Search

Your search keyword '"Arduino S"' showing total 7 results
Start Over Author "Arduino S" Topic pregnancy, twin
7 results on '"Arduino S"'

1. Maternal Circulating Vitamin D Level, Targeted Supplementation, and Perinatal Outcomes in Twin Pregnancy.

Author

Roero S, Ingala A, Arduino S, Folino Gallo M, Arese A, Ferrando I, Bossotti C, and Revelli A

Subjects
Humans, Female, Pregnancy, Adult, Hypertension, Pregnancy-Induced blood, Hypertension, Pregnancy-Induced epidemiology, Pregnancy Trimester, First blood, Pregnancy Complications blood, Vitamin D blood, Vitamin D administration & dosage, Vitamin D analogs & derivatives, Pregnancy, Twin blood, Dietary Supplements, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology, Pregnancy Outcome
Abstract

Background: Vitamin D deficiency is associated with several obstetric complications in singleton pregnancy. The aim of this study was to assess whether vitamin D levels affect the outcomes of twin pregnancy and if targeted supplementation can improve perinatal outcomes., Methods: The serum vitamin D levels of 143 women with twin pregnancies were measured during their first trimester. Those with insufficient (10-30 ng/mL; IL group) or severely deficient (<10 ng/mL, DL group) vitamin D levels were supplemented. In the third trimester, vitamin D levels were reassessed. Perinatal outcomes of the IL and DL groups were compared with those of patients with sufficient levels (>30 ng/mL, SL group) since the beginning of pregnancy., Results: Women in the IL and DL groups had a higher incidence of hypertensive disorders of pregnancy (HDP) compared to the SL group (24.8% and 27.8% vs. 12.5%, p = 0.045): OR = 1.58 for the IL group and 1.94 for the DL group compared to the SL group. In patients whose vitamin D levels were restored after supplementation, HDP incidence was lower than in patients who remained in the IL or DL groups (23.4% vs. 27.3%) but higher than those who were always in the SL group (12.5%)., Conclusions: Insufficient or severely deficient levels of vitamin D in the first trimester are associated with an increased risk of HDP in twin pregnancy. The beneficial effect of targeted vitamin D supplementation in reducing HDP seems limited.

Published
2024
Full Text
View/download PDF

2. Retrospective comparison of monochorionic diamniotic twin pregnancies stratified by spontaneous or artificial conception.

Author

Roero S, Arduino S, Arese A, Fea T, Ferrando I, Scaltrito G, Casula V, Ronco A, Bossotti C, Zizzo R, Scali R, and Revelli A

Subjects
Pregnancy, Infant, Newborn, Female, Humans, Retrospective Studies, Fertilization in Vitro adverse effects, Maternal Age, Pregnancy Outcome epidemiology, Pregnancy, Twin, Fertilization
Abstract

Objectives: To compare outcomes of monochorionic diamniotic (MCDA) twin pregnancies by in vitro fertilization (IVF) vs. spontaneously conceived counterparts., Methods: Retrospective comparison. Data about MCDA twin pregnancies, conceived spontaneously or by IVF, attending the Twin Pregnancy Care Unit of Sant'Anna Hospital in Turin (Italy) between January 1st 2010 and March 31st 2022, were collected retrospectively. Obstetric, fetal, and neonatal outcomes of MCDA twin pregnancies by IVF were compared to those of spontaneously conceived counterparts. Data were described by univariate and multivariate analysis., Results: 541 MCDA twin pregnancies were included in the study, among which 45 conceived by IVF and 496 spontaneously conceived. Women with IVF twins were older than those who conceived spontaneously (36.7 ± 5.7 vs. 32.1 ± 5.2 years; p<0.001). No significant difference in the prevalence of pregnancy complications between the two groups was found, except for an increased incidence of hypertensive disorders among IVF pregnancies (17.8 vs. 8.5 %; p=0.039), which resulted nonsignificant after adjusting for maternal age and parity (aOR 1.9, 95 % CI 0.8-4.6). Data about 1,046 live born babies (90 conceived by IVF and 956 spontaneously) were also collected: perinatal outcomes did not differ between the two groups., Conclusions: Our results suggest that MCDA twin pregnancies following IVF are not at increased risk of adverse outcomes compared to spontaneous MCDA twin pregnancies., (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)

