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Your search keyword '"Chevallier, Camille"' showing total 4 results
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4 results on '"Chevallier, Camille"'

1. Tedanolide C: a potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp.

Author

Chevallier C, Bugni TS, Feng X, Harper MK, Orendt AM, and Ireland CM

Subjects
Animals, Cell Cycle drug effects, Drug Screening Assays, Antitumor, HCT116 Cells, Humans, Macrolides isolation & purification, Magnetic Resonance Spectroscopy methods, Magnetic Resonance Spectroscopy standards, Molecular Conformation, Reference Standards, Stereoisomerism, Structure-Activity Relationship, Macrolides chemistry, Macrolides pharmacology, Porifera chemistry
Abstract

Cytotoxicity-guided fractionation of the crude methanol extract of a marine sponge, Ircinia sp., yielded tedanolide C (1), a new 18-membered macrolide. The structure was solved by interpreting NMR and MS data, and the relative stereochemistry was determined from a combination of homo- and heteronuclear coupling constants in conjunction with molecular modeling. Compound 1 exhibited potent cytotoxicity against HCT-116 cells in vitro. Cell cycle analysis showed that treatment of cells with compound 1 arrested cells in the S-phase.

Published
2006
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2. Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp.

Author

Rubnov S, Chevallier C, Thoison O, Debitus C, Laprevote O, Guénard D, and Sévenet T

Subjects
Alkaloids chemistry, Alkaloids pharmacology, Animals, Antineoplastic Agents, Phytogenic chemistry, Humans, Indole Alkaloids chemistry, Inhibitory Concentration 50, KB Cells drug effects, Sulfonic Acids chemistry, Antineoplastic Agents, Phytogenic pharmacology, Indole Alkaloids pharmacology, Phytotherapy, Porifera, Sulfonic Acids pharmacology
Abstract

A new bromoindolesulfonic acid derivative, echinosulfonic acid D (1) was isolated from the New-Caledonian sponge Psammoclemma sp. in a minute quantity. The structure of the alkaloid was established by spectroscopic methods and, in particular, by ESI MSn experiments. Echinosulfonic acid D was cytotoxic to KB cells (IC50 2 microg/mL).

Published
2005
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3. Isolation of cytotoxic chondropsins, macrolide lactams from the New-Caledonian marine sponge Psammoclemma sp. and electrospray ion trap multiple stage MS study of these macrolides.

Author

Chevallier C, Laprévote O, Bignon J, Debitus C, Guénard D, and Sévenet T

Subjects
Animals, Antineoplastic Agents, Phytogenic chemistry, Cell Cycle drug effects, Cell Line, Tumor drug effects, Flow Cytometry, HL-60 Cells drug effects, Humans, Inhibitory Concentration 50, KB Cells drug effects, Lactams chemistry, Lactams pharmacology, Macrolides chemistry, Macrolides pharmacology, Mass Spectrometry, Antineoplastic Agents, Phytogenic pharmacology, Porifera
Abstract

Psammoclemma sp. (Phoriospongiidae) was selected for study through biological screening carried out in New Caledonia. The crude extract of Psammoclemma sp. was highly active on KB cells and its fractionation led to the isolation of two macrolides chondropsin A 1 and 73-deoxychondropsin A 2. The complex structures were elucidated by a combination of spectroscopic methods (NMR, ESI-MS/MS). These known compounds were evaluated for their cytotoxic activity towards several tumor cell lines and exhibited an IC50 of approximately 10(-10) M. Flow-cytometric analysis revealed that chondropsin A 1 and 73-deoxychondropsin A 2 blocked the entry of HL 60 and KB cells into G2/M phase, leading to cell death by apoptosis.

Published
2004
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4. A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp.

Author

Chevallier C, Richardson AD, Edler MC, Hamel E, Harper MK, and Ireland CM

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oligopeptides chemistry, Tubulin metabolism, Oligopeptides isolation & purification, Oligopeptides pharmacology, Porifera chemistry, Tubulin chemistry
Abstract

[structure: see text] The crude methanol extract of a marine sponge Cymbastela sp. collected in Papua New Guinea was selected for chemical investigation due to its significant cytotoxicity. Fractionation of the extract led to the isolation of jaspamide (1), hemiasterlin (2), milnamide A (3), and a new metabolite, milnamide D (4). The structure was solved by interpretation of NMR and mass spectra data. The cytotoxic and antitubulin activities of milnamide D (4) were evaluated.

Published
2003
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