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Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [ 11 C]CO 2 conversion into the highly reactive methylating agents [ 11 C]CH 3 I and [ 11 C]CH 3 OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind “[ 11 C]kit” for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses. [ABSTRACT FROM AUTHOR]