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Your search keyword '"Gong Ga, Lan Zi"' showing total 2 results
Start Over Author "Gong Ga, Lan Zi" Topic polymorphism, restriction fragment length
2 results on '"Gong Ga, Lan Zi"'

1. Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population.

Author

Guo WJ, Gong-ga-lan-zi, Ou-zhu-luo-bu, Ma XH, Wang YC, Pu Z, Wei G, Ji YL, Wang Z, Yan CY, Ba-sang-zhu-ma, Shi XM, Liu XH, Collier DA, Ball D, and Li T

Subjects
Adult, Alcohol Drinking epidemiology, Alcohol Drinking ethnology, Alleles, China epidemiology, China ethnology, Female, Humans, Male, Middle Aged, Polymerase Chain Reaction, Tibet epidemiology, Tibet ethnology, Alcohol Drinking genetics, Cytochrome P-450 CYP2E1 genetics, Polymorphism, Restriction Fragment Length
Abstract

Objective: To investigate the relationship between the CYP2E1*c1/*c2 polymorphism and alcohol use disorders, and the potential influence of the CYP2E1*c1/*c2 polymorphism on the severity and dimensions of alcohol use disorders in Tibetan., Methods: Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test (AUDIT) score >or=10 and another 315 matched control subjects with AUDIT score

Published
2008

2. Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population

Author

Wan-jun, Guo, Gong-ga-lan-zi, Ou-zhu-luo-bu, Xiao-hong, Ma, Ying-cheng, Wang, Zhen, Pu, Geng, Wei, Yu-lin, Ji, Zheng, Wang, Cheng-yin, Yan, Ba-sang-zhu-ma, Xiao-ming, Shi, Xie-he, Liu, David A, Collier, David, Ball, and Tao, Li

Subjects
Adult, Male, China, Alcohol Drinking, Humans, Cytochrome P-450 CYP2E1, Female, Middle Aged, Tibet, Polymerase Chain Reaction, Alleles, Polymorphism, Restriction Fragment Length
Abstract

To investigate the relationship between the CYP2E1*c1/*c2 polymorphism and alcohol use disorders, and the potential influence of the CYP2E1*c1/*c2 polymorphism on the severity and dimensions of alcohol use disorders in Tibetan.Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test (AUDIT) scoreor=10 and another 315 matched control subjects with AUDIT scoreor=5 were enrolled. The CYP2E1*c1/*c2 polymorphism was determined by the standard PCR-RFLP method.The frequency of the CYP2E1*c2 allele in subjects with alcohol use disorders (16.2%) was significantly higher than that of the controls (10.8%), with a P value of 0.005 and OR value of 1.60 (95% CI: 1.15 approximately 2.21). There was also a significant difference in genotype frequencies between the 2 groups (chi2=8.75, P=0.01). Subjects with alcohol use disorders had higher frequencies of genotypes with at least one copy of allele c2 (28.5% vs. 18.7%; chi2=8.65, P=0.003; OR=1.73) than the control group. The association of CYP2E1*c2 allele with alcohol use disorders was much stronger in males than in females, with a male OR value of 2.30. CYP2E1*c2 allele was associated with increased alcohol consumption and alcohol use disorders in males.There is the positive association among CYP2E1*c2 allele, alcohol use disorders, and the amount of alcohol consumption in Tibetan population.

Published
2008

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