1. Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251.
- Author
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Portmann C, Sieber S, Wirthensohn S, Blom JF, Da Silva L, Baudat E, Kaiser M, Brun R, and Gademann K
- Subjects
- Animals, Myoblasts drug effects, Nuclear Magnetic Resonance, Biomolecular, Parasitic Sensitivity Tests, Peptides, Cyclic chemistry, Rats, Trypanosoma brucei rhodesiense drug effects, Microcystis chemistry, Peptides, Cyclic isolation & purification, Plasmodium falciparum drug effects
- Abstract
The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
- Published
- 2014
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