Published
2023
Full Text
View/download PDF

3. Arabin cervical pessary to prevent preterm birth in twin pregnancies with short cervix.

Author

Di Tommaso M, Seravalli V, Arduino S, Bossotti C, Sisti G, and Todros T

Subjects
Adult, Case-Control Studies, Cervical Length Measurement, Female, Humans, Pregnancy, Pregnancy Complications etiology, Retrospective Studies, Cervix Uteri abnormalities, Pessaries, Pregnancy Complications therapy, Pregnancy, Twin, Premature Birth prevention & control
Abstract

A retrospective study was conducted to evaluate the effect of Arabin cervical pessary in twin pregnancies with cervical length (CL)  <25 mm between 21 and 31 weeks. Forty patients receiving pessary were matched with 40 controls without pessary. They were matched for gestational age (GA) at admission and CL. GA at delivery, delivery before 36, 34 and 32 weeks, latency between detection of short cervix and delivery, and duration of hospital admission were compared between groups. Women with the pessary delivered at higher GA compared to controls (35 vs. 33 weeks, p = 0.02). Cervical pessary significantly reduced the incidence of delivery  <36 and  < 34 weeks (p < 0.05), but not before 32 weeks. Interval between detection of short cervix and delivery was longer in the pessary group and duration of hospital admission was shorter (p = 0.03) compared to women without pessary.

Published
2016
Full Text
View/download PDF

4. Multiple pregnancies in CKD patients: an explosive mix.

Author

Piccoli GB, Arduino S, Attini R, Parisi S, Fassio F, Biolcati M, Pagano A, Bossotti C, Vasario E, Borgarello V, Daidola G, Ferraresi M, Gaglioti P, and Todros T

Subjects
Adult, Female, Humans, Hypertension, Pregnancy-Induced epidemiology, Italy epidemiology, Logistic Models, Multivariate Analysis, Pre-Eclampsia epidemiology, Pregnancy, Premature Birth epidemiology, Prevalence, Risk Factors, Pregnancy Complications epidemiology, Pregnancy Outcome epidemiology, Pregnancy, Multiple statistics & numerical data, Pregnancy, Twin statistics & numerical data, Renal Insufficiency, Chronic epidemiology
Abstract

Background and Objectives: CKD and multiple pregnancies bear important risks for pregnancy outcomes. The aim of the study was to define the risk for adverse pregnancy-related outcomes in multiple pregnancies in CKD patients in comparison with a control group of "low-risk" multiple pregnancies., Design, Setting, Participants, & Measurements: The study was performed in the Maternal Hospital of the University of Turin, Italy. Of 314 pregnancies referred in CKD (2000-2011), 20 were multiple (15 twin deliveries). Control groups consisted of 379 low-risk multiple pregnancies (314 twin deliveries) and 19 (15 twin deliveries) cases with hypertension-collagen diseases. Baseline data and outcomes were compared by univariate and logistic regression analyses., Results: The prevalence of multiple pregnancies was relatively high in the CKD population (6.4%); all referred cases were in early CKD stages (I-II); both creatinine (0.68 to 0.79 mg/dl; P=0.010) and proteinuria (0.81 to 3.42 g/d; P=0.041) significantly increased from referral to delivery. No significant difference in demographic data at baseline was found between cases and low-risk controls. CKD was associated with higher risk of adverse pregnancy outcomes versus low-risk twin pregnancies. Statistical significance was reached for preterm delivery (<34 weeks: 60% vs 26.4%; P=0.005; <32 weeks: 53.3% vs 12.7%; P<0.001), small for gestational age babies (28.6% vs 8.1%; P<0.001), need for Neonatal Intensive Care Unit (60% vs 12.7%; P<0.001), weight discordance between twins (40% vs 17.8%; P=0.032), and neonatal and perinatal mortality (6.6% vs 0.8%; P=0.032)., Conclusion: This study suggests that maternal-fetal risks are increased in multiple pregnancies in the early CKD stages.

