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1. Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism.

Author

Norell MC, Andersson HS, and Nicholls IA

Subjects
Caffeine administration & dosage, Caffeine pharmacokinetics, Chromatography, High Pressure Liquid, Delayed-Action Preparations, Drug Delivery Systems, Humans, In Vitro Techniques, Kinetics, Spectrophotometry, Ultraviolet, Theophylline pharmacokinetics, Molecular Mimicry, Polymers, Theophylline administration & dosage
Abstract

The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release drug dosage form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non-imprinted (reference) polymers have been observed.

Published
1998
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