHD, 6.8% were in modified World Health Organization risk class IV, approximately 10% had pulmonary hypertension (PH), and 3% were cyanotic prior to pregnancy. Maternal mortality and heart failure (HF) in the women with uncorrected CHD were 0.7% and 8.7%, respectively. Eisenmenger syndrome was associated with a very high risk of cardiac events (65.5%), maternal mortality (10.3%), and HF (48.3%). Coming from an emerging country was associated with higher pre-pregnancy signs of HF, PH, and cyanosis (p < 0.001) and worse maternal and fetal outcomes, with a 3-fold higher rate of hospital admissions for cardiac events and intrauterine growth retardation (p < 0.001). Conclusions Marked differences between cardiac conditions in pregnant women with uncorrected CHD and those in corrected CHD were found, with a markedly worse outcome, particularly in women with Eisenmenger syndrome and from emerging countries.
Published: 2020

3. Influence of socioeconomic factors on pregnancy outcome in women with structural heart disease

Author: Van Hagen I. M., Baart S., Fong Soe Khioe R., Sliwa-Hahnle K., Taha N., Lelonek M., Tavazzi L., Maggioni A. P., Johnson M. R., Maniadakis N., Fordham R., Hall R., Roos-Hesselink J. W., Ferrari R., Marelli A., Webb G., Kaemmerer H., Popelova J., Sliwa K., Parsonage W. A., Stein J., Elkayam U., Thilen U., Budts W., Ruys T., Vardas P., Komajda M., Pinto F., Alonso A., Wood D., Ferreira T., Gracia G., Laroche C., Missiamenou V., Taylor C., Konte M., Andarala M., Fiorucci E., Lefrancq E. F., Glemot M., McNeill P-A., Pommier C., Lafay M., Aquieri A., Vega H. R., Blanco M. V., Lust K., Fagermo N., Gabriel H., Donhauser E., Gasimov Z., Jahangirov T., Hasanova I., De Backer J., Demulier L., de Hosson M., Beckx M., Moissens M., Kovacevic-Preradovic T., Kozic M., Lovric M., Freire C. V., Chilingirova N., Kratunkov P., Montesclaros A. R., Beaubien E., Gordon E., Walter L., Lindsay C., Wahab N., Vavera Z., El Nagar A., Ebaid H. H., El Sayed Makled W. A., Dardier A., Shabaan M., Elrakshy Y., Eltamawey K., Abd-El Aziz M. G., Saad A., Aboleineen W., Ashour Z., Sorour K., Mahdy M. A. M., Iserin L., Ladouceur M., Cohen S., Iung B., Maisuradze D., Mebus S., Gembruch U., Hammerstingl C., Merz W. M., Wald C., Baumgartner H., Orwat S., Schmidt R., Motz R., Olsson A., Berger F., Nagdyman N., Frogoudaki A., Anastasiou-Nana M., Temesvari A., Kohalmi D., Balint H., Merkely B., Liptai C., Bowen M., Cullen M., Thornton P., Husarova V., Blatt A., Elbaz-Greener G., Moravsky G., Vered Z., Fuhrmann A. V., Shotan A., Goland S., Festa P., Ali L. A., Sinagra G., Puggia I., Mottolese B. D., Carmina M. G., Romeo C., Crepaz R., Fesslova V., Azzarelli A., Baldi D., Bovenzi F., Donvito V., Vasario E., Todros T., Niwa K., Mussagaliyeva A., Mekebekova D., Sharipova S., Zaliunas R., Jonkaitiene R., Petrauskaite J., Gumbiene L., Jovanova S., Cassar A., Caruana M., Karamermer Y., Cornette J. M. J., van Dijk A., Bellersen L., Duijnhouwer T., De Groot C., Pieper E. P. G., van Oppen C., Polak P., Wajon E., Wagenaar L., Estensen M., Lesniak-Sobelga A., Podolec P., Wisniowska-Smialek S., Trybuch A., Hoffman P., Cichocka-Radwan A., Sobczak S., Faflik U., Tomaszuk-Kazberuk A., Przepiesc J., Gil M., Plaskota K., Trojnarska O., Guerra N., de Sousa L., Petrescu V., Ginghina C., Jurcut R., Coman I. M., Gaisin I. R., Shilina L. V., Sharashkina N., Tkacheva O., Ivanov D., Irtyuga O., Jovovic L., Prokselj K., Kozelj M., Elliott C., Galian-Gay L., Pijuan-Domenech A., Subirana-Domenech M. T., Tornos P., Murga N., Oliver J. M., Escribano-Subias P., Ruiz-Cano M. J., Delgado-Jimenez J., Furenas E., Dellborg M., Schwerzmann M., Bouchardy J., Rutz T., Tobler D., Sarac L., Esen O. B., Enar S. C., Al Mulla A., Bazargani N., Al Hatou E., Farook F., Almahmeed W., Salih B., Clifford P., Bowers N., Veldtman G., Kerr J., Tellett L., Hudsmith L., Thompson P., Thorne S., Bowater S., Nihoyannopoulos P., Curry R., Freeman L., Schroeder F., Wendler R., Hammond S., Talluto C., Murphy D., Perlroth M. G., Chintala K., Gupta P., Pare E., Khatri N., Scott N., De Faria-Yeh D., Bhatt A. B., Tsiaras S., Gurvitz M., Otto C., Botti J., Ting J., Davidson W. R., Cardiology, Van Hagen, I. M., Baart, S., Fong Soe Khioe, R., Sliwa-Hahnle, K., Taha, N., Lelonek, M., Tavazzi, L., Maggioni, A. P., Johnson, M. R., Maniadakis, N., Fordham, R., Hall, R., Roos-Hesselink, J. W., Ferrari, R., Marelli, A., Webb, G., Kaemmerer, H., Popelova, J., Sliwa, K., Parsonage, W. A., Stein, J., Elkayam, U., Thilen, U., Budts, W., Ruys, T., Vardas, P., Komajda, M., Pinto, F., Alonso, A., Wood, D., Ferreira, T., Gracia, G., Laroche, C., Missiamenou, V., Taylor, C., Konte, M., Andarala, M., Fiorucci, E., Lefrancq, E. F., Glemot, M., Mcneill, P-A., Pommier, C., Lafay, M., Aquieri, A., Vega, H. R., Blanco, M. V., Lust, K., Fagermo, N., Gabriel, H., Donhauser, E., Gasimov, Z., Jahangirov, T., Hasanova, I., De Backer, J., Demulier, L., de Hosson, M., Beckx, M., Moissens, M., Kovacevic-Preradovic, T., Kozic, M., Lovric, M., Freire, C. V., Chilingirova, N., Kratunkov, P., Montesclaros, A. R., Beaubien, E., Gordon, E., Walter, L., Lindsay, C., Wahab, N., Vavera, Z., El Nagar, A., Ebaid, H. H., El Sayed Makled, W. A., Dardier, A., Shabaan, M., Elrakshy, Y., Eltamawey, K., Abd-El Aziz, M. G., Saad, A., Aboleineen, W., Ashour, Z., Sorour, K., Mahdy, M. A. M., Iserin, L., Ladouceur, M., Cohen, S., Iung, B., Maisuradze, D., Mebus, S., Gembruch, U., Hammerstingl, C., Merz, W. M., Wald, C., Baumgartner, H., Orwat, S., Schmidt, R., Motz, R., Olsson, A., Berger, F., Nagdyman, N., Frogoudaki, A., Anastasiou-Nana, M., Temesvari, A., Kohalmi, D., Balint, H., Merkely, B., Liptai, C., Bowen, M., Cullen, M., Thornton, P., Husarova, V., Blatt, A., Elbaz-Greener, G., Moravsky, G., Vered, Z., Fuhrmann, A. V., Shotan, A., Goland, S., Festa, P., Ali, L. A., Sinagra, G., Puggia, I., Mottolese, B. D., Carmina, M. G., Romeo, C., Crepaz, R., Fesslova, V., Azzarelli, A., Baldi, D., Bovenzi, F., Donvito, V., Vasario, E., Todros, T., Niwa, K., Mussagaliyeva, A., Mekebekova, D., Sharipova, S., Zaliunas, R., Jonkaitiene, R., Petrauskaite, J., Gumbiene, L., Jovanova, S., Cassar, A., Caruana, M., Karamermer, Y., Cornette, J. M. J., van Dijk, A., Bellersen, L., Duijnhouwer, T., De Groot, C., Pieper, E. P. G., van Oppen, C., Polak, P., Wajon, E., Wagenaar, L., Estensen, M., Lesniak-Sobelga, A., Podolec, P., Wisniowska-Smialek, S., Trybuch, A., Hoffman, P., Cichocka-Radwan, A., Sobczak, S., Faflik, U., Tomaszuk-Kazberuk, A., Przepiesc, J., Gil, M., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Petrescu, V., Ginghina, C., Jurcut, R., Coman, I. M., Gaisin, I. R., Shilina, L. V., Sharashkina, N., Tkacheva, O., Ivanov, D., Irtyuga, O., Jovovic, L., Prokselj, K., Kozelj, M., Elliott, C., Galian-Gay, L., Pijuan-Domenech, A., Subirana-Domenech, M. T., Tornos, P., Murga, N., Oliver, J. M., Escribano-Subias, P., Ruiz-Cano, M. J., Delgado-Jimenez, J., Furenas, E., Dellborg, M., Schwerzmann, M., Bouchardy, J., Rutz, T., Tobler, D., Sarac, L., Esen, O. B., Enar, S. C., Al Mulla, A., Bazargani, N., Al Hatou, E., Farook, F., Almahmeed, W., Salih, B., Clifford, P., Bowers, N., Veldtman, G., Kerr, J., Tellett, L., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Nihoyannopoulos, P., Curry, R., Freeman, L., Schroeder, F., Wendler, R., Hammond, S., Talluto, C., Murphy, D., Perlroth, M. G., Chintala, K., Gupta, P., Pare, E., Khatri, N., Scott, N., De Faria-Yeh, D., Bhatt, A. B., Tsiaras, S., Gurvitz, M., Otto, C., Botti, J., Ting, J., and Davidson, W. R.
Subjects: Registrie, Pediatrics, Cardiac & Cardiovascular Systems, Heart disease, global health, heart failure, Disease, 030204 cardiovascular system & hematology, Cardiovascular, 0302 clinical medicine, Pregnancy, Residence Characteristics, Prospective Studies, Registries, PREDICTORS, 1102 Cardiorespiratory Medicine and Haematology, CARDIOLOGY, 030219 obstetrics & reproductive medicine, valvular heart disease, Pregnancy Outcome, SOUTH-AFRICA, congenital heart disease, pregnancy, Adult, Analysis of Variance, Female, Global Health, Heart Diseases, Humans, Maternal Age, Pregnancy Complications, Cardiovascular, Socioeconomic Factors, EUROPEAN-SOCIETY, Heart Disease, CARDIOVASCULAR-DISEASE, RISK-ASSESSMENT, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Human, Acute coronary syndrome, medicine.medical_specialty, ROPAC investigators, Birth rate, 03 medical and health sciences, medicine, CARDIAC-DISEASE, MATERNAL OUTCOMES, Socioeconomic status, Science & Technology, business.industry, INCOME INEQUALITY, medicine.disease, Pregnancy Complications, Prospective Studie, Cardiovascular System & Hematology, Residence Characteristic, Heart failure, REGISTRY, Cardiovascular System & Cardiology, business
Abstract: ObjectiveCardiac disease is the leading cause of indirect maternal mortality. The aim of this study was to analyse to what extent socioeconomic factors influence the outcome of pregnancy in women with heart disease.MethodsThe Registry of Pregnancy and Cardiac disease is a global prospective registry. For this analysis, countries that enrolled ≥10 patients were included. A combined cardiac endpoint included maternal cardiac death, arrhythmia requiring treatment, heart failure, thromboembolic event, aortic dissection, endocarditis, acute coronary syndrome, hospitalisation for cardiac reason or intervention. Associations between patient characteristics, country characteristics (income inequality expressed as Gini coefficient, health expenditure, schooling, gross domestic product, birth rate and hospital beds) and cardiac endpoints were checked in a three-level model (patient–centre–country).ResultsA total of 30 countries enrolled 2924 patients from 89 centres. At least one endpoint occurred in 645 women (22.1%). Maternal age, New York Heart Association classification and modified WHO risk classification were associated with the combined endpoint and explained 37% of variance in outcome. Gini coefficient and country-specific birth rate explained an additional 4%. There were large differences between the individual countries, but the need for multilevel modelling to account for these differences disappeared after adjustment for patient characteristics, Gini and country-specific birth rate.ConclusionWhile there are definite interregional differences in pregnancy outcome in women with cardiac disease, these differences seem to be mainly driven by individual patient characteristics. Adjustment for country characteristics refined the results to a limited extent, but maternal condition seems to be the main determinant of outcome.
Published: 2018

4. Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease Results From the Registry of Pregnancy and Cardiac Disease

Author: Van Hagen I. M., Thorne S. A., Taha N., Youssef G., Elnagar A., Gabriel H., ElRakshy Y., Iung B., Johnson M. R., Hall R., Roos-Hesselink J. W., Ferrari R., Maggioni A. P., Marelli A., Webb G., Kaemmerer H., Popelova J., Sliwa K., Tavazzi L., Anthony Parsonage W., Stein J., Elkayam U., Thilen U., Budts W., Ruys T., Ferreira T., Missiamenou V., Folkesson Lefrancq E., Aquieri A., Ruda Vega H., Vazquez Blanco M., Lust K., Fagermo N., Donhauser E., Gasimov Z., Jahangirov T., Hasanova I., De Backer J., Demulier L., de Hosson M., Beckx M., Moissens M., Kovacevic-Preradovic T., Kozic M., Lovric M., Vilas Freire C., Chilingirova N., Kratunkov P., Montesclaros A. R., Beaubien E., Gordon E., Walter L., Lindsay C., Wahab N., Vavera Z., El Nagar A., Ebaid H. H., A. El Sayed Makled W., Dardier A., Shabaan M., Eltamawey K., Gamal Abd-El Aziz M., Saad A., Aboleineen W., Ashour Z., Sorour K., A. Meguid Mahdy M., Iserin L., Ladouceur M., Cohen S., Maisuradze D., Mebus S., Gembruch U., Hammerstingl C., Merz W. M., Wald C., Hellige A., Baumgartner H., Schmidt R., Motz R., Olsson A., Berger F., Nagdyman N., Frogoudaki A., Anastasiou-Nana M., Temesvari A., Kohalmi D., Balint H., Merkely B., Liptai C., Bowen M., Cullen M., Thornton P., Husarova V., Blatt A., Elbaz-Greener G., Moravsky G., Vered Z., Vazan Fuhrmann A., Shotan A., Goland S., Festa P., Ait Ali L., Sinagra G., Puggia I., D'Agata Mottolese B., Carmina M. G., Romeo C., Crepaz R., Fesslova V., Azzarelli A., Baldi D., Bovenzi F., Donvito V., Vasario E., Todros T., Niwa K., Mussagaliyeva A., Mekebekova D., Sharipova S., Zaliunas R., Jonkaitiene R., Petrauskaite J., Gumbiene L., Jovanova S., Cassar A., Caruana M., Karamermer Y., Cornette J. M. J., van Dijk A., Bellersen L., Duijnhouwer T., De Groot C., PG Pieper E., van Oppen C., Polak P., Wajon E., Wagenaar L., Estensen M., Lesniak-Sobelga A., Podolec P., Wisniowska-Smialek S., Trybuch A., Hoffman P., Cichocka-Radwan A., Lelonek M., Sobczak S., Faflik U., Tomaszuk-Kazberuk A., Przepiesc J., Gil M., Plaskota K., Trojnarska O., Guerra N., de Sousa L., Petrescu V., Ginghina C., Jurcut R., Mircea Coman I., Ravilevich Gaisin I., Valeryevna Shilina L., Sharashkina N., Tkacheva O., Ivanov D., Irtyuga O., Jovovic L., Prokselj K., Kozelj M., Elliott C., Galian-Gay L., Pijuan-Domenech A., Subirana-Domenech M. T., Tornos P., Murga N., M. Oliver J., Escribano-Subias P., J. Ruiz-Cano M., Delgado-Jimenez J., Furenas E., Dellborg M., Schwerzmann M., Bouchardy J., Rutz T., Tobler D., Sarac L., Batukan Esen O., Catirli Enar S., Al Mulla A., Bazargani N., Al Hatou E., Farook F., Almahmeed W., Cardiology, Van Hagen, I. M., Thorne, S. A., Taha, N., Youssef, G., Elnagar, A., Gabriel, H., Elrakshy, Y., Iung, B., Johnson, M. R., Hall, R., Roos-Hesselink, J. W., Ferrari, R., Maggioni, A. P., Marelli, A., Webb, G., Kaemmerer, H., Popelova, J., Sliwa, K., Tavazzi, L., Anthony Parsonage, W., Stein, J., Elkayam, U., Thilen, U., Budts, W., Ruys, T., Ferreira, T., Missiamenou, V., Folkesson Lefrancq, E., Aquieri, A., Ruda Vega, H., Vazquez Blanco, M., Lust, K., Fagermo, N., Donhauser, E., Gasimov, Z., Jahangirov, T., Hasanova, I., De Backer, J., Demulier, L., de Hosson, M., Beckx, M., Moissens, M., Kovacevic-Preradovic, T., Kozic, M., Lovric, M., Vilas Freire, C., Chilingirova, N., Kratunkov, P., Montesclaros, A. R., Beaubien, E., Gordon, E., Walter, L., Lindsay, C., Wahab, N., Vavera, Z., El Nagar, A., Ebaid, H. H., A. El Sayed Makled, W., Dardier, A., Shabaan, M., Eltamawey, K., Gamal Abd-El Aziz, M., Saad, A., Aboleineen, W., Ashour, Z., Sorour, K., A. Meguid Mahdy, M., Iserin, L., Ladouceur, M., Cohen, S., Maisuradze, D., Mebus, S., Gembruch, U., Hammerstingl, C., Merz, W. M., Wald, C., Hellige, A., Baumgartner, H., Schmidt, R., Motz, R., Olsson, A., Berger, F., Nagdyman, N., Frogoudaki, A., Anastasiou-Nana, M., Temesvari, A., Kohalmi, D., Balint, H., Merkely, B., Liptai, C., Bowen, M., Cullen, M., Thornton, P., Husarova, V., Blatt, A., Elbaz-Greener, G., Moravsky, G., Vered, Z., Vazan Fuhrmann, A., Shotan, A., Goland, S., Festa, P., Ait Ali, L., Sinagra, G., Puggia, I., D'Agata Mottolese, B., Carmina, M. G., Romeo, C., Crepaz, R., Fesslova, V., Azzarelli, A., Baldi, D., Bovenzi, F., Donvito, V., Vasario, E., Todros, T., Niwa, K., Mussagaliyeva, A., Mekebekova, D., Sharipova, S., Zaliunas, R., Jonkaitiene, R., Petrauskaite, J., Gumbiene, L., Jovanova, S., Cassar, A., Caruana, M., Karamermer, Y., Cornette, J. M. J., van Dijk, A., Bellersen, L., Duijnhouwer, T., De Groot, C., PG Pieper, E., van Oppen, C., Polak, P., Wajon, E., Wagenaar, L., Estensen, M., Lesniak-Sobelga, A., Podolec, P., Wisniowska-Smialek, S., Trybuch, A., Hoffman, P., Cichocka-Radwan, A., Lelonek, M., Sobczak, S., Faflik, U., Tomaszuk-Kazberuk, A., Przepiesc, J., Gil, M., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Petrescu, V., Ginghina, C., Jurcut, R., Mircea Coman, I., Ravilevich Gaisin, I., Valeryevna Shilina, L., Sharashkina, N., Tkacheva, O., Ivanov, D., Irtyuga, O., Jovovic, L., Prokselj, K., Kozelj, M., Elliott, C., Galian-Gay, L., Pijuan-Domenech, A., Subirana-Domenech, M. T., Tornos, P., Murga, N., M. Oliver, J., Escribano-Subias, P., J. Ruiz-Cano, M., Delgado-Jimenez, J., Furenas, E., Dellborg, M., Schwerzmann, M., Bouchardy, J., Rutz, T., Tobler, D., Sarac, L., Batukan Esen, O., Catirli Enar, S., Al Mulla, A., Bazargani, N., Al Hatou, E., Farook, F., and Almahmeed, W.
Subjects: Registrie, Cardiac & Cardiovascular Systems, VALVULAR HEART-DISEASE, heart disease, Disease, 030204 cardiovascular system & hematology, Cardiovascular, 0302 clinical medicine, Pregnancy, Models, Mitral valve, Rheumatic heart disease, Valvular heart disease, Women, Women and minorities, Adult, Female, Humans, Prospective Studies, Mitral Valve Insufficiency, Models, Cardiovascular, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Registries, Rheumatic Heart Disease, Prospective cohort study, 1102 Cardiorespiratory Medicine and Haematology, 030219 obstetrics & reproductive medicine, valvular heart disease, ROPAC Investigators and EORP Team, SOUTH-AFRICA, EUROPEAN-SOCIETY, OUTPUT, medicine.anatomical_structure, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Women and minoritie, Human, medicine.medical_specialty, DEATHS, STENOSIS, 1117 Public Health and Health Services, 03 medical and health sciences, Physiology (medical), Internal medicine, MANAGEMENT, medicine, Pregnancy outcomes, Science & Technology, business.industry, 1103 Clinical Sciences, medicine.disease, Pregnancy Complications, Prospective Studie, Stenosis, Peripheral Vascular Disease, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, rheumatic, business
Abstract: Background: Cardiac disease is 1 of the major causes of maternal mortality. We studied pregnancy outcomes in women with rheumatic mitral valve disease. Methods: The Registry of Pregnancy and Cardiac Disease is an international prospective registry, and consecutive pregnant women with cardiac disease were included. Pregnancy outcomes in all women with rheumatic mitral valve disease and no prepregnancy valve replacement is described in the present study (n=390). A maternal cardiac event was defined as cardiac death, arrhythmia requiring treatment, heart failure, thromboembolic event, aortic dissection, endocarditis, acute coronary syndrome, and hospitalization for other cardiac reasons or cardiac intervention. Associations between patient characteristics and cardiac outcomes were checked in a 3-level model (patient–center–country). Results: Most patients came from emerging countries (75%). Mitral stenosis (MS) with or without mitral regurgitation (MR) was present in 273 women, isolated MR in 117. The degree of MS was mild in 20.9%, moderate in 39.2%, severe in 19.8%, and severity not classified in the remainder. Maternal death during pregnancy occurred in 1 patient with severe MS. Hospital admission occurred in 23.1% of the women with MS, and the main reason was heart failure (mild MS 15.8%, moderate 23.4%, severe 48.1%; P 1 was an independent predictor of maternal cardiac events. Follow-up at 6 months postpartum was available for 53%, and 3 more patients died (1 with severe MS, 1 with moderate MS, 1 with moderate to severe MR). Conclusions: Although mortality was only 1.9% during pregnancy, ≈50% of the patients with severe rheumatic MS and 23% of those with significant MR developed heart failure during pregnancy. Prepregnancy counseling and considering mitral valve interventions in selected patients are important to prevent these complications.
Published: 2018

5. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)