Published
2013
Full Text
View/download PDF

5. Inpatientvsoutpatient management and timing of delivery of uncomplicated monochorionic monoamniotic twin pregnancy: the MONOMONO study

Author

Saccone, Gabriele, Berghella, Vincenzo, Locci, Mariavittoria, Ghi, Tullio, Frusca, Tiziana, Lanna, Mariano, Faiola, Stefano, Fichera, Anna, Prefumo, Federico, Rizzo, Giuseppe, Bosi, Costanza, Arduino, Bruno, D'Alessandro, Pietro, Borgo, Maria, Arduino, Silvana, Cantanna, Elisabetta, Simonazzi, Giuliana, Rizzo, Nicola, Francesca, Giorgetta, Seravalli, Viola, Miller, Jena L., Magro-Malosso, Elena Rita, Di Tommaso, Mariarosaria, Dall'Asta, Andrea, Galli, Letizia, Volpe, Nicola, Visentin, Silvia, Cosmi, Erich, Sarno, Laura, Caissutti, Claudia, Driul, Lorenza, Anastasio, Hannah, Di Mascio, Daniele, Panici, Pierluigi Benedetti, Vena, Flaminia, Brunelli, Roberto, Ciardulli, Andrea, D'Antonio, Francesco, Schoen, Corina, Suhag, Anju, Gambacorti-Passerini, Zita Maria, Baz, Maria Angeles Anaya, Magoga, Giulia, Busato, Enrico, Filippi, Elisa, Suárez, María José Rodriguez, Alderete, Francisco Gamez, Ortuno, Paula Alonso, Vitagliano, Amerigo, Mollo, Antonio, Raffone, Antonio, Vendola, Marianne, Navaneethan, Preethi, Wimalasundera, Ruwan, Napolitano, Raffaele, Aquino, Carmen Imma, D'Agostino, Serena, Gallo, Cinzia, Maruotti, Giuseppe Maria, Flacco, Maria Elena, Baschat, Ahmet A., Venturella, Roberta, Guida, Maurizio, Martinelli, Pasquale, Zullo, Fulvio, Saccone G, Berghella V, Locci M, Ghi T, Frusca T, Lanna M, Faiola S, Fichera A, Prefumo F, Rizzo G, Bosi C, Arduino B, D'Alessandro P, Borgo M, Arduino S, Cantanna E, Simonazzi G, Rizzo N, Francesca G, Seravalli V, Miller JL, Magro-Malosso ER, Di Tommaso M, Dall'Asta A, Galli L, Volpe N, Visentin S, Cosmi E, Sarno L, Caissutti C, Driul L, Anastasio H, Di Mascio D, Panici PB, Vena F, Brunelli R, Ciardulli A, D'Antonio F, Schoen C, Suhag A, Gambacorti-Passerini ZM, Baz MAA, Magoga G, Busato E, Filippi E, Suárez MJR, Alderete FG, Ortuno PA, Vitagliano A, Mollo A, Raffone A, Vendola M, Navaneethan P, Wimalasundera R, Napolitano R, Aquino CI, D'Agostino S, Gallo C, Maruotti GM, Flacco ME, Baschat AA, Venturella R, Guida M, Martinelli P, Zullo F., Saccone, G., Berghella, V., Locci, M., Ghi, T., Frusca, T., Lanna, M., Faiola, S., Fichera, A., Prefumo, F., Rizzo, G., Bosi, C., Arduino, B., D'Alessandro, P., Borgo, M., Arduino, S., Cantanna, E., Simonazzi, G., Rizzo, N., Francesca, G., Seravalli, V., Miller, J. L., Magro-Malosso, E. R., Di Tommaso, M., Dall'Asta, A., Galli, L., Volpe, N., Visentin, S., Cosmi, E., Sarno, L., Caissutti, C., Driul, L., Anastasio, H., Di Mascio, D., Panici, P. B., Vena, F., Brunelli, R., Ciardulli, A., D'Antonio, F., Schoen, C., Suhag, A., Gambacorti-Passerini, Z. M., Baz, M. A. A., Magoga, G., Busato, E., Filippi, E., Suarez, M. J. R., Alderete, F. G., Ortuno, P. A., Vitagliano, A., Mollo, A., Raffone, A., Vendola, M., Navaneethan, P., Wimalasundera, R., Napolitano, R., Aquino, C. I., D'Agostino, S., Gallo, C., Maruotti, G. M., Flacco, M. E., Baschat, A. A., Venturella, R., Guida, M., Martinelli, P., and Zullo, F.

