1. PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders.
- Author
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Palomer X, Barroso E, Pizarro-Delgado J, Peña L, Botteri G, Zarei M, Aguilar D, Montori-Grau M, and Vázquez-Carrera M
- Subjects
- Animals, Humans, Metabolic Diseases drug therapy, Metabolic Diseases metabolism, Molecular Targeted Therapy methods, PPAR delta genetics, PPAR delta metabolism, PPAR-beta genetics, PPAR-beta metabolism, Metabolic Diseases genetics, PPAR delta agonists, PPAR-beta agonists
- Abstract
Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
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