1. Preparation of coix seed oil bioactive delivery systems based on homologous polysaccharides and proteins.
- Author
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Chen LC, Kong YP, Zheng Y, Zhang SY, Zhang LY, and Wang JY
- Subjects
- Cell Line, Tumor, Cell Survival drug effects, Drug Carriers chemistry, Drug Compounding, Drug Delivery Systems, Humans, Nanoparticles chemistry, Nanoparticles ultrastructure, Particle Size, Plant Oils pharmacology, Polysaccharides pharmacology, Coix chemistry, Plant Oils chemistry, Polysaccharides chemistry, Proteins chemistry, Seeds chemistry
- Abstract
Natural products belonging to a class of generally-recognized-as-safe biomaterials have exceptional biocompatibility and biodegradability and can be used as delivery vehicles for a variety of functional foods. Adlay (Coix lacryma-jobi), is a nutritious food, rich in various bioactive ingredients. Coix seed oil extract (CSO) is also bioactive but it is sensitive to oxidation. In this study, a bioactive delivery system based on homologous polysaccharides and proteins was developed to deliver coix seed oil. The results show that the CSO nanoparticles have high encapsulation efficiency, narrow particle size distribution, and good stability. Moreover, the fusion of the nanoparticles with the membrane enabled the transport of CSO through the Caco-2 cell monolayer and improved the intestinal permeability. These findings could provide useful information for designing homologous polysaccharide and protein-based delivery systems to increase the bioavailability of lipophilic nutraceuticals in the food industry., Competing Interests: Declaration of competing interest None, (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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