Subjects
Cardiotocography, chorionicity, Twins, Cesarean delivery, cord accident, cord entanglement, healthcare, monochorionic, multiple gestation, perinatal death, respiratory distress syndrome, twin pregnancy, Radiological and Ultrasound Technology, Reproductive Medicine, Radiology, Nuclear Medicine and Imaging, Obstetrics and Gynecology, 0302 clinical medicine, Pregnancy, Nuclear Medicine and Imaging, Outpatients, Health care, Prenatal, Medicine, 030212 general & internal medicine, Twin Pregnancy, Monochorionic monoamniotic twin pregnancy, Ultrasonography, Cord entanglement, 030219 obstetrics & reproductive medicine, Obstetrics, Adult, Female, Fetal Death, Humans, Infant, Newborn, Inpatients, Length of Stay, Live Birth, Perinatal Death, Pregnancy, Twin, Prenatal Care, Retrospective Studies, Statistics, Nonparametric, Twins, Monozygotic, Ultrasonography, Prenatal, Perinatal Mortality, Statistics, General Medicine, cesarean delivery, health care, Radiology, medicine.medical_specialty, Socio-culturale, Monozygotic, Multiple Gestation, 03 medical and health sciences, Nonparametric, Radiology, Nuclear Medicine and imaging, business.industry, Infant, Twin, Newborn, Settore MED/40 - Ginecologia e Ostetricia, business, Outpatient management
Abstract

OBJECTIVES: Monoamniotic twin pregnancies are at increased risk of perinatal complications, primarily owing to the risk of cord entanglement. There is no recommendation on whether such pregnancies should be managed in hospital or can be safely managed in an outpatient setting, and the timing of planned delivery is also a subject of debate. The aim of this study was to compare the perinatal outcomes of inpatient vs outpatient fetal surveillance approaches employed among 22 participating study centers, and to calculate the fetal and neonatal death rates according to gestational age, in non-anomalous monoamniotic twins from 26 weeks' gestation. METHODS: The MONOMONO study was a multinational cohort study of consecutive women with monochorionic monoamniotic twin pregnancies, who were referred to 22 university hospitals in Italy, the USA, the UK and Spain, from January 2010 to January 2017. Only non-anomalous uncomplicated monoamniotic twin pregnancies with two live fetuses at 26 + 0 weeks' gestation were included in the study. In 10 of the centers, monoamniotic twins were managed routinely as inpatients, whereas in the other 12 centers they were managed routinely as outpatients. The primary outcome was intrauterine fetal death. We also planned to assess fetal and neonatal death rates according to gestational age per 1-week interval. Outcomes are presented as odds ratio (OR) with 95% CIs. The main outcome was analyzed using both standard logistic regression analysis, in which each fetus was treated as an independent unit, and a generalized mixed-model approach, with each twin pair treated as a cluster unit, considering that the outcome for a twin is not independent of that of its cotwin. RESULTS: 195 consecutive pregnant women with a non-anomalous uncomplicated monoamniotic twin gestation (390 fetuses) were included. Of these, 75 (38.5%) were managed as inpatients and 120 (61.5%) as outpatients. The overall perinatal loss rate was 10.8% (42/390) with a peak fetal death rate of 4.3% (15/348) occurring at 29 weeks' gestation. There was no significant difference in mean gestational age at delivery (31 weeks), birth weight (∼1.6 kg), or emergency delivery rate between the inpatient and outpatient surveillance groups. Based on generalized mixed-model analysis, there was no statistically significant difference in fetal death rates between inpatient management commencing from around 26 weeks compared with outpatient surveillance protocols from 30 weeks (3.3% vs 10.8%; adjusted OR 0.21 (95% CI, 0.04-1.17)). Maternal length of stay in the hospital was 42.1 days in the inpatient group, and 7.4 days in the outpatient group (mean difference 34.70 days (95% CI, 31.36-38.04 days). From 32 + 0 to 36 + 6 weeks, no fetal or neonatal death in either group was recorded. 46 fetuses were delivered after 34 + 0 weeks, and none of them died in utero or within the first 28 days postpartum. CONCLUSION: In uncomplicated monoamniotic twins, inpatient surveillance is associated with similar fetal mortality as outpatient management. After 31 + 6 weeks, and up to 36 + 6 weeks, there were no intrauterine fetal deaths or neonatal deaths. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Published
2018

