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The present work objective are to investigate indigenous plants used in wound healing in India, we hereby reported our findings related to wound healing activities of plant Solanum xanthocarpum Schrad and Wendl (Solanaceae) from some in vitro and in vivo model studies. The plant ethanolic extracts of the leaves of Solanum xanthocarpum was identified qualitative phytochemical constituents and tested wound healing activity. The important secondary metabolites alkaloid, glycosides, saponins, carbohydrates, tannins, phenolic compounds, protein, and fats were identified in extracts. Solanum xathocarpum leaves ethanolic extract showed wound healing activity significantly in the excision and incision wound model in rats on topical application. The animals were divided into five groups with six rats in each group. Topically applied 10% w/v of plant Solanum xanthocarpum leaves extracts in saline taking Silver Sulphadizine ointment as standard. The results showed that ethanolic extract of Solanum xathocarpum leaves on topical application was reduced the epithelization period from 25.30±0.23 to 19.75±0.28 days control and ethanol extract respectively along with a marked decrease in the scar area from 53.88±0.42 to 37.76±0.17 mm2 control and ethanol extract respectively. Significant increase in tensile strength and hydroxyproline content of plant extract were also observed and compared to the control and silver sulphadiazine. The above result revealed that the ethanol extract has remarkable wound healing potency and appear to justify the traditional use of Solanum xanthocarpum in wound healing in India and offer a scientific support to the treatment of traditional healers.