Author: Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Tornos Mas, P, Vilacosta, I, Zamorano, Jl, Document, Reviewers., Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, Dm, Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, Document Reviewers., Erol Ç, Nihoyannopoulos P, Aboyans V, Agewall S, Athanassopoulos G, Aytekin S, Benzer W, Bueno H, Broekhuizen L, Carerj S, Cosyns B, De Backer J, De Bonis M, Dimopoulos K, Donal E, Drexel H, Flachskampf FA, Hall R, Halvorsen S, Hoen B, Kirchhof P, Lainscak M, Leite-Moreira AF, Lip GY, Mestres CA, Piepoli MF, Punjabi PP, Rapezzi C, Rosenhek R, Siebens K, Tamargo J, Walker DM, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska gosciniak, E, Price, S, Roos hesselink, J, Snygg martin, U, Thuny, F, Mas, Pt, Vilacosta, I, Zamorano, Jl, Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, DE BONIS, Michele, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, Dm
Subjects: Microbiological Techniques, Heart disease, Embolism, Heart Valve Diseases, Cardiac device, Cardiac imaging, Cardiac surgery, Congenital heart disease, Echocardiography, Endocarditis, Guidelines, Infection, Nuclear imaging, Pregnancy, Prevention, Prognosis, Prophylaxis, Prosthetic heart valves, Valve disease, Guideline, Arrhythmias, Cardiovascular, Congenital, Postoperative Complications, Recurrence, Risk Factors, Neoplasms, Ambulatory Care, Non-Infective, Pericarditis, Endocarditi, Musculoskeletal Diseases, Prophylaxi, Heart Defects, Cross Infection, Acute Kidney Injury, Operative, Anti-Bacterial Agents, Myocarditis, Prosthetic heart valve, Endocarditis, Non-Infective, Infective endocarditis, Cardiology, Female, Cardiology and Cardiovascular Medicine, Infected, Cardiac, Heart Defects, Congenital, Diagnostic Imaging, medicine.medical_specialty, Prosthesis-Related Infections, Critical Care, Prognosi, Pregnancy Complications, Cardiovascular, Risk Assessment, NO, Aneurysm, Infected, Antibiotic Prophylaxis, Arrhythmias, Cardiac, Clinical Laboratory Techniques, Dentistry, Operative, Fibrinolytic Agents, Heart Failure, Humans, Long-Term Care, Nervous System Diseases, Patient Care Team, Splenic Diseases, Thoracic Surgical Procedures, Internal medicine, medicine, business.industry, medicine.disease, Aneurysm, Pregnancy Complications, Heart failure, Dentistry, business, Fibrinolytic agent
Abstract: none 53 si The disclosure forms of all experts involved in the development of these guidelines are available on the ESC website http://www.escardio.org/guidelines. Representing the European Association of Nuclear Medicine (EANM); Representing the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); and Representing the European Association for Cardio-Thoracic Surgery (EACTS). Guidelines for the management of infective endocarditis Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM
Published: 2015

6. Validation of maternal cardiac output assessed by transthoracic echocardiography against pulmonary artery catheterization in severely ill pregnant women: prospective comparative study and systematic review.

Author: Cornette, J., Laker, S., Jeffery, B., Lombaard, H., Alberts, A., Rizopoulos, D., Roos‐Hesselink, J. W., Pattinson, R. C., and Roos-Hesselink, J W
Subjects: PREGNANCY complications, HEMODYNAMIC monitoring, CARDIAC output, PULMONARY artery -- Catheterization, ECHOCARDIOGRAPHY, HEMODYNAMICS, LONGITUDINAL method, META-analysis, SYSTEMATIC reviews, SWAN-Ganz catheterization
Abstract: Objective: Most severe pregnancy complications are characterized by profound hemodynamic disturbances, thus there is a need for validated hemodynamic monitoring systems for pregnant women. Pulmonary artery catheterization (PAC) using thermodilution is the clinical gold standard for the measurement of cardiac output (CO), however this reference method is rarely performed owing to its invasive nature. Transthoracic echocardiography (TTE) allows non-invasive determination of CO. We aimed to validate TTE against PAC for the determination of CO in severely ill pregnant women.Methods: This study consisted of a meta-analysis combining data from a prospective study and a systematic review. The prospective arm was conducted in Pretoria, South Africa, in 2003. Women with severe pregnancy complications requiring invasive monitoring with PAC according to contemporary guidelines were included. TTE was performed within 15 min of PAC and the investigator was blinded to the PAC measurements. Comparative measurements were extracted from similar studies retrieved from a systematic review of the literature and added to a database. Simultaneous CO measurements by TTE and PAC were compared. Agreement between methods was assessed using Bland-Altman statistics and intraclass correlation coefficients (ICC).Results: Thirty-four comparative measurements were included in the meta-analysis. Mean CO values obtained by PAC and TTE were 7.39 L/min and 7.18 L/min, respectively. The bias was 0.21 L/min with lower and upper limits of agreement of -1.18 L/min and 1.60 L/min, percentage error was 19.1%, and ICC between the two methods was 0.94.Conclusions: CO measurements by TTE show excellent agreement with those obtained by PAC in pregnant women. Given its non-invasive nature and availability, TTE could be considered as a reference for the validation of other CO techniques in pregnant women. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.Resumen Objetivo: Las complicaciones del embarazo más graves se caracterizan por trastornos hemodinámicos serios, debido a los cuales existe la necesidad de sistemas validados de monitorización hemodinámica para mujeres embarazadas. Aunque la cateterización de la arteria pulmonar (CAP) mediante termodilución es el patrón de referencia clínico para la medición del gasto cardíaco (GC), este método se usa con poca frecuencia debido a su naturaleza invasiva. La ecocardiografía transtorácica (ETT) permite la determinación no invasiva del GC. El objetivo de este estudio fue validar la ETT frente al CAP para determinar el GC en mujeres embarazadas gravemente enfermas. MÉTODOS: Este estudio consistió en un metaanálisis que combinó datos de un estudio prospectivo y una revisión sistemática. El estudio prospectivo se llevó a cabo en Pretoria (Sudáfrica) en 2003. Se incluyeron mujeres con complicaciones graves en el embarazo que requerían una monitorización invasiva mediante CAP según las directrices de ese momento. Se realizó una ETT en un plazo de 15 minutos de haber realizado el CAP y el investigador no tuvo acceso a las mediciones del CAP. Las mediciones comparativas se extrajeron de estudios similares obtenidos a partir de una revisión sistemática de la literatura y se añadieron a una base de datos. Se compararon las mediciones simultáneas del GC mediante ETT y CAP. La concordancia entre métodos se evaluó a través del método estadístico de Bland-Altman y de coeficientes de correlación intraclase (CCI).Resultados: Se incluyeron treinta y cuatro mediciones comparativas en el metaanálisis. Los valores medios del GC obtenidos mediante CAP y ETT fueron de 7,39 l/min y 7.18 l/min, respectivamente. El sesgo fue de 0,21 l/min, siendo los límites inferior y superior de la concordancia de -1,18 l/min y 1.60 l/min; el error porcentual fue del 19,1%, y el CCI entre ambos métodos fue de 0,94.Conclusiones: Las mediciones del GC en mujeres embarazadas mediante ETT muestran una excelente concordancia con las obtenidas mediante CAP. Dada su naturaleza no invasiva y su disponibilidad, la ETT podría considerarse como referencia para la validación de otras técnicas relacionadas con el GC en mujeres embarazadas. : ,。(pulmonary artery catheterization,PAC)(cardiac output,CO),,。(transthoracic echocardiography,TTE)CO。PACTTECO。 : meta。2003。PAC。PAC 15 minTTE,PAC。,。TTEPACCO。Bland-Altman(intraclass correlation coefficients,ICC)。 : meta34。PACTTECO7.39 L/min7.18 L/min。-1.18 L/min、1.60 L/min0.21 L/min,19.1%,ICC0.94。 : TTECOPACCO。,TTECO。. [ABSTRACT FROM AUTHOR]
Published: 2017
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7. ESC Guidelines on the management of cardiovascular diseases during pregnancy

Author: European Society of Gynecology, Association for European Paediatric Cardiology, German Society for Gender Medicine, Authors/Task Force Members, Regitz Zagrosek V., Blomstrom Lundqvist C., Cifkova R., Ferreira R., Foidart J. M., Gibbs J. S., Gohlke Baerwolf C., Gorenek B., Iung B., Kirby M., Maas A. H., Morais J., Nihoyannopoulos P., Pieper P. G., Presbitero P., Roos Hesselink J. W., Schaufelberger M., Seeland U., Torracca L, ESC Committee for Practice Guidelines, Bax J., Auricchio A., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck Brentano C., Hasdai D., Hoes A., Knuuti J., Kolh P., McDonagh T., Moulin C., Poldermans D., Popescu B. A., Reiner Z., Sechtem U., Sirnes P. A., Torbicki A., Vahanian A., Windecker S., Document Reviewers, Aguiar C., Al Attar N., Garcia A. A., Antoniou A., Coman I., Elkayam U., Gomez Sanchez M. A., Gotcheva N., Hilfiker Kleiner D., Kiss R. G., Kitsiou A., Konings K. T., Lip G. Y., Manolis A., Mebaaza A., Mintale I., Morice M. C., Mulder B. J., Pasquet A., Price S., Priori S. G., Salvador M. J., Shotan A., Silversides C. K., Skouby S. O., Stein J. I., Tornos P., Vejlstrup N., Walker F., Warnes C., BORGHI, CLAUDIO, European Society of Gynecology, Association for European Paediatric Cardiology, German Society for Gender Medicine, Authors/Task Force Members, Regitz-Zagrosek V., Blomstrom Lundqvist C., Borghi C., Cifkova R., Ferreira R., Foidart J.M., Gibbs J.S., Gohlke-Baerwolf C., Gorenek B., Iung B., Kirby M., Maas A.H., Morais J., Nihoyannopoulos P., Pieper P.G., Presbitero P., Roos-Hesselink J.W., Schaufelberger M., Seeland U., Torracca L, ESC Committee for Practice Guidelines, Bax J., Auricchio A., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck-Brentano C., Hasdai D., Hoes A., Knuuti J., Kolh P., McDonagh T., Moulin C., Poldermans D., Popescu B.A., Reiner Z., Sechtem U., Sirnes P.A., Torbicki A., Vahanian A., Windecker S., and Document Reviewers, Baumgartner H., Deaton C., Aguiar C., Al-Attar N., Garcia A.A., Antoniou A., Coman I., Elkayam U., Gomez-Sanchez M.A., Gotcheva N., Hilfiker-Kleiner D., Kiss R.G., Kitsiou A., Konings K.T., Lip G.Y., Manolis A., Mebaaza A., Mintale I., Morice M.C., Mulder B.J., Pasquet A., Price S., Priori S.G., Salvador M.J., Shotan A., Silversides C.K., Skouby S.O., Stein J.I., Tornos P., Vejlstrup N., Walker F., Warnes C.
Subjects: Counseling, Prenatal Diagnosi, Pregnancy Complications, Cardiovascular, Heart failure, Abortion, Induced, Prenatal Care, Venous Thromboembolism, Guideline, Cardiovascular disease, Aortic Disease, Valvular heart disease, Management, Congential heart disease, Heart Disease, Cardiovascular Agent, Pregnancy, Hypertension, Pregnancy Complications, Infectiou, Female, Cardiology and Cardiovascular Medicine, Arrhythmia, Risk assessment, Human
Abstract: not available
Published: 2011

8. Pregnancy in women with hypertrophic cardiomyopathy: data fromthe European Society of Cardiology initiated Registry of Pregnancy and Cardiac disease (ROPAC).