6. Weight discordance and perinatal mortality in monoamniotic twin pregnancy: analysis of MONOMONO, NorSTAMP and STORK multiple-pregnancy cohorts

Author

Gabriele, Saccone, Asma, Khalil, Basky, Thilanagathan, Svetlana, Glinianaia, Vincenzo, Berghella, Francesco, D'Antonio, Mariavittoria, Locci, Tullio, Ghi, Tiziana, Frusca, Mariano, Lanna, Stefano, Faiola, Anna, Fichera, Federico, Prefumo, Giuseppe, Rizzo, Costanza, Bosi, Bruno, Arduino, Pietro, D'Alessandro, Maria, Borgo, Silvana, Arduino, Elisabetta, Cantanna, Giuliana, Simonazzi, Nicola, Rizzo, Giorgetta, Francesca, Viola, Seravalli, Miller, Jena L., Elena Rita Magro‐Malosso, Mariarosaria Di Tommaso, Andrea, Dall'Asta, Letizia, Galli, Nicola, Volpe, Silvia, Visentin, Erich, Cosmi, Laura, Sarno, Claudia, Caissutti, Lorenza, Driul, Hannah, Anastasio, DI MASCIO, Daniele, BENEDETTI PANICI, Pierluigi, Vena, Flaminia, Brunelli, Roberto, Andrea, Ciardulli, Corina, Schoen, Anju, Suhag, Zita Maria Gambacorti‐Passerini, Maria Angeles Anaya Baz, Giulia, Magoga, Enrico, Busato, Elisa, Filippi, María José Rodriguez Suárez, Francisco Gamez Alderete, Paula Alonso Ortuno, Amerigo, Vitagliano, Antonio, Mollo, Antonio, Raffone, Marianne, Vendola, Preethi, Navaneethan, Ruwan, Wimalasundera, Raffaele, Napolitano, Carmen Imma Aquino, Serena, D'Agostino, Cinzia, Gallo, Giuseppe Maria Maruotti, Maria Elena Flacco, Baschat, Ahmet A., Roberta, Venturella, Maurizio, Guida, Pasquale, Martinelli, Fulvio Zullo Therese Hannon, Sturgiss, Stephen N., Judith, Rankin, Nicola, Miller, Danielle, Martin, Arash, Bahamie, Amar, Bhide, Aris, Papageorghiou, Anne, Deans, Kim, Morgan, Michael, Egbor, Adetunji, Matiluko, Cheryl, Ellis, Hina, Gandhi, Rosol, Hamid, Renata, Hutt, Lesley, Roberts, Faz, Pakarian, Elisabeth, Peregrine, Saccone, G, Khalil, A, Thilaganathan, B, Glinianaia, Sv, Berghella, V, D'Antonio, F, Guida, M, et al., : MONOMONO, Norstamp, STORK research, Collaboratives, Papageorghiou, A, Saccone G1, Khalil A2,3, Thilaganathan B2,3, Glinianaia SV4, Berghella V5, D'Antonio F6, and MONOMONO, NorSTAMP and STORK research collaboratives. Zullo F, Locci M, Guida M, Anastasio H, Ghi T, Frusca T, Dall'Asta A, Galli L, Volpe N, Lanna M, Faiola S, Fichera A, Prefumo F, Rizzo G, Arduino S, Cantanna E, Simonazzi G, Seravalli V, Rita Magro-Malosso E, Di Tommaso M, L Miller J, A Baschat A, Vitagliano A, Visentin S, Cosmi E, Caissutti C, Driul L, Di Mascio D, Benedetti Panici P, Vena F, Brunelli R, Ciardulli A, Schoen C, Suhag A, Maria Gambacorti-Passerini Z, Angeles Anaya Baz M, Magoga G, Busato E, Filippi E, José Rodriguez Suárez M, Gamez Alderete F, Alonso Ortuno P, Vendola M, Navaneethan P, Wimalasundera R, Napolitano R, Mollo A, Imma Aquino C, D'Agostino S, Gallo C, Venturella R, Flacco M, Hannon T, N Sturgiss S, Rankin J, Miller N, Martin D, Bahamie A, Bhide A, Papageorghiou A, Deans A, Morgan K, Egbor M, Matiluko A, Ellis C, Gandhi H, Hamid R, Hutt R, Roberts L, Pakarian F, Peregrine E.

