1. Fentanyl and fentanyl-analog involvement in drug-related deaths
- Author
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James C. Kraner, Gordon S. Smith, Allen R. Mock, Marie A. Abate, and Zheng Dai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Poison control ,Toxicology ,Article ,Heroin ,Fentanyl ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Injury prevention ,medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Mortality ,Medical prescription ,Retrospective Studies ,Pharmacology ,Illicit Drugs ,business.industry ,Middle Aged ,West Virginia ,United States ,Analgesics, Opioid ,Psychiatry and Mental health ,Alprazolam ,Hydrocodone ,Female ,Drug Overdose ,business ,Oxycodone ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background To describe and analyze the involvement of fentanyl and fentanyl analogs (FAs) in drug-related deaths in West Virginia (WV), United States. Methods Retrospective analyses of all WV drug-related deaths from 2005 to 2017 were performed, including comparisons of demographic and toxicological characteristics among total deaths, deaths in which fentanyl/FAs were present, deaths in which they were absent, heroin-related deaths, and prescription opioid-related deaths. Results Most of the 8813 drug-related deaths were overdoses, with about 11% resulting from transportation/other injuries in which drugs were contributors. Prescription opioid presence (without fentanyl) decreased by 75% from 2005–14 to 2015–17 (3545 deaths to 859 deaths, respectively), while fentanyl involvement in the deaths increased by 122% between these periods (487 to 1082 deaths). Ten FAs were identified (427 instances) after 2015. Alprazolam and ethanol were among the top five most frequently identified substances across years. Fentanyl, heroin and cocaine replaced oxycodone, diazepam and hydrocodone in the top five beginning in 2015. Few decedents had a prescription for fentanyl after 2015, with fewer prescriptions also present for other controlled substances identified. Conclusions Fentanyl, rapidly emerging FAs, and other illicit drugs in recent years pose a serious health threat even though prescription opioid-related deaths decreased over the same time period.
- Published
- 2019
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