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Your search keyword '"Luo, Lian-Zhong"' showing total 2 results
Start Over Author "Luo, Lian-Zhong" Topic polyketides
2 results on '"Luo, Lian-Zhong"'

1. Asperochratides A-J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus.

Author

Zou ZB, Zhang G, Li SM, He ZH, Yan QX, Lin YK, Xie CL, Xia JM, Luo ZH, Luo LZ, and Yang XW

Subjects
Anti-Inflammatory Agents pharmacology, Antineoplastic Agents pharmacology, Cell Line, Tumor, Complex Mixtures pharmacology, Drug Evaluation, Preclinical, Humans, Models, Molecular, Molecular Conformation, Nitric Oxide metabolism, Polyketides pharmacology, Anti-Inflammatory Agents chemistry, Antineoplastic Agents chemistry, Aspergillus ochraceus chemistry, Complex Mixtures chemistry, Polyketides chemistry, Seawater microbiology
Abstract

Ten new C 9 polyketides (asperochratides A-J, 1-10) and 14 known miscellaneous compounds (11-24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo 2 (OAc) 4 induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1-11 and 16-18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5-8 and 13-17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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2. Cladosporactone A, a Unique Polyketide with 7-Methylisochromen-3-one Skeleton from the Deep-Sea-Derived Fungus Cladosporium cladosporioides.

Author

He ZH, Zhang G, Yan QX, Zou ZB, Xiao HX, Xie CL, Tang XX, Luo LZ, and Yang XW

Subjects
Circular Dichroism, Cladosporium isolation & purification, Cladosporium metabolism, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Conformation, Polyketides isolation & purification, Cladosporium chemistry, Polyketides chemistry, Seawater microbiology
Abstract

A unique polyketide cladosporactone A along with eight known compounds were isolated from the deep-sea-derived Cladosporium cladosporioides. The structure of cladosporactone A was established by spectroscopic analyses, and the absolute configuration was clarified by the theoretical ECD calculation. Cladosporactone A is the first member of polyketide with the 7-methylisochromen-3-one skeleton., (© 2020 Wiley-VHCA AG, Zurich, Switzerland.)

Published
2020
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