Subjects
chorionicity, Predictive Value of Test, Logistic regression, Cohort Studies, 0302 clinical medicine, Pregnancy, Risk of mortality, Birth Weight, 030212 general & internal medicine, Fetal Monitoring, Twin Pregnancy, 030219 obstetrics & reproductive medicine, Fetal Growth Retardation, Radiological and Ultrasound Technology, Obstetrics, Perinatal mortality, cord entanglement, Obstetrics and Gynecology, Cesarean delivery, healthcare, Prenatal Care, General Medicine, twin pregnancy, cesarean delivery, cord accident, health care, monochorionic, multiple gestation, perinatal death, respiratory distress syndrome, Fetal Weight, Female, Human, Adult, medicine.medical_specialty, Logistic Model, Risk Assessment, Multiple Gestation, 03 medical and health sciences, Predictive Value of Tests, medicine, Humans, Radiology, Nuclear Medicine and imaging, Perinatal Mortality, Fetus, business.industry, Infant, Newborn, Odds ratio, Twins, Monozygotic, medicine.disease, Logistic Models, Reproductive Medicine, ROC Curve, Pregnancy, Twin, Settore MED/40 - Ginecologia e Ostetricia, Cohort Studie, business
Abstract

Objectives:The primary objective was to quantify the risk of perinatal mortality in non‐anomalous monochorionic monoamniotic (MCMA) twin pregnancies complicated by birth‐weight (BW) discordance. The secondary objectives were to investigate the effect of inpatientvsoutpatient fetal monitoring on the risk of mortality in weight‐discordant MCMA twin pregnancies, and to explore the predictive accuracy of BW discordance for perinatal mortality. Methods:This analysis included data on 242 MCMA twin pregnancies (484 fetuses) from three major research collaboratives on twin pregnancy (MONOMONO, STORK and NorSTAMP). The primary outcomes were the risks of intrauterine (IUD), neonatal (NND) and perinatal (PND) death, according to weight discordance at birth from ≥ 10% to ≥ 30%. The secondary outcomes were the association of inpatientvsoutpatient fetal monitoring with the risk of mortality in weight‐discordant pregnancies, and the accuracy of BW discordance in predicting mortality. Logistic regression and receiver‐operating‐characteristics‐curve analyses were used to analyze the data. Results:The risk of IUD was significantly increased in MCMA twin pregnancies with BW discordance ≥ 10% (odds ratio (OR), 2.2; 95% CI, 1.1–4.4;P= 0.022) and increased up to an OR of 4.4 (95% CI, 1.3–14.4;P= 0.001) in those with BW discordance ≥ 30%. This association remained significant on multivariate logistic regression analysis for BW‐discordance cut‐offs ≥ 20%. However, weight discordance had low predictive accuracy for mortality, with areas under the receiver‐operating‐characteristics curve of 0.60 (95% CI, 0.46–0.73), 0.52 (95% CI, 0.33–0.72) and 0.57 (95% CI, 0.45–0.68) for IUD, NND and PND, respectively. There was no difference in the risk of overall IUD, single IUD, double IUD, NND or PND between pregnancies managed as an inpatient compared with those managed as an outpatient, for any BW‐discordance cut‐off. Conclusions:MCMA twin pregnancies with BW discordance are at increased risk of fetal death, signaling a need for increased levels of monitoring. Despite this, the predictive accuracy for mortality is low; thus, detection of BW discordance alone should not trigger intervention, such as iatrogenic delivery. The current data do not demonstrate an advantage of inpatient over outpatient management in these cases. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