Author: Goland, S., van Hagen, I. M., Elbaz-Greener, G., Elkayam, U., Shotan, A., Merz, W. M., Enar, S. C., Gaisin, I. R., Pieper, P. G., Johnson, M. R., Hall, R., Blatt, A., and Roos-Hesselink, J. W.
Abstract: Aims We report the maternal and foetal outcomes at birth and after 6 months in a cohort of pregnant women with hypertrophic cardiomyopathy (HCM). Although most women with HCM tolerate pregnancy well, there is an increased risk of obstetric and cardiovascular complications. Methods and results All pregnant women with HCM entered into the prospective worldwide Registry of Pregnancy and Cardiac disease (ROPAC) were included in this analysis. The primary endpoint was a major adverse cardiovascular event (MACE), which included death, heart failure (HF), thrombo-embolic event, and arrhythmia. Baseline and outcome data were analysed and compared for patients with MACE vs. without MACE and for patients with obstructive HCM vs. nonobstructive HCM. Sixty pregnant women (mean age 30.4 ± 6.0 years) with HCM (41.7% obstructive) were included. No maternal mortality occurred in this cohort. In 14 (23%) patients at least one MACE occurred: 9 (15.0%) HF and 7 (12%) an arrhythmia (6 ventricular and 1 atrial fibrillation). MACE occurred most commonly during the 3rd trimester and postpartum period. In total, 3 (5.0%) women experienced foetal loss. Women with MACE had a higher rate of emergency Caesarean delivery for cardiac reasons (21.4% vs. 0%, P = 0.01). No significant differences in pregnancy outcome were found between women with obstructive and non-obstructive HCM. NYHA functional class of ≥II and signs of HF before pregnancy, were associated with MACE. Conclusion Although most women with HCM tolerated pregnancy well, cardiovascular complications were not uncommon and predicted by pre-pregnancy status facilitating pre-pregnancy counselling and targeted antenatal care. [ABSTRACT FROM AUTHOR]
Published: 2017
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9. Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot.

Author: Kampman, M. A. M., Siegmund, A. S., Bilardo, C. M., van Veldhuisen, D. J., Balci, A., Oudijk, M. A., Groen, H., Mulder, B. J. M., Roos‐Hesselink, J. W., Sieswerda, G., de Laat, M. W. M., Sollie‐Szarynska, K. M., and Pieper, P. G.
Subjects: PREGNANCY complication risk factors, TETRALOGY of Fallot, HEART disease risk factors, DOPPLER ultrasonography, PLACENTA, ECHOCARDIOGRAPHY, GESTATIONAL age, THERAPEUTICS, ARRHYTHMIA, BIRTH size, LOW birth weight, DOPPLER echocardiography, FETAL ultrasonic imaging, LONGITUDINAL method, EVALUATION of medical care, PREGNANCY, SECOND trimester of pregnancy, THIRD trimester of pregnancy, DISEASE complications
Abstract: Objective: Pregnancy in women with surgically corrected tetralogy of Fallot (ToF) is associated with cardiac, obstetric and neonatal complications. We compared uteroplacental Doppler flow (UDF) measurements and pregnancy outcome in women with ToF and in healthy women and aimed to assess whether a relationship exists between cardiac function and UDF in women with ToF.Methods: We evaluated prospectively pregnant women with ToF and healthy pregnant women from the ZAHARA studies. Clinical evaluation, standardized echocardiography and UDF measurements were performed at 20 and 32 weeks' gestation.Results: We included 62 women with ToF and 69 healthy controls. Cardiac complications, mostly arrhythmia, occurred in 8.1% of women with ToF. There was a higher incidence of small-for-gestational age (21.0% vs 4.4%, P = 0.004) and low birth weight (16.1% vs 2.9%, P = 0.009) in the group of women with ToF than in healthy controls. In women with ToF, early diastolic notching of uterine artery waveform at 20 and 32 weeks occurred more frequently (9.8% vs 1.5%, P = 0.034 and 7.0% vs 0%, P = 0.025, respectively) and the umbilical artery pulsatility index at 32 weeks was higher (1.02 ± 0.20 vs 0.94 ± 0.17, P = 0.015) than in healthy controls. Right ventricular function parameters prepregnancy and at 20 weeks' gestation were significantly associated with abnormal UDF. UDF parameters were associated with adverse neonatal outcome.Conclusion: The majority of women with surgically corrected ToF tolerate pregnancy well. However, UDF indices are more frequently abnormal in these women, suggesting impaired placentation. The association of impaired right ventricular function parameters with abnormal UDF suggests that cardiac dysfunction contributes to defective placentation or placental perfusion mismatch and may explain the increased incidence of obstetric and neonatal complications. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]
Published: 2017
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10. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect.

Author: Yap, S.-C., Drenthen, W., Pieper, P. G., Moons, P., Mulder, B. J. M., Vliegen, H. W., van Dijk, A. P. J., Meijboom, F. J., Jaddoe, V. W. V., Steegers, E. A. P., Boersma, E., and Roos-Hesselink, J. W.
Subjects: VENTRICULAR septal defects, HEART septum abnormalities, PREGNANCY, PREECLAMPSIA
Abstract: Please cite this paper as: Yap S-C, Drenthen W, Pieper P, Moons P, Mulder B, Vliegen H, van Dijk A, Meijboom F, Jaddoe V, Steegers E, Boersma E, Roos-Hesselink J on behalf of the ZAHARA investigators. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect. BJOG 2010; DOI: 10.1111/j.1471-0528.2010.02512.x. Objective To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD). Design A retrospective multicentre study. Setting Tertiary centres in the Netherlands and Belgium. Methods Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy ( n = 147; unrepaired VSD, n = 104; repaired VSD, n = 43) was obtained using medical records and telephone interviews. Data from the Generation R database (prospective cohort study; n = 9667) were used to determine the background risk (controls). Odds ratios and 95% CI were estimated using general estimation equation analysis adjusted for multiple pregnancies per woman, maternal age and parity status. Main outcome measures Adjusted odds ratios (AORs) for developing pregnancy complications in relation to corrective status. Results Pregnancies in women with an unrepaired VSD were associated with a higher risk of pre-eclampsia (AOR 4.59, 95% CI 2.01–10.5, P < 0.001) compared with controls. No differences were observed when comparing women with repaired VSD and controls. Pregnancies in women with repaired VSD were associated with a higher risk of premature labour (AOR 4.02, 95% CI 1.12–14.4, P = 0.03) and small-for-gestational-age (SGA) births (AOR 4.09, 95% CI 1.27–13.2, P = 0.02) compared with women with unrepaired VSD. Conclusions Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD. [ABSTRACT FROM AUTHOR]
Published: 2010
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11. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect.

Author: Yap, S.-C., Drenthen, W., Meijboom, F. J., Moons, P., Mulder, B. J. M., Vliegen, H. W., van Dijk, A. P. J., Jaddoe, V. W. V., Steegers, E. A. P., Roos-Hesselink, J. W., and Pieper, P. G.
Subjects: PREGNANCY complication risk factors, ATRIAL septal defects, CARDIAC surgery, PRENATAL care, RETROSPECTIVE studies, MISCARRIAGE, PREECLAMPSIA, MULTIPLE pregnancy
Abstract: Objective To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design A retrospective multicentre study. Setting Tertiary centres in the Netherlands and Belgium. Population Women with ASD without associated complex cardiac lesions. Methods Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 miscarriages and six terminations of pregnancy. Detailed information on each completed pregnancy ( n = 188; unrepaired ASD, n = 133; repaired ASD, n = 55) was obtained using medical records and telephone interviews. In addition, data from the Generation R database (a prospective cohort study; n = 9667) were used to determine the background risk (control group). Main outcome measures Adjusted odds ratios (AORs) for cardiac, obstetric and neonatal events controlled for multiple pregnancies per woman using general estimating equation analysis. Results Women with an unrepaired ASD had a higher risk of neonatal events (AOR = 2.99, 95% confidence interval [CI] 1.14–7.89, P = 0.027) than women with a repaired ASD. The risk of cardiac and obstetric complications was comparable between women with unrepaired and repaired ASDs. Compared with the general population, women with an unrepaired ASD had higher risks of pre-eclampsia (AOR = 3.54, 95% CI 1.26–9.98, P = 0.017), small-for-gestational-age births (AOR = 1.95, 95% CI 1.15–3.30, P = 0.013) and fetal mortality (AOR = 5.55, 95% CI 1.77–17.4, P = 0.003). By contrast, no differences were observed when comparing women with a repaired ASD versus controls. Conclusions Women with an unrepaired ASD are at increased risk of neonatal events in comparison with women with a repaired ASD. Compared with the general population, women with an unrepaired ASD are at increased risk of pre-eclampsia, small-for-gestational-age births and fetal mortality. [ABSTRACT FROM AUTHOR]
Published: 2009
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12. Pregnancy, fertility, and recurrence risk in corrected tetralogy of Fallot.

Author: Meijer, J. M., Pieper, P. G., Drenthen, W., Voors, A. A., Roos-Hesselink, J. W., van Dijk, A. P. J., Mulder, B. J. M., Ebels, T., and vanVeldhuisen, D. J.
Subjects: PREGNANCY, TETRALOGY of Fallot, FERTILITY, CONGENITAL heart disease, HEART failure, ABORTION
Abstract: Objective: To determine in women with surgically corrected tetralogy of Fallot the risk of pregnancy for mother and fetus, whether fertility was compromised, and the recurrence risk of congenital heart disease. Design: Data were collected from 83 patients through interviews and review of medical records. Results: In 29 patients 63 pregnancies were observed, of which 13 ended in an abortion. Fifty successful pregnancies were observed in 26 patients. During six successful pregnancies (12%) complications (symptomatic right sided heart failure, arrhythmias, or both) occurred. Both patients who developed symptomatic heart failure had severe pulmonary regurgitation. No clear relation between offspring mortality, premature birth or being small for gestational age, and cardiac characteristics of the mother was identified. Fifty seven patients were childless (41 (72%) voluntarily). Recurrence risk for congenital heart disease was 2.2%. Infertility was uncommon. Conclusions: Although complications did occur in five of 26(19%) of the patients with a corrected tetralogy of Fallot, pregnancy was generally well tolerated in this largest report so far. No obvious predictors for maternal events or child outcome were determined, except for a possible relation between severe pulmonary regurgitation and symptomatic heart failure. [ABSTRACT FROM AUTHOR]
Published: 2005
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13. Coronavirus disease 2019 in adults with congenital heart disease

Author: Jolien W. Roos-Hesselink, Adrienne H. Kovacs, Jamil Aboulhosn, G P Diller, Massimo Chessa, Margarita Brida, Markus Schwerzmann, Craig S. Broberg, Michael A. Gatzoulis, Cardiology, Diller, G. -P., Gatzoulis, M. A., Broberg, C. S., Aboulhosn, J., Brida, M., Schwerzmann, M., Chessa, M., Kovacs, A. H., and Roos-Hesselink, J.
Subjects: Adult, Heart Defects, Congenital, Pediatrics, medicine.medical_specialty, Heart disease, Hemodynamics, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, 03 medical and health sciences, Special Article, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Pandemic, Medicine, Humans, AcademicSubjects/MED00200, Adult congenital heart disease, Position paper, 030212 general & internal medicine, 610 Medicine & health, Pandemics, Coronavirus, Pregnancy, business.industry, SARS-CoV-2, Congenital Heart Disease, COVID-19, medicine.disease, Pathophysiology, Cardiovascular Diseases, Corona, business, Cardiology and Cardiovascular Medicine, Psychosocial
Abstract: We are witnessing an unparalleled pandemic caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) associated with coronavirus disease 2019 (COVID-19). Current data show that SARS-CoV-2 results in mild flu-like symptoms in the majority of healthy and young patients affected. Nevertheless, the severity of COVID-19 respiratory syndrome and the risk of adverse or catastrophic outcomes are increased in patients with pre-existing cardiovascular disease. Patients with adult congenital heart disease (ACHD)—by definition—have underlying cardiovascular disease. Many patients with ACHD are also afflicted with residual haemodynamic lesions such as valve dysfunction, diminished ventricular function, arrhythmias or cyanosis, have extracardiac comorbidities, and face additional challenges regarding pregnancy. Currently, there are emerging data of the effect of COVID-19 on ACHD patients, but many aspects, especially risk stratification and treatment considerations, remain unclear. In this article, we aim to discuss the broad impact of COVID-19 on ACHD patients, focusing specifically on pathophysiology, risk stratification for work, self-isolation, hospitalization, impact on pregnancy, psychosocial health, and longer-term implications for the provision of ACHD care.
Published: 2021
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14. Pregnancy Outcomes in Women After Arterial Switch Operation for Transposition of the Great Arteries: Results From ROPAC (Registry of Pregnancy and Cardiac Disease) of the European Society of Cardiology EURObservational Research Programme

