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Atomic force microscopy was used to identify the early stages of intravascular platelet activation in patients with stable angina and in patients with unstable ischemic heart disease to characterize hemostasiological status of the patients. A comparative analysis of morpho-functional platelet parameters has shown the increase of intravascular platelet activation and the formation of spontaneous platelet aggregates in bloodstream in patients with unstable angina.

Atomic force microscopy was used to estimate the intravascular platelet activation and determine local elastic modulus, adhesion and stiffness of the platelets membrane in patients with end-stage of chronic heart failure with heart ventricle implantation before surgery and intrasurgical: before the heparin injection, after the heparin injection and after neutralization of heparin with protamine.