Search

Your search keyword '"Penza, O."' showing total 2 results
Start Over Author "Penza, O." Topic pneumonia
2 results on '"Penza, O."'

1. Community-acquired pneumonia in adults: a multicentric observational AIPO study.

Author

Logroscino CD, Penza O, Locicero S, Losito G, Nardini S, Bertoli L, Cioffi R, and Del Prato B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Chi-Square Distribution, Community-Acquired Infections drug therapy, Community-Acquired Infections microbiology, Community-Acquired Infections mortality, Comorbidity, Female, Humans, Italy epidemiology, Male, Middle Aged, Pneumonia drug therapy, Pneumonia mortality, Prospective Studies, Risk Factors, Pneumonia microbiology
Abstract

The aim of this study was to obtain reliable data about the current aetiology (i.e. the frequency of the individual pathogens) of community-acquired pneumonia (CAP) while surveying the diagnostic and therapeutic behaviour of Italian chest physicians, compared with existing guidelines, and to test the usefulness of the current severity "criteria" or score as a predictor of disease outcome and guide for appropriate hospitalization. A prospective multicentre observational trial was carried out between October 1994 and February 1996 by the Italian Association of Hospital Pneumologists (AIPO) study group on respiratory infections. A total of 613 consecutive patients suffering from CAP were enrolled in 25 centres throughout Italy. Clinical, radiological and microbiological data were collected and patients were followed-up until complete resolution or death. Aetiological tests were not carried out in 204 patients. In the remaining 409 cases, the aetiology was defined by serological and quantitative microbiological tests in 184 (44.9%) patients. A total of 194 strains of pathogen were detected. The most frequently detected micro-organism was Streptococcus pneumoniae (18.5% of pathogen strains) but, unlike in other series of patients, high percentages of intracellular pathogens (32.5%, all with serological confirmation, mostly due to Chlamydia pneumoniae (13.4%) and of Gram-negative enterobacteria and Pseudomonas aeruginosa (12.5%) were also found. Antibiotic treatment differed from that recommended in American Thoracic Society guidelines, with a greater use of third-generation cephalosporins. Overall, a higher rate of hospitalization and a lower death rate than in other comparable studies was observed.

Published
1999

2. GP management of community-acquired pneumonia in Italy: The ISOCAP study

Author

Sanguinetti, C. M., Benedetto, F., Donner, C. F., Del Prato, B., Fogliani, V., Lorgroscino, C., Mistretta, A., Schito, G., Cacciani, G., GIORGIO WALTER CANONICA, Dolcetti, A., Falcone, F., Lo Cicero, S., Neri, M., Pozzi, E., Schiavina, M., Munafò, G., Parentini, G., Penza, O., Principe, R. S., Saltini, C., Tubaldi, A., Agati, G., Crimi, N., Ferrara, G., Francesca, F., Lsedda, M., Logroscino, C., Mirabella, S., Moretti, A., Picciolo, F., Viola, B., Parola, D., and Zanello, A.

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Community-acquired pneumonia, diagnosis, lcsh:Medicine, Physical examination, remission, medicine, COPD, medicine.diagnostic_test, treatment, business.industry, Mortality rate, Incidence (epidemiology), lcsh:R, medicine.disease, Pneumonia, Concomitant, general practitioner, pulmonary specialist, Ceftriaxone, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background. Community-Acquired Pneumonia (CAP) is still a significant problem in terms of incidence, mortality rate, particularly in infants and the elderly, and socioeconomic burden. General Practitioners (GPs) are the first reference for patients with this disease, but there are few published studies regarding the outpatient treatment of CAP. Methods. The ISOCAP study aimed to identify the type and outcome of the diagnostic-therapeutic management of CAP by GPs in Italy, within the framework of developing a closer interrelationship between GPs and pulmonary specialists. Thirty-six Pulmonary Divisions throughout Italy each contacted 5 local GPs who agreed to recruit the first 5 consecutive patients who consulted them for suspected CAP within the study’s 1-year observation period. Results. A total of 183 GPs took part in the study and enrolled, by the end of the observation period, 763 CAP patients; of these, complete data was available for 737 patients [males=373, females=364, mean age (±SD) 58.8±19.6 years]. 64.4% of patients had concomitant diseases, mainly systemic arterial hypertension and COPD. Diagnosis of CAP was based by GPs on physical examination only in 41.6% of cases; in the remaining chest X-ray was also performed. In only 4.6% of patients were samples sent for microbiological analysis. All patients were treated with antibiotics: 76.7% in mono-therapy, 23.3% with a combination of antibiotics. The antibiotic class most prevalently used in mono-therapy was cephalosporin, primarily ceftriaxone; the most frequently used combinations were cephalosporin+macrolide and cephalosporin+quinolone. Mono-therapy was effective in 70% of cases, the combination of two or more antibiotics in 91.2% of patients. Overall treatment efficacy was 94.7%; hospitalisation was required in 8.5% of cases. Conclusions. Outpatient management of CAP by GPs in Italy is effective, hospitalisation being necessary only in the most severe cases due to age, co-morbidities or extent of pneumonia. This signifies a very significant savings in national health costs.

Catalog

Books, media, physical & digital resources
See catalog results