Author: Oktay Tutarel, Karishma P. Ramlakhan, Lucia Baris, Maria T. Subirana, Judith Bouchardy, Attila Nemes, Niels G. Vejlstrup, Olga A. Osipova, Mark R. Johnson, Roger Hall, Jolien W. Roos‐Hesselink, Christopher Peter Gale, Branko Beleslin, Andrzej Budaj, Ovidiu Chioncel, Nikolaos Dagres, Nicolas Danchin, David Erlinge, Jonathan Emberson, Michael Glikson, Alastair Gray, Meral Kayikcioglu, Aldo Maggioni, Klaudia Vivien Nagy, Aleksandr Nedoshivin, Anna‐Sonia Petronio, Jolien Roos‐Hesselink, Lars Wallentin, Uwe Zeymer, Joerg Stein, William Anthony Parsonage, Werner Budts, Julie De Backer, Jasmin Grewal, Ariane Marelli, Harald Kaemmerer, Guillaume Jondeau, Mark Johnson, Aldo P. Maggioni, Luigi Tavazzi, Ulf Thilen, Uri Elkayam, Catherine Otto, Karen Sliwa, A. Aquieri, A. Saad, H. Ruda Vega, J. Hojman, J. M. Caparros, M. Vazquez Blanco, M. Arstall, C. M. Chung, G. Mahadavan, E. Aldridge, M. Wittwer, Y. Y. Chow, W. A. Parsonage, K. Lust, N. Collins, G. Warner, R. Hatton, A. Gordon, E. Nyman, J. Stein, E. Donhauser, H. Gabriel, A. Bahshaliyev, F. Guliyev, I. Hasanova, T. Jahangirov, Z. Gasimov, A. Salim, C. M. Ahmed, F. Begum, M. H. Hoque, M. Mahmood, M. N. Islam, P. P. Haque, S. K. Banerjee, T. Parveen, M. Morissens, J. De Backer, L. Demulier, M. de Hosson, W. Budts, M. Beckx, M. Kozic, M. Lovric, T. Kovacevic‐Preradovic, N. Chilingirova, P. Kratunkov, N. Wahab, S. McLean, E. Gordon, L. Walter, A. Marelli, A. R. Montesclaros, G. Monsalve, C. Rodriguez, F. Balthazar, V. Quintero, W. Palacio, L. A. Mejía Cadavid, E. Munoz Ortiz, F. Fortich Hoyos, E. Arevalo Guerrero, J. Gandara Ricardo, J. Velasquez Penagos, Z. Vavera, J. Popelova, N. Vejlstrup, L. Grønbeck, M. Johansen, A. Ersboll, Y. Elrakshy, K. Eltamawy, M. Gamal Abd‐El Aziz, A. El Nagar, H. Ebaid, H. Abo Elenin, M. Saed, S. Farag, W. Makled, K. Sorour, Z. Ashour, G. El‐Sayed, M. Abdel Meguid Mahdy, N. Taha, A. Dardeer, M. Shabaan, M. Ali, P. Moceri, G. Duthoit, M. Gouton, J. Nizard, L. Baris, S. Cohen, M. Ladouceur, D. Khimoud, B. Iung, F. Berger, A. Olsson, U. Gembruch, W. M. Merz, E. Reinert, S. Clade, Y. Kliesch, C. Wald, C. Sinning, R. Kozlik‐Feldmann, S. Blankenberg, E. Zengin‐Sahm, G. Mueller, M. Hillebrand, P. Hauck, Y. von Kodolitsch, N. Zarniko, H. Baumgartner, R. Schmidt, A. Hellige, O. Tutarel, H. Kaemmerer, B. Kuschel, N. Nagdyman, R. Motz, D. Maisuradze, A. Frogoudaki, E. Iliodromitis, M. Anastasiou‐Nana, D. Triantafyllis, G. Bekiaris, H. Karvounis, G. Giannakoulas, D. Ntiloudi, S. A. Mouratoglou, A. Temesvari, H. Balint, D. Kohalmi, B. Merkely, C. Liptai, A. Nemes, T. Forster, A. Kalapos, K. Berek, K. Havasi, N. Ambrus, A. Shelke, R. Kawade, S. Patil, E. Martanto, T. M. Aprami, A. Purnomowati, C. J. Cool, M. Hasan, R. Akbar, S. Hidayat, T. I. Dewi, W. Permadi, D. A. Soedarsono, M. M. Ansari‐Ramandi, N. Samiei, A. Tabib, F. Kashfi, S. Ansari‐Ramandi, S. Rezaei, H. Ali Farhan, A. Al‐Hussein, G. Al‐Saedi, G. Mahmood, I. F. Yaseen, L. Al‐Yousuf, M. AlBayati, S. Mahmood, S. Raheem, T. AlHaidari, Z. Dakhil, P. Thornton, J. Donnelly, M. Bowen, A. Blatt, G. Elbaz‐Greener, A. Shotan, S. Yalonetsky, S. Goland, M. Biener, G. Egidy Assenza, M. Bonvicini, A. Donti, A. Bulgarelli, D. Prandstraller, C. Romeo, R. Crepaz, E. Sciatti, M. Metra, R. Orabona, L. Ait Ali, P. Festa, V. Fesslova, C. Bonanomi, M. Calcagnino, F. Lombardi, null Colli, M. W. Ossola, C. Gobbi, E. Gherbesi, L. Tondi, M. Schiavone, M. Squillace, M. G. Carmina, A. Maina, C. Macchi, E. Gollo, F. M. Comoglio, N. Montali, P. Re, R. Bordese, T. Todros, V. Donvito, W. Grosso Marra, G. Sinagra, B. D'Agata Mottolese, M. Bobbo, V. Gesuete, S. Rakar, F. Ramani, K. Niwa, D. Mekebekova, A. Mussagaliyeva, T. Lee, E. Mirrakhimov, S. Abilova, E. Bektasheva, K. Neronova, O. Lunegova, R. Žaliūnas, R. Jonkaitienė, J. Petrauskaitė, A. Laucevicius, D. Jancauskaite, L. Lauciuviene, L. Gumbiene, L. Lankutiene, S. Glaveckaite, M. Laukyte, S. Solovjova, V Rudiene, K. H. Chee, C. C.‐W. Yim, H. L. Ang, R. Kuppusamy, T. Watson, M. Caruana, M.‐E. Estensen, M. G. A. Mahmood Kayani, R. Munir, A. Tomaszuk‐Kazberuk, B. Sobkowicz, J. Przepiesc, A. Lesniak‐Sobelga, L. Tomkiewicz‐Pajak, M. Komar, M. Olszowska, P. Podolec, S. Wisniowska‐Smialek, M. Lelonek, U. Faflik, A. Cichocka‐Radwan, K. Plaskota, O. Trojnarska, N. Guerra, L. de Sousa, C. Cruz, V. Ribeiro, S. Jovanova, V. Petrescu, R. Jurcut, C. Ginghina, I. Mircea Coman, M. Musteata, O. Osipova, T. Golivets, I. Khamnagadaev, O. Golovchenko, A. Nagibina, I. Ropatko, I. R. Gaisin, L. Valeryevna Shilina, N. Sharashkina, E. Shlyakhto, O. Irtyuga, O. Moiseeva, E. Karelkina, I. Zazerskaya, A. Kozlenok, I. Sukhova, L. Jovovic, K. Prokšelj, M. Koželj, A. O. Askar, A. A. Abdilaahi, M. H. Mohamed, A. M. Dirir, K. Sliwa, P. Manga, A. Pijuan‐Domenech, L. Galian‐Gay, P. Tornos, M. T. Subirana, N. Murga, J. M. Oliver, B. Garcia‐Aranda Dominguez, I. Hernandez Gonzalez, J. F. Delgado Jimenez, P. Escribano Subias, A. Elbushi, A. Suliman, K. Jazzar, M. Murtada, N. Ahamed, M. Dellborg, E. Furenas, M. Jinesjo, K. Skoglund, P. Eriksson, T. Gilljam, U. Thilen, D. Tobler, K. Wustmann, F. Schwitz, M. Schwerzmann, T. Rutz, J. Bouchardy, M. Greutmann, B. M. Santos Lopes, L. Meier, M. Arrigo, K. de Boer, T. Konings, E. Wajon, L. J. Wagenaar, P. Polak, E. P. G. Pieper, J. Roos‐Hesselink, I. van Hagen, H. Duvekot, J. M. J. Cornette, C. De Groot, C. van Oppen, L. Sarac, O. Batukan Esen, S. Catirli Enar, C. Mondo, P. Ingabire, B. Nalwanga, T. Semu, B. T. Salih, W. A. R. Almahmeed, S. Wani, F. S. Mohamed Farook, Al Ain, F. Gerges, A. M. Komaranchath, F. Al bakshi, A. Al Mulla, A. H. Yusufali, E. I. Al Hatou, N. Bazargani, F. Hussain, L. Hudsmith, P. Thompson, S. Thorne, S. Bowater, A. Money‐Kyrle, P. Clifford, P. Ramrakha, S. Firoozan, J. Chaplin, N. Bowers, D. Adamson, F. Schroeder, R. Wendler, S. Hammond, P. Nihoyannopoulos, R. Hall, L. Freeman, G. Veldtman, J. Kerr, L. Tellett, N. Scott, A. B. Bhatt, D. DeFaria Yeh, M. A. Youniss, M. Wood, A. A. Sarma, S. Tsiaras, A. Stefanescu, J. M. Duran, L. Stone, D. S. Majdalany, J. Chapa, K. Chintala, P. Gupta, J. Botti, J. Ting, W. R. Davidson, G. Wells, D. Sparks, V. Paruchuri, K. Marzo, D. Patel, W. Wagner, S. N. Ahanya, L. Colicchia, T. Jentink, K. Han, M. Loichinger, M. Parker, C. Longtin, A. Yetman, K. Erickson, J. Cramer, S. Tsai, B. Fletcher, S. Warta, C. Cohen, C. Lindblade, R. Puntel, K. Nagaran, N. Croft, M. Gurvitz, C. Otto, C. Talluto, D. Murphy, M. G. Perlroth, ROPAC (Registry of Pregnancy and Cardiac Disease) Investigators Group, Gale, C.P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Erlinge, D., Emberson, J., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A., Nagy, K.V., Nedoshivin, A., Petronio, A.S., Roos-Hesselink, J., Wallentin, L., Zeymer, U., Hall, R., Stein, J., Parsonage, W.A., Budts, W., De Backer, J., Grewal, J., Marelli, A., Kaemmerer, H., Jondeau, G., Johnson, M., Maggioni, A.P., Tavazzi, L., Thilen, U., Elkayam, U., Otto, C., Sliwa, K., Aquieri, A., Saad, A., Ruda Vega, H., Hojman, J., Caparros, J.M., Vazquez Blanco, M., Arstall, M., Chung, C.M., Mahadavan, G., Aldridge, E., Wittwer, M., Chow, Y.Y., Lust, K., Collins, N., Warner, G., Hatton, R., Gordon, A., Nyman, E., Donhauser, E., Gabriel, H., Bahshaliyev, A., Guliyev, F., Hasanova, I., Jahangirov, T., Gasimov, Z., Salim, A., Ahmed, C.M., Begum, F., Hoque, M.H., Mahmood, M., Islam, M.N., Haque, P.P., Banerjee, S.K., Parveen, T., Morissens, M., Demulier, L., de Hosson, M., Beckx, M., Kozic, M., Lovric, M., Kovacevic-Preradovic, T., Chilingirova, N., Kratunkov, P., Wahab, N., McLean, S., Gordon, E., Walter, L., Montesclaros, A.R., Monsalve, G., Rodriguez, C., Balthazar, F., Quintero, V., Palacio, W., Mejía Cadavid, L.A., Munoz Ortiz, E., Fortich Hoyos, F., Arevalo Guerrero, E., Gandara Ricardo, J., Velasquez Penagos, J., Vavera, Z., Popelova, J., Vejlstrup, N., Grønbeck, L., Johansen, M., Ersboll, A., Elrakshy, Y., Eltamawy, K., Gamal Abd-El Aziz, M., El Nagar, A., Ebaid, H., Abo Elenin, H., Saed, M., Farag, S., Makled, W., Sorour, K., Ashour, Z., El-Sayed, G., Abdel Meguid Mahdy, M., Taha, N., Dardeer, A., Shabaan, M., Ali, M., Moceri, P., Duthoit, G., Gouton, M., Nizard, J., Baris, L., Cohen, S., Ladouceur, M., Khimoud, D., Iung, B., Berger, F., Olsson, A., Gembruch, U., Merz, W.M., Reinert, E., Clade, S., Kliesch, Y., Wald, C., Sinning, C., Kozlik-Feldmann, R., Blankenberg, S., Zengin-Sahm, E., Mueller, G., Hillebrand, M., Hauck, P., von Kodolitsch, Y., Zarniko, N., Baumgartner, H., Schmidt, R., Hellige, A., Tutarel, O., Kuschel, B., Nagdyman, N., Motz, R., Maisuradze, D., Frogoudaki, A., Iliodromitis, E., Anastasiou-Nana, M., Triantafyllis, D., Bekiaris, G., Karvounis, H., Giannakoulas, G., Ntiloudi, D., Mouratoglou, S.A., Temesvari, A., Balint, H., Kohalmi, D., Merkely, B., Liptai, C., Nemes, A., Forster, T., Kalapos, A., Berek, K., Havasi, K., Ambrus, N., Shelke, A., Kawade, R., Patil, S., Martanto, E., Aprami, T.M., Purnomowati, A., Cool, C.J., Hasan, M., Akbar, R., Hidayat, S., Dewi, T.I., Permadi, W., Soedarsono, D.A., Ansari-Ramandi, M.M., Samiei, N., Tabib, A., Kashfi, F., Ansari-Ramandi, S., Rezaei, S., Ali Farhan, H., Al-Hussein, A., Al-Saedi, G., Mahmood, G., Yaseen, I.F., Al-Yousuf, L., AlBayati, M., Mahmood, S., Raheem, S., AlHaidari, T., Dakhil, Z., Thornton, P., Donnelly, J., Bowen, M., Blatt, A., Elbaz-Greener, G., Shotan, A., Yalonetsky, S., Goland, S., Biener, M., Egidy Assenza, G., Bonvicini, M., Donti, A., Bulgarelli, A., Prandstraller, D., Romeo, C., Crepaz, R., Sciatti, E., Metra, M., Orabona, R., Ait Ali, L., Festa, P., Fesslova, V., Bonanomi, C., Calcagnino, M., Lombardi, F., Colli, C., Ossola, M.W., Gobbi, C., Gherbesi, E., Tondi, L., Schiavone, M., Squillace, M., Carmina, M.G., Maina, A., Macchi, C., Gollo, E., Comoglio, F.M., Montali, N., Re, P., Bordese, R., Todros, T., Donvito, V., Grosso Marra, W., Sinagra, G., D'Agata Mottolese, B., Bobbo, M., Gesuete, V., Rakar, S., Ramani, F., Niwa, K., Mekebekova, D., Mussagaliyeva, A., Lee, T., Mirrakhimov, E., Abilova, S., Bektasheva, E., Neronova, K., Lunegova, O., Žaliūnas, R., Jonkaitienė, R., Petrauskaitė, J., Laucevicius, A., Jancauskaite, D., Lauciuviene, L., Gumbiene, L., Lankutiene, L., Glaveckaite, S., Laukyte, M., Solovjova, S., Rudiene, V., Chee, K.H., Yim, C.C., Ang, H.L., Kuppusamy, R., Watson, T., Caruana, M., Estensen, M.E., Mahmood Kayani, MGA, Munir, R., Tomaszuk-Kazberuk, A., Sobkowicz, B., Przepiesc, J., Lesniak-Sobelga, A., Tomkiewicz-Pajak, L., Komar, M., Olszowska, M., Podolec, P., Wisniowska-Smialek, S., Lelonek, M., Faflik, U., Cichocka-Radwan, A., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Cruz, C., Ribeiro, V., Jovanova, S., Petrescu, V., Jurcut, R., Ginghina, C., Mircea Coman, I., Musteata, M., Osipova, O., Golivets, T., Khamnagadaev, I., Golovchenko, O., Nagibina, A., Ropatko, I., Gaisin, I.R., Valeryevna Shilina, L., Sharashkina, N., Shlyakhto, E., Irtyuga, O., Moiseeva, O., Karelkina, E., Zazerskaya, I., Kozlenok, A., Sukhova, I., Jovovic, L., Prokšelj, K., Koželj, M., Askar, A.O., Abdilaahi, A.A., Mohamed, M.H., Dirir, A.M., Manga, P., Pijuan-Domenech, A., Galian-Gay, L., Tornos, P., Subirana, M.T., Murga, N., Oliver, J.M., Garcia-Aranda Dominguez, B., Hernandez Gonzalez, I., Delgado Jimenez, J.F., Escribano Subias, P., Elbushi, A., Suliman, A., Jazzar, K., Murtada, M., Ahamed, N., Dellborg, M., Furenas, E., Jinesjo, M., Skoglund, K., Eriksson, P., Gilljam, T., Tobler, D., Wustmann, K., Schwitz, F., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Santos Lopes, B.M., Meier, L., Arrigo, M., de Boer, K., Konings, T., Wajon, E., Wagenaar, L.J., Polak, P., Pieper, EPG, van Hagen, I., Duvekot, H., Cornette, JMJ, De Groot, C., van Oppen, C., Sarac, L., Batukan Esen, O., Catirli Enar, S., Mondo, C., Ingabire, P., Nalwanga, B., Semu, T., Salih, B.T., Almahmeed, WAR, Wani, S., Mohamed Farook, F.S., Ain, A., Gerges, F., Komaranchath, A.M., Al Bakshi, F., Al Mulla, A., Yusufali, A.H., Al Hatou, E.I., Bazargani, N., Hussain, F., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Money-Kyrle, A., Clifford, P., Ramrakha, P., Firoozan, S., Chaplin, J., Bowers, N., Adamson, D., Schroeder, F., Wendler, R., Hammond, S., Nihoyannopoulos, P., Freeman, L., Veldtman, G., Kerr, J., Tellett, L., Scott, N., Bhatt, A.B., DeFaria Yeh, D., Youniss, M.A., Wood, M., Sarma, A.A., Tsiaras, S., Stefanescu, A., Duran, J.M., Stone, L., Majdalany, D.S., Chapa, J., Chintala, K., Gupta, P., Botti, J., Ting, J., Davidson, W.R., Wells, G., Sparks, D., Paruchuri, V., Marzo, K., Patel, D., Wagner, W., Ahanya, S.N., Colicchia, L., Jentink, T., Han, K., Loichinger, M., Parker, M., Longtin, C., Yetman, A., Erickson, K., Cramer, J., Tsai, S., Fletcher, B., Warta, S., Cohen, C., Lindblade, C., Puntel, R., Nagaran, K., Croft, N., Gurvitz, M., Talluto, C., Murphy, D., Perlroth, M.G., Neurosurgery, Pediatrics, Cardiology, ACS - Heart failure & arrhythmias, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Institut Català de la Salut, [Tutarel O] Department of Congenital Heart Disease and Paediatric Cardiology German Heart Centre MunichTechnical University of Munich School of MedicineTechnical University of Munich Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance Munich Germany. [Ramlakhan KP, Baris L] Department of Cardiology Erasmus University Medical Center Rotterdam the Netherlands. [Subirana MT] Unitat de Cardiopaties congènites de l’adult, Vall d'Hebron Hospital Universitari, Barcelona Spain. Hospital Sant Pau, Barcelona Spain. [Bouchardy J] Service of Cardiology University Hospital Lausanne and University of Lausanne Switzerland. Service of Cardiology University of Geneva Switzerland. [Nemes A] 2nd Department of Medicine and Cardiology Centre Medical Faculty Albert Szent-Györgyi Clinical Center University of Szeged Hungary, Szeged, Hungary, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Male, Transposition of Great Vessels, pregnancy outcomes, enfermedades cardiovasculares::anomalías cardiovasculares::cardiopatías congénitas::transposición de los grandes vasos [ENFERMEDADES], Disease, 030204 cardiovascular system & hematology, Sistema cardiovascular - Malalties, Ventricular tachycardia, Vasos sanguinis - Cirurgia, 0302 clinical medicine, Pregnancy, Clinical endpoint, Registries, 030212 general & internal medicine, Cardiovascular Diseases::Pregnancy Complications, Cardiovascular [DISEASES], Original Research, Aortic dissection, Pregnancy Outcome, Congenital Heart Disease, Other subheadings::Other subheadings::/surgery [Other subheadings], arterial switch operation, pregnancy and cardiac disease, transposition of the great arteries, Europe, Great arteries, Cardiology, enfermedades cardiovasculares::complicaciones cardiovasculares del embarazo [ENFERMEDADES], Female, Maternal death, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, diagnóstico::pronóstico::resultado del embarazo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Pregnancy Complications, Cardiovascular, Embaràs - Complicacions, Cardiovascular Diseases::Cardiovascular Abnormalities::Heart Defects, Congenital::Transposition of Great Vessels [DISEASES], Risk Assessment, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Heart Failure, business.industry, Infant, Newborn, Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], Diagnosis::Prognosis::Pregnancy Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], medicine.disease, Arterial Switch Operation, Heart failure, Tachycardia, Ventricular, business
Abstract: Embaràs i malaltia cardíaca; Resultats de l’embaràs; Transposició de les grans artèries Embarazo y enfermedad cardíaca; Resultados del embarazo; Transposición de las grandes arterias Pregnancy and cardiac disease; Pregnancy outcomes, Transposition of the great arteries Background In the past 3 decades, the arterial switch procedure has replaced the atrial switch procedure as treatment of choice for transposition of the great arteries. Although survival is superior after the arterial switch procedure, data on pregnancy outcomes are scarce and transposition of the great arteries after arterial switch is not yet included in the modified World Health Organization classification of maternal cardiovascular risk. Methods and Results The ROPAC (Registry of Pregnancy and Cardiac disease) is an international prospective registry of pregnant women with cardiac disease, part of the European Society of Cardiology EURObservational Research Programme. Pregnancy outcomes in all women after an arterial switch procedure for transposition of the great arteries are described. The primary end point was a major adverse cardiovascular event, defined as combined end point of maternal death, supraventricular or ventricular arrhythmias requiring treatment, heart failure, aortic dissection, endocarditis, ischemic coronary events, and thromboembolic events. Altogether, 41 pregnant women (mean age, 26.7±3.9 years) were included, and there was no maternal mortality. A major adverse cardiovascular event occurred in 2 women (4.9%): heart failure in one (2.4%) and ventricular tachycardia in another (2.4%). One woman experienced fetal loss, whereas no neonatal mortality was observed. Conclusions Women after an arterial switch procedure for transposition of the great arteries tolerate pregnancy well, with a favorable maternal and fetal outcome. During counseling, most women should be reassured that the risk of pregnancy is low. Classification as modified World Health Organization risk class II seems appropriate. Funding from “Zabawas Foundation” and “De Hoop Foundation” in addition to the support from EURObservational Research Programme (EORP) is greatly acknowledged. Since the start of EORP, the following companies have supported the program: Abbott Vascular Int (2011–2021), Amgen Cardiovascular (2009–2018), AstraZeneca (2014–2021), Bayer AG (2009–2018), Boehringer Ingelheim (2009–2019), Boston Scientific (2009–2012), The Bristol Myers Squibb and Pfizer Alliance (2011–2019), Daiichi Sankyo Europe GmbH (2011–2020), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–2017), Edwards (2016–2019), Gedeon Richter Plc (2014–2016), Menarini Int Op (2009–2012), MSD‐Merck & Co (2011–2014), Novartis Pharma AG (2014–2020), ResMed (2014–2016), Sanofi (2009–2011), SERVIER (2009–2021), and Vifor (2019–2022).
Published: 2021
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15. Management of acute cardiovascular complications in pregnancy

