1. Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile
- Author
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Baro, Barbara, Deroost, Katrien, Raiol, Tainá, Brito, Marcelo, Almeida, Anne C.G., de Menezes-Neto, Armando, Figueiredo, Erick F. G., Alencar, Aline, Leitão, Rodrigo, Val, Fernando, Monteiro, Wuelton, Oliveira, Anna, Armengol, Maria del Pilar, Fernández Becerra, Carmen, Lacerda, Marcus V., del Portillo, Hernando A., and Universitat Autònoma de Barcelona
- Subjects
0301 basic medicine ,Male ,Pathology ,Plasmodium ,Physiology ,Plasmodium vivax ,Sang ,Disease ,Gametocytes ,Biochemistry ,0302 clinical medicine ,Animal Cells ,Bone Marrow ,Immune Physiology ,Medicine and Health Sciences ,Erythropoiesis ,biology ,lcsh:Public aspects of medicine ,Middle Aged ,Body Fluids ,Nucleic acids ,Infectious Diseases ,medicine.anatomical_structure ,Blood ,Anatomy ,Cellular Types ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030231 tropical medicine ,Immunology ,Spleen ,Bone Marrow Cells ,03 medical and health sciences ,Erythroid Cells ,parasitic diseases ,Parasite Groups ,medicine ,Gametocyte ,Parasitic Diseases ,Genetics ,Malaria, Vivax ,Humans ,Non-coding RNA ,Symposium ,Public Health, Environmental and Occupational Health ,Biology and Life Sciences ,lcsh:RA1-1270 ,Cell Biology ,biology.organism_classification ,medicine.disease ,Gene regulation ,Hematopoiesis ,MicroRNAs ,030104 developmental biology ,Germ Cells ,Immune System ,RNA ,Parasitology ,Bone marrow ,Gene expression ,Physiological Processes ,Transcriptome ,Apicomplexa ,Malaria - Abstract
Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease and burden [1]. The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as an accessory to examinations of peripheral blood in malaria, including P. vivax [3]. Since then, little progress has been made in studying P. vivax infections in this tissue. One report explored accumulation of dyserythropoietic cells in anaemic infected patients [4]. In addition, two case studies reported P. vivax infections after autologous bone marrow transplantation [5][6], and a third one documented an accidental P. vivax infection due to bone marrow transplantation between a malaria-infected donor and a malaria-free receptor [7]. In Brazil, one patient with persistent thrombocytopaenia and an enlarged spleen was diagnosed with chronic P. vivax malaria after the finding of schizonts in the bone marrow aspirate [8]. In all these reports and case studies, however, parasite loads and life stages found in the bone marrow were not investigated, and no molecular tools were available to rule out mixed infections or to characterize specific parasite stages.
- Published
- 2017