Published
2020

7. Development of customized fetal growth charts in twins

Author

Giuseppe Ettore, C. Zanardini, Paolo Volpe, Enrico Periti, Giuseppe Maria Maruotti, E. Pappalardo, S. Visentin, Claudio Celentano, Giuseppe Rizzo, Tullia Todros, Nicola Persico, Nicola Volpe, Tullio Ghi, Domenico Arduini, N. Chianchiano, S. Arduino, Enrico Ferrazzi, Pantaleo Greco, Tiziana Frusca, Mariangela Rustico, Mariano Lanna, A. Mazzocco, I. Lauriola, C. Di Pietro, Anna Fichera, E. Aiello, E. V. Cosmi, A. Piastra, Sandro Gabrielli, E. Viora, Danila Morano, V. D’addario, Simona Boito, Federico Prefumo, Tamara Stampalija, Graziano Clerici, Ghi, T., Prefumo, F., Fichera, A., Lanna, M., Periti, E., Persico, N., Viora, E., Rizzo, G., Arduini, D., Arduino, S., Aiello, E., Boito, S., Celentano, C., Chianchiano, N., Clerici, G., Cosmi, E., D'Addario, V., Di Pietro, C., Ettore, G., Ferrazzi, E., Frusca, T., Gabrielli, S., Greco, P., Lauriola, I., Maruotti, G. M., Mazzocco, A., Morano, D., Pappalardo, E., Piastra, A., Rustico, M., Todros, T., Stampalija, T., Visentin, S., Volpe, N., Volpe, P., and Zanardini, C.

Subjects
Parents, fetal biometric parameter, Sex Factor, fetal biometric parameters, fetal growth restriction, Fetal Development, 0302 clinical medicine, Obstetrics and gynaecology, Retrospective Studie, Pregnancy, Abdomen, Fetal growth, Prenatal, 030212 general & internal medicine, Femur, Growth Charts, Twin Pregnancy, parental characteristics, Ultrasonography, fetal growth, twin pregnancies, Obstetrics and Gynecology, 030219 obstetrics & reproductive medicine, Biparietal diameter, Obstetrics, embryonic structures, Gestation, Female, Monochorionic twins, Human, Adult, medicine.medical_specialty, Cephalometry, twin pregnancie, Body Height, Body Weight, Humans, Retrospective Studies, Sex Factors, Pregnancy, Twin, Ultrasonography, Prenatal, NO, 03 medical and health sciences, medicine, Gynecology, Fetus, business.industry, Twin, parental characteristic, medicine.disease, Growth Chart, Parent, Settore MED/40 - Ginecologia e Ostetricia, business
Abstract

Background Twin gestations are at significantly higher risk of fetal growth restriction in comparison with singletons. Using fetal biometric charts customized for obstetrical and parental characteristics may facilitate an accurate assessment of fetal growth. Objective The objective of the study was to construct reference charts for the gestation of fetal biometric parameters stratified by chorionicity and customized for obstetrical and parental characteristics. Study Design Fetal biometric measurements obtained from serial ultrasound examinations in uncomplicated twin pregnancies delivering after 36 weeks of gestation were collected by 19 Italian fetal medicine units under the auspices of the Societa Italiana di Ecografia Ostetrica e Ginecologica. The measurements acquired in each fetus at each examination included biparietal diameter, head circumference, abdominal circumference, and femur length. Multilevel linear regression models were used to adjust for the serial ultrasonographic measurements obtained and the clustering of each fetus in twin pregnancy. The impact of maternal and paternal characteristics (height, weight, ethnicity), parity, fetal sex, and mode of conception was also considered. Models for each parameter were stratified by fetal chorionicity and compared with our previously constructed growth curves for singletons. Results The data set included 1781 twin pregnancies (dichorionic, n = 1289; monochorionic diamniotic, n = 492) with 8923 ultrasonographic examinations with a median of 5 (range, 2–8) observations per pregnancy in dichorionic and 6 in (range, 2–11) monochorionic pregnancies. Growth curves of twin pregnancies differed from those of singletons, and differences were more marked in monochorionic twins and during the third trimester. A significant influence of parental characteristics was found. Conclusion Curves of fetal biometric measurements in twins are influenced by parental characteristics. There is a reduction in the growth rate during the third trimester. The reference limits for gestation constructed in this study may provide a useful tool for a more accurate assessment of fetal growth in twin pregnancies.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results