Author: Andrea Donti, Werner Budts, Jolien W. Roos-Hesselink, Gaetano Gargiulo, Gabriele Egidy Assenza, Michael J. Landzberg, Anne Marie Valente, Konstantinos Dimopoulos, Michael A. Gatzoulis, Katherine E. Economy, Egidy Assenza G., Dimopoulos K., Budts W., Donti A., Economy K.E., Gargiulo G.D., Gatzoulis M., Landzberg M.J., Valente A.M., and Roos-Hesselink J.
Subjects: Acute coronary syndrome, medicine.medical_specialty, Heart disease, Heart Diseases, Cardiovascular Complication, Population, Pregnancy Complications, Cardiovascular, Aortic dissection, Coronary Artery Disease, Coronary artery disease, Pregnancy, medicine, Humans, Intensive care medicine, education, Congenital heart disease, Heart Failure, education.field_of_study, business.industry, valvular heart disease, Pregnancy Outcome, Prenatal Care, medicine.disease, Valvular heart disease, Heart Disease, Heart failure, Female, Cardiology and Cardiovascular Medicine, business, Arrhythmia, Human
Abstract: The growing population of women with heart disease of reproductive age has been associated with an increasing number of high-risk pregnancies. Pregnant women with heart disease are a very heterogeneous population, with different risks for maternal cardiovascular, obstetric, and foetal complications. Adverse cardiovascular events during pregnancy pose significant clinical challenges, with uncertainties regarding diagnostic and therapeutic approaches potentially compromising maternal and foetal health. This review summarizes best practice for the treatment of common cardiovascular complications during pregnancy, based on expert opinion, current guidelines, and available evidence. Topics covered include heart failure (HF), arrhythmias, coronary artery disease, aortic and thromboembolic events, and the management of mechanical heart valves during pregnancy. Cardiovascular pathology is the leading cause of non-obstetric morbidity and mortality during pregnancy in developed countries. For women with pre-existing cardiac conditions, preconception counselling and structured follow-up during pregnancy are important measures for reducing the risk of acute cardiovascular complications during gestation and at the time of delivery. However, many women do not receive pre-pregnancy counselling often due to gaps in what should be lifelong care, and physicians are increasingly encountering pregnant women who present acutely with cardiac complications, including HF, arrhythmias, aortic events, coronary syndromes, and bleeding or thrombotic events. This review provides a summary of recommendations on the management of acute cardiovascular complication during pregnancy, based on available literature and expert opinion. This article covers the diagnosis, risk stratification, and therapy and is organized according to the clinical presentation and the type of complication, providing a reference for the practicing cardiologist, obstetrician, and acute medicine specialist, while highlighting areas of need and potential future research.
Published: 2021

16. Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease

Author: Jasmine Grewal, Lucia Baris, Jolien W Roos-Hesselink, Julie De Backer, Laurence Campens, Guillaume Jondeau, Antione Bondue, Mark R. Johnson, Craig S. Broberg, Nandita S. Scott, Roger Hall, Cardiology, Aquieri, A., Saad, A., Ruda Vega, H., Hojman, J., Caparros, J M, Vazquez Blanco, M., Arstall, M., Chung, C M, Mahadavan, G., Aldridge, E., Wittwer, M., Chow, Y Y, Parsonage, W A, Lust, K., Collins, N., Warner, G., Hatton, R., Gordon, A., Nyman, E., Stein, J., Donhauser, E., Gabriel, H., Bahshaliyev, A., Guliyev, F., Hasanova, I., Jahangirov, T., Gasimov, Z., Salim, A., Ahmed, C M, Begum, F., Mahmood, M., Islam, M N, Haque, P P, Banerjee, S K, Parveen, T., Morissens, M., De Backer, J., Demulier, L., de Hosson, M., Budts, W., Beckx, M., Kozic, M., Lovric, M., Kovacevic-Preradovic, T., Chilingirova, N., Kratunkov, P., Wahab, N., Gordon, E., Walter, L., Marelli, A., Montesclaros, A R, Monsalve, G., Rodriguez, C., Balthazar, F., Quintero, V., Palacio, W., Mejía Cadavid, L A, Munoz Ortiz, E., Fortich Hoyos, F., Arevalo Guerrero, E., Gandara Ricardo, J., Velasquez Penagos, J., Vavera, Z., Popelova, J., Vejlstrup, N., Grønbeck, L., Johansen, M., Ersboll, A., Elrakshy, Y., Eltamawy, K., Gamal Abd-El Aziz, M., El Nagar, A., Ebaid, H., Abo Elenin, H., Saed, M., Farag, S., Makled, W., Sorour, K., Ashour, Z., El-Sayed, G., Abdel Meguid Mahdy, M., Taha, N., Dardeer, A., Shabaan, M., Ali, M., Moceri, P., Duthoit, G., Gouton, M., Nizard, J., Baris, L., Cohen, S., Ladouceur, M., Khimoud, D., Iung, B., Berger, F., Olsson, A., Gembruch, U., Merz, W M, Reinert, E., Clade, S., Kliesch, Y., Sinning, C., Kozlik-Feldmann, R., Blankenberg, S., Zengin-Sahm, E., Mueller, G., Hillebrand, M., Hauck, P., von Kodolitsch, Y., Zarniko, N., Baumgartner, H., Hellige, A., Tutarel, O., Kaemmerer, H., Kuschel, B., Motz, R., Maisuradze, D., Frogoudaki, A., Iliodromitis, E., Anastasiou-Nana, M., Marousi, D., Triantafyllis, G., Bekiaris, H., Karvounis, G., Giannakoulas, D., Ntiloudi, S A, Mouratoglou, A., Temesvari, H Balint, Kohalmi, D., Merkely, B., Liptai, C., Nemes, A., Forster, T., Kalapos, A., Berek, K., Havasi, K., Ambrus, N., Shelke, A., Patil, S., Martanto, E., Aprami, T M, Purnomowati, A., Cool, C J, Hasan, M., Akbar, R., Hidayat, S., Dewi, T I, Permadi, W., Soedarsono, D A, Ansari-Ramandi, M M, Samiei, N., Tabib, A., Kashfi, F., Ansari-Ramandi, S., Rezaei, S., Ali Farhan, H., Al-Hussein, A., Al-Saedi, G., Mahmood, G., Yaseen, I F, Al-Yousuf, L., AlBayati, M., Mahmood, S., Raheem, S., AlHaidari, T., Dakhil, Z., Thornton, P., Donnelly, J., Bowen, M., Blatt, A., Elbaz-Greener, G., Shotan, A., Yalonetsky, S., Goland, S., Biener, M., Egidy Assenza, G., Bonvicini, M., Donti, A., Bulgarelli, A., Prandstraller, D., Romeo, C., Crepaz, R., Sciatti, E., Metra, M., Orabona, R., Ait Ali, L., Festa, P., Fesslova, V., Bonanomi, C., Calcagnino, M., Lombardi, F., Colli, A M, Ossola, M W, Gobbi, C., Gherbesi, E., Tondi, L., Schiavone, M., Squillace, M., Carmina, M G, Maina, A., Macchi, C., Gollo, E., Comoglio, F M, Montali, N., Re, P., Bordese, R., Todros, T., Donvito, V., Grosso Marra, W., Sinagra, G., D'Agata Mottolese, B., Bobbo, M., Gesuete, V., Rakar, S., Ramani, F., Niwa, K., Mekebekova, D., Mussagaliyeva, A., Lee, T., Mirrakhimov, E., Abilova, S., Bektasheva, E., Neronova, K., Lunegova, O., Žaliūnas, R., Jonkaitienė, R., Petrauskaitė, J., Laucevičius, Aleksandras, Žebrauskienė, Dovilė, Laučiuvienė, Laimutė, Gumbienė, Lina, Lankutienė, Lina, Glaveckaitė, Sigita, Laukytė, Monika, Solovjova, Svetlana, Rudienė, Virginija, C C-W, Yim, Ang, H L, Kuppusamy, R., Watson, T., Caruana, M., Estensen, M-E, Mahmood Kayani, M G A, Munir, R., Sobkowicz, B., Przepiesc, J., Lesniak-Sobelga, A., Tomkiewicz-Pajak, L., Komar, M., Olszowska, M., Podolec, P., Wisniowska-Smialek, S., Lelonek, M., Faflik, U., Cichocka-Radwan, A., Plaskota, K., Trojnarska, O., de Sousa, L., Cruz, C., Ribeiro, V., Jovanova, S., Petrescu, V., Jurcut, R., Ginghina, C., Mircea Coman, I., Musteata, M., Osipova, O., Golivets, T., Khamnagadaev, I., Golovchenko, O., Nagibina, A., Ropatko, I., Gaisin, I R, Valeryevna Shilina, L., Sharashkina, N., Shlyakhto, E., Irtyuga, O., Moiseeva, O., Karelkina, E., Zazerskaya, I., Kozlenok, A., Sukhova, I., Jovovic, L., Prokšelj, K., Koželj, M., Askar, A O, Abdilaahi, A A, Mohamed, M H, Sliwa, K., Manga, P., Galian-Gay, L., Tornos, P., Subirana, M T, Murga, N., Oliver, J M, Garcia-Aranda Dominguez, B., Hernandez Gonzalez, I., Escribano Subias, P., Elbushi, A., Suliman, A., Jazzar, K., Murtada, M., Ahamed, N., Dellborg, M., Furenas, E., Jinesjo, M., Skoglund, K., Eriksson, P., Gilljam, T., Thilen, U., Tobler, D., Wustmann, K., Schwitz, F., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Santos Lopes, B M, Meier, L., Arrigo, M., de Boer, K., Konings, T., Wajon, E., Wagenaar, L J, Polak, P., Pieper, E Pg, Roos-Hesselink, J., van Hagen, I., Duvekot, H., Cornette, J M J, De Groot, C., van Oppen, C., Sarac, L., Batukan Esen, O., Catirli Enar, S., Mondo, C., Ingabire, P., Nalwanga, B., Semu, T., Salih, B T, Almahmeed, W A R, Wani, S., Mohamed Farook, F S, Al Ain, F Gerges, Gerges, F., Komaranchath, A M, Al Bakshi, F., Al Mulla, A., Yusufali, A H, Al Hatou, E I, Bazargani, N., Hussain, F., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Money-Kyrle, A., Clifford, P., Ramrakha, P., Firoozan, S., Chaplin, J., Bowers, N., Adamson, D., Schroeder, F., Wendler, R., Nihoyannopoulos, P., Hall, R., Freeman, L., Veldtman, G., Kerr, J., Tellett, L., Scott, N., Bhatt, A B, DeFaria Yeh, D., Youniss, M A, Wood, M., Sarma, A A, Tsiaras, S., Stefanescu, A., Duran, J M, Stone, L., Majdalany, D S, Chapa, J., Chintala, K., Gupta, P., Botti, J., Ting, J., Davidson, W R, Wells, G., Sparks, D., Paruchuri, V., Marzo, K., Patel, D., Wagner, W., Ahanya, S N, Colicchia, L., Jentink, T., Han, K., Loichinger, M., Parker, M., Longtin, C., Yetman, A., Erickson, K., Tsai, S., Fletcher, B., Warta, S., Cohen, C., Lindblade, C., Puntel, R., Nagaran, K., Croft, N., Gurvitz, M., Otto, C., Talluto, C., Murphy, D., Perlroth, M G, and Jančauskaitė, Dovilė
Subjects: Marfan syndrome, Heart malformation, Aorta, Thoracic, Comorbidity, 030204 cardiovascular system & hematology, Global Health, Aortic aneurysm, 0302 clinical medicine, Bicuspid aortic valve, Pregnancy, Cause of Death, Turner syndrome, Medicine and Health Sciences, Prospective Studies, Registries, DISSECTION, Cause of death, Aortic dissection, 030219 obstetrics & reproductive medicine, Incidence, Pregnancy Outcome, WOMEN, Aortic and Vascular Disease, MARFAN-SYNDROME, Survival Rate, Marfan and associated disorders, aortic and arterial disease, aortic aneurysm, bicuspid aortic valve, pregnancy, Cardiology, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Heart Diseases, Pregnancy Complications, Cardiovascular, Aortic Diseases, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, business.industry, Infant, Newborn, medicine.disease, business
Abstract: BackgroundCardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy.MethodsThe ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease.ResultsThoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358–3390 g) vs 3270 g (2750–3570 g), p value 0.25).ConclusionThis ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good.
Published: 2021

17. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

Author: Regitz-Zagrosek, V, Roos-Hesselink, JW, Bauersachs, J, Blomström-Lundqvist, C, Cífková, R, De Bonis, M, Iung, B, Johnson, MR, Kintscher, U, Kranke, P, Lang, IM, Morais, J, Pieper, PG, Presbitero, P, Price, S, Rosano, GMC, Seeland, U, Simoncini, T, Swan, L, Warnes, CA, Deaton, C, Simpson, IA, Aboyans, V, Agewall, S, Barbato, E, Calda, P, Coca, A, Coman, IM, De Backer, J, Delgado, V, Di Salvo, G, Fitzsimmons, S, Fitzsimons, D, Garbi, M, Gevaert, S, Hindricks, G, Jondeau, G, Kluin, J, Lionis, C, McDonagh, TA, Meier, P, Moons, P, Pantazis, A, Piepoli, MF, Rocca, B, Roffi, M, Rosenkranz, S, Sarkozy, A, Shlyakhto, E, Silversides, CK, Sliwa, K, Sousa-Uva, M, Tamargo, J, Thorne, S, Van de Velde, M, Williams, B, Zamorano, JL, Windecker, S, Bueno, H, Collet, J-P, Dean, V, Gaemperli, O, Jüni, P, Katus, HA, Knuuti, J, Lancellotti, P, Leclercq, C, Ponikowski, P, Richter, DJ, Hammoudi, N, Piruzyan, A, Mascherbauer, J, Samadov, F, Prystrom, A, Pasquet, A, Caluk, J, Gotcheva, N, Skoric, B, Heracleous, H, Vejlstrup, N, Maser, M, Kaaja, RJ, Srbinovska-Kostovska, E, Mounier-Vehier, C, Vakhtangadze, T, Rybak, K, Giannakoulas, G, Kiss, RG, Thrainsdottir, IS, Erwin, RJ, Porter, A, Geraci, G, Ibrahimi, P, Lunegova, O, Mintale, I, Kadri, Z, Benlamin, H, Barysiene, J, Banu, CA, Caruana, M, Gratii, C, Haddour, L, Bouma, BJ, Estensen, M-E, Hoffman, P, Petris, AO, Moiseeva, O, Bertelli, L, Tesic, BV, Dubrava, J, Koželj, M, Prieto-Arévalo, R, Furenäs, E, Schwerzmann, M, Mourali, MS, Ozer, N, Mitchenko, O, Nelson-Piercy, C, Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomstrom-Lundqvist, C., Cifkova, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., Lang, I. M., Morais, J., Pieper, P. G., Presbitero, P., Price, S., Rosano, G. M. C., Seeland, U., Simoncini, T., Swan, L., Warnes, C. A., Regitz-Zagrosek, Vera, Roos-Hesselink, Jolien W, Bauersachs, Johann, Blomström-Lundqvist, Carina, Cífková, Renata, De Bonis, Michele, Iung, Bernard, Johnson, Mark Richard, Kintscher, Ulrich, Kranke, Peter, Lang, Irene Marthe, Morais, Joao, Pieper, Petronella G, Presbitero, Patrizia, Price, Susanna, Rosano, Giuseppe MC, Seeland, Ute, Simoncini, Tommaso, Swan, Lorna, Warnes, Carole A, and Cardiology
Subjects: Counseling, Prenatal Diagnosi, 030204 cardiovascular system & hematology, Guideline, Cardiovascular, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, Societies, Medical, Risk assessment, Advisory Committee, Advisory Committees, Cardiology, Cardiovascular Agents, Europe, Female, Humans, Poland, Pregnancy Complications, Cardiovascular, Practice Guidelines as Topic, valvular heart disease, Cardiovascular disease, Management, Hypertension, Drug therapy, Cardiology and Cardiovascular Medicine, Arrhythmia, Human, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, Cardiomyopathy, Heart failure, Cardiovascular therapy, Pulmonary hypertension, Aortic pathology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Medical, medicine, Cardiovascular diagnosis, Intensive care medicine, Congenital heart disease, Pharmacology, business.industry, ta3121, medicine.disease, Valvular heart disease, Pregnancy Complications, Cardiovascular System & Hematology, Cardiovascular Agent, Societies, business
Published: 2019

18. 2015 ESC Guidelines for the management of infective endocarditis

Author: Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, del Zotti, Francesco, Dulgheru, Raluca, El Khoury, Gebrine, Erba, Paola Anna, Iung, Bernard, Miro, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Tornos Mas, Pilar, Vilacosta, Isidre, Zamorano, Jose Luis, Erol, Çetin, Nihoyannopoulos, Petros, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, de Backer, Julie, de Bonis, Michele, Dimopoulos, Konstantinos, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulus, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y. H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, Walker, David M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, ACS - Amsterdam Cardiovascular Sciences, and Cardiology
Subjects: Microbiological Techniques, Embolism, Heart Valve Diseases, Guideline, Arrhythmias, Cardiovascular, Congenital, Postoperative Complications, Pregnancy, Recurrence, Risk Factors, Neoplasms, Ambulatory Care, Non-Infective, Pericarditis, Endocarditi, Musculoskeletal Diseases, Prophylaxi, Heart Defects, Cross Infection, Endocarditis, Thoracic Surgery, Cardiac surgery, Acute Kidney Injury, Prognosis, Operative, Anti-Bacterial Agents, Myocarditis, Prosthetic heart valve, Echocardiography, Female, Infection, Cardiology and Cardiovascular Medicine, Nuclear imaging, Infected, Cardiac, Diagnostic Imaging, Prosthesis-Related Infections, Critical Care, Prognosi, Guidelines, Prosthetic heart valves, Cardiac device, Risk Assessment, Valve disease, Cardiac imaging, Congenital heart disease, Prevention, Prophylaxis, Aneurysm, Infected, Antibiotic Prophylaxis, Arrhythmias, Cardiac, Clinical Laboratory Techniques, Dentistry, Operative, Endocarditis, Non-Infective, Fibrinolytic Agents, Heart Defects, Congenital, Heart Failure, Humans, Long-Term Care, Nervous System Diseases, Patient Care Team, Pregnancy Complications, Cardiovascular, Splenic Diseases, Thoracic Surgical Procedures, Endocarditis, Bacterial, Aneurysm, Pregnancy Complications, Dentistry
Abstract: Take-home message of the full 2015 ESC Guidelines, also endorsed by the European Association for Cardio-Thoracic Surgery, European Association of Nuclear Medicine, and European Society of Clinical Microbiology and Infectious Diseases.
Published: 2015

19. Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position

Author: Adriaan Moelker, Robert-Jan van Geuns, Mark R. Johnson, Petra Opic, Yusuf Karamermer, Alexia Rossi, Gabriel P. Krestin, Jérôme Cornette, Eric A.P. Steegers, Tirza Springeling, Jolien W. Roos-Hesselink, Rossi, Alexia, Cornette, J, Johnson, Mr, Karamermer, Y, Springeling, T, Opic, P, Moelker, A, Krestin, Gp, Steegers, E, Roos Hesselink, J, van Geuns, R. J., Radiology & Nuclear Medicine, Obstetrics & Gynecology, and Cardiology
Subjects: DYNAMICS, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiac output, Supine position, Cardiac & Cardiovascular Systems, INFORMATION, Hemodynamics, Atrial Function, Right, Ventricular Function, Left, Pregnancy, Supine Position, Cardiac Output, 1102 Cardiorespiratory Medicine and Haematology, Netherlands, Medicine(all), Ejection fraction, Radiological and Ultrasound Technology, Radiology, Nuclear Medicine & Medical Imaging, Stroke volume, CONGENITAL HEART-DISEASE, Nuclear Medicine & Medical Imaging, Cardiology, cardiovascular system, Gestation, LEFT-VENTRICULAR ANALYSIS, Atrial Function, Left, Female, Cardiac Magnetic Resonance, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Pregnancy Complications, Cardiovascular, Magnetic Resonance Imaging, Cine, Gestational Age, Patient Positioning, Young Adult, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, CARDIAC-OUTPUT, INTRACARDIAC PRESSURES, Congenital heart disease, Science & Technology, business.industry, Research, Stroke Volume, medicine.disease, LATERAL POSITIONS, POSTURE, lcsh:RC666-701, Case-Control Studies, Cardiovascular System & Cardiology, Ventricular Function, Right, business, Venous return curve
Abstract: Background There are physiological reasons for the effects of positioning on hemodynamic variables and cardiac dimensions related to altered intra-abdominal and intra-thoracic pressures. This problem is especially evident in pregnant women due to the additional aorto-caval compression by the enlarged uterus. The purpose of this study was to investigate the effect of postural changes on cardiac dimensions and function during mid and late pregnancy using cardiovascular magnetic resonance (CMR). Methods Healthy non-pregnant women, pregnant women at 20th week of gestation and at 32nd week of gestation without history of cardiac disease were recruited to the study and underwent CMR in supine and left lateral positions. Cardiac hemodynamic parameters and dimensions were measured and compared between both positions. Results Five non-pregnant women, 6 healthy pregnant women at mid pregnancy and 8 healthy pregnant women at late pregnancy were enrolled in the study. In the group of non-pregnant women left ventricular (LV) cardiac output (CO) significantly decreased by 9% (p = 0.043) and right ventricular (RV) end-diastolic volume (EDV) significantly increased by 5% (p = 0.043) from the supine to the left lateral position. During mid pregnancy LV ejection fraction (EF), stroke volume (SV), left atrium lateral diameter and left atrial supero-inferior diameter increased significantly from the supine position to the left lateral position: 8%, 27%, 5% and 11%, respectively (p < 0.05). RV EDV, SV and right atrium supero-inferior diameter significantly increased from the supine to the left lateral position: 25%, 31% and 13% (p < 0.05), respectively. During late pregnancy a significant increment of LV EF, EDV, SV and CO was observed in the left lateral position: 11%, 21%, 35% and 24% (p < 0.05), respectively. Left atrial diameters were significantly larger in the left lateral position compared to the supine position (p < 0.05). RV CO was significantly increased in the left lateral position compared to the supine position (p < 0.05). Conclusions During pregnancy positional changes affect significantly cardiac hemodynamic parameters and dimensions. Pregnant women who need serial studies by CMR should be imaged in a consistent position. From as early as 20 weeks the left lateral position should be preferred on the supine position because it positively affects venous return, SV and CO.
Published: 2011

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19 results on '"Hesselink, J"'

1. Pregnancy in Adult Congenital Heart Disease

2. Pregnant Women With Uncorrected Congenital Heart Disease Heart Failure and Mortality

3. Influence of socioeconomic factors on pregnancy outcome in women with structural heart disease

4. Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease Results From the Registry of Pregnancy and Cardiac Disease

5. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)

6. Validation of maternal cardiac output assessed by transthoracic echocardiography against pulmonary artery catheterization in severely ill pregnant women: prospective comparative study and systematic review.

7. ESC Guidelines on the management of cardiovascular diseases during pregnancy

8. Pregnancy in women with hypertrophic cardiomyopathy: data fromthe European Society of Cardiology initiated Registry of Pregnancy and Cardiac disease (ROPAC).

9. Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot.

10. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect.

11. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect.

12. Pregnancy, fertility, and recurrence risk in corrected tetralogy of Fallot.

13. Coronavirus disease 2019 in adults with congenital heart disease

14. Pregnancy Outcomes in Women After Arterial Switch Operation for Transposition of the Great Arteries: Results From ROPAC (Registry of Pregnancy and Cardiac Disease) of the European Society of Cardiology EURObservational Research Programme

15. Management of acute cardiovascular complications in pregnancy

16. Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease

17. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

18. 2015 ESC Guidelines for the management of infective endocarditis

19. Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position

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