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Polymerization‐induced self‐assembly (PISA) with (in situ) encapsulation of (therapeutic) cargo has proven to be an efficient preparation method for loaded polymeric micelles and polymersomes, thereby presenting significant opportunities in the field of drug delivery. However, despite extensive research efforts, no significant advances toward systematic in vivo studies or clinical applications have been achieved to date. In this Review, we outline the current state‐of‐the‐art of cargo encapsulation via PISA with a specific focus on developments achieved in the past 5 years. Considering the general requirements for functional drug delivery systems, we identify the major hurdles that still need to be overcome in order to push PISA‐derived systems from a promising academic exercise to viable candidates for clinical translation. [ABSTRACT FROM AUTHOR]

We report a switchable, templated polymerization system where the strength of the templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through a dendritic polyamidoamine‐based template of which the charge density depends on pH. The dendrimers act as a template for the polymerization of an oppositely charged monomer, namely sodium styrene sulfonate. We show that the rate of polymerization and maximum achievable monomer conversion are directly related to the charge density of the template, and hence the environmental pH. The polymerization could effectively be switched "ON" and "OFF" on demand, by cycling between acidic and alkaline reaction environments. These findings break ground for a novel concept, namely harnessing co‐assembly of a template and growing polymer chains with tunable association strength to create and control coupled polymerization and self‐assembly pathways of (charged) macromolecular building blocks. [ABSTRACT FROM AUTHOR]

B Polymerisationen b Philipp Gerdt und Armido Studer berichten in ihrem Forschungsartikel (e202206964) über eine Methode für die Synthese von funktionalisierten alternierenden Copolymeren durch radikalische Polymerisation mit reversibler Deaktivierung. Keywords: Complex Core Coacervate Micelles; PIESA; Polyelectrolytes; RAFT Polymerization; Templated Polymerizations EN Complex Core Coacervate Micelles PIESA Polyelectrolytes RAFT Polymerization Templated Polymerizations 1 1 1 09/21/22 20220926 NES 220926 B Schaltbare templatierte Polymerisationen b werden von Bas G. P. van Ravensteijn, Ilja K. Voets et al. in ihrem Forschungsartikel vorgestellt (e202206780). Complex Core Coacervate Micelles, PIESA, Polyelectrolytes, RAFT Polymerization, Templated Polymerizations. [Extracted from the article]

Keywords: Complex Core Coacervate Micelles; PIESA; Polyelectrolytes; RAFT Polymerization; Templated Polymerizations EN Complex Core Coacervate Micelles PIESA Polyelectrolytes RAFT Polymerization Templated Polymerizations 1 1 1 09/21/22 20220926 NES 220926 B Switchable templated polymerization b is reported by Bas G. P. van Ravensteijn, Ilja K. Voets et al. in their Research Article (e202206780), as illustrated in the cover picture. Cover Picture: Switchable Electrostatically Templated Polymerization (Angew. Complex Core Coacervate Micelles, PIESA, Polyelectrolytes, RAFT Polymerization, Templated Polymerizations. [Extracted from the article]

Wereport a versatile emulsion-based synthesis for the preparationof nanometer-sized dumbbell-shaped particles that contain two chemicallydifferent patches. One patch consists of solely polystyrene and istherefore chemically inert toward most chemical reactions. The otherpatch contains reactive surface chlorine groups. To achieve this,we prepared seed particles with a chlorinated surface that were transformedinto dumbbell-shaped particles by introducing a liquid styrene protrusionon the surface, which was polymerized to form a solid, anisotropiccolloidal particle. The chlorinated layer on the seed particles providesboth sufficient hydrophilicity to set a finite contact angle betweenthe liquid protrusion and the seed particle and a chemical handlefor further site-specific modification of the reactive patch. Thechlorine groups can be easily converted to other functionalities,making these particles an ideal platform for the preparation of colloidswith complex (surface) properties. As an example, it was shown thatthis patch could participate in copper-catalyzed Huisgen 1,3-dipolarcycloaddition reactions after conversion of the chlorines to azides.This very robust form of click chemistry allows us to decorate thereactive patch with a wide variety of molecules. [ABSTRACT FROM